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Aliases for FBXL5 Gene

Aliases for FBXL5 Gene

  • F-Box And Leucine-Rich Repeat Protein 5 2 3 4 5
  • F-Box Protein FBL4/FBL5 3 4
  • P45SKP2-Like Protein 3 4
  • FBL4 3 4
  • FBL5 3 4
  • FLR1 3 4
  • F-Box Protein FBL5 3

External Ids for FBXL5 Gene

Previous GeneCards Identifiers for FBXL5 Gene

  • GC04M015421
  • GC04M015548
  • GC04M015294
  • GC04M015357
  • GC04M015282
  • GC04M014956

Summaries for FBXL5 Gene

Entrez Gene Summary for FBXL5 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]

GeneCards Summary for FBXL5 Gene

FBXL5 (F-Box And Leucine-Rich Repeat Protein 5) is a Protein Coding gene. Among its related pathways are Chaperonin-mediated protein folding and Transport to the Golgi and subsequent modification. GO annotations related to this gene include ubiquitin-protein transferase activity and iron ion binding.

UniProtKB/Swiss-Prot for FBXL5 Gene

  • Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.

Gene Wiki entry for FBXL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL5 Gene

Genomics for FBXL5 Gene

Regulatory Elements for FBXL5 Gene

Enhancers for FBXL5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXL5 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXL5 Gene

Chromosome:
4
Start:
15,604,384 bp from pter
End:
15,681,679 bp from pter
Size:
77,296 bases
Orientation:
Minus strand

Genomic View for FBXL5 Gene

Genes around FBXL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL5 Gene

Proteins for FBXL5 Gene

  • Protein details for FBXL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKA1-FBXL5_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 5
    Protein Accession:
    Q9UKA1
    Secondary Accessions:
    • A8MSK4
    • B4DIB5
    • Q4W5A8
    • Q8NHP3
    • Q9NXN2
    • Q9P0I0
    • Q9P0X5
    • Q9UJT7
    • Q9UKC8

    Protein attributes for FBXL5 Gene

    Size:
    691 amino acids
    Molecular mass:
    78555 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with ACO1/IRP1, IREB2/IRP2; the interaction depends on the 4Fe-4S cluster. Interacts with DCTN1/p150-glued.
    SequenceCaution:
    • Sequence=AAF66616.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF67489.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH30656.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW92737.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FBXL5 Gene

    Alternative splice isoforms for FBXL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL5 Gene

Proteomics data for FBXL5 Gene at MOPED

Post-translational modifications for FBXL5 Gene

  • Polybiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXL5 Gene

Domains & Families for FBXL5 Gene

Gene Families for FBXL5 Gene

Suggested Antigen Peptide Sequences for FBXL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKA1

UniProtKB/Swiss-Prot:

FBXL5_HUMAN :
  • The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron metal-center. In absence of oxygen and iron, the protein is ubiquitinated and degraded.
  • Contains 7 LRR (leucine-rich) repeats.
Domain:
  • The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron metal-center. In absence of oxygen and iron, the protein is ubiquitinated and degraded.
  • Contains 1 F-box domain.
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL5: view

Function for FBXL5 Gene

Molecular function for FBXL5 Gene

UniProtKB/Swiss-Prot Function:
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.

Gene Ontology (GO) - Molecular Function for FBXL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
genes like me logo Genes that share ontologies with FBXL5: view
genes like me logo Genes that share phenotypes with FBXL5: view

Animal Models for FBXL5 Gene

MGI Knock Outs for FBXL5:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXL5 Gene

Localization for FBXL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL5 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL5 Gene COMPARTMENTS Subcellular localization image for FBXL5 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for FBXL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019005 SCF ubiquitin ligase complex IDA 19762596
genes like me logo Genes that share ontologies with FBXL5: view

Pathways & Interactions for FBXL5 Gene

genes like me logo Genes that share pathways with FBXL5: view

UniProtKB/Swiss-Prot Q9UKA1-FBXL5_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA 17532294
genes like me logo Genes that share ontologies with FBXL5: view

No data available for SIGNOR curated interactions for FBXL5 Gene

Drugs & Compounds for FBXL5 Gene

No Compound Related Data Available

Transcripts for FBXL5 Gene

Unigene Clusters for FBXL5 Gene

F-box and leucine-rich repeat protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7:

Relevant External Links for FBXL5 Gene

GeneLoc Exon Structure for
FBXL5
ECgene alternative splicing isoforms for
FBXL5

Expression for FBXL5 Gene

mRNA expression in normal human tissues for FBXL5 Gene

mRNA differential expression in normal tissues according to GTEx for FBXL5 Gene

This gene is overexpressed in Whole Blood (x7.6).

SOURCE GeneReport for Unigene cluster for FBXL5 Gene Hs.643433

genes like me logo Genes that share expression patterns with FBXL5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FBXL5 Gene

Orthologs for FBXL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXL5 35
  • 92.91 (n)
  • 94.5 (a)
FBXL5 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL5 35
  • 94.69 (n)
  • 96.24 (a)
FBXL5 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl5 35
  • 90.63 (n)
  • 93.77 (a)
Fbxl5 16
Fbxl5 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXL5 35
  • 99.57 (n)
  • 99.71 (a)
FBXL5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl5 35
  • 90.11 (n)
  • 93.72 (a)
oppossum
(Monodelphis domestica)
Mammalia FBXL5 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL5 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXL5 35
  • 80.76 (n)
  • 81.05 (a)
FBXL5 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL5 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl5 35
  • 69.14 (n)
  • 69.24 (a)
Str.19634 35
African clawed frog
(Xenopus laevis)
Amphibia fbxl5-prov 35
zebrafish
(Danio rerio)
Actinopterygii fbxl5 35
  • 59.85 (n)
  • 58.95 (a)
wufb52d06 35
fbxl5 36
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7300 35
Species with no ortholog for FBXL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL5 Gene

ENSEMBL:
Gene Tree for FBXL5 (if available)
TreeFam:
Gene Tree for FBXL5 (if available)

Paralogs for FBXL5 Gene

Pseudogenes.org Pseudogenes for FBXL5 Gene

genes like me logo Genes that share paralogs with FBXL5: view

No data available for Paralogs for FBXL5 Gene

Variants for FBXL5 Gene

Sequence variations from dbSNP and Humsavar for FBXL5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10214 -- 15,604,808(+) AGATA(C/T)ACTTA nc-transcript-variant, utr-variant-3-prime
rs10303 -- 15,604,637(+) GCAAA(A/G)TGCAA nc-transcript-variant, utr-variant-3-prime
rs872678 -- 15,654,075(+) TTAAA(C/T)TGCTG intron-variant
rs1127154 -- 15,655,274(-) CTTTC(C/G/T)TGAAG intron-variant, nc-transcript-variant, reference, missense
rs952281 -- 15,629,853(-) CTTAA(A/C)GTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL5 Gene

Variant ID Type Subtype PubMed ID
dgv1586e1 CNV Complex 17122850
dgv1587e1 CNV Complex 17122850
nsv428439 CNV Gain+Loss 18775914
esv26392 CNV Gain 19812545
dgv315n21 CNV Loss 19592680
esv1293360 CNV Insertion 17803354
esv27769 CNV Gain 19812545
nsv292453 CNV Loss 16902084

Variation tolerance for FBXL5 Gene

Residual Variation Intolerance Score: 12.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.27% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FBXL5 Gene

Disorders for FBXL5 Gene

Relevant External Links for FBXL5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXL5

No disorders were found for FBXL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL5 Gene

Publications for FBXL5 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 67
  2. FBXL5 interacts with p150Glued and regulates its ubiquitination. (PMID: 17532294) Zhang N. … Yao X. (Biochem. Biophys. Res. Commun. 2007) 3 23
  3. FBXL5 inhibits metastasis of gastric cancer through suppressing Snail1. (PMID: 25832584) Wu W. … Zhang W. (Cell. Physiol. Biochem. 2015) 3
  4. FBXL5 modulates HIF-1I+ transcriptional activity by degradation of CITED2. (PMID: 25956243) Machado-Oliveira G. … BraganAsa J. (Arch. Biochem. Biophys. 2015) 3
  5. Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability. (PMID: 24157836) ViA+as-Castells R. … DA-az V.M. (Nucleic Acids Res. 2014) 3

Products for FBXL5 Gene

Sources for FBXL5 Gene

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