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GCID:
GC21M033503
GIFtS:
65

GART Gene(Protein Coding)

Phosphoribosylglycinamide Formyltransferase, Phosphoribosylglycinamide Synthetase, Phosphoribosylaminoimidazole Synthetase

Aliases for GART Gene

Aliases for GART Gene

  • Phosphoribosylglycinamide Formyltransferase, Phosphoribosylglycinamide Synthetase, Phosphoribosylaminoimidazole Synthetase 2 3
  • PGFT 3 4
  • PRGS 3 4
  • Trifunctional Purine Biosynthetic Protein Adenosine-3 3
  • Phosphoribosylaminoimidazole Synthetase) 6
  • EC 6.3.4.13 64
  • EC 6.3.3.1 64
  • GARTF 3
  • AIRS 3
  • GARS 3
  • PAIS 3

External Ids for GART Gene

Previous Symbols for GART Gene

  • PRGS
  • PGFT

Summaries for GART Gene

Entrez Gene Summary for GART Gene

  • The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for GART Gene

GART (Phosphoribosylglycinamide Formyltransferase, Phosphoribosylglycinamide Synthetase, Phosphoribosylaminoimidazole Synthetase) is a Protein Coding gene. Diseases associated with GART include benign mesothelioma. Among its related pathways are Signaling by GPCR and Heart Development. GO annotations related to this gene include methyltransferase activity and phosphoribosylformylglycinamidine cyclo-ligase activity.

Gene Wiki entry for GART Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GART Gene

Genomics for GART Gene

Genomic Location for GART Gene

Start:
33,503,931 bp from pter
End:
33,543,491 bp from pter
Size:
39,561 bases
Orientation:
Minus strand

Genomic View for GART Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GART Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GART Gene

Regulatory Elements for GART Gene

Transcription factor binding sites by QIAGEN in the GART gene promoter:

Proteins for GART Gene

  • Protein details for GART Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22102-PUR2_HUMAN
    Recommended name:
    Trifunctional purine biosynthetic protein adenosine-3
    Protein Accession:
    P22102
    Secondary Accessions:
    • A8K945
    • A8KA32
    • D3DSF3
    • D3DSF4
    • O14659
    • Q52M77

    Protein attributes for GART Gene

    Size:
    1010 amino acids
    Molecular mass:
    107767 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GART Gene

    Alternative splice isoforms for GART Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GART Gene

Proteomics data for GART Gene at MOPED

Post-translational modifications for GART Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys28, Lys44, Lys107, Lys125, Lys148, Lys156, Lys162, Lys251, Lys285, Lys350, Lys467, Lys480, Lys485, Lys676, Lys697, Lys743, Lys779, Lys852, and Lys910

Domains for GART Gene

UniProtKB/Swiss-Prot:

PUR2_HUMAN
Domain:
  • Contains 1 ATP-grasp domain.:
    • P22102
Family:
  • In the N-terminal section; belongs to the GARS family.:
    • P22102
  • In the central section; belongs to the AIR synthase family.:
    • P22102
  • In the C-terminal section; belongs to the GART family.:
    • P22102
genes like me logo Genes that share domains with GART: view

No data available for Gene Families for GART Gene

Function for GART Gene

Molecular function for GART Gene

GENATLAS Biochemistry: glycineamide formyltransferase,catalyzing the third step of the de novo purine biosynthesis,leading to formylglycinamide ribonucleotide (FGAR)
UniProtKB/Swiss-Prot CatalyticActivity: ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide
UniProtKB/Swiss-Prot CatalyticActivity: ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole
UniProtKB/Swiss-Prot CatalyticActivity: 10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide

Enzyme Numbers (IUBMB) for GART Gene

Gene Ontology (GO) - Molecular Function for GART Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004637 phosphoribosylamine-glycine ligase activity IEA --
GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity IEA --
GO:0004644 phosphoribosylglycinamide formyltransferase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with GART: view

Phenotypes for GART Gene

GenomeRNAi human phenotypes for GART:
genes like me logo Genes that share phenotypes with GART: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GART Gene

Localization for GART Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GART Gene COMPARTMENTS Subcellular localization image for GART gene
Compartment Confidence
cytosol 4
mitochondrion 2
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GART Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with GART: view

Pathways for GART Gene

genes like me logo Genes that share pathways with GART: view

UniProtKB/Swiss-Prot P22102-PUR2_HUMAN

  • Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2
  • Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2
  • Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1

Interacting Proteins for GART Gene

Gene Ontology (GO) - Biological Process for GART Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003360 brainstem development IEA --
GO:0006144 purine nucleobase metabolic process TAS --
GO:0006189 de novo IMP biosynthetic process IEA --
GO:0006544 glycine metabolic process IEA --
GO:0009058 biosynthetic process --
genes like me logo Genes that share ontologies with GART: view

Compounds for GART Gene

(16) HMDB Compounds for GART Gene

Compound Synonyms Cas Number PubMed IDs
2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
  • 1-(5'-Phosphoribosyl)-N-formylglycinamidine
6157-85-3
5,10-Methenyltetrahydrofolic acid
  • 5,10-Methenyltetrahydrofolate
7444-29-3
5-Aminoimidazole ribonucleotide
  • 1-(5'-phosphoribosyl)-5-aminoimidazole
25635-88-5
5-Phosphoribosylamine
  • 5-P-beta-D-ribosyl-amine
Not Available
5'-phosphoribosyl-a-N-formylglycineamidine
Not Available

(3) Drugbank Compounds for GART Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
10-CF3C(OH)2-DDACTHF
target
Glycinamide Ribonucleotide
target
Pemetrexed
  • LY231514
150399-23-8 target inhibitor

(17) Novoseek inferred chemical compound relationships for GART Gene

Compound -log(P) Hits PubMed IDs
glycinamide ribonucleotide 97.9 31
aminoimidazole ribonucleotide 88.8 4
lometrexol 88.5 1
phosphoribosylamine 88.2 3
1843u89 86.2 1
genes like me logo Genes that share compounds with GART: view

Transcripts for GART Gene

Unigene Clusters for GART Gene

Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GART Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - - - -
SP7: -
SP8: -
SP9:
SP10: - -
SP11:
SP12: - - - - - - -
SP13: - - - -
SP14: - -
SP15: - -
SP16: -
SP17: - -
SP18:

ExUns: 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28
SP1: - - -
SP2: - - -
SP3: - - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - -
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:

Relevant External Links for GART Gene

GeneLoc Exon Structure for
GART
ECgene alternative splicing isoforms for
GART

Expression for GART Gene

mRNA expression in normal human tissues for GART Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GART Gene

SOURCE GeneReport for Unigene cluster for GART Gene Hs.473648

genes like me logo Genes that share expressions with GART: view

Orthologs for GART Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GART Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GART 36
  • 99.5 (n)
  • 99.31 (a)
GART 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GART 36
  • 88.02 (n)
  • 88.42 (a)
GART 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 87 (a)
OneToMany
-- 37
  • 90 (a)
OneToMany
LOC100856570 36
  • 89.31 (n)
  • 90.59 (a)
mouse
(Mus musculus)
Mammalia Gart 36
  • 83.2 (n)
  • 85.94 (a)
Gart 16
Gart 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 80 (a)
OneToMany
-- 37
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GART 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gart 36
  • 83.89 (n)
  • 86.53 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 59 (a)
OneToMany
GART 36
  • 73.4 (n)
  • 75.1 (a)
GART 37
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 73 (a)
OneToMany
-- 37
  • 54 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gart 36
  • 71.33 (n)
  • 75.23 (a)
Str.2889 36
zebrafish
(Danio rerio)
Actinopterygii gart 36
  • 62.73 (n)
  • 67.36 (a)
gart 37
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009786 36
  • 52.82 (n)
  • 53.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta ade3 36
  • 52.49 (n)
  • 48.46 (a)
ade3 37
  • 36 (a)
OneToOne
ade3 38
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea F38B6.4 36
  • 52.4 (n)
  • 45.39 (a)
F38B6.4 37
  • 44 (a)
OneToOne
F38B6.4 38
  • 43 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR254C 36
  • 51.76 (n)
  • 46.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADE5,7 36
  • 51.96 (n)
  • 46.32 (a)
ADE5,7 37
  • 45 (a)
OneToOne
ADE5,7 39
ADE5,7 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A00957g 36
  • 52.49 (n)
  • 47.69 (a)
soybean
(Glycine max)
eudicotyledons Gma.5959 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G09830 36
  • 52.82 (n)
  • 46.4 (a)
corn
(Zea mays)
Liliopsida Zm.12249 36
rice
(Oryza sativa)
Liliopsida Os.8635 36
Os12g0197100 36
  • 52.35 (n)
  • 46.54 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00177 36
  • 52.32 (n)
  • 49.87 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ade1 36
  • 53.11 (n)
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToOne
Species with no ortholog for GART:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GART Gene

ENSEMBL:
Gene Tree for GART (if available)
TreeFam:
Gene Tree for GART (if available)

Paralogs for GART Gene

genes like me logo Genes that share paralogs with GART: view

No data available for Paralogs for GART Gene

Variants for GART Gene

Sequence variations from dbSNP and Humsavar for GART Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs8788 - 33,524,806(-) AAGAC(A/G/T)TCGGC missense, reference
rs8971 - 33,511,311(-) GAGGG(A/G)TATCC reference, missense
rs1023147 -- 33,515,864(+) CTTTT(A/G)ACCTA intron-variant
rs1023353 -- 33,516,811(+) ATAAA(G/T)ACAGA intron-variant
rs1051053 -- 33,524,117(-) TTTTA(A/T)CACTG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GART Gene

Variant ID Type Subtype PubMed ID
nsv913724 CNV Loss 21882294
nsv509795 CNV Insertion 20534489
nsv913725 CNV Loss 21882294

Relevant External Links for GART Gene

HapMap Linkage Disequilibrium report
GART

Disorders for GART Gene

(1) MalaCards Diseases for GART Gene

Search for GART Gene in MalaCards »

(2) University of Copenhagen DISEASES for GART Gene

(6) Novoseek inferred disease relationships for GART Gene

Disease -log(P) Hits PubMed IDs
down syndrome 35.7 2
amyotrophic lateral sclerosis 21.3 1
leukemia 3.56 1
tumors 0 3
carcinoma 0 3

Relevant External Links for GART

Genetic Association Database (GAD)
GART
Human Genome Epidemiology (HuGE) Navigator
GART
genes like me logo Genes that share disorders with GART: view

No data available for UniProtKB/Swiss-Prot for GART Gene

Publications for GART Gene

  1. Cloning and in vivo expression of the human GART gene using yeast artificial chromosomes. (PMID: 2050105) Gnirke A. … Olson M.V. (EMBO J. 1991) 2 3 23
  2. De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli. (PMID: 2147474) Aimi J. … Dixon J.E. (Nucleic Acids Res. 1990) 3 4 23
  3. Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations. (PMID: 2183217) Schild D. … Barr P.J. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4 23
  4. Intronic polyadenylation in the human glycinamide ribonucleotide formyltransferase gene. (PMID: 9224613) Kan J.L.C. … Moran R.G. (Nucleic Acids Res. 1997) 3 4 23
  5. Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR. (PMID: 12450384) Zhang Y. … Wilson I.A. (Biochemistry 2002) 3 4

Products for GART Gene

Sources for GART Gene

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