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Aliases for TENM4 Gene

Aliases for TENM4 Gene

  • Teneurin Transmembrane Protein 4 2 3 4 5
  • Protein Odd Oz/Ten-M Homolog 4 3 4
  • Tenascin-M4 3 4
  • Ten-M4 3 4
  • Ten-4 3 4
  • ODZ4 3 4
  • TNM4 3 4
  • Odz, Odd Oz/Ten-M Homolog 4 (Drosophila) 2
  • Odz, Odd Oz/Ten-M Homolog 4 3
  • Odd Oz/Ten-M Homolog 4 3
  • KIAA1302 4
  • Doc4 3
  • ETM5 3

External Ids for TENM4 Gene

Previous HGNC Symbols for TENM4 Gene

  • ODZ4

Previous GeneCards Identifiers for TENM4 Gene

  • GC11M078363

Summaries for TENM4 Gene

GeneCards Summary for TENM4 Gene

TENM4 (Teneurin Transmembrane Protein 4) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is WIF1.

UniProtKB/Swiss-Prot for TENM4 Gene

  • Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TENM4 Gene

Genomics for TENM4 Gene

Regulatory Elements for TENM4 Gene

Enhancers for TENM4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TENM4 on UCSC Golden Path with GeneCards custom track

Promoters for TENM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TENM4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TENM4 Gene

Chromosome:
11
Start:
78,652,831 bp from pter
End:
79,440,989 bp from pter
Size:
788,159 bases
Orientation:
Minus strand

Genomic View for TENM4 Gene

Genes around TENM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TENM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TENM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TENM4 Gene

Proteins for TENM4 Gene

  • Protein details for TENM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N022-TEN4_HUMAN
    Recommended name:
    Teneurin-4
    Protein Accession:
    Q6N022
    Secondary Accessions:
    • A6ND26
    • Q7Z3C7
    • Q96MS6
    • Q9P2P4
    • Q9Y4S2

    Protein attributes for TENM4 Gene

    Size:
    2769 amino acids
    Molecular mass:
    307957 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (Probable). May also form heterodimer with either TENM1 or TENM2 or TENM3 (By similarity).
    SequenceCaution:
    • Sequence=BAB71206.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TENM4 Gene

Proteomics data for TENM4 Gene at MOPED

Post-translational modifications for TENM4 Gene

  • Glycosylation at Asn 467, Asn 940, Asn 1259, Asn 1609, Asn 1705, Asn 1741, Asn 1799, Asn 1884, Asn 1985, Asn 2188, Asn 2328, and Asn 2646
  • Modification sites at PhosphoSitePlus

Other Protein References for TENM4 Gene

No data available for DME Specific Peptides for TENM4 Gene

Domains & Families for TENM4 Gene

Suggested Antigen Peptide Sequences for TENM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6N022

UniProtKB/Swiss-Prot:

TEN4_HUMAN :
  • EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
  • Belongs to the tenascin family. Teneurin subfamily.
  • Contains 5 NHL repeats.
Domain:
  • EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
  • Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.
  • Contains 8 EGF-like domains.
  • Contains 1 teneurin N-terminal domain.
Family:
  • Belongs to the tenascin family. Teneurin subfamily.
Similarity:
  • Contains 5 NHL repeats.
  • Contains 23 YD repeats.
genes like me logo Genes that share domains with TENM4: view

No data available for Gene Families for TENM4 Gene

Function for TENM4 Gene

Molecular function for TENM4 Gene

UniProtKB/Swiss-Prot Function:
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity).
genes like me logo Genes that share phenotypes with TENM4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TENM4

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TENM4 Gene

Localization for TENM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TENM4 Gene

Membrane; Single-pass membrane protein. Nucleus. Cytoplasm. Cell projection.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TENM4 Gene COMPARTMENTS Subcellular localization image for TENM4 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TENM4 Gene

Pathways & Interactions for TENM4 Gene

SuperPathways for TENM4 Gene

No Data Available

Interacting Proteins for TENM4 Gene

Selected Interacting proteins: Q6N022-TEN4_HUMAN for TENM4 Gene via I2D

Symbol External ID(s) Details
YWHAB

Gene Ontology (GO) - Biological Process for TENM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001702 gastrulation with mouth forming second IEA --
GO:0060912 cardiac cell fate specification IEA --
GO:0097264 self proteolysis IEA --
GO:2000543 positive regulation of gastrulation ISS --
genes like me logo Genes that share ontologies with TENM4: view

No data available for Pathways by source and SIGNOR curated interactions for TENM4 Gene

Drugs & Compounds for TENM4 Gene

No Compound Related Data Available

Transcripts for TENM4 Gene

mRNA/cDNA for TENM4 Gene

(11) REFSEQ mRNAs :
(19) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TENM4 Gene

Teneurin transmembrane protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TENM4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1:
SP2: - -

Relevant External Links for TENM4 Gene

GeneLoc Exon Structure for
TENM4
ECgene alternative splicing isoforms for
TENM4

Expression for TENM4 Gene

mRNA expression in normal human tissues for TENM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TENM4 Gene

This gene is overexpressed in Ovary (x6.4) and Pituitary (x4.9).

Protein differential expression in normal tissues from HIPED for TENM4 Gene

This gene is overexpressed in Adipocyte (26.9), Fetal Brain (21.6), and Platelet (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TENM4 Gene



SOURCE GeneReport for Unigene cluster for TENM4 Gene Hs.213087

genes like me logo Genes that share expression patterns with TENM4: view

Protein tissue co-expression partners for TENM4 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TENM4 Gene

Orthologs for TENM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TENM4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ODZ4 35
  • 91.25 (n)
  • 97.08 (a)
TENM4 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TENM4 35
  • 92.57 (n)
  • 98.23 (a)
TENM4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tenm4 35
  • 90.01 (n)
  • 97.22 (a)
Tenm4 16
Tenm4 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ODZ4 35
  • 99.55 (n)
  • 99.64 (a)
TENM4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tenm4 35
  • 89.45 (n)
  • 97.26 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ODZ4 35
  • 81.92 (n)
  • 93.71 (a)
-- 36
  • 93 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 87 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tenm4 35
  • 78.31 (n)
  • 89.18 (a)
zebrafish
(Danio rerio)
Actinopterygii odz4 35
  • 72.57 (n)
  • 77.87 (a)
odz4 36
  • 76 (a)
ManyToMany
Species with no ortholog for TENM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TENM4 Gene

ENSEMBL:
Gene Tree for TENM4 (if available)
TreeFam:
Gene Tree for TENM4 (if available)

Paralogs for TENM4 Gene

Paralogs for TENM4 Gene

(8) SIMAP similar genes for TENM4 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TENM4 Gene

genes like me logo Genes that share paralogs with TENM4: view

Variants for TENM4 Gene

Sequence variations from dbSNP and Humsavar for TENM4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs3812723 - 78,863,031(+) GGAGA(C/T)GTCGG reference, missense
rs17137261 - 78,854,269(+) CGCCT(C/G)CTGGG reference, missense
rs58537389 - 79,069,904(+) GGCGC(C/T)GGGTC reference, missense, utr-variant-5-prime
rs519063 -- 78,806,535(+) TTACA(C/T)GCTAA intron-variant
rs519671 -- 79,383,654(-) CCCAC(C/T)GGCCA intron-variant

Variation tolerance for TENM4 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.52; 77.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TENM4 Gene

Human Gene Mutation Database (HGMD)
TENM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TENM4 Gene

Disorders for TENM4 Gene

Relevant External Links for TENM4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TENM4

No disorders were found for TENM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TENM4 Gene

Publications for TENM4 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 67
  2. All four members of the Ten-m/Odz family of transmembrane proteins form dimers. (PMID: 12000766) Feng K. … FAossler R. (J. Biol. Chem. 2002) 2 3
  3. The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles. (PMID: 10625539) Ben-Zur T. … Wides R. (Dev. Biol. 2000) 2 3
  4. Genome-wide association study reveals two new risk loci for bipolar disorder. (PMID: 24618891) MA1hleisen T.W. … Cichon S. (Nat Commun 2014) 3
  5. Teneurin-4, a transmembrane protein, is a novel regulator that suppresses chondrogenic differentiation. (PMID: 24648313) Suzuki N. … Akazawa C. (J. Orthop. Res. 2014) 3

Products for TENM4 Gene

Sources for TENM4 Gene

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