External Ids for GANC Gene
Previous GeneCards Identifiers for GANC Gene
Glycosyl hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2014]
GeneCards Summary for GANC Gene
GANC (Glucosidase, Alpha; Neutral C) is a Protein Coding gene. Diseases associated with GANC include glycogen storage disease ii. Among its related pathways are Metabolism and Glucuronidation. GO annotations related to this gene include carbohydrate binding and maltose alpha-glucosidase activity. An important paralog of this gene is MGAM.
UniProtKB/Swiss-Prot for GANC Gene
Has alpha-glucosidase activity.
Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, alpha- and beta-glucosidase (EC numbers 22.214.171.124 and 126.96.36.199 respectively), which are both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose respectively