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Aliases for GBP1 Gene

Aliases for GBP1 Gene

  • Guanylate Binding Protein 1, Interferon-Inducible 2 3
  • Guanylate Binding Protein 1, Interferon-Inducible, 67kDa 2 3
  • Guanine Nucleotide-Binding Protein 1 3 4
  • GTP-Binding Protein 1 3 4
  • HuGBP-1 3 4
  • GBP-1 3 4
  • Interferon-Induced Guanylate-Binding Protein 1 3

External Ids for GBP1 Gene

Previous GeneCards Identifiers for GBP1 Gene

  • GC01M089994
  • GC01M088687
  • GC01M088854
  • GC01M088985
  • GC01M088986
  • GC01M089230
  • GC01M089290
  • GC01M089517
  • GC01M087635

Summaries for GBP1 Gene

Entrez Gene Summary for GBP1 Gene

  • Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]

GeneCards Summary for GBP1 Gene

GBP1 (Guanylate Binding Protein 1, Interferon-Inducible) is a Protein Coding gene. Diseases associated with GBP1 include pseudopseudohypoparathyroidism and aneurysmal bone cysts. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include identical protein binding and GTPase activity. An important paralog of this gene is GBP7.

UniProtKB/Swiss-Prot for GBP1 Gene

  • Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.

Gene Wiki entry for GBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBP1 Gene

Genomics for GBP1 Gene

Regulatory Elements for GBP1 Gene

Genomic Location for GBP1 Gene

Start:
89,052,304 bp from pter
End:
89,065,360 bp from pter
Size:
13,057 bases
Orientation:
Minus strand

Genomic View for GBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GBP1 Gene

Proteins for GBP1 Gene

  • Protein details for GBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32455-GBP1_HUMAN
    Recommended name:
    Interferon-induced guanylate-binding protein 1
    Protein Accession:
    P32455
    Secondary Accessions:
    • D3DT26
    • Q5T8M1

    Protein attributes for GBP1 Gene

    Size:
    592 amino acids
    Molecular mass:
    67931 Da
    Quaternary structure:
    • Homodimerizes upon GTP-binding, dimerization is required for the second hydrolysis step from GDP to GMP. Can also heterodimerize with other members of the family.

    Three dimensional structures from OCA and Proteopedia for GBP1 Gene

neXtProt entry for GBP1 Gene

Proteomics data for GBP1 Gene at MOPED

Post-translational modifications for GBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GBP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GBP1 Gene

Domains for GBP1 Gene

Protein Domains for GBP1 Gene

Suggested Antigen Peptide Sequences for GBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32455

UniProtKB/Swiss-Prot:

GBP1_HUMAN :
  • P32455
Domain:
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with GBP1: view

No data available for Gene Families for GBP1 Gene

Function for GBP1 Gene

Molecular function for GBP1 Gene

GENATLAS Biochemistry: guanylate binding protein 1,67kDa,interferon inducibleGTPase converting GTP to GMP,mediating an antiviral effect against stomatites virus and encephalomyocarditis virus
UniProtKB/Swiss-Prot Function: Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
UniProtKB/Swiss-Prot Induction: By IFNG/IFN-gamma during macrophage activation, and by TNF-alpha and IL-1beta.

Gene Ontology (GO) - Molecular Function for GBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 24337748
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 24337748
GO:0005525 GTP binding IEA --
GO:0019899 enzyme binding IPI 24337748
genes like me logo Genes that share ontologies with GBP1: view
genes like me logo Genes that share phenotypes with GBP1: view

Animal Model Products

CRISPR Products

miRNA for GBP1 Gene

miRTarBase miRNAs that target GBP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GBP1 Gene

Localization for GBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GBP1 Gene

Cytoplasm. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Secreted. Note=Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of interferon-gamma induction. Golgi membrane localization requires isoprenylation and the presence of another IFN-gamma-induced factor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GBP1 Gene COMPARTMENTS Subcellular localization image for GBP1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
cytosol 4
cytoskeleton 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005576 extracellular region IEA --
GO:0005794 Golgi apparatus --
GO:0005829 cytosol TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with GBP1: view

Pathways for GBP1 Gene

genes like me logo Genes that share pathways with GBP1: view

Pathways by source for GBP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • JAK / STAT Signaling Pathway in human,mouse,rat
    • Type I Interferon Response in human,mouse,rat

Gene Ontology (GO) - Biological Process for GBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0008152 metabolic process IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0050848 regulation of calcium-mediated signaling IMP 24337748
GO:0050860 negative regulation of T cell receptor signaling pathway IMP 24337748
genes like me logo Genes that share ontologies with GBP1: view

Compounds for GBP1 Gene

(1) HMDB Compounds for GBP1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(4) Novoseek inferred chemical compound relationships for GBP1 Gene

Compound -log(P) Hits PubMed IDs
guanylate 82 25
gdp 63 1
gtp 59 7
guanine 27.5 1
genes like me logo Genes that share compounds with GBP1: view

Transcripts for GBP1 Gene

Unigene Clusters for GBP1 Gene

Guanylate binding protein 1, interferon-inducible:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GBP1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GBP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for GBP1 Gene

GeneLoc Exon Structure for
GBP1
ECgene alternative splicing isoforms for
GBP1

Expression for GBP1 Gene

mRNA expression in normal human tissues for GBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GBP1 Gene

SOURCE GeneReport for Unigene cluster for GBP1 Gene Hs.62661

genes like me logo Genes that share expressions with GBP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GBP1 Gene

Orthologs for GBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GBP1 35
  • 99.04 (n)
  • 98.82 (a)
GBP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 82 (a)
ManyToMany
LOC512486 35
  • 85.07 (n)
  • 82.79 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 80 (a)
OneToMany
GBP1 35
  • 84.29 (n)
  • 80.51 (a)
mouse
(Mus musculus)
Mammalia Gbp2 16
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Gbp1 35
  • 78.73 (n)
  • 72.73 (a)
chicken
(Gallus gallus)
Aves GBP7 35
  • 59.46 (n)
  • 49.61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10068 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-209n20.1 35
  • 59.24 (n)
  • 54.89 (a)
si:ch211-209n20.1 36
  • 53 (a)
ManyToMany
Species with no ortholog for GBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GBP1 Gene

ENSEMBL:
Gene Tree for GBP1 (if available)
TreeFam:
Gene Tree for GBP1 (if available)

Paralogs for GBP1 Gene

Paralogs for GBP1 Gene

Selected SIMAP similar genes for GBP1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for GBP1 Gene

genes like me logo Genes that share paralogs with GBP1: view

Variants for GBP1 Gene

Sequence variations from dbSNP and Humsavar for GBP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2624 -- 89,052,940(+) TCTAA(C/T)GGATA utr-variant-3-prime
rs2625 -- 89,052,822(-) GAATC(C/T)CTTTA utr-variant-3-prime
rs7911 -- 89,052,437(-) TTGAC(C/T)CATTT utr-variant-3-prime
rs14866 -- 89,052,467(-) GAAGA(A/G)AATAT utr-variant-3-prime
rs1048401 - 89,060,283(-) AAGGA(A/G)TCTGG reference, missense, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GBP1 Gene

Variant ID Type Subtype PubMed ID
dgv68e1 CNV Complex 17122850
esv33356 CNV Loss 17666407

Relevant External Links for GBP1 Gene

HapMap Linkage Disequilibrium report
GBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBP1 Gene

Disorders for GBP1 Gene

(4) Novoseek inferred disease relationships for GBP1 Gene

Disease -log(P) Hits PubMed IDs
kaposi sarcoma 30.2 1
necrosis 3.61 3
inflammation 0.997 2
tumors 0.501 4

Relevant External Links for GBP1

Genetic Association Database (GAD)
GBP1
Human Genome Epidemiology (HuGE) Navigator
GBP1
genes like me logo Genes that share disorders with GBP1: view

No data available for UniProtKB/Swiss-Prot for GBP1 Gene

Publications for GBP1 Gene

  1. The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1. (PMID: 7518790) Strehlow I. … Decker T. (Gene 1994) 2 3 23
  2. Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1. (PMID: 8830800) Nantais D.E. … Buss J.E. (J. Leukoc. Biol. 1996) 3 4 23
  3. Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins. (PMID: 10676968) Prakash B. … Herrmann C. (Nature 2000) 3 4 23
  4. Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor. (PMID: 15937107) Modiano N. … Cresswell P. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23
  5. Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of patients with bacterial meningitis. (PMID: 16936281) Naschberger E. … Sturzl M. (Am. J. Pathol. 2006) 3 4 23

Products for GBP1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • JAK / STAT Signaling Pathway in human,mouse,rat
    • Type I Interferon Response in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate GBP1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for GBP1
  • Block miRNA regulation of GBP1 using miScript Target Protectors

Sources for GBP1 Gene

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