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Aliases for GAP43 Gene

Aliases for GAP43 Gene

  • Growth Associated Protein 43 2 3
  • Axonal Membrane Protein GAP-43 2 3 4
  • Neural Phosphoprotein B-50 2 3 4
  • Neuron Growth-Associated Protein 43 2 3
  • Nerve Growth-Related Peptide GAP43 2 3
  • Calmodulin-Binding Protein P-57 2 3
  • Growth-Associated Protein 43 3 4
  • Neuromodulin 2 3
  • Protein F1 2 3
  • PP46 3 4
  • B-50 3

External Ids for GAP43 Gene

Previous GeneCards Identifiers for GAP43 Gene

  • GC03P112171
  • GC03P114924
  • GC03P116623
  • GC03P116663
  • GC03P116825
  • GC03P115342
  • GC03P112715

Summaries for GAP43 Gene

Entrez Gene Summary for GAP43 Gene

  • The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAP43 Gene

GAP43 (Growth Associated Protein 43) is a Protein Coding gene. Diseases associated with GAP43 include appendicitis and status epilepticus. Among its related pathways are N-cadherin signaling events and Cytoskeletal Signaling. GO annotations related to this gene include calmodulin binding.

UniProtKB/Swiss-Prot for GAP43 Gene

  • This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

Gene Wiki entry for GAP43 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAP43 Gene

Genomics for GAP43 Gene

Regulatory Elements for GAP43 Gene

Genomic Location for GAP43 Gene

Start:
115,623,304 bp from pter
End:
115,721,490 bp from pter
Size:
98,187 bases
Orientation:
Plus strand

Genomic View for GAP43 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAP43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAP43 Gene

Proteins for GAP43 Gene

  • Protein details for GAP43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17677-NEUM_HUMAN
    Recommended name:
    Neuromodulin
    Protein Accession:
    P17677
    Secondary Accessions:
    • A8K0Y4

    Protein attributes for GAP43 Gene

    Size:
    238 amino acids
    Molecular mass:
    24803 Da
    Quaternary structure:
    • Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.

    Alternative splice isoforms for GAP43 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAP43 Gene

Proteomics data for GAP43 Gene at MOPED

Post-translational modifications for GAP43 Gene

  • Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2
  • Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GAP43 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GAP43 (GAP43)

No data available for DME Specific Peptides for GAP43 Gene

Domains for GAP43 Gene

Suggested Antigen Peptide Sequences for GAP43 Gene

Graphical View of Domain Structure for InterPro Entry

P17677

UniProtKB/Swiss-Prot:

NEUM_HUMAN :
  • P17677
Domain:
  • Contains 1 IQ domain.
Family:
  • Belongs to the neuromodulin family.
genes like me logo Genes that share domains with GAP43: view

No data available for Gene Families for GAP43 Gene

Function for GAP43 Gene

Molecular function for GAP43 Gene

GENATLAS Biochemistry: growth associated protein 43,expressed in elongating terminals of neurites,located in granules diffusely dispersed throughout the anterior horn neuropil and at the surface of horn cells,overexpressed in amyotropic lateral sclerosis,component of neurons regenerative response
UniProtKB/Swiss-Prot Function: This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

Gene Ontology (GO) - Molecular Function for GAP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9139733
GO:0005516 calmodulin binding IBA --
genes like me logo Genes that share ontologies with GAP43: view
genes like me logo Genes that share phenotypes with GAP43: view

Animal Models for GAP43 Gene

MGI Knock Outs for GAP43:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAP43

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GAP43 Gene

Localization for GAP43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAP43 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane; Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAP43 Gene COMPARTMENTS Subcellular localization image for GAP43 gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
cytoskeleton 2
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GAP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IDA --
GO:0014069 postsynaptic density IBA --
GO:0030054 cell junction IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with GAP43: view

Pathways for GAP43 Gene

genes like me logo Genes that share pathways with GAP43: view

Pathways by source for GAP43 Gene

2 Cell Signaling Technology pathways for GAP43 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GAP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway TAS 3272162
GO:0007399 nervous system development --
GO:0007411 axon guidance --
GO:0009611 response to wounding TAS 3272162
GO:0010001 glial cell differentiation IEA --
genes like me logo Genes that share ontologies with GAP43: view

Compounds for GAP43 Gene

(66) Novoseek inferred chemical compound relationships for GAP43 Gene

Compound -log(P) Hits PubMed IDs
dbc-amp 39.6 8
palmitate 38.3 2
tyrosine 31.9 20
retinoic acid 31.2 7
calcium 29.6 28
genes like me logo Genes that share compounds with GAP43: view

Transcripts for GAP43 Gene

mRNA/cDNA for GAP43 Gene

Unigene Clusters for GAP43 Gene

Growth associated protein 43:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAP43

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAP43 Gene

No ASD Table

Relevant External Links for GAP43 Gene

GeneLoc Exon Structure for
GAP43
ECgene alternative splicing isoforms for
GAP43

Expression for GAP43 Gene

mRNA expression in normal human tissues for GAP43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAP43 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (8.3), Brain - Frontal Cortex (BA9) (7.5), Brain - Cortex (7.1), Brain - Amygdala (5.1), and Brain - Hypothalamus (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for GAP43 Gene

SOURCE GeneReport for Unigene cluster for GAP43 Gene Hs.134974

genes like me logo Genes that share expressions with GAP43: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GAP43 Gene

Orthologs for GAP43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAP43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GAP43 35
  • 96.36 (n)
  • 95.8 (a)
GAP43 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GAP43 35
  • 88.38 (n)
  • 86.13 (a)
GAP43 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAP43 35
  • 87.82 (n)
  • 84.03 (a)
GAP43 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gap43 35
  • 81.86 (n)
  • 74.78 (a)
Gap43 16
Gap43 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GAP43 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gap43 35
  • 81.19 (n)
  • 72.89 (a)
chicken
(Gallus gallus)
Aves GAP43 35
  • 77.49 (n)
  • 67.98 (a)
GAP43 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAP43 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia gap43-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gap43 35
  • 61.11 (n)
  • 57.07 (a)
zebrafish
(Danio rerio)
Actinopterygii gap43 35
gap43 36
  • 39 (a)
OneToOne
Species with no ortholog for GAP43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAP43 Gene

ENSEMBL:
Gene Tree for GAP43 (if available)
TreeFam:
Gene Tree for GAP43 (if available)

Paralogs for GAP43 Gene

Selected SIMAP similar genes for GAP43 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GAP43: view

No data available for Paralogs for GAP43 Gene

Variants for GAP43 Gene

Sequence variations from dbSNP and Humsavar for GAP43 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6291 - 115,676,157(+) ATGAT(A/G)TCCAA missense, reference
rs6292 -- 115,676,474(+) GAGGA(A/G)CCTAA synonymous-codon, reference
rs14360 -- 115,721,160(+) CATTT(G/T)GGGAA utr-variant-3-prime
rs166891 -- 115,717,043(-) atgac(A/C)aagcc intron-variant
rs172220 -- 115,710,700(-) TGAAA(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAP43 Gene

Variant ID Type Subtype PubMed ID
nsv877356 CNV Gain 21882294
esv2672570 CNV Deletion 23128226
esv274109 CNV Insertion 20981092
esv270312 CNV Insertion 20981092
dgv5234n71 CNV Gain 21882294
esv1060470 CNV Insertion 17803354

Relevant External Links for GAP43 Gene

HapMap Linkage Disequilibrium report
GAP43
Human Gene Mutation Database (HGMD)
GAP43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAP43 Gene

Disorders for GAP43 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (5) Diseases for GAP43 Gene including...

Search for GAP43 Gene in MalaCards »

(40) Novoseek inferred disease relationships for GAP43 Gene

Disease -log(P) Hits PubMed IDs
senile plaques 44.8 5
alzheimers disease 42.3 10
neurodegeneration 36.9 2
neurofibrillary tangles 32.2 5
amyotrophic lateral sclerosis 29.1 2

Relevant External Links for GAP43

Genetic Association Database (GAD)
GAP43
Human Genome Epidemiology (HuGE) Navigator
GAP43
genes like me logo Genes that share disorders with GAP43: view

No data available for UniProtKB/Swiss-Prot for GAP43 Gene

Publications for GAP43 Gene

  1. Structure of the human gene for the neural phosphoprotein B-50 (GAP- 43). (PMID: 8231732) Nielander H.B. … Schotman P. (Brain Res. Mol. Brain Res. 1993) 2 3 4 23
  2. Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human. (PMID: 3272162) Kosik K.S. … Neve R. (Neuron 1988) 2 3 4
  3. Cloning of human GAP-43: growth association and ischemic resurgence. (PMID: 3272163) Ng S.-C. … Fishman M.C. (Neuron 1988) 3 4
  4. Phosphorylation of GAP-43 (growth-associated protein of 43 kDa) by conventional, novel and atypical isotypes of the protein kinase C gene family: differences between oligopeptide and polypeptide phosphorylation. (PMID: 8694767) Oehrlein S.A. … Herget T. (Biochem. J. 1996) 3 23
  5. Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD. (PMID: 12034726) Beckel-Mitchener A.C. … Perrone-Bizzozero N.I. (J. Biol. Chem. 2002) 3 23

Products for GAP43 Gene

  • Addgene plasmids for GAP43

Sources for GAP43 Gene

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