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Aliases for KLK13 Gene

Aliases for KLK13 Gene

  • Kallikrein Related Peptidase 13 2 3 5
  • Kallikrein-Like Protein 4 3 4
  • KLK-L4 3 4
  • KLKL4 3 4
  • Kallikrein-Like Gene 4 3
  • Kallikrein 13 2
  • Kallikrein-13 3
  • EC 3.4.21.- 4
  • EC 3.4.21 58

External Ids for KLK13 Gene

Previous GeneCards Identifiers for KLK13 Gene

  • GC19M052189
  • GC19M051920
  • GC19M056235
  • GC19M056251
  • GC19M051559
  • GC19M047892

Summaries for KLK13 Gene

Entrez Gene Summary for KLK13 Gene

  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. [provided by RefSeq, Jan 2017]

GeneCards Summary for KLK13 Gene

KLK13 (Kallikrein Related Peptidase 13) is a Protein Coding gene. Among its related pathways are Keratinization and Collagen chain trimerization. GO annotations related to this gene include hydrolase activity and endopeptidase activity. An important paralog of this gene is KLK8.

Gene Wiki entry for KLK13 Gene

Additional gene information for KLK13 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLK13 Gene

Genomics for KLK13 Gene

Regulatory Elements for KLK13 Gene

Enhancers for KLK13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H051064 1.1 Ensembl ENCODE 16.1 -0.2 -178 1 BCOR HDAC1 SOX13 CHD4 ZMYM3 ZBTB40 CCNT2 ZFHX2 ZNF766 ZNF316 KLK13 KLK14
GH19H051016 1.2 Ensembl ENCODE 11.2 +47.7 47738 1 PKNOX1 ATF1 SIN3A GLI4 ZNF121 GLIS2 ZNF143 KLF7 SP3 REST ZNF175 ZNF615 KLK10 ZNF577 LRRC4B POLD1 SPACA6 ZNF613 ZNF350 KLK13
GH19H051018 1.1 Ensembl ENCODE 11.2 +45.7 45682 2 TCF12 GLIS2 ZNF302 EGR1 ZNF366 ZNF416 ETV6 EGR2 SMARCA5 SP3 ZNF577 ZNF649 KLK10 ZNF175 ENSG00000269483 KLK13 KLK6 ZNF350 ZNF615 KLK14
GH19H051070 0.7 ENCODE 0.4 -6.0 -6014 0 PKNOX1 NFIB CTBP1 ARID3A GATA3 NCOR1 FOS RCOR1 HES1 TCF7L2 POLD1 CTU1 KLK10 KLK11 KLK2 KLK13 KLK14
GH19H051045 0.7 ENCODE 0.4 +18.2 18239 2 PKNOX1 ZNF687 RFX1 MAX ELF1 ETS1 NFIC MTA1 ZNF366 POLR2A ENSG00000267808 ENSG00000268390 KLK13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLK13 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLK13 Gene

Chromosome:
19
Start:
51,056,206 bp from pter
End:
51,065,114 bp from pter
Size:
8,909 bases
Orientation:
Minus strand

Genomic View for KLK13 Gene

Genes around KLK13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLK13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLK13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLK13 Gene

Proteins for KLK13 Gene

  • Protein details for KLK13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKR3-KLK13_HUMAN
    Recommended name:
    Kallikrein-13
    Protein Accession:
    Q9UKR3
    Secondary Accessions:
    • A7UNK6
    • Q86VI8
    • Q9Y433

    Protein attributes for KLK13 Gene

    Size:
    277 amino acids
    Molecular mass:
    30570 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLK13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLK13 Gene

Selected DME Specific Peptides for KLK13 Gene

Q9UKR3:
  • VLTAAHC
  • GDSGGPL
  • CGGVLVH
  • EGGKDSC
  • SGGPLVC
  • WVLTAAH

Post-translational modifications for KLK13 Gene

  • Glycosylation at isoforms=30 and posLast=225225
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for KLK13 (Kallikrein 13)

Protein Products

Assay Products

  • Cloud-Clone Corp. Assay Kits for KLK13

Domains & Families for KLK13 Gene

Gene Families for KLK13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

Q9UKR3

UniProtKB/Swiss-Prot:

KLK13_HUMAN :
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
Family:
  • Belongs to the peptidase S1 family. Kallikrein subfamily.
genes like me logo Genes that share domains with KLK13: view

Function for KLK13 Gene

Enzyme Numbers (IUBMB) for KLK13 Gene

Phenotypes From GWAS Catalog for KLK13 Gene

Gene Ontology (GO) - Molecular Function for KLK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS,IEA 10766816
GO:0005515 protein binding IPI 14687906
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IDA,IEA 14687906
genes like me logo Genes that share ontologies with KLK13: view
genes like me logo Genes that share phenotypes with KLK13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KLK13
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KLK13 Gene

Localization for KLK13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLK13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLK13 gene
Compartment Confidence
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for KLK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10766816
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IDA 12642628
GO:0030141 secretory granule IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with KLK13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLK13 Gene

Pathways & Interactions for KLK13 Gene

genes like me logo Genes that share pathways with KLK13: view

Gene Ontology (GO) - Biological Process for KLK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,NAS 10766816
GO:0016485 protein processing IEA --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KLK13: view

No data available for SIGNOR curated interactions for KLK13 Gene

Drugs & Compounds for KLK13 Gene

(1) Drugs for KLK13 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KLK13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLK13: view

Transcripts for KLK13 Gene

Unigene Clusters for KLK13 Gene

Kallikrein-related peptidase 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KLK13
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KLK13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8: - - - - - - -

Relevant External Links for KLK13 Gene

GeneLoc Exon Structure for
KLK13
ECgene alternative splicing isoforms for
KLK13

Expression for KLK13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLK13 Gene

mRNA differential expression in normal tissues according to GTEx for KLK13 Gene

This gene is overexpressed in Esophagus - Mucosa (x33.1), Vagina (x6.2), Cervix - Ectocervix (x6.2), and Minor Salivary Gland (x5.1).

Protein differential expression in normal tissues from HIPED for KLK13 Gene

This gene is overexpressed in Cervix (59.3) and Oral epithelium (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLK13 Gene



Protein tissue co-expression partners for KLK13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLK13 Gene:

KLK13

SOURCE GeneReport for Unigene cluster for KLK13 Gene:

Hs.165296

mRNA Expression by UniProt/SwissProt for KLK13 Gene:

Q9UKR3-KLK13_HUMAN
Tissue specificity: Expressed in prostate, breast, testis and salivary gland.

Evidence on tissue expression from TISSUES for KLK13 Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with KLK13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLK13 Gene

Orthologs for KLK13 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLK13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLK13 33 34
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia KLK13 33 34
  • 86.4 (n)
cow
(Bos Taurus)
Mammalia LOC540297 33
  • 83.87 (n)
KLK13 34
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klk13 33 16 34
  • 78.91 (n)
rat
(Rattus norvegicus)
Mammalia Klk13 33
  • 78.79 (n)
oppossum
(Monodelphis domestica)
Mammalia KLK13 34
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17239 35
  • 35 (a)
CG11911 35
  • 34 (a)
Species where no ortholog for KLK13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLK13 Gene

ENSEMBL:
Gene Tree for KLK13 (if available)
TreeFam:
Gene Tree for KLK13 (if available)

Paralogs for KLK13 Gene

genes like me logo Genes that share paralogs with KLK13: view

Variants for KLK13 Gene

Sequence variations from dbSNP and Humsavar for KLK13 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000550319 -- 51,058,029(+) CTCTT(C/T)CTAAT intron-variant
rs1000577423 -- 51,061,924(+) CCAGG(C/T)ATTTA intron-variant
rs1000784158 -- 51,067,023(+) ATCCA(A/T)TGTAC downstream-variant-500B, upstream-variant-2KB
rs1001474517 -- 51,056,721(+) TCCCC(A/G)GGAGA nc-transcript-variant, reference, missense
rs1001560544 -- 51,059,512(+) AAAAT(A/T)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLK13 Gene

Variant ID Type Subtype PubMed ID
esv2763209 CNV loss 21179565
esv34104 CNV loss 18971310
nsv1140251 OTHER inversion 24896259
nsv524556 CNV gain 19592680
nsv819004 CNV gain 19587683
nsv828585 CNV loss 20364138

Variation tolerance for KLK13 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLK13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLK13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLK13 Gene

Disorders for KLK13 Gene

Relevant External Links for KLK13

Genetic Association Database (GAD)
KLK13
Human Genome Epidemiology (HuGE) Navigator
KLK13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLK13

No disorders were found for KLK13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLK13 Gene

Publications for KLK13 Gene

  1. Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues. (PMID: 10766816) Yousef GM … Diamandis EP (The Journal of biological chemistry 2000) 3 4 22 60
  2. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. (PMID: 20424135) Klein RJ … Lilja H (Cancer prevention research (Philadelphia, Pa.) 2010) 3 45 60
  3. Understanding the accuracy of statistical haplotype inference with sequence data of known phase. (PMID: 17922479) Andrés AM … Hixson JE (Genetic epidemiology 2007) 3 4 60
  4. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PMID: 16800723) (Biological chemistry 2006) 2 3 60
  5. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PMID: 16800724) Lundwall A … Yousef GM (Biological chemistry 2006) 2 3 60

Products for KLK13 Gene

Sources for KLK13 Gene

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