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Aliases for DHRS7B Gene

Aliases for DHRS7B Gene

  • Dehydrogenase/Reductase 7B 2 3 5
  • Short-Chain Dehydrogenase/Reductase Family 32C Member 1 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 7B 2 3
  • SDR32C1 3 4
  • Short Chain Dehydrogenase/Reductase Family 32C, Member 1 2
  • Dehydrogenase/Reductase SDR Family Member 7B 3
  • EC 1.1.-.- 4
  • CGI-93 3

External Ids for DHRS7B Gene

Previous GeneCards Identifiers for DHRS7B Gene

  • GC17P020971
  • GC17P021030
  • GC17P020232
  • GC17P021269
  • GC17P021531
  • GC17P022221
  • GC17P021672
  • GC17P021844
  • GC17P022680
  • GC17P023010
  • GC17P023298
  • GC17P023586
  • GC17P023888

Summaries for DHRS7B Gene

Entrez Gene Summary for DHRS7B Gene

  • This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHRS7B Gene

DHRS7B (Dehydrogenase/Reductase 7B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is DHRS7C.

UniProtKB/Swiss-Prot for DHRS7B Gene

  • Putative oxidoreductase.

Additional gene information for DHRS7B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS7B Gene

Genomics for DHRS7B Gene

GeneHancer (GH) Regulatory Elements for DHRS7B Gene

Promoters and enhancers for DHRS7B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I021126 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.6 +3.7 3731 2.8 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 FOS DHRS7B TMEM11 MAP2K3 KCNJ18 NATD1 GC17M021160
GH17I021124 Enhancer 0.6 Ensembl dbSUPER 550.8 +1.0 966 0.5 ETV6 ELF1 RUNX3 DHRS7B GC17M021160
GH17I021125 Enhancer 0.5 ENCODE dbSUPER 550.8 +2.0 1972 0.4 ATF4 DHRS7B GC17M021160
GH17I021208 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 18.8 +89.4 89374 7.6 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143 TMEM11 ENSG00000235530 DHRS7B FAM106B NATD1 GC17M021160
GH17I021281 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.4 +162.8 162796 9.2 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 IRF4 YY1 ZNF213 MAP2K3 GC17P024329 KCNJ12 DHRS7B NATD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DHRS7B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHRS7B gene promoter:

Genomic Locations for DHRS7B Gene

Genomic Locations for DHRS7B Gene
chr17:21,123,364-21,193,265
(GRCh38/hg38)
Size:
69,902 bases
Orientation:
Plus strand
chr17:21,026,677-21,096,578
(GRCh37/hg19)

Genomic View for DHRS7B Gene

Genes around DHRS7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS7B Gene

Proteins for DHRS7B Gene

  • Protein details for DHRS7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IAN0-DRS7B_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 7B
    Protein Accession:
    Q6IAN0
    Secondary Accessions:
    • B5MEF4
    • Q6UX59
    • Q9BTF9
    • Q9UFM6
    • Q9Y3A1

    Protein attributes for DHRS7B Gene

    Size:
    325 amino acids
    Molecular mass:
    35119 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34088.1; Type=Frameshift; Positions=12, 266; Evidence={ECO:0000305}; Sequence=AAQ88862.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DHRS7B Gene

Post-translational modifications for DHRS7B Gene

No data available for DME Specific Peptides for DHRS7B Gene

Domains & Families for DHRS7B Gene

Gene Families for DHRS7B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for DHRS7B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IAN0

UniProtKB/Swiss-Prot:

DRS7B_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS7B: view

Function for DHRS7B Gene

Molecular function for DHRS7B Gene

UniProtKB/Swiss-Prot Function:
Putative oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS7B Gene

Gene Ontology (GO) - Molecular Function for DHRS7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS7B: view
genes like me logo Genes that share phenotypes with DHRS7B: view

Animal Model Products

miRNA for DHRS7B Gene

miRTarBase miRNAs that target DHRS7B

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHRS7B Gene

Localization for DHRS7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS7B Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHRS7B gene
Compartment Confidence
endoplasmic reticulum 3
golgi apparatus 3
plasma membrane 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHRS7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DHRS7B: view

Pathways & Interactions for DHRS7B Gene

SuperPathways for DHRS7B Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHRS7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS7B: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS7B Gene

Drugs & Compounds for DHRS7B Gene

No Compound Related Data Available

Transcripts for DHRS7B Gene

Unigene Clusters for DHRS7B Gene

Dehydrogenase/reductase (SDR family) member 7B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS7B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2: - - - - - - -
SP3:
SP4: - - -
SP5: - -
SP6: - - -
SP7: -

Relevant External Links for DHRS7B Gene

GeneLoc Exon Structure for
DHRS7B
ECgene alternative splicing isoforms for
DHRS7B

Expression for DHRS7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHRS7B Gene

Protein differential expression in normal tissues from HIPED for DHRS7B Gene

This gene is overexpressed in Nasal epithelium (60.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHRS7B Gene



Protein tissue co-expression partners for DHRS7B Gene

NURSA nuclear receptor signaling pathways regulating expression of DHRS7B Gene:

DHRS7B

SOURCE GeneReport for Unigene cluster for DHRS7B Gene:

Hs.386989

Evidence on tissue expression from TISSUES for DHRS7B Gene

  • Kidney(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with DHRS7B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS7B Gene

Orthologs for DHRS7B Gene

This gene was present in the common ancestor of animals.

Orthologs for DHRS7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHRS7B 33 34
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia DHRS7B 33 34
  • 86.52 (n)
mouse
(Mus musculus)
Mammalia Dhrs7b 33 16 34
  • 82.46 (n)
cow
(Bos Taurus)
Mammalia DHRS7B 33 34
  • 81.74 (n)
rat
(Rattus norvegicus)
Mammalia Dhrs7b 33
  • 81.23 (n)
oppossum
(Monodelphis domestica)
Mammalia DHRS7B 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHRS7B 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHRS7B 33 34
  • 71.3 (n)
lizard
(Anolis carolinensis)
Reptilia DHRS7B 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs7b 33
  • 66.24 (n)
Str.1806 33
zebrafish
(Danio rerio)
Actinopterygii dhrs7b 33 34
  • 61.51 (n)
Dr.14424 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5249 33
African malaria mosquito
(Anopheles gambiae)
Insecta DHRS7_ANOGA 33
  • 52.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7601 33 34
  • 51.55 (n)
worm
(Caenorhabditis elegans)
Secernentea dhs-30 33 34
  • 49.23 (n)
T25G12.13 34
  • 35 (a)
ManyToMany
C33E10.10 34
  • 32 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToMany
Species where no ortholog for DHRS7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRS7B Gene

ENSEMBL:
Gene Tree for DHRS7B (if available)
TreeFam:
Gene Tree for DHRS7B (if available)

Paralogs for DHRS7B Gene

Paralogs for DHRS7B Gene

(3) SIMAP similar genes for DHRS7B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DHRS7B: view

Variants for DHRS7B Gene

Sequence variations from dbSNP and Humsavar for DHRS7B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000008299 -- 21,122,256(+) G/A upstream_transcript_variant
rs1000036376 -- 21,167,823(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000113713 -- 21,156,118(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000231815 -- 21,160,888(+) A/G/T genic_upstream_transcript_variant, intron_variant
rs1000286181 -- 21,136,624(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS7B Gene

Variant ID Type Subtype PubMed ID
nsv1059146 CNV gain 25217958
nsv1059210 CNV gain 25217958
nsv1078306 OTHER inversion 25765185
nsv1123101 CNV deletion 24896259

Variation tolerance for DHRS7B Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHRS7B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHRS7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS7B Gene

Disorders for DHRS7B Gene

Additional Disease Information for DHRS7B

No disorders were found for DHRS7B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS7B Gene

Publications for DHRS7B Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 4 58
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for DHRS7B Gene

Sources for DHRS7B Gene

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