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Aliases for TKFC Gene

Aliases for TKFC Gene

  • Triokinase And FMN Cyclase 2 3
  • Bifunctional ATP-Dependent Dihydroxyacetone Kinase/FAD-AMP Lyase (Cyclizing) 3 4
  • Triokinase/FMN Cyclase 2 5
  • DAK 3 4
  • Dihydroxyacetone Kinase 2 Homolog (S. Cerevisiae) 2
  • Testis Tissue Sperm-Binding Protein Li 84P 3
  • Dihydroxyacetone Kinase 2 Homolog (Yeast) 2
  • ATP-Dependent Dihydroxyacetone Kinase 3
  • Dihydroxyacetone Kinase 2 Homolog 3
  • FAD-AMP Lyase Cyclic FMN Forming 3
  • FAD-AMP Lyase (Cyclizing) 2
  • FAD-AMP Lyase Cyclizing 3
  • Dha Kinase/FMN Cyclase 3
  • Glycerone Kinase 3
  • DHA Kinase 3
  • NET45 3

External Ids for TKFC Gene

Previous HGNC Symbols for TKFC Gene

  • DAK

Summaries for TKFC Gene

Entrez Gene Summary for TKFC Gene

  • This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TKFC Gene

TKFC (Triokinase And FMN Cyclase) is a Protein Coding gene. Among its related pathways are Fructose metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include glycerone kinase activity and triokinase activity.

UniProtKB/Swiss-Prot for TKFC Gene

  • Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090).

Gene Wiki entry for TKFC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TKFC Gene

Genomics for TKFC Gene

Regulatory Elements for TKFC Gene

Enhancers for TKFC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TKFC on UCSC Golden Path with GeneCards custom track

Promoters for TKFC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TKFC on UCSC Golden Path with GeneCards custom track

Genomic Location for TKFC Gene

Chromosome:
11
Start:
61,333,182 bp from pter
End:
61,353,295 bp from pter
Size:
20,114 bases
Orientation:
Plus strand

Genomic View for TKFC Gene

Genes around TKFC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TKFC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TKFC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TKFC Gene

Proteins for TKFC Gene

  • Protein details for TKFC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LXA3-TKFC_HUMAN
    Recommended name:
    Triokinase/FMN cyclase
    Protein Accession:
    Q3LXA3
    Secondary Accessions:
    • Q2L9C1
    • Q53EQ9
    • Q9BVA7
    • Q9H895

    Protein attributes for TKFC Gene

    Size:
    575 amino acids
    Molecular mass:
    58947 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    • Homodimer (By similarity). Interacts with IFIH1 (via the CARD domains), the interaction is inhibited by viral infection (PubMed:17600090).

    Alternative splice isoforms for TKFC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TKFC Gene

Proteomics data for TKFC Gene at MOPED

Post-translational modifications for TKFC Gene

  • Ubiquitination at Lys 372 and Lys 522
  • Modification sites at PhosphoSitePlus

Other Protein References for TKFC Gene

No data available for DME Specific Peptides for TKFC Gene

Domains & Families for TKFC Gene

Protein Domains for TKFC Gene

Graphical View of Domain Structure for InterPro Entry

Q3LXA3

UniProtKB/Swiss-Prot:

TKFC_HUMAN :
  • DhaK and DhaL domains have differential roles, individually DhaK is inactive and DhaL displays cyclase but not kinase activity.
  • Belongs to the dihydroxyacetone kinase (DAK) family.
Domain:
  • DhaK and DhaL domains have differential roles, individually DhaK is inactive and DhaL displays cyclase but not kinase activity.
  • Contains 1 DhaK domain.
  • Contains 1 DhaL domain.
Family:
  • Belongs to the dihydroxyacetone kinase (DAK) family.
genes like me logo Genes that share domains with TKFC: view

No data available for Gene Families for TKFC Gene

Function for TKFC Gene

Molecular function for TKFC Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.5 uM for dihydroxyacetone {ECO:0000269 PubMed:4688871}; KM=11 uM for glyceraldehyde {ECO:0000269 PubMed:4688871}; KM=1.55 uM for dihydroxyacetone {ECO:0000269 PubMed:24569995}; KM=43.2 uM for ATP {ECO:0000269 PubMed:24569995}; KM=18.1 uM for glyceraldehyde {ECO:0000269 PubMed:24569995}; KM=7 uM for FAD {ECO:0000269 PubMed:24569995}; KM=12 uM for ADP-glucose {ECO:0000269 PubMed:24569995}; KM=317 uM for UDP-glucose {ECO:0000269 PubMed:24569995}; KM=263 uM for UDP-galactose {ECO:0000269 PubMed:24569995}; pH dependence: Optimum pH is 6.6. {ECO:0000269 PubMed:4688871};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + glycerone = ADP + glycerone phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
FAD = AMP + riboflavin cyclic-4,5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Each activity is inhibited by the substrate(s) of the other.
UniProtKB/Swiss-Prot Function:
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090).

Gene Ontology (GO) - Molecular Function for TKFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034012 FAD-AMP lyase (cyclizing) activity IDA 16289032
genes like me logo Genes that share ontologies with TKFC: view
genes like me logo Genes that share phenotypes with TKFC: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TKFC

miRNA for TKFC Gene

miRTarBase miRNAs that target TKFC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TKFC Gene

Localization for TKFC Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TKFC Gene

Pathways & Interactions for TKFC Gene

genes like me logo Genes that share pathways with TKFC: view

Gene Ontology (GO) - Biological Process for TKFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006000 fructose metabolic process TAS --
GO:0016310 phosphorylation IEA --
GO:0044281 small molecule metabolic process TAS --
GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate TAS --
genes like me logo Genes that share ontologies with TKFC: view

No data available for SIGNOR curated interactions for TKFC Gene

Drugs & Compounds for TKFC Gene

(5) Drugs for TKFC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Dihydroxyacetone Experimental Pharma 0
Glyceraldehyde-3-Phosphate Experimental Pharma 0

(3) Additional Compounds for TKFC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Dihydroxyacetone phosphate
  • 1,3-Dihydroxy-2-Propanone mono(dihydrogen phosphate)
  • 1,3-Dihydroxy-2-propanone phosphate
  • 1,3-Dihydroxyacetone 1-phosphate
  • 1-Hydroxy-3-(phosphonooxy)-2-Propanone
  • 1-Hydroxy-3-(phosphonooxy)acetone
57-04-5
glyceraldehyde
  • (+/-)-2,3-dihydroxy-Propanal
  • (+/-)-Glyceraldehyde
  • 2,3-Dihydroxypropanal
  • 2,3-Dihydroxypropionaldehyde
  • alpha,beta-Dihydroxypropionaldehyde
56-82-6
genes like me logo Genes that share compounds with TKFC: view

Transcripts for TKFC Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TKFC Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ·
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - -
SP7: - -
SP8: - - - - - -
SP9:
SP10:
SP11: -
SP12: - -
SP13:
SP14: - -
SP15: -

ExUns: 11c ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b
SP1: - -
SP2:
SP3: - - - - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for TKFC Gene

GeneLoc Exon Structure for
TKFC
ECgene alternative splicing isoforms for
TKFC

Expression for TKFC Gene

mRNA expression in normal human tissues for TKFC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TKFC Gene

This gene is overexpressed in Liver, secretome (26.0) and Liver (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TKFC Gene



mRNA Expression by UniProt/SwissProt for TKFC Gene

Q3LXA3-TKFC_HUMAN
Tissue specificity: Detected in erythrocytes (at protein level).
genes like me logo Genes that share expression patterns with TKFC: view

Protein tissue co-expression partners for TKFC Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for TKFC Gene

Orthologs for TKFC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TKFC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DAK 35
  • 89.57 (n)
  • 93.57 (a)
DAK 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAK 35
  • 89.62 (n)
  • 91.48 (a)
DAK 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dak 35
  • 83.59 (n)
  • 85.39 (a)
Tkfc 16
Dak 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DAK 35
  • 99.36 (n)
  • 100 (a)
DAK 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dak 35
  • 83.83 (n)
  • 85.91 (a)
oppossum
(Monodelphis domestica)
Mammalia DAK 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DAK 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAK 35
  • 73.83 (n)
  • 77.41 (a)
-- 36
  • 75 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia DAK 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dak 35
  • 62.3 (n)
  • 63.64 (a)
zebrafish
(Danio rerio)
Actinopterygii dak 35
  • 60.59 (n)
  • 55.96 (a)
dak 36
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea W02H5.8 35
  • 49.38 (n)
  • 43.49 (a)
W02H5.8 36
  • 40 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER139C 35
  • 47.79 (n)
  • 40.88 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAK1 36
  • 33 (a)
OneToMany
DAK2 36
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G17770 35
  • 49.03 (n)
  • 43.61 (a)
rice
(Oryza sativa)
Liliopsida Os.46088 35
Os03g0719300 35
  • 48.95 (n)
  • 42.88 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04400 35
  • 46.06 (n)
  • 34.69 (a)
Species with no ortholog for TKFC:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TKFC Gene

ENSEMBL:
Gene Tree for TKFC (if available)
TreeFam:
Gene Tree for TKFC (if available)

Paralogs for TKFC Gene

No data available for Paralogs for TKFC Gene

Variants for TKFC Gene

Sequence variations from dbSNP and Humsavar for TKFC Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2260655 - 61,341,502(+) TGGTC(A/G)CCAAG reference, missense
rs35723406 - 61,343,874(+) TGCAG(C/G)AGCCT reference, missense
rs752122 -- 61,336,176(-) TAAGA(C/T)TGGTT intron-variant
rs2305465 -- 61,345,330(+) TCTGT(C/T)CTGCT reference, synonymous-codon
rs11823506 -- 61,336,486(+) AGCAG(A/C)CTCTG intron-variant

Variation tolerance for TKFC Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TKFC Gene

Disorders for TKFC Gene

Relevant External Links for TKFC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TKFC

No disorders were found for TKFC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TKFC Gene

Publications for TKFC Gene

  1. Bifunctional homodimeric triokinase/FMN cyclase: contribution of protein domains to the activities of the human enzyme and molecular dynamics simulation of domain movements. (PMID: 24569995) Rodrigues J.R. … Cameselle J.C. (J. Biol. Chem. 2014) 2 3 4 67
  2. Identification of human and rat FAD-AMP lyase (cyclic FMN forming) as ATP-dependent dihydroxyacetone kinases. (PMID: 16289032) Cabezas A. … Cameselle J.C. (Biochem. Biophys. Res. Commun. 2005) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for TKFC Gene

Sources for TKFC Gene

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