Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GANC Gene

Aliases for GANC Gene

  • Glucosidase, Alpha; Neutral C 2 3
  • EC 3.2.1.20 4
  • EC 3.2.1 63

External Ids for GANC Gene

Previous GeneCards Identifiers for GANC Gene

  • GC15U990022
  • GC15P040282
  • GC15P040354
  • GC15P042566
  • GC15P019414

Summaries for GANC Gene

Entrez Gene Summary for GANC Gene

  • Glycosyl hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2014]

GeneCards Summary for GANC Gene

GANC (Glucosidase, Alpha; Neutral C) is a Protein Coding gene. Diseases associated with GANC include glycogen storage disease ii. Among its related pathways are Metabolism and Glucuronidation. GO annotations related to this gene include carbohydrate binding and maltose alpha-glucosidase activity. An important paralog of this gene is MGAM.

UniProtKB/Swiss-Prot for GANC Gene

  • Has alpha-glucosidase activity.

Tocris Summary for GANC Gene

  • Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, alpha- and beta-glucosidase (EC numbers 3.2.1.20 and 3.2.1.21 respectively), which are both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose respectively

Gene Wiki entry for GANC Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GANC Gene

Genomics for GANC Gene

Genomic Location for GANC Gene

Start:
42,273,233 bp from pter
End:
42,356,935 bp from pter
Size:
83,703 bases
Orientation:
Plus strand

Genomic View for GANC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GANC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GANC Gene

Proteins for GANC Gene

  • Protein details for GANC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TET4-GANC_HUMAN
    Recommended name:
    Neutral alpha-glucosidase C
    Protein Accession:
    Q8TET4
    Secondary Accessions:
    • Q52LQ4
    • Q8IWZ0
    • Q8IZM4
    • Q8IZM5

    Protein attributes for GANC Gene

    Size:
    914 amino acids
    Molecular mass:
    104334 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84863.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for GANC Gene

Proteomics data for GANC Gene at MOPED

Selected DME Specific Peptides for GANC Gene

Post-translational modifications for GANC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for GANC Gene

Suggested Antigen Peptide Sequences for GANC Gene

Graphical View of Domain Structure for InterPro Entry

Q8TET4

UniProtKB/Swiss-Prot:

GANC_HUMAN :
  • Q8TET4
Family:
  • Belongs to the glycosyl hydrolase 31 family.
genes like me logo Genes that share domains with GANC: view

No data available for Gene Families for GANC Gene

Function for GANC Gene

Molecular function for GANC Gene

GENATLAS Biochemistry: glucosidase,alpha-,neutral C
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose
UniProtKB/Swiss-Prot Function: Has alpha-glucosidase activity.

Enzyme Numbers (IUBMB) for GANC Gene

Gene Ontology (GO) - Molecular Function for GANC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds --
GO:0004558 alpha-1,4-glucosidase activity NAS 12370436
GO:0030246 carbohydrate binding IEA --
GO:0032450 maltose alpha-glucosidase activity IEA --
genes like me logo Genes that share ontologies with GANC: view

Phenotypes for GANC Gene

genes like me logo Genes that share phenotypes with GANC: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GANC Gene

Localization for GANC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GANC Gene COMPARTMENTS Subcellular localization image for GANC gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2
cytoskeleton 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GANC Gene

Pathways for GANC Gene

genes like me logo Genes that share pathways with GANC: view

Pathways by source for GANC Gene

Interacting Proteins for GANC Gene

Gene Ontology (GO) - Biological Process for GANC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
genes like me logo Genes that share ontologies with GANC: view

Compounds for GANC Gene

(5) Tocris Compounds for GANC Gene

Compound Action Cas Number
1-Deoxynojirimycin Glucosidase I and II inhibitor [19130-96-2]
Castanospermine Glucosidases alpha and beta inhibitor [79831-76-8]
Kifunensine Inhibitor of class I alpha-mannosidases [109944-15-2]
Miglustat hydrochloride alpha-glucosidase I and II inhibitor. Also inhibits ceramide-specific glycosyltransferases [210110-90-0]
Voglibose Orally active alpha-glucosidase inhibitor [83480-29-9]

(7) HMDB Compounds for GANC Gene

Compound Synonyms Cas Number PubMed IDs
Alpha-D-Glucose
  • Hexopyranose
492-62-6
D-Galactose
  • (+)-Galactose
59-23-4
D-Glucose
  • (+)-Glucose
50-99-7
D-Maltose
  • alpha-Malt sugar
69-79-4
Melibiose
  • 6-(D-galactosido)-D-glucose
585-99-9
genes like me logo Genes that share compounds with GANC: view

Transcripts for GANC Gene

Unigene Clusters for GANC Gene

Glucosidase, alpha; neutral C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GANC Gene

No ASD Table

Relevant External Links for GANC Gene

GeneLoc Exon Structure for
GANC
ECgene alternative splicing isoforms for
GANC

Expression for GANC Gene

mRNA expression in normal human tissues for GANC Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GANC Gene

SOURCE GeneReport for Unigene cluster for GANC Gene Hs.730806

genes like me logo Genes that share expressions with GANC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GANC Gene

Orthologs for GANC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GANC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GANC 35
  • 99.34 (n)
  • 99.23 (a)
GANC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GANC 35
  • 88.17 (n)
  • 86.86 (a)
GANC 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GANC 35
  • 89.05 (n)
  • 87.73 (a)
GANC 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ganc 35
  • 85.53 (n)
  • 84.43 (a)
Ganc 16
Ganc 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GANC 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GANC 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ganc 35
  • 85.12 (n)
  • 83.44 (a)
chicken
(Gallus gallus)
Aves GANC 35
  • 70.65 (n)
  • 66.48 (a)
GANC 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GANC 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ganc 35
  • 62.84 (n)
  • 60.47 (a)
zebrafish
(Danio rerio)
Actinopterygii GANC 36
  • 53 (a)
OneToOne
LOC100536353 35
  • 56.5 (n)
  • 53.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14476 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea aagr-3 36
  • 40 (a)
ManyToMany
aagr-4 36
  • 41 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROT2 36
  • 32 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.6669 35
corn
(Zea mays)
Liliopsida Zm.13759 35
wheat
(Triticum aestivum)
Liliopsida Ta.1604 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for GANC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GANC Gene

ENSEMBL:
Gene Tree for GANC (if available)
TreeFam:
Gene Tree for GANC (if available)

Paralogs for GANC Gene

Paralogs for GANC Gene

Selected SIMAP similar genes for GANC Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with GANC: view

Variants for GANC Gene

Sequence variations from dbSNP and Humsavar for GANC Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs12939 -- 42,284,378(+) TATTT(A/T)CGCCT intron-variant
rs765830 -- 42,313,808(+) cacgc(C/G)tgtaa intron-variant
rs936603 -- 42,291,690(-) GACAA(C/T)TAAAT intron-variant
rs1659212 -- 42,333,754(-) AGCCA(A/G)GTGTT intron-variant
rs1659213 -- 42,332,501(-) GTAGT(A/G)TTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GANC Gene

Variant ID Type Subtype PubMed ID
nsv904133 CNV Gain 21882294
esv2671493 CNV Deletion 23128226
nsv832986 CNV Loss 17160897
esv2660428 CNV Deletion 23128226
nsv832987 CNV Gain 17160897
esv2661604 CNV Deletion 23128226

Relevant External Links for GANC Gene

HapMap Linkage Disequilibrium report
GANC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GANC Gene

Disorders for GANC Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GANC Gene including...

Search for GANC Gene in MalaCards »

(1) University of Copenhagen DISEASES for GANC Gene

Relevant External Links for GANC

Genetic Association Database (GAD)
GANC
Human Genome Epidemiology (HuGE) Navigator
GANC
genes like me logo Genes that share disorders with GANC: view

No data available for UniProtKB/Swiss-Prot for GANC Gene

Publications for GANC Gene

  1. Computer assisted cloning of human neutral alpha glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31. (PMID: 12370436) Hirschhorn R. … Kasper J.S. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 23
  2. Newly identified exons encoding novel variants of p94/calpain 3 are expressed ubiquitously and overlap the alpha-glucosidase C gene. (PMID: 14675785) Kawabata Y. … Sorimachi H. (FEBS Lett. 2003) 3 23
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Assignment of the gene for human neutral alpha-glucosidase C to chromosome 15. (PMID: 6995030) Martiniuk F. … Smith M. (Cytogenet. Cell Genet. 1980) 2 3

Products for GANC Gene

Sources for GANC Gene

Back to Top

Content