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RCHY1 Gene(Protein Coding)

Ring Finger And CHY Zinc Finger Domain Containing 1

GCID:
GC04M075479
GIFtS:
63
Genes Participants
UDN Logo

Aliases for RCHY1 Gene

Aliases for RCHY1 Gene

  • Ring Finger And CHY Zinc Finger Domain Containing 1 2 3
  • Ring Finger And CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase 2 3 5
  • Zinc Finger Protein 363 2 3 4
  • Androgen-Receptor N-Terminal-Interacting Protein 2 3
  • P53-Induced Protein With A RING-H2 Domain 2 3
  • E3 Ubiquitin-Protein Ligase Pirh2 3 4
  • RING Finger Protein 199 3 4
  • ZNF363 3 4
  • RNF199 3 4
  • ARNIP 3 4
  • CHIMP 3 4
  • PIRH2 3 4
  • Androgen Receptor N-Terminal-Interacting Protein 4
  • CH-Rich Interacting Match With PLAG1 3
  • CH-Rich-Interacting Match With PLAG1 4
  • P53-Induced RING-H2 Protein 4
  • Zinc Finger, CHY-Type 3
  • Zinc Finger 2
  • EC 6.3.2.- 4
  • CHY-Type 2
  • PRO1996 3
  • HPirh2 4
  • ZCHY 3

External Ids for RCHY1 Gene

Previous HGNC Symbols for RCHY1 Gene

  • ZNF363

Previous GeneCards Identifiers for RCHY1 Gene

  • GC04M076866
  • GC04M076762
  • GC04M076623
  • GC04M076405
  • GC04M072150

Summaries for RCHY1 Gene

Entrez Gene Summary for RCHY1 Gene

  • The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for RCHY1 Gene

RCHY1 (Ring Finger And CHY Zinc Finger Domain Containing 1) is a Protein Coding gene. Diseases associated with RCHY1 include Variola Minor. Among its related pathways are p53 Pathway (RnD) and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include protein homodimerization activity and ligase activity.

UniProtKB/Swiss-Prot for RCHY1 Gene

  • Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.

Gene Wiki entry for RCHY1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCHY1 Gene

Genomics for RCHY1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for RCHY1 Gene

Enhancers for RCHY1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RCHY1 on UCSC Golden Path with GeneCards custom track

Promoters for RCHY1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RCHY1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RCHY1 gene promoter:

Genomic Location for RCHY1 Gene

Chromosome:
4
Start:
75,479,037 bp from pter
End:
75,514,764 bp from pter
Size:
35,728 bases
Orientation:
Minus strand

Genomic View for RCHY1 Gene

Genes around RCHY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCHY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCHY1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RCHY1 Gene

Proteins for RCHY1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RCHY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PM5-ZN363_HUMAN
    Recommended name:
    RING finger and CHY zinc finger domain-containing protein 1
    Protein Accession:
    Q96PM5
    Secondary Accessions:
    • B3KRG3
    • C7E541
    • C7E542
    • C7E543
    • D3YRV2
    • E7EMC8
    • E7ETW5
    • J3KPI0
    • Q2KN33
    • Q59GN7
    • Q86X26
    • Q96PR5

    Protein attributes for RCHY1 Gene

    Size:
    261 amino acids
    Molecular mass:
    30110 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE, UBE2D2 and GORAB/NTKLBP1.
    SequenceCaution:
    • Sequence=BAD92309.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RCHY1 Gene

    Alternative splice isoforms for RCHY1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RCHY1 Gene

Proteomics data for RCHY1 Gene at MOPED

Protein Expression for RCHY1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RCHY1 Gene

  • Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability.
  • Ubiquitination at Lys 241
  • Modification sites at PhosphoSitePlus

Other Protein References for RCHY1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RCHY1 Gene

Domains & Families for RCHY1 Gene

Gene Families for RCHY1 Gene

HGNC:

Protein Domains for RCHY1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RCHY1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PM5

UniProtKB/Swiss-Prot:

ZN363_HUMAN :
  • Contains 1 CHY-type zinc finger.
Similarity:
  • Contains 1 CHY-type zinc finger.
  • Contains 1 CTCHY-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RCHY1: view

Function for RCHY1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for RCHY1 Gene

UniProtKB/Swiss-Prot Function:
Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated during the S phase of the cell cycle. Expressed at low levels during G phase.

Enzyme Numbers (IUBMB) for RCHY1 Gene

Gene Ontology (GO) - Molecular Function for RCHY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 15781263
GO:0016874 ligase activity IEA --
GO:0042803 protein homodimerization activity IPI 19483087
genes like me logo Genes that share ontologies with RCHY1: view

Phenotypes for RCHY1 Gene

MGI mutant phenotypes for RCHY1:
inferred from 1 alleles
GenomeRNAi human phenotypes for RCHY1:
genes like me logo Genes that share phenotypes with RCHY1: view

Animal Models for RCHY1 Gene

MGI Knock Outs for RCHY1:

Animal Model Products

  • Taconic Biosciences Mouse Models for RCHY1

miRNA for RCHY1 Gene

miRTarBase miRNAs that target RCHY1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RCHY1 Gene

Localization for RCHY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCHY1 Gene

Nucleus. Nucleus speckle. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RCHY1 Gene COMPARTMENTS Subcellular localization image for RCHY1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RCHY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with RCHY1: view

Pathways & Interactions for RCHY1 Gene

genes like me logo Genes that share pathways with RCHY1: view

Pathways by source for RCHY1 Gene

1 Cell Signaling Technology pathway for RCHY1 Gene
1 R&D Systems pathway for RCHY1 Gene

UniProtKB/Swiss-Prot Q96PM5-ZN363_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for RCHY1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RCHY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IDA 19043414
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA 19483087
GO:0070987 error-free translesion synthesis TAS --
genes like me logo Genes that share ontologies with RCHY1: view

Drugs & Compounds for RCHY1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for RCHY1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for RCHY1 Gene

(9) REFSEQ mRNAs :
(20) Additional mRNA sequences :
(175) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RCHY1 Gene

Ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCHY1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: -
SP2: -
SP3:
SP4: - -
SP5: -

Relevant External Links for RCHY1 Gene

GeneLoc Exon Structure for
RCHY1
ECgene alternative splicing isoforms for
RCHY1

Expression for RCHY1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for RCHY1 Gene

mRNA expression in normal human tissues for RCHY1 Gene
mRNA expression by BioGPS for RCHY1 GenemRNA expression by GTEx for RCHY1 Gene

Protein differential expression in normal tissues from HIPED for RCHY1 Gene

This gene is overexpressed in NK cells (15.5), Peripheral blood mononuclear cells (13.6), and Fetal ovary (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RCHY1 Gene



SOURCE GeneReport for Unigene cluster for RCHY1 Gene Hs.48297

genes like me logo Genes that share expression patterns with RCHY1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RCHY1 Gene

Orthologs for RCHY1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RCHY1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia RCHY1 35
  • 90.29 (n)
  • 91.19 (a)
RCHY1 36
  • 91 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia RCHY1 35
  • 92.66 (n)
  • 95.75 (a)
RCHY1 36
  • 96 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Rchy1 35
  • 88.25 (n)
  • 90.42 (a)
Rchy1 16
Rchy1 36
  • 90 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia RCHY1 35
  • 99.74 (n)
  • 99.62 (a)
RCHY1 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Rchy1 35
  • 86.33 (n)
  • 90.04 (a)
oppossum
(Monodelphis domestica)
 Mammalia RCHY1 36
  • 87 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia RCHY1 36
  • 84 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves RCHY1 35
  • 70.65 (n)
  • 78.49 (a)
RCHY1 36
  • 82 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia rchy1 35
  • 74.5 (n)
  • 78.63 (a)
Str.10607 35
zebrafish
(Danio rerio)
 Actinopterygii rchy1 35
  • 68.37 (n)
  • 72.34 (a)
rchy1 36
  • 66 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG16947 35
  • 53.19 (n)
  • 50.42 (a)
CG16947 36
  • 28 (a)
 OneToOne
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT3G62970 35
  • 54.99 (n)
  • 49.21 (a)
rice
(Oryza sativa)
 Liliopsida Os12g0538500 35
  • 53.1 (n)
  • 48.05 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.11347 36
  • 47 (a)
 OneToOne
Species with no ortholog for RCHY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RCHY1 Gene

ENSEMBL:
Gene Tree for RCHY1 (if available)
TreeFam:
Gene Tree for RCHY1 (if available)

Paralogs for RCHY1 Gene

(1) SIMAP similar genes for RCHY1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RCHY1: view

No data available for Paralogs for RCHY1 Gene

Variants for RCHY1 Gene

Sequence variations from dbSNP and Humsavar for RCHY1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs9189 -- 75,482,209(+) GCACG(C/T)GTAGT nc-transcript-variant, utr-variant-3-prime
rs16732 -- 75,482,008(-) TGAAA(C/G)TGTTT nc-transcript-variant, utr-variant-3-prime
rs1046662 -- 75,479,373(-) CTGGC(A/C)ATAGG nc-transcript-variant, utr-variant-3-prime
rs1047970 -- 75,482,009(-) TTGAA(A/G)CTGTT nc-transcript-variant, utr-variant-3-prime
rs1351093 -- 75,485,490(-) ACTTA(C/T)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RCHY1 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855

Variation tolerance for RCHY1 Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RCHY1 Gene

Disorders for RCHY1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RCHY1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
variola minor
  • alastrim
- elite association - COSMIC cancer census association via MalaCards
Search RCHY1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RCHY1

Genetic Association Database (GAD)
RCHY1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RCHY1
genes like me logo Genes that share disorders with RCHY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RCHY1 Gene

Publications for RCHY1 Gene

  1. PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53. (PMID: 17950244) Zheng G. … Yang Y.-C. (Biochem. Biophys. Res. Commun. 2007) 3 4 23 67
  2. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. (PMID: 12654245) Leng R.P. … Benchimol S. (Cell 2003) 2 3 23
  3. p53-induced RING-H2 protein, a novel marker for poor survival in hepatocellular carcinoma after hepatic resection. (PMID: 19551892) Wang X.M. … Wu F. (Cancer 2009) 3 23
  4. Molecular basis of Pirh2-mediated p53 ubiquitylation. (PMID: 19043414) Sheng Y. … Arrowsmith C.H. (Nat. Struct. Mol. Biol. 2008) 3 23
  5. Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53. (PMID: 17568776) Duan S. … Wu M. (EMBO J. 2007) 3 23

Products for RCHY1 Gene

  • Addgene plasmids for RCHY1

Sources for RCHY1 Gene

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