Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRPC4AP Gene

Aliases for TRPC4AP Gene

  • Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein 2 3
  • TNF-Receptor Ubiquitous Scaffolding/Signaling Protein 3 4
  • Trpc4-Associated Protein 3 4
  • C20orf188 3 4
  • TRRP4AP 3 4
  • TRUSS 3 6
  • Tumor Necrosis Factor Receptor-Associated Ubiquitous Scaffolding And Signaling Protein 3
  • Short Transient Receptor Potential Channel 4 Associated Protein 3
  • Short Transient Receptor Potential Channel 4-Associated Protein 3
  • Protein Phosphatase 1, Regulatory Subunit 158 3
  • Chromosome 20 Open Reading Frame 188 2
  • TRP4-Associated Protein 3
  • Trp4-Associated Protein 4
  • Regulatory Subunit 158 2
  • Protein Phosphatase 1 2
  • Protein TRUSS 4
  • Protein TAP1 4
  • PPP1R158 3

External Ids for TRPC4AP Gene

Previous HGNC Symbols for TRPC4AP Gene

  • C20orf188

Previous GeneCards Identifiers for TRPC4AP Gene

  • GC20M034258
  • GC20M034305
  • GC20M033053
  • GC20M033590
  • GC20M030368

Summaries for TRPC4AP Gene

GeneCards Summary for TRPC4AP Gene

TRPC4AP (Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein) is a Protein Coding gene. Diseases associated with TRPC4AP include plantar fasciitis and epididymo-orchitis. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include phosphatase binding.

UniProtKB/Swiss-Prot for TRPC4AP Gene

  • Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.

Gene Wiki entry for TRPC4AP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPC4AP Gene

Genomics for TRPC4AP Gene

Regulatory Elements for TRPC4AP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRPC4AP Gene

Start:
35,002,404 bp from pter
End:
35,092,871 bp from pter
Size:
90,468 bases
Orientation:
Minus strand

Genomic View for TRPC4AP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRPC4AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPC4AP Gene

Proteins for TRPC4AP Gene

  • Protein details for TRPC4AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEL6-TP4AP_HUMAN
    Recommended name:
    Short transient receptor potential channel 4-associated protein
    Protein Accession:
    Q8TEL6
    Secondary Accessions:
    • E1P5Q0
    • E1P5Q1
    • Q96H82
    • Q9BVB8
    • Q9H429
    • Q9UFS6

    Protein attributes for TRPC4AP Gene

    Size:
    797 amino acids
    Molecular mass:
    90852 Da
    Quaternary structure:
    • Constitutively associated with TNFRSF1A. Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG. Interacts with TRPC1, TRPC4 and TRPC5 (By similarity). Component of the DCX(TRUSS) E3 ubiquitin ligase complex, at least composed of CUL4A, DDB1, TRPC4AP/TRUSS and RBX1. Interacts directly with DDB1. Interacts with MYC.
    SequenceCaution:
    • Sequence=BAB84932.1; Type=Frameshift; Positions=43; Evidence={ECO:0000305};

    Alternative splice isoforms for TRPC4AP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPC4AP Gene

Proteomics data for TRPC4AP Gene at MOPED

Post-translational modifications for TRPC4AP Gene

  • Ubiquitination at Lys70, Lys275, Lys303, Lys426, Lys472, Lys557, and Lys598
  • Modification sites at PhosphoSitePlus

Other Protein References for TRPC4AP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TRPC4AP Gene

Domains for TRPC4AP Gene

Protein Domains for TRPC4AP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRPC4AP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TRPC4AP Gene

Function for TRPC4AP Gene

Molecular function for TRPC4AP Gene

UniProtKB/Swiss-Prot Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.

Gene Ontology (GO) - Molecular Function for TRPC4AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19389623
GO:0019902 phosphatase binding IDA 19389623
genes like me logo Genes that share ontologies with TRPC4AP: view

Phenotypes for TRPC4AP Gene

genes like me logo Genes that share phenotypes with TRPC4AP: view

Animal Model Products

CRISPR Products

miRNA for TRPC4AP Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRPC4AP Gene

Localization for TRPC4AP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRPC4AP Gene COMPARTMENTS Subcellular localization image for TRPC4AP gene
Compartment Confidence
mitochondrion 2
cytoskeleton 1
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRPC4AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex IDA 20551172
genes like me logo Genes that share ontologies with TRPC4AP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRPC4AP Gene

Pathways for TRPC4AP Gene

genes like me logo Genes that share pathways with TRPC4AP: view

Pathways by source for TRPC4AP Gene

UniProtKB/Swiss-Prot Q8TEL6-TP4AP_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRPC4AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IDA 20551172
GO:0016567 protein ubiquitination IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
GO:0070588 calcium ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with TRPC4AP: view

Transcripts for TRPC4AP Gene

Unigene Clusters for TRPC4AP Gene

Transient receptor potential cation channel, subfamily C, member 4 associated protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRPC4AP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TRPC4AP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRPC4AP Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for TRPC4AP Gene

GeneLoc Exon Structure for
TRPC4AP
ECgene alternative splicing isoforms for
TRPC4AP

Expression for TRPC4AP Gene

mRNA expression in normal human tissues for TRPC4AP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRPC4AP Gene

SOURCE GeneReport for Unigene cluster for TRPC4AP Gene Hs.168073

genes like me logo Genes that share expressions with TRPC4AP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRPC4AP Gene

Orthologs for TRPC4AP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRPC4AP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPC4AP 35
  • 99.62 (n)
  • 99.87 (a)
TRPC4AP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRPC4AP 35
  • 93.06 (n)
  • 98.87 (a)
TRPC4AP 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRPC4AP 35
  • 94.23 (n)
  • 99 (a)
TRPC4AP 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trpc4ap 35
  • 91.55 (n)
  • 97.62 (a)
Trpc4ap 16
Trpc4ap 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRPC4AP 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRPC4AP 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trpc4ap 35
  • 91.3 (n)
  • 97.74 (a)
chicken
(Gallus gallus)
Aves TRPC4AP 35
  • 77.45 (n)
  • 85.32 (a)
TRPC4AP 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRPC4AP 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22642 35
tropical clawed frog
(Silurana tropicalis)
Amphibia trpc4ap 35
  • 74.24 (n)
  • 80.52 (a)
zebrafish
(Danio rerio)
Actinopterygii tap1a 35
trpc4apa 35
  • 71.23 (n)
  • 75.4 (a)
trpc4apa 36
  • 74 (a)
OneToMany
trpc4apb 36
  • 70 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for TRPC4AP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRPC4AP Gene

ENSEMBL:
Gene Tree for TRPC4AP (if available)
TreeFam:
Gene Tree for TRPC4AP (if available)

Paralogs for TRPC4AP Gene

No data available for Paralogs for TRPC4AP Gene

Variants for TRPC4AP Gene

Sequence variations from dbSNP and Humsavar for TRPC4AP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs14329 -- 35,006,451(+) TGTTG(A/G)TATAT missense, reference
rs717593 -- 35,065,161(-) GCATT(C/G)AGGAA intron-variant
rs752075 -- 35,003,788(+) GCAGC(A/C)CCAGT intron-variant
rs752448 -- 35,004,445(-) GCCCC(A/G)GCAGA intron-variant
rs752449 -- 35,004,671(-) GCTCC(C/T)AGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRPC4AP Gene

Variant ID Type Subtype PubMed ID
nsv833962 CNV Loss 17160897
nsv3362 CNV Insertion 18451855
esv2618405 CNV Deletion 19546169
esv2294766 CNV Deletion 18987734
esv3757 CNV Deletion 18987735
esv2722358 CNV Deletion 23290073
esv1332184 CNV Deletion 17803354
esv993031 CNV Deletion 20482838
esv9162 CNV Loss 19470904
esv2722359 CNV Deletion 23290073
esv2722360 CNV Deletion 23290073
esv2722363 CNV Deletion 23290073

Relevant External Links for TRPC4AP Gene

HapMap Linkage Disequilibrium report
TRPC4AP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPC4AP Gene

Disorders for TRPC4AP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (5) Diseases for TRPC4AP Gene including...

Search for TRPC4AP Gene in MalaCards »

(4) University of Copenhagen DISEASES for TRPC4AP Gene

Relevant External Links for TRPC4AP

Genetic Association Database (GAD)
TRPC4AP
Human Genome Epidemiology (HuGE) Navigator
TRPC4AP
genes like me logo Genes that share disorders with TRPC4AP: view

No data available for UniProtKB/Swiss-Prot for TRPC4AP Gene

Publications for TRPC4AP Gene

  1. TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH(2)-terminal kinase and transcription factor AP-1. (PMID: 16876162) Soond S.M. … Riches D.W. (FEBS Lett. 2006) 3 23
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis. (PMID: 18449908) Poduslo S.E. … Smith S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48
  5. The frequency of the TRPC4AP haplotype in Alzheimer's patients. (PMID: 19059308) Poduslo S.E. … Huang J. (Neurosci. Lett. 2009) 3 48

Products for TRPC4AP Gene

Sources for TRPC4AP Gene

Back to Top

Content