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Aliases for TRPC4AP Gene

Aliases for TRPC4AP Gene

  • Transient Receptor Potential Cation Channel Subfamily C Member 4 Associated Protein 2 3 5
  • TNF-Receptor Ubiquitous Scaffolding/Signaling Protein 3 4
  • Protein Phosphatase 1, Regulatory Subunit 158 2 3
  • Trpc4-Associated Protein 3 4
  • C20orf188 3 4
  • TRRP4AP 3 4
  • Tumor Necrosis Factor Receptor-Associated Ubiquitous Scaffolding And Signaling Protein 3
  • Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein 2
  • Short Transient Receptor Potential Channel 4-Associated Protein 3
  • Chromosome 20 Open Reading Frame 188 2
  • TRP4-Associated Protein 3
  • Trp4-Associated Protein 4
  • Protein TRUSS 4
  • Protein TAP1 4
  • PPP1R158 3
  • TRUSS 3

External Ids for TRPC4AP Gene

Previous HGNC Symbols for TRPC4AP Gene

  • C20orf188

Previous GeneCards Identifiers for TRPC4AP Gene

  • GC20M034258
  • GC20M034305
  • GC20M033053
  • GC20M033590
  • GC20M030368

Summaries for TRPC4AP Gene

GeneCards Summary for TRPC4AP Gene

TRPC4AP (Transient Receptor Potential Cation Channel Subfamily C Member 4 Associated Protein) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include phosphatase binding.

UniProtKB/Swiss-Prot for TRPC4AP Gene

  • Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.

Gene Wiki entry for TRPC4AP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPC4AP Gene

Genomics for TRPC4AP Gene

Regulatory Elements for TRPC4AP Gene

Enhancers for TRPC4AP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G035765 1.8 FANTOM5 ENCODE dbSUPER 19.9 -676.7 -676675 9.2 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF548 SP3 NFYC CPNE1 RBM12 NCOA6 PHF20 AAR2 TRPC4AP PROCR RPL36P4 TGIF2 RBM39
GH20G035739 3.1 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -648.9 -648853 7.0 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 CPNE1 RBM12 PHF20 RBM39 EIF6 AAR2 TRPC4AP RPL36P4 SPAG4 SCAND1
GH20G035207 1.3 Ensembl ENCODE 24.3 -115.5 -115530 1.4 FOXA2 ATF1 ARNT ARID4B SIN3A YY1 TCF12 GTF3C2 GATA2 ZNF143 TRPC4AP RBM12 NCOA6 RPL36P4 CPNE1 EIF6 EDEM2 MMP24-AS1 ENSG00000201151 MIR499A
GH20G035874 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -782.6 -782647 2.6 PKNOX1 FOXA2 ATF1 ARNT SIN3A FEZF1 BRCA1 ZNF2 GTF3C2 KLF7 CPNE1 RBM12 RPL36P4 TRPC4AP NFS1 EIF6 RBM39 AAR2 PHF20 ROMO1
GH20G035881 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -790.9 -790915 4.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZNF143 FOS DEK CPNE1 RBM12 RPL36P4 TRPC4AP EIF6 AAR2 RNU6-937P PHF20 RBM39 NFS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRPC4AP on UCSC Golden Path with GeneCards custom track

Promoters for TRPC4AP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136506 671 1601 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A

Genomic Location for TRPC4AP Gene

Chromosome:
20
Start:
35,002,404 bp from pter
End:
35,092,871 bp from pter
Size:
90,468 bases
Orientation:
Minus strand

Genomic View for TRPC4AP Gene

Genes around TRPC4AP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPC4AP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPC4AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPC4AP Gene

Proteins for TRPC4AP Gene

  • Protein details for TRPC4AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEL6-TP4AP_HUMAN
    Recommended name:
    Short transient receptor potential channel 4-associated protein
    Protein Accession:
    Q8TEL6
    Secondary Accessions:
    • E1P5Q0
    • E1P5Q1
    • Q96H82
    • Q9BVB8
    • Q9H429
    • Q9UFS6

    Protein attributes for TRPC4AP Gene

    Size:
    797 amino acids
    Molecular mass:
    90852 Da
    Quaternary structure:
    • Constitutively associated with TNFRSF1A. Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG. Interacts with TRPC1, TRPC4 and TRPC5 (By similarity). Component of the DCX(TRUSS) E3 ubiquitin ligase complex, at least composed of CUL4A, DDB1, TRPC4AP/TRUSS and RBX1. Interacts directly with DDB1. Interacts with MYC.
    SequenceCaution:
    • Sequence=BAB84932.1; Type=Frameshift; Positions=43; Evidence={ECO:0000305};

    Alternative splice isoforms for TRPC4AP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPC4AP Gene

Post-translational modifications for TRPC4AP Gene

  • Ubiquitination at Lys70, posLast=275275, isoforms=2, 3303, isoforms=2, 3426, Lys472, Lys557, and posLast=598598
  • Modification sites at PhosphoSitePlus

Other Protein References for TRPC4AP Gene

No data available for DME Specific Peptides for TRPC4AP Gene

Domains & Families for TRPC4AP Gene

Gene Families for TRPC4AP Gene

Protein Domains for TRPC4AP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRPC4AP: view

No data available for UniProtKB/Swiss-Prot for TRPC4AP Gene

Function for TRPC4AP Gene

Molecular function for TRPC4AP Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.

Gene Ontology (GO) - Molecular Function for TRPC4AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005262 calcium channel activity TAS --
GO:0005515 protein binding IPI 19389623
GO:0019902 phosphatase binding IDA 19389623
genes like me logo Genes that share ontologies with TRPC4AP: view
genes like me logo Genes that share phenotypes with TRPC4AP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRPC4AP Gene

Localization for TRPC4AP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPC4AP gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TRPC4AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex IDA 20551172
genes like me logo Genes that share ontologies with TRPC4AP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRPC4AP Gene

Pathways & Interactions for TRPC4AP Gene

genes like me logo Genes that share pathways with TRPC4AP: view

Pathways by source for TRPC4AP Gene

UniProtKB/Swiss-Prot Q8TEL6-TP4AP_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRPC4AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IDA 20551172
GO:0016567 protein ubiquitination IEA --
GO:0048820 hair follicle maturation IEA --
GO:0070588 calcium ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with TRPC4AP: view

No data available for SIGNOR curated interactions for TRPC4AP Gene

Drugs & Compounds for TRPC4AP Gene

No Compound Related Data Available

Transcripts for TRPC4AP Gene

Unigene Clusters for TRPC4AP Gene

Transient receptor potential cation channel, subfamily C, member 4 associated protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRPC4AP Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for TRPC4AP Gene

GeneLoc Exon Structure for
TRPC4AP
ECgene alternative splicing isoforms for
TRPC4AP

Expression for TRPC4AP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRPC4AP Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRPC4AP Gene



Protein tissue co-expression partners for TRPC4AP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRPC4AP Gene:

TRPC4AP

SOURCE GeneReport for Unigene cluster for TRPC4AP Gene:

Hs.168073

Evidence on tissue expression from TISSUES for TRPC4AP Gene

  • Nervous system(4.6)
  • Muscle(4.2)
  • Lung(3.2)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with TRPC4AP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPC4AP Gene

Orthologs for TRPC4AP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRPC4AP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPC4AP 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia TRPC4AP 34 35
  • 94.23 (n)
cow
(Bos Taurus)
Mammalia TRPC4AP 34 35
  • 93.06 (n)
mouse
(Mus musculus)
Mammalia Trpc4ap 34 16 35
  • 91.55 (n)
rat
(Rattus norvegicus)
Mammalia Trpc4ap 34
  • 91.3 (n)
oppossum
(Monodelphis domestica)
Mammalia TRPC4AP 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRPC4AP 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRPC4AP 34 35
  • 77.45 (n)
lizard
(Anolis carolinensis)
Reptilia TRPC4AP 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpc4ap 34
  • 74.24 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22642 34
zebrafish
(Danio rerio)
Actinopterygii trpc4apa 34 35
  • 71.23 (n)
trpc4apb 35
  • 70 (a)
OneToMany
tap1a 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToOne
Species where no ortholog for TRPC4AP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRPC4AP Gene

ENSEMBL:
Gene Tree for TRPC4AP (if available)
TreeFam:
Gene Tree for TRPC4AP (if available)

Paralogs for TRPC4AP Gene

No data available for Paralogs for TRPC4AP Gene

Variants for TRPC4AP Gene

Sequence variations from dbSNP and Humsavar for TRPC4AP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000009485 -- 35,026,360(+) TAGGT(A/G)GGTGT intron-variant
rs1000096363 -- 35,017,145(+) TTATG(A/G)TATGC intron-variant
rs1000101864 -- 35,074,893(+) TTATT(A/G)TGTGG intron-variant
rs1000117125 -- 35,078,958(+) CTACT(C/T)GGGAG intron-variant
rs1000121826 -- 35,033,039(+) TAAAA(C/T)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRPC4AP Gene

Variant ID Type Subtype PubMed ID
dgv2245n106 CNV deletion 24896259
esv1332184 CNV deletion 17803354
esv2294766 CNV deletion 18987734
esv2618405 CNV deletion 19546169
esv2722358 CNV deletion 23290073
esv2722359 CNV deletion 23290073
esv2722360 CNV deletion 23290073
esv2722363 CNV deletion 23290073
esv3066013 CNV deletion 24192839
esv3557027 CNV deletion 23714750
esv3757 CNV loss 18987735
esv9162 CNV loss 19470904
esv993031 CNV deletion 20482838
nsv1055447 CNV loss 25217958
nsv1063673 CNV loss 25217958
nsv1073055 CNV deletion 25765185
nsv1110753 CNV insertion 24896259
nsv1123482 CNV deletion 24896259
nsv1150514 CNV deletion 26484159
nsv1153786 CNV insertion 26484159
nsv3362 CNV insertion 18451855
nsv478118 CNV novel sequence insertion 20440878
nsv833962 CNV loss 17160897
nsv956213 CNV deletion 24416366

Variation tolerance for TRPC4AP Gene

Residual Variation Intolerance Score: 5.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRPC4AP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPC4AP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPC4AP Gene

Disorders for TRPC4AP Gene

Relevant External Links for TRPC4AP

Genetic Association Database (GAD)
TRPC4AP
Human Genome Epidemiology (HuGE) Navigator
TRPC4AP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRPC4AP

No disorders were found for TRPC4AP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRPC4AP Gene

Publications for TRPC4AP Gene

  1. Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells. (PMID: 20551172) Choi S.H. … Cole M.D. (Genes Dev. 2010) 3 4 64
  2. Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis. (PMID: 18449908) Poduslo S.E. … Smith S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 64
  3. The frequency of the TRPC4AP haplotype in Alzheimer's patients. (PMID: 19059308) Poduslo S.E. … Huang J. (Neurosci. Lett. 2009) 3 46 64
  4. TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH(2)-terminal kinase and transcription factor AP-1. (PMID: 16876162) Soond S.M. … Riches D.W. (FEBS Lett. 2006) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TRPC4AP Gene

Sources for TRPC4AP Gene

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