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Aliases for ZBTB20 Gene

Aliases for ZBTB20 Gene

  • Zinc Finger And BTB Domain Containing 20 2 3 5
  • Zinc Finger Protein 288 2 3 4
  • ZNF288 3 4
  • DPZF 3 4
  • Dendritic-Derived BTB/POZ Zinc Finger Protein 4
  • Dendritic Cell-Derived BTB/POZ Zinc Finger 3
  • BTB/POZ Zinc Finger Protein DPZF 3
  • ODA-8S 3
  • PRIMS 3
  • HOF 3

External Ids for ZBTB20 Gene

Previous HGNC Symbols for ZBTB20 Gene

  • ZNF288

Previous GeneCards Identifiers for ZBTB20 Gene

  • GC03M115540
  • GC03M114056
  • GC03M111429

Summaries for ZBTB20 Gene

GeneCards Summary for ZBTB20 Gene

ZBTB20 (Zinc Finger And BTB Domain Containing 20) is a Protein Coding gene. Diseases associated with ZBTB20 include primrose syndrome and intellectual disability-cataracts-calcified pinnae-myopathy syndrome. GO annotations related to this gene include transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is ZBTB22.

UniProtKB/Swiss-Prot for ZBTB20 Gene

  • May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.

Gene Wiki entry for ZBTB20 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB20 Gene

Genomics for ZBTB20 Gene

Regulatory Elements for ZBTB20 Gene

Promoters for ZBTB20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBTB20 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBTB20 Gene

Chromosome:
3
Start:
114,314,500 bp from pter
End:
115,147,280 bp from pter
Size:
832,781 bases
Orientation:
Minus strand

Genomic View for ZBTB20 Gene

Genes around ZBTB20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB20 Gene

Proteins for ZBTB20 Gene

  • Protein details for ZBTB20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC78-ZBT20_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 20
    Protein Accession:
    Q9HC78
    Secondary Accessions:
    • Q63HP6
    • Q8N6R5
    • Q9Y410

    Protein attributes for ZBTB20 Gene

    Size:
    741 amino acids
    Molecular mass:
    81083 Da
    Quaternary structure:
    • Can homodimerize. Binds to DNA.

    Alternative splice isoforms for ZBTB20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB20 Gene

Proteomics data for ZBTB20 Gene at MOPED

Post-translational modifications for ZBTB20 Gene

Antibody Products

No data available for DME Specific Peptides for ZBTB20 Gene

Domains & Families for ZBTB20 Gene

Gene Families for ZBTB20 Gene

Protein Domains for ZBTB20 Gene

Suggested Antigen Peptide Sequences for ZBTB20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HC78

UniProtKB/Swiss-Prot:

ZBT20_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 5 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB20: view

Function for ZBTB20 Gene

Molecular function for ZBTB20 Gene

UniProtKB/Swiss-Prot Function:
May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.
genes like me logo Genes that share phenotypes with ZBTB20: view

Human Phenotype Ontology for ZBTB20 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ZBTB20 Gene

MGI Knock Outs for ZBTB20:

Animal Model Products

miRNA for ZBTB20 Gene

miRTarBase miRNAs that target ZBTB20

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for ZBTB20 Gene

Localization for ZBTB20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB20 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB20 Gene COMPARTMENTS Subcellular localization image for ZBTB20 gene
Compartment Confidence
nucleus 5
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for ZBTB20 Gene

Pathways & Interactions for ZBTB20 Gene

SuperPathways for ZBTB20 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032755 positive regulation of interleukin-6 production IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB20: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB20 Gene

Drugs & Compounds for ZBTB20 Gene

No Compound Related Data Available

Transcripts for ZBTB20 Gene

Unigene Clusters for ZBTB20 Gene

Zinc finger and BTB domain containing 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB20 Gene

No ASD Table

Relevant External Links for ZBTB20 Gene

GeneLoc Exon Structure for
ZBTB20
ECgene alternative splicing isoforms for
ZBTB20

Expression for ZBTB20 Gene

mRNA expression in normal human tissues for ZBTB20 Gene

mRNA differential expression in normal tissues according to GTEx for ZBTB20 Gene

This gene is overexpressed in Testis (x16.4).

Protein differential expression in normal tissues from HIPED for ZBTB20 Gene

This gene is overexpressed in Ovary (26.4), Adrenal (17.0), and Gallbladder (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB20 Gene



SOURCE GeneReport for Unigene cluster for ZBTB20 Gene Hs.655108

mRNA Expression by UniProt/SwissProt for ZBTB20 Gene

Q9HC78-ZBT20_HUMAN
Tissue specificity: Expressed in spleen, lymph node, thymus, peripheral blood leukocytes, and fetal liver.
genes like me logo Genes that share expression patterns with ZBTB20: view

Protein tissue co-expression partners for ZBTB20 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ZBTB20 Gene

Orthologs for ZBTB20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB20 36
  • 100 (a)
OneToOne
ZBTB20 35
  • 99.87 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia ZBTB20 36
  • 98 (a)
OneToOne
ZBTB20 35
  • 94.6 (n)
  • 98.38 (a)
dog
(Canis familiaris)
Mammalia ZBTB20 35
  • 95.73 (n)
  • 99.19 (a)
ZBTB20 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb20 16
Zbtb20 36
  • 98 (a)
OneToOne
Zbtb20 35
  • 92.85 (n)
  • 97.71 (a)
oppossum
(Monodelphis domestica)
Mammalia ZBTB20 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb20 35
  • 92.17 (n)
  • 97.46 (a)
chicken
(Gallus gallus)
Aves ZBTB20 35
  • 83.11 (n)
  • 91.58 (a)
ZBTB20 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB20 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb20 35
  • 78.41 (n)
  • 84.1 (a)
zebrafish
(Danio rerio)
Actinopterygii zbtb20 36
  • 66 (a)
OneToOne
Dr.27779 35
zbtb20 35
  • 71.53 (n)
  • 72.06 (a)
Species with no ortholog for ZBTB20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB20 Gene

ENSEMBL:
Gene Tree for ZBTB20 (if available)
TreeFam:
Gene Tree for ZBTB20 (if available)

Paralogs for ZBTB20 Gene

Pseudogenes.org Pseudogenes for ZBTB20 Gene

genes like me logo Genes that share paralogs with ZBTB20: view

Variants for ZBTB20 Gene

Sequence variations from dbSNP and Humsavar for ZBTB20 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_072583 Primrose syndrome (PRIMS)
VAR_072584 Primrose syndrome (PRIMS)
VAR_072585 Primrose syndrome (PRIMS)
VAR_072586 Primrose syndrome (PRIMS)
rs437008 -- 114,912,256(-) cattt(C/T)tttta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB20 Gene

Variant ID Type Subtype PubMed ID
nsv829679 CNV Gain 17160897
esv2664589 CNV Deletion 23128226
dgv77n68 CNV Gain 17160897
nsv3952 CNV Insertion 18451855
esv998582 CNV Deletion 20482838
esv2671955 CNV Deletion 23128226
esv22752 CNV Loss 19812545
esv2535300 CNV Insertion 19546169
esv272930 CNV Insertion 20981092
esv267795 CNV Insertion 20981092
esv2438147 CNV Deletion 19546169
esv1006341 CNV Deletion 20482838
esv2097985 CNV Deletion 18987734
esv2725787 CNV Deletion 23290073
esv1002866 CNV Deletion 20482838
nsv237808 CNV Loss 16902084
esv2572379 CNV Deletion 19546169
esv8517 CNV Loss 19470904
esv1548513 CNV Deletion 17803354
esv267895 CNV Insertion 20981092
esv2577063 CNV Deletion 19546169
nsv521467 CNV Loss 19592680
dgv5233n71 CNV Loss 21882294
esv2725788 CNV Deletion 23290073
nsv3953 CNV Loss 18451855
nsv10308 CNV Loss 18304495
esv2599243 CNV Deletion 19546169
dgv881e199 CNV Deletion 23128226
esv2505508 CNV Loss 19546169
nsv436390 CNV Deletion 17901297
esv2725789 CNV Deletion 23290073
nsv499011 CNV Loss 21111241
esv21675 CNV Loss 19812545
nsv514164 CNV Loss 21397061
nsv437878 CNV Loss 16468122
esv2421899 CNV Deletion 20811451
nsv442871 CNV CNV 18776908
nsv433365 CNV Loss 18776910
nsv437337 CNV Loss 16327808
nsv829683 CNV Gain 17160897
esv2656651 CNV Deletion 23128226
esv29079 CNV Loss 19812545

Variation tolerance for ZBTB20 Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB20 Gene

HapMap Linkage Disequilibrium report
ZBTB20
Human Gene Mutation Database (HGMD)
ZBTB20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB20 Gene

Disorders for ZBTB20 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ZBTB20 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
primrose syndrome
  • ossified ear cartilages with mental deficiency, muscle wasting, and bony changes
intellectual disability-cataracts-calcified pinnae-myopathy syndrome
  • primrose syndrome
juvenile pilocytic astrocytoma
childhood pilocytic astrocytoma
  • pediatric pilocytic astrocytoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZBT20_HUMAN
  • Primrose syndrome (PRIMS) [MIM:259050]: A disease characterized by macrocephaly, intellectual disability, disturbed behavior, dysmorphic facial features, ectopic calcifications, large calcified ear auricles, and progressive muscle wasting. {ECO:0000269 PubMed:25017102}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZBTB20

Genetic Association Database (GAD)
ZBTB20
Human Genome Epidemiology (HuGE) Navigator
ZBTB20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB20
genes like me logo Genes that share disorders with ZBTB20: view

No data available for Genatlas for ZBTB20 Gene

Publications for ZBTB20 Gene

  1. Identification and characterization of DPZF, a novel human BTB/POZ zinc finger protein sharing homology to BCL-6. (PMID: 11352661) Zhang W. … Cao X. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 67
  2. Assignment of the human zinc finger gene, ZNF288, to chromosome 3 band q13.2 by radiation hybrid mapping and fluorescence in situ hybridisation. (PMID: 10965110) Harboe T.L. … Tommerup N. (Cytogenet. Cell Genet. 2000) 2 3
  3. Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. (PMID: 24694013) Davies M.N. … Wang J. (Genome Biol. 2014) 3
  4. A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels. (PMID: 25240745) LA^pez S. … Soria J.M. (Mitochondrion 2014) 3
  5. Zbtb20 defines a hippocampal neuronal identity through direct repression of genes that control projection neuron development in the isocortex. (PMID: 23283686) Nielsen J.V. … Jensen N.A. (Cereb. Cortex 2014) 3

Products for ZBTB20 Gene

Sources for ZBTB20 Gene

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