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Aliases for EHF Gene

Aliases for EHF Gene

  • Ets Homologous Factor 2 3
  • ESE3 3 4 6
  • Epithelium-Specific Ets Transcription Factor 3 3 4
  • ETS Domain-Containing Transcription Factor 3 4
  • ESE3 Transcription Factor 2 3
  • ESE3B 3 4
  • ESEJ 3 4
  • HEHF 3 4
  • Epithelium-Specific Ets Factor 3 2
  • ESE-3 4

External Ids for EHF Gene

Previous GeneCards Identifiers for EHF Gene

  • GC11P036195
  • GC11P035320
  • GC11P034681
  • GC11P034606
  • GC11P034339

Summaries for EHF Gene

Entrez Gene Summary for EHF Gene

  • This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for EHF Gene

EHF (Ets Homologous Factor) is a Protein Coding gene. Diseases associated with EHF include allergic urticaria and vertebrobasilar insufficiency. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ELF4.

UniProtKB/Swiss-Prot for EHF Gene

  • Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.

Gene Wiki entry for EHF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EHF Gene

Genomics for EHF Gene

Regulatory Elements for EHF Gene

Genomic Location for EHF Gene

Start:
34,621,041 bp from pter
End:
34,663,288 bp from pter
Size:
42,248 bases
Orientation:
Plus strand

Genomic View for EHF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EHF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EHF Gene

Proteins for EHF Gene

  • Protein details for EHF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZC4-EHF_HUMAN
    Recommended name:
    ETS homologous factor
    Protein Accession:
    Q9NZC4
    Secondary Accessions:
    • D3DR08
    • D3DR10
    • E9PSB2
    • Q9H509
    • Q9UKF9
    • Q9Y5V4
    • Q9Y5V5

    Protein attributes for EHF Gene

    Size:
    300 amino acids
    Molecular mass:
    34892 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EHF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EHF Gene

Proteomics data for EHF Gene at MOPED

Post-translational modifications for EHF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EHF Gene

Domains for EHF Gene

Protein Domains for EHF Gene

Suggested Antigen Peptide Sequences for EHF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZC4

UniProtKB/Swiss-Prot:

EHF_HUMAN :
  • Q9NZC4
Domain:
  • The PNT domain acts as a transcriptional activator.
  • Contains 1 ETS DNA-binding domain.
  • Contains 1 PNT (pointed) domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with EHF: view

No data available for Gene Families for EHF Gene

Function for EHF Gene

Molecular function for EHF Gene

GENATLAS Biochemistry: ETS homologous factor,ETS transcription regulator family,differentially expressed in normal tissues and carcinomas,noteworthy in carcinomas associated with an 11p12 deletion (see TSG11G) repressing ETS2 induced activity of stromelysin 1 (MMP3) and collagenase 1 (MMP8) promoters
UniProtKB/Swiss-Prot Function: Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.
UniProtKB/Swiss-Prot Induction: By IL1B/interleukin-1 beta and TNF in bronchial smooth muscle cells and fibroblasts. By IL10/interleukin-10 and IFNG/IFN-gamma in monocyte-derived dendritic cells.

Gene Ontology (GO) - Molecular Function for EHF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 17027647
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 17027647
GO:0003677 DNA binding TAS 10527851
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 10644770
genes like me logo Genes that share ontologies with EHF: view

Phenotypes for EHF Gene

GenomeRNAi human phenotypes for EHF:
genes like me logo Genes that share phenotypes with EHF: view

miRNA for EHF Gene

miRTarBase miRNAs that target EHF
Targeting motifs for EHF Gene
HOMER Transcription Factor Regulatory Elements motif EHF
  • Consensus sequence: AVCAGGAAGT Submotif: canonical Cell Type: LoVo GeoId: GSE49402

No data available for Enzyme Numbers (IUBMB) , Animal Models and Transcription Factor Targeting for EHF Gene

Localization for EHF Gene

Subcellular locations from UniProtKB/Swiss-Prot for EHF Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EHF Gene COMPARTMENTS Subcellular localization image for EHF gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EHF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 10644770
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with EHF: view

Pathways for EHF Gene

SuperPathways for EHF Gene

No Data Available

Gene Ontology (GO) - Biological Process for EHF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
GO:0007275 multicellular organismal development TAS 10644770
GO:0008283 cell proliferation TAS 10644770
genes like me logo Genes that share ontologies with EHF: view

No data available for Pathways by source for EHF Gene

Transcripts for EHF Gene

Unigene Clusters for EHF Gene

Ets homologous factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EHF Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - -
SP6: -
SP7: - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - -
SP11: -
SP12: - - - - - - -
SP13: - - -
SP14: -
SP15:
SP16: - - - -

ExUns: 16a · 16b ^ 17a · 17b · 17c · 17d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for EHF Gene

GeneLoc Exon Structure for
EHF
ECgene alternative splicing isoforms for
EHF

Expression for EHF Gene

mRNA expression in normal human tissues for EHF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EHF Gene

This gene is overexpressed in Esophagus - Mucosa (11.9), Minor Salivary Gland (10.2), and Vagina (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EHF Gene

SOURCE GeneReport for Unigene cluster for EHF Gene Hs.653859

mRNA Expression by UniProt/SwissProt for EHF Gene

Q9NZC4-EHF_HUMAN
Tissue specificity: Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, prostate, and lung. Weakly expressed in kidney and colon. Not detected in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, testis, ovary, small intestine or peripheral blood leukocytes.
genes like me logo Genes that share expressions with EHF: view

Orthologs for EHF Gene

This gene was present in the common ancestor of animals.

Orthologs for EHF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EHF 35
  • 99.78 (n)
  • 99.33 (a)
EHF 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EHF 35
  • 92.56 (n)
  • 95 (a)
EHF 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EHF 35
  • 91.78 (n)
  • 93.42 (a)
EHF 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ehf 35
  • 89 (n)
  • 93.67 (a)
Ehf 16
Ehf 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EHF 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EHF 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ehf 35
  • 88.33 (n)
  • 94.33 (a)
chicken
(Gallus gallus)
Aves EHF 35
  • 79.53 (n)
  • 86.24 (a)
EHF 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EHF 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ehf 35
  • 72.26 (n)
  • 72.26 (a)
zebrafish
(Danio rerio)
Actinopterygii ehf 35
  • 62.53 (n)
  • 60.64 (a)
ehf 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta aop 36
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-97 36
  • 15 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3628 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 10 (a)
OneToMany
Species with no ortholog for EHF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EHF Gene

ENSEMBL:
Gene Tree for EHF (if available)
TreeFam:
Gene Tree for EHF (if available)

Paralogs for EHF Gene

Paralogs for EHF Gene

Selected SIMAP similar genes for EHF Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EHF: view

Variants for EHF Gene

Sequence variations from dbSNP and Humsavar for EHF Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs286886 -- 34,662,375(-) CCCAA(C/T)GGCCT utr-variant-3-prime
rs286887 -- 34,661,220(-) CATGC(A/G)TTATA utr-variant-3-prime
rs286888 -- 34,661,000(-) ACAGA(A/G)GTGAC utr-variant-3-prime
rs286889 -- 34,659,306(-) CATGT(A/C)ACATA utr-variant-3-prime
rs286890 -- 34,659,087(-) TCGAC(C/T)GTAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EHF Gene

Variant ID Type Subtype PubMed ID
nsv832116 CNV Gain 17160897
nsv832117 CNV Loss 17160897
dgv63n21 CNV Gain 19592680

Relevant External Links for EHF Gene

HapMap Linkage Disequilibrium report
EHF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EHF Gene

Disorders for EHF Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for EHF Gene including...

Search for EHF Gene in MalaCards »

(3) Novoseek inferred disease relationships for EHF Gene

Disease -log(P) Hits PubMed IDs
carcinoma 5.87 1
tumors 0 2
cancer 0 1

Relevant External Links for EHF

Genetic Association Database (GAD)
EHF
Human Genome Epidemiology (HuGE) Navigator
EHF
genes like me logo Genes that share disorders with EHF: view

No data available for UniProtKB/Swiss-Prot for EHF Gene

Publications for EHF Gene

  1. Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF. (PMID: 10527851) Kleinbaum L.A. … Burton F.H. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1. (PMID: 10644770) Kas K. … Libermann T.A. (J. Biol. Chem. 2000) 3 4 23
  3. The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades. (PMID: 11259407) Tugores A. … McCormick M.K. (J. Biol. Chem. 2001) 3 4 23
  4. Expression of the ETS transcription factor ELF3 in the retinal pigment epithelium. (PMID: 12407165) Jobling A.I. … Tymms M.J. (Invest. Ophthalmol. Vis. Sci. 2002) 3 23
  5. Influence of small interfering RNA corresponding to ets homologous factor on senescence-associated modulation of prostate carcinogenesis. (PMID: 17172423) Park C. … Kang W.K. (Mol. Cancer Ther. 2006) 3 23

Products for EHF Gene

Sources for EHF Gene

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