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Aliases for SIN3A Gene

Aliases for SIN3A Gene

  • SIN3 Transcription Regulator Family Member A 2 3
  • SIN3 Homolog A, Transcription Regulator (Yeast) 2
  • SIN3 Transcription Regulator Homolog A (Yeast) 2
  • Histone Deacetylase Complex Subunit Sin3a 4
  • Transcriptional Corepressor Sin3a 4

External Ids for SIN3A Gene

Previous GeneCards Identifiers for SIN3A Gene

  • GC15M071541
  • GC15M068754
  • GC15M073239
  • GC15M073379
  • GC15M073450
  • GC15M075661
  • GC15M052420

Summaries for SIN3A Gene

Entrez Gene Summary for SIN3A Gene

  • The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIN3A Gene

SIN3A (SIN3 Transcription Regulator Family Member A) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Hemostasis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is SIN3B.

UniProtKB/Swiss-Prot for SIN3A Gene

  • Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation.

Gene Wiki entry for SIN3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIN3A Gene

Genomics for SIN3A Gene

Regulatory Elements for SIN3A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SIN3A Gene

Start:
75,369,379 bp from pter
End:
75,455,842 bp from pter
Size:
86,464 bases
Orientation:
Minus strand

Genomic View for SIN3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIN3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIN3A Gene

Proteins for SIN3A Gene

  • Protein details for SIN3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ST3-SIN3A_HUMAN
    Recommended name:
    Paired amphipathic helix protein Sin3a
    Protein Accession:
    Q96ST3
    Secondary Accessions:
    • B2RNS5
    • Q8N8N4
    • Q8NC83
    • Q8WV18
    • Q96L98
    • Q9UFQ1

    Protein attributes for SIN3A Gene

    Size:
    1273 amino acids
    Molecular mass:
    145175 Da
    Quaternary structure:
    • Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase (By similarity). Interacts with BAZ2A, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with TET1; the interaction recruits SIN3A to gene promoters. The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A. Interacts with KLF11 (By similarity).

    Three dimensional structures from OCA and Proteopedia for SIN3A Gene

neXtProt entry for SIN3A Gene

Proteomics data for SIN3A Gene at MOPED

Post-translational modifications for SIN3A Gene

  • SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.
  • Ubiquitination at Lys343, Lys727, and Lys747
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SIN3A (SIN3A)

No data available for DME Specific Peptides for SIN3A Gene

Domains for SIN3A Gene

Protein Domains for SIN3A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SIN3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96ST3

UniProtKB/Swiss-Prot:

SIN3A_HUMAN :
  • Q96ST3
Domain:
  • Contains 3 PAH (paired amphipathic helix) domains.
genes like me logo Genes that share domains with SIN3A: view

No data available for Gene Families for SIN3A Gene

Function for SIN3A Gene

Molecular function for SIN3A Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation.

Gene Ontology (GO) - Molecular Function for SIN3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding ISS --
GO:0001102 RNA polymerase II activating transcription factor binding IPI 22783022
GO:0001103 RNA polymerase II repressing transcription factor binding IEA --
GO:0001106 RNA polymerase II transcription corepressor activity IBA --
GO:0003677 DNA binding --
genes like me logo Genes that share ontologies with SIN3A: view

Phenotypes for SIN3A Gene

genes like me logo Genes that share phenotypes with SIN3A: view

Animal Models for SIN3A Gene

MGI Knock Outs for SIN3A:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIN3A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SIN3A Gene

Localization for SIN3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIN3A Gene

Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIN3A Gene COMPARTMENTS Subcellular localization image for SIN3A gene
Compartment Confidence
nucleus 5
cytoskeleton 1
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SIN3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000785 chromatin --
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with SIN3A: view

Pathways for SIN3A Gene

genes like me logo Genes that share pathways with SIN3A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SIN3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 22783022
GO:0001701 in utero embryonic development IEA --
GO:0002218 activation of innate immune response IMP 22783022
GO:0002230 positive regulation of defense response to virus by host IMP 22783022
GO:0002244 hematopoietic progenitor cell differentiation IEA --
genes like me logo Genes that share ontologies with SIN3A: view

Transcripts for SIN3A Gene

Unigene Clusters for SIN3A Gene

SIN3 transcription regulator homolog A (yeast):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIN3A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SIN3A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIN3A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - - - - - - - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - -
SP10: - - - -
SP11:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SIN3A Gene

GeneLoc Exon Structure for
SIN3A
ECgene alternative splicing isoforms for
SIN3A

Expression for SIN3A Gene

mRNA expression in normal human tissues for SIN3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIN3A Gene

SOURCE GeneReport for Unigene cluster for SIN3A Gene Hs.513039

genes like me logo Genes that share expressions with SIN3A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SIN3A Gene

Orthologs for SIN3A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SIN3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIN3A 35
  • 99.74 (n)
  • 99.92 (a)
SIN3A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SIN3A 35
  • 93.43 (n)
  • 98.82 (a)
SIN3A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIN3A 35
  • 93.11 (n)
  • 98.9 (a)
SIN3A 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sin3a 35
  • 90.91 (n)
  • 98.11 (a)
Sin3a 16
Sin3a 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SIN3A 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIN3A 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sin3a 35
  • 90.25 (n)
  • 98.05 (a)
chicken
(Gallus gallus)
Aves SIN3A 35
  • 81.95 (n)
  • 94.16 (a)
SIN3A 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIN3A 36
  • 45 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Sin3 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sin3a 35
  • 74.08 (n)
  • 82.82 (a)
Str.14936 35
zebrafish
(Danio rerio)
Actinopterygii sin3aa 36
  • 77 (a)
OneToMany
sin3ab 36
  • 75 (a)
OneToMany
wufb95g11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007892 35
  • 58.26 (n)
  • 58.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sin3A 35
  • 58.9 (n)
  • 60.59 (a)
Sin3A 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sin-3 36
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIN3 36
  • 18 (a)
OneToMany
SIN3 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4585 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3742 36
  • 39 (a)
OneToMany
Species with no ortholog for SIN3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIN3A Gene

ENSEMBL:
Gene Tree for SIN3A (if available)
TreeFam:
Gene Tree for SIN3A (if available)

Paralogs for SIN3A Gene

Paralogs for SIN3A Gene

Selected SIMAP similar genes for SIN3A Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SIN3A: view

Variants for SIN3A Gene

Sequence variations from dbSNP and Humsavar for SIN3A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs4243033 -- 75,402,337(+) tgaaa(C/T)cccgt intron-variant
rs4297648 -- 75,435,454(+) gcact(C/T)tggga intron-variant
rs4327014 -- 75,429,189(+) ctggc(G/T)ggggg intron-variant
rs4368141 -- 75,388,659(+) AGGAC(C/G)AATAA intron-variant
rs4412948 -- 75,398,151(+) CACAA(A/G)TAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIN3A Gene

Variant ID Type Subtype PubMed ID
esv2749894 CNV Deletion 23290073
nsv1615 CNV Insertion 18451855
nsv904386 CNV Gain 21882294
nsv525265 CNV Gain 19592680
nsv904387 CNV Gain 21882294
esv2749895 CNV Deletion 23290073
dgv2414n71 CNV Loss 21882294
nsv827389 CNV Gain 20364138

Relevant External Links for SIN3A Gene

HapMap Linkage Disequilibrium report
SIN3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIN3A Gene

Disorders for SIN3A Gene

(1) University of Copenhagen DISEASES for SIN3A Gene

Relevant External Links for SIN3A

Genetic Association Database (GAD)
SIN3A
genes like me logo Genes that share disorders with SIN3A: view

No data available for UniProtKB/Swiss-Prot for SIN3A Gene

Publications for SIN3A Gene

  1. PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. (PMID: 11259580) Mathur M. … Samuels H.H. (Mol. Cell. Biol. 2001) 3 4 23
  2. The minimal repression domain of MBD2b overlaps with the methyl-CpG- binding domain and binds directly to Sin3A. (PMID: 10950960) Boeke J. … Renkawitz R. (J. Biol. Chem. 2000) 3 23
  3. Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. (PMID: 10491605) Huang Y. … Dingledine R. (Nat. Neurosci. 1999) 3 23
  4. Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein- associated splicing factor, and SF-1, a complex that also participates in repression of transcription. (PMID: 11897684) Sewer M.B. … Waterman M.R. (Endocrinology 2002) 3 4
  5. Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2. (PMID: 10773092) Yu F. … StrAotling W.H. (Nucleic Acids Res. 2000) 2 3

Products for SIN3A Gene

Sources for SIN3A Gene

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