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Aliases for ZNF451 Gene

Aliases for ZNF451 Gene

  • Zinc Finger Protein 451 2 3
  • COASTER 3 4 6
  • Coactivator For Steroid Receptors 3 4
  • DJ417I1.1 3
  • KIAA0576 4
  • KIAA1702 4

External Ids for ZNF451 Gene

Summaries for ZNF451 Gene

GeneCards Summary for ZNF451 Gene

ZNF451 (Zinc Finger Protein 451) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZNF451 Gene

  • May be involved in transcriptional regulation. Coactivator for steroid receptors

Gene Wiki entry for ZNF451 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF451 Gene

Genomics for ZNF451 Gene

Genomic Location for ZNF451 Gene

Start:
57,086,844 bp from pter
End:
57,170,307 bp from pter
Size:
83,464 bases
Orientation:
Plus strand

Genomic View for ZNF451 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF451 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF451 Gene

Regulatory Elements for ZNF451 Gene

Proteins for ZNF451 Gene

  • Protein details for ZNF451 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4E5-ZN451_HUMAN
    Recommended name:
    Zinc finger protein 451
    Protein Accession:
    Q9Y4E5
    Secondary Accessions:
    • Q5VVE9
    • Q5VVF1
    • Q86YE4
    • Q8N380
    • Q8TD15
    • Q9C0G1
    • Q9NQM1

    Protein attributes for ZNF451 Gene

    Size:
    1061 amino acids
    Molecular mass:
    121484 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH21712.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH42450.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=AAH58853.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BAA25502.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB21793.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF451 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF451 Gene

Proteomics data for ZNF451 Gene at MOPED

Post-translational modifications for ZNF451 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys106, Lys139, Lys144, Lys153, Lys316, Lys357, Lys387, Lys423, Lys434, Lys452, Lys454, Lys464, Lys585, Lys706, Lys779, Lys790, Lys817, Lys827, Lys832, Lys845, Lys852, Lys286, Lys356, and Lys522

No data available for DME Specific Peptides for ZNF451 Gene

Domains for ZNF451 Gene

Gene Families for ZNF451 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF451 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ZN451_HUMAN
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9Y4E5
Similarity:
  • Contains 11 C2H2-type zinc fingers.:
    • Q9Y4E5
genes like me logo Genes that share domains with ZNF451: view

Function for ZNF451 Gene

Molecular function for ZNF451 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation. Coactivator for steroid receptors

Gene Ontology (GO) - Molecular Function for ZNF451 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF451: view

miRNA for ZNF451 Gene

miRTarBase miRNAs that target ZNF451

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF451 Gene

Localization for ZNF451 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF451 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF451 Gene COMPARTMENTS Subcellular localization image for ZNF451 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZNF451 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF451: view

Pathways for ZNF451 Gene

SuperPathways for ZNF451 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF451 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF451: view

No data available for Pathways by source for ZNF451 Gene

Transcripts for ZNF451 Gene

Unigene Clusters for ZNF451 Gene

Zinc finger protein 451:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF451 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - -
SP6:

Relevant External Links for ZNF451 Gene

GeneLoc Exon Structure for
ZNF451
ECgene alternative splicing isoforms for
ZNF451

Expression for ZNF451 Gene

mRNA expression in normal human tissues for ZNF451 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF451 Gene

SOURCE GeneReport for Unigene cluster for ZNF451 Gene Hs.485628

genes like me logo Genes that share expressions with ZNF451: view

Orthologs for ZNF451 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF451 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF451 36
  • 99.56 (n)
  • 99.43 (a)
ZNF451 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF451 36
  • 84.46 (n)
  • 82.4 (a)
ZNF451 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF451 36
  • 91.18 (n)
  • 89.32 (a)
ZNF451 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp451 36
  • 82.87 (n)
  • 79.77 (a)
Zfp451 16
Zfp451 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF451 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 71 (a)
OneToMany
-- 37
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp451 36
  • 82.64 (n)
  • 78.8 (a)
chicken
(Gallus gallus)
Aves ZNF451 36
  • 67.08 (n)
  • 59.9 (a)
ZNF451 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF451 37
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3549 36
znf451 36
  • 59.56 (n)
  • 50.97 (a)
zebrafish
(Danio rerio)
Actinopterygii znf451 36
  • 50.78 (n)
  • 42.47 (a)
znf451 37
  • 37 (a)
OneToOne
Species with no ortholog for ZNF451:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF451 Gene

ENSEMBL:
Gene Tree for ZNF451 (if available)
TreeFam:
Gene Tree for ZNF451 (if available)

Paralogs for ZNF451 Gene

Selected SIMAP similar genes for ZNF451 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZNF451: view

No data available for Paralogs for ZNF451 Gene

Variants for ZNF451 Gene

Sequence variations from dbSNP and Humsavar for ZNF451 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3800020 -- 57,103,685(-) AAAAA(C/T)GCAGA intron-variant, utr-variant-3-prime
rs3800021 -- 57,101,936(-) ATTTG(C/T)GATCT intron-variant, reference, missense
rs3800022 -- 57,101,279(-) CACAA(C/T)CAGGT intron-variant, reference, missense
rs3800023 -- 57,100,898(-) CCTCA(C/G)AAGAG intron-variant, reference, missense
rs3800024 -- 57,090,053(-) GAGCC(G/T)CTTTC utr-variant-5-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF451 Gene

Variant ID Type Subtype PubMed ID
esv2732127 CNV Deletion 23290073
nsv350038 CNV Loss 16902084
nsv5316 CNV Insertion 18451855
nsv462949 CNV Loss 19166990

Relevant External Links for ZNF451 Gene

HapMap Linkage Disequilibrium report
ZNF451
Human Gene Mutation Database (HGMD)
ZNF451

Disorders for ZNF451 Gene

No disorders were found for ZNF451 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF451 Gene

Publications for ZNF451 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for ZNF451 Gene

Sources for ZNF451 Gene

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