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Aliases for OR2K2 Gene

Aliases for OR2K2 Gene

  • Olfactory Receptor, Family 2, Subfamily K, Member 2 2 3
  • Olfactory Receptor OR9-17 3 4
  • HTPCRH06 3 4
  • OR2AR1P 3 4
  • Olfactory Receptor, Family 2, Subfamily AN, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily AR, Member 1 Pseudogene 3
  • Olfactory Receptor 2K2 3
  • HSHTPCRH06 3
  • OR2AN1P 3

External Ids for OR2K2 Gene

Previous HGNC Symbols for OR2K2 Gene

  • OR2AR1P

Previous GeneCards Identifiers for OR2K2 Gene

  • GC09M104887
  • GC09M105821
  • GC09M107547
  • GC09M109469
  • GC09M111169
  • GC09M113129
  • GC09M114089

Summaries for OR2K2 Gene

Entrez Gene Summary for OR2K2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2K2 Gene

OR2K2 (Olfactory Receptor, Family 2, Subfamily K, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR13C7.

UniProtKB/Swiss-Prot for OR2K2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2K2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2K2 Gene

Genomics for OR2K2 Gene

Regulatory Elements for OR2K2 Gene

Genomic Location for OR2K2 Gene

Start:
111,327,483 bp from pter
End:
111,329,672 bp from pter
Size:
2,190 bases
Orientation:
Minus strand

Genomic View for OR2K2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2K2 Gene

Proteins for OR2K2 Gene

  • Protein details for OR2K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGT1-OR2K2_HUMAN
    Recommended name:
    Olfactory receptor 2K2
    Protein Accession:
    Q8NGT1
    Secondary Accessions:
    • Q2TA61
    • Q5VYK4
    • Q6IFI5

    Protein attributes for OR2K2 Gene

    Size:
    345 amino acids
    Molecular mass:
    38473 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05929.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH73239.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for OR2K2 Gene

Proteomics data for OR2K2 Gene at MOPED

Post-translational modifications for OR2K2 Gene

  • Glycosylation at Asn34
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2K2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2K2 Gene

Domains for OR2K2 Gene

Gene Families for OR2K2 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2K2 Gene

Suggested Antigen Peptide Sequences for OR2K2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGT1

UniProtKB/Swiss-Prot:

OR2K2_HUMAN :
  • Q8NGT1
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2K2: view

Function for OR2K2 Gene

Molecular function for OR2K2 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2K2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2K2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2K2 Gene

Localization for OR2K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2K2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2K2 Gene COMPARTMENTS Subcellular localization image for OR2K2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2K2: view

Pathways for OR2K2 Gene

genes like me logo Genes that share pathways with OR2K2: view

Pathways by source for OR2K2 Gene

Interacting Proteins for OR2K2 Gene

Gene Ontology (GO) - Biological Process for OR2K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2K2: view

Transcripts for OR2K2 Gene

mRNA/cDNA for OR2K2 Gene

(3) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2K2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR2K2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2K2 Gene

No ASD Table

Relevant External Links for OR2K2 Gene

GeneLoc Exon Structure for
OR2K2
ECgene alternative splicing isoforms for
OR2K2

Expression for OR2K2 Gene

mRNA expression in normal human tissues for OR2K2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2K2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (8.0), Muscle - Skeletal (6.6), and Brain - Substantia nigra (6.4).

SOURCE GeneReport for Unigene cluster for OR2K2 Gene Hs.381312

genes like me logo Genes that share expressions with OR2K2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for OR2K2 Gene

Orthologs for OR2K2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2K2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473017 35
  • 99.05 (n)
  • 98.1 (a)
OR2K2 36
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC539574 35
  • 87.55 (n)
  • 86.39 (a)
OR2K2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100856036 35
  • 87.66 (n)
  • 85.76 (a)
OR2K2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr267 35
  • 85.15 (n)
  • 87.5 (a)
Olfr267 16
Olfr267 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR2K2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr854 35
  • 84.47 (n)
  • 87.38 (a)
Species with no ortholog for OR2K2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2K2 Gene

ENSEMBL:
Gene Tree for OR2K2 (if available)
TreeFam:
Gene Tree for OR2K2 (if available)

Paralogs for OR2K2 Gene

Selected SIMAP similar genes for OR2K2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR2K2 Gene

genes like me logo Genes that share paralogs with OR2K2: view

Variants for OR2K2 Gene

Sequence variations from dbSNP and Humsavar for OR2K2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs314451 -- 111,329,707(-) TTGAT(C/G)ACAAG upstream-variant-2KB
rs314452 -- 111,327,999(-) ATGGC(C/T)ACGGT synonymous-codon, reference
rs5899953 -- 111,330,394(+) GTTTT(-/G)GGGGA upstream-variant-2KB
rs7019317 -- 111,331,237(+) ggctc(C/T)ttggg upstream-variant-2KB
rs7030601 -- 111,331,469(+) tgtac(A/G)ttatt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2K2 Gene

Variant ID Type Subtype PubMed ID
nsv893722 CNV Gain 21882294

Relevant External Links for OR2K2 Gene

HapMap Linkage Disequilibrium report
OR2K2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2K2 Gene

Disorders for OR2K2 Gene

No disorders were found for OR2K2 Gene.

No data available for UniProtKB/Swiss-Prot for OR2K2 Gene

Publications for OR2K2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Ancient genomic architecture for mammalian olfactory receptor clusters. (PMID: 17010214) Aloni R. … Lancet D. (Genome Biol. 2006) 2 3
  5. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M. … Vassart G. (Nature 1992) 2 3

Products for OR2K2 Gene

Sources for OR2K2 Gene

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