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Aliases for PCDHGA12 Gene

Aliases for PCDHGA12 Gene

  • Protocadherin Gamma Subfamily A, 12 2 3
  • Fibroblast Cadherin FIB3 2 3
  • Fibroblast Cadherin-3 3 4
  • PCDH-GAMMA-A12 3 4
  • Cadherin 21 2 3
  • Cadherin-21 3 4
  • CDH21 3 4
  • FIB3 3 4
  • Protocadherin Gamma-A12 3
  • KIAA0588 4

External Ids for PCDHGA12 Gene

Previous HGNC Symbols for PCDHGA12 Gene

  • CDH21

Previous GeneCards Identifiers for PCDHGA12 Gene

  • GC05P140597
  • GC05P141318
  • GC05P140721
  • GC05P140780
  • GC05P140800
  • GC05P140740
  • GC05P140815
  • GC05P140838
  • GC05P140927
  • GC05P140949
  • GC05P140970
  • GC05P140992
  • GC05P141022
  • GC05P141052
  • GC05P141080
  • GC05P135955
  • GC05P141119
  • GC05P141144
  • GC05P141182
  • GC05P141213
  • GC05P141252
  • GC05P141298
  • GC05P141379

Summaries for PCDHGA12 Gene

Entrez Gene Summary for PCDHGA12 Gene

  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHGA12 Gene

PCDHGA12 (Protocadherin Gamma Subfamily A, 12) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA11.

UniProtKB/Swiss-Prot for PCDHGA12 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Wiki entry for PCDHGA12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHGA12 Gene

Genomics for PCDHGA12 Gene

Regulatory Elements for PCDHGA12 Gene

Genomic Location for PCDHGA12 Gene

Start:
141,430,589 bp from pter
End:
141,512,979 bp from pter
Size:
82,391 bases
Orientation:
Plus strand

Genomic View for PCDHGA12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHGA12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHGA12 Gene

Proteins for PCDHGA12 Gene

  • Protein details for PCDHGA12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60330-PCDGC_HUMAN
    Recommended name:
    Protocadherin gamma-A12
    Protein Accession:
    O60330
    Secondary Accessions:
    • O15100
    • Q6UW70
    • Q9Y5D7

    Protein attributes for PCDHGA12 Gene

    Size:
    932 amino acids
    Molecular mass:
    100955 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ89305.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA25514.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PCDHGA12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCDHGA12 Gene

Proteomics data for PCDHGA12 Gene at MOPED

Post-translational modifications for PCDHGA12 Gene

  • Glycosylation at Asn265, Asn419, and Asn545
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHGA12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCDHGA12 Gene

Domains for PCDHGA12 Gene

Gene Families for PCDHGA12 Gene

HGNC:
  • PCDHC :Cadherins / Protocadherins : Clustered

Protein Domains for PCDHGA12 Gene

Suggested Antigen Peptide Sequences for PCDHGA12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60330

UniProtKB/Swiss-Prot:

PCDGC_HUMAN :
  • O60330
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHGA12: view

Function for PCDHGA12 Gene

Molecular function for PCDHGA12 Gene

UniProtKB/Swiss-Prot Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Ontology (GO) - Molecular Function for PCDHGA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHGA12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHGA12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PCDHGA12 Gene

Localization for PCDHGA12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHGA12 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCDHGA12 Gene COMPARTMENTS Subcellular localization image for PCDHGA12 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PCDHGA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHGA12: view

Pathways for PCDHGA12 Gene

SuperPathways for PCDHGA12 Gene

No Data Available

Interacting Proteins for PCDHGA12 Gene

Gene Ontology (GO) - Biological Process for PCDHGA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with PCDHGA12: view

No data available for Pathways by source for PCDHGA12 Gene

Compounds for PCDHGA12 Gene

(1) HMDB Compounds for PCDHGA12 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with PCDHGA12: view

Transcripts for PCDHGA12 Gene

mRNA/cDNA for PCDHGA12 Gene

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHGA12

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHGA12 Gene

No ASD Table

Relevant External Links for PCDHGA12 Gene

GeneLoc Exon Structure for
PCDHGA12
ECgene alternative splicing isoforms for
PCDHGA12

Expression for PCDHGA12 Gene

mRNA expression in normal human tissues for PCDHGA12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PCDHGA12 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PCDHGA12 Gene

genes like me logo Genes that share expressions with PCDHGA12: view

Expression partners for PCDHGA12 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCDHGA12 Gene

Orthologs for PCDHGA12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHGA12 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PCDHGA12 35
  • 83.11 (n)
  • 79.96 (a)
mouse
(Mus musculus)
Mammalia Pcdhga12 35
  • 83.93 (n)
  • 85.71 (a)
Pcdhga12 16
chimpanzee
(Pan troglodytes)
Mammalia PCDHGA12 35
  • 99.46 (n)
  • 99.46 (a)
rat
(Rattus norvegicus)
Mammalia Pcdhga12 35
  • 83.75 (n)
  • 85.17 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 50 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
Species with no ortholog for PCDHGA12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCDHGA12 Gene

ENSEMBL:
Gene Tree for PCDHGA12 (if available)
TreeFam:
Gene Tree for PCDHGA12 (if available)

Paralogs for PCDHGA12 Gene

genes like me logo Genes that share paralogs with PCDHGA12: view

Variants for PCDHGA12 Gene

Structural Variations from Database of Genomic Variants (DGV) for PCDHGA12 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850
dgv6352n71 CNV Loss 21882294
esv2730847 CNV Deletion 23290073
nsv462470 CNV Loss 19166990
esv25744 CNV Gain 19812545

Relevant External Links for PCDHGA12 Gene

HapMap Linkage Disequilibrium report
PCDHGA12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PCDHGA12 Gene

Disorders for PCDHGA12 Gene

Relevant External Links for PCDHGA12

Genetic Association Database (GAD)
PCDHGA12

No disorders were found for PCDHGA12 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PCDHGA12 Gene

Publications for PCDHGA12 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4
  2. Multiple cadherins are expressed in human fibroblasts. (PMID: 9199196) Matsuyoshi N. … Imamura S. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for PCDHGA12 Gene

Sources for PCDHGA12 Gene

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