Aliases for MRGPRX1 Gene
External Ids for MRGPRX1 Gene
Previous GeneCards Identifiers for MRGPRX1 Gene
GeneCards Summary for MRGPRX1 Gene
MRGPRX1 (MAS Related GPR Family Member X1) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX3.
UniProtKB/Swiss-Prot for MRGPRX1 Gene
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.