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Aliases for RCHY1 Gene

Aliases for RCHY1 Gene

  • Ring Finger And CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase 2 3
  • Zinc Finger Protein 363 2 3 4
  • Androgen-Receptor N-Terminal-Interacting Protein 2 3
  • P53-Induced Protein With A RING-H2 Domain 2 3
  • E3 Ubiquitin-Protein Ligase Pirh2 3 4
  • RING Finger Protein 199 3 4
  • ZNF363 3 4
  • RNF199 3 4
  • ARNIP 3 4
  • CHIMP 3 4
  • PIRH2 3 4
  • RING Finger And CHY Zinc Finger Domain-Containing Protein 1 3
  • Ring Finger And CHY Zinc Finger Domain Containing 1 2
  • Androgen Receptor N-Terminal-Interacting Protein 4
  • CH-Rich Interacting Match With PLAG1 3
  • CH-Rich-Interacting Match With PLAG1 4
  • P53-Induced RING-H2 Protein 4
  • Zinc Finger, CHY-Type 3
  • Zinc Finger 2
  • EC 6.3.2.- 4
  • CHY-Type 2
  • PRO1996 3
  • HPirh2 4
  • ZCHY 3

External Ids for RCHY1 Gene

Previous HGNC Symbols for RCHY1 Gene

  • ZNF363

Previous GeneCards Identifiers for RCHY1 Gene

  • GC04M076866
  • GC04M076762
  • GC04M076623
  • GC04M076405
  • GC04M072150

Summaries for RCHY1 Gene

Entrez Gene Summary for RCHY1 Gene

  • The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for RCHY1 Gene

RCHY1 (Ring Finger And CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle / Checkpoint Control. GO annotations related to this gene include protein homodimerization activity and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RCHY1 Gene

  • Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.

Gene Wiki entry for RCHY1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCHY1 Gene

Genomics for RCHY1 Gene

Regulatory Elements for RCHY1 Gene

Genomic Location for RCHY1 Gene

Start:
75,479,037 bp from pter
End:
75,514,764 bp from pter
Size:
35,728 bases
Orientation:
Minus strand

Genomic View for RCHY1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RCHY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCHY1 Gene

Proteins for RCHY1 Gene

  • Protein details for RCHY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PM5-ZN363_HUMAN
    Recommended name:
    RING finger and CHY zinc finger domain-containing protein 1
    Protein Accession:
    Q96PM5
    Secondary Accessions:
    • B3KRG3
    • C7E541
    • C7E542
    • C7E543
    • D3YRV2
    • E7EMC8
    • E7ETW5
    • J3KPI0
    • Q2KN33
    • Q59GN7
    • Q86X26
    • Q96PR5

    Protein attributes for RCHY1 Gene

    Size:
    261 amino acids
    Molecular mass:
    30110 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE, UBE2D2 and GORAB/NTKLBP1.
    SequenceCaution:
    • Sequence=BAD92309.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RCHY1 Gene

    Alternative splice isoforms for RCHY1 Gene

neXtProt entry for RCHY1 Gene

Proteomics data for RCHY1 Gene at MOPED

Post-translational modifications for RCHY1 Gene

  • Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability.
  • Ubiquitination at Lys241
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RCHY1 (RCHY1)

No data available for DME Specific Peptides for RCHY1 Gene

Domains for RCHY1 Gene

Gene Families for RCHY1 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RCHY1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PM5

UniProtKB/Swiss-Prot:

ZN363_HUMAN :
  • Q96PM5
Similarity:
  • Contains 1 CHY-type zinc finger.
  • Contains 1 CTCHY-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RCHY1: view

Function for RCHY1 Gene

Molecular function for RCHY1 Gene

UniProtKB/Swiss-Prot Function: Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.
UniProtKB/Swiss-Prot Induction: Up-regulated during the S phase of the cell cycle. Expressed at low levels during G phase

Enzyme Numbers (IUBMB) for RCHY1 Gene

Gene Ontology (GO) - Molecular Function for RCHY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 19043414
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 15781263
GO:0008270 zinc ion binding IDA 19043414
genes like me logo Genes that share ontologies with RCHY1: view

Phenotypes for RCHY1 Gene

MGI mutant phenotypes for RCHY1:
inferred from 1 alleles
GenomeRNAi human phenotypes for RCHY1:
genes like me logo Genes that share phenotypes with RCHY1: view

Animal Models for RCHY1 Gene

MGI Knock Outs for RCHY1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RCHY1

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for RCHY1 Gene

Localization for RCHY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCHY1 Gene

Nucleus. Nucleus speckle. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RCHY1 Gene COMPARTMENTS Subcellular localization image for RCHY1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for RCHY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 19043414
GO:0005634 nucleus IDA 19483087
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with RCHY1: view

Pathways for RCHY1 Gene

genes like me logo Genes that share pathways with RCHY1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q96PM5-ZN363_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RCHY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0016567 protein ubiquitination IDA 19043414
GO:0019985 translesion synthesis TAS --
GO:0031398 positive regulation of protein ubiquitination IDA 19483087
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA 19483087
genes like me logo Genes that share ontologies with RCHY1: view

Transcripts for RCHY1 Gene

Unigene Clusters for RCHY1 Gene

Ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RCHY1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCHY1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: -
SP2: -
SP3:
SP4: - -
SP5: -

Relevant External Links for RCHY1 Gene

GeneLoc Exon Structure for
RCHY1
ECgene alternative splicing isoforms for
RCHY1

Expression for RCHY1 Gene

mRNA expression in normal human tissues for RCHY1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RCHY1 Gene

SOURCE GeneReport for Unigene cluster for RCHY1 Gene Hs.48297

genes like me logo Genes that share expressions with RCHY1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RCHY1 Gene

Orthologs for RCHY1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RCHY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RCHY1 35
  • 99.74 (n)
  • 99.62 (a)
RCHY1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RCHY1 35
  • 90.29 (n)
  • 91.19 (a)
RCHY1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RCHY1 35
  • 92.66 (n)
  • 95.75 (a)
RCHY1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rchy1 35
  • 88.25 (n)
  • 90.42 (a)
Rchy1 16
Rchy1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RCHY1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RCHY1 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rchy1 35
  • 86.33 (n)
  • 90.04 (a)
chicken
(Gallus gallus)
Aves RCHY1 35
  • 70.65 (n)
  • 78.49 (a)
RCHY1 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rchy1 35
  • 74.5 (n)
  • 78.63 (a)
Str.10607 35
zebrafish
(Danio rerio)
Actinopterygii rchy1 35
  • 68.37 (n)
  • 72.34 (a)
rchy1 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16947 35
  • 53.19 (n)
  • 50.42 (a)
CG16947 36
  • 28 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62970 35
  • 54.99 (n)
  • 49.21 (a)
rice
(Oryza sativa)
Liliopsida Os12g0538500 35
  • 53.1 (n)
  • 48.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11347 36
  • 47 (a)
OneToOne
Species with no ortholog for RCHY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RCHY1 Gene

ENSEMBL:
Gene Tree for RCHY1 (if available)
TreeFam:
Gene Tree for RCHY1 (if available)

Paralogs for RCHY1 Gene

Selected SIMAP similar genes for RCHY1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RCHY1: view

No data available for Paralogs for RCHY1 Gene

Variants for RCHY1 Gene

Sequence variations from dbSNP and Humsavar for RCHY1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs9189 -- 75,482,209(+) GCACG(C/T)GTAGT utr-variant-3-prime, nc-transcript-variant
rs11637 -- 75,482,007(+) AACAC(A/T)GTTTC utr-variant-3-prime, nc-transcript-variant
rs16732 -- 75,482,008(-) TGAAA(C/G)TGTTT utr-variant-3-prime, nc-transcript-variant
rs1046662 -- 75,479,373(-) CTGGC(A/C)ATAGG utr-variant-3-prime, nc-transcript-variant
rs1047970 -- 75,482,009(-) TTGAA(A/G)CTGTT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for RCHY1 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855

Relevant External Links for RCHY1 Gene

HapMap Linkage Disequilibrium report
RCHY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCHY1 Gene

Disorders for RCHY1 Gene

(2) Novoseek inferred disease relationships for RCHY1 Gene

Disease -log(P) Hits PubMed IDs
cancer lung 21.9 6
tumors 11.2 4

Relevant External Links for RCHY1

Genetic Association Database (GAD)
RCHY1
genes like me logo Genes that share disorders with RCHY1: view

No data available for UniProtKB/Swiss-Prot for RCHY1 Gene

Publications for RCHY1 Gene

  1. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. (PMID: 12654245) Leng R.P. … Benchimol S. (Cell 2003) 2 3 23
  2. Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome. (PMID: 14701804) Logan I.R. … Robson C.N. (J. Biol. Chem. 2004) 3 4 23
  3. PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53. (PMID: 17950244) Zheng G. … Yang Y.-C. (Biochem. Biophys. Res. Commun. 2007) 3 4 23
  4. Molecular basis of Pirh2-mediated p53 ubiquitylation. (PMID: 19043414) Sheng Y. … Arrowsmith C.H. (Nat. Struct. Mol. Biol. 2008) 3 4 23
  5. p53-induced RING-H2 protein, a novel marker for poor survival in hepatocellular carcinoma after hepatic resection. (PMID: 19551892) Wang X.M. … Wu F. (Cancer 2009) 3 23

Products for RCHY1 Gene

  • Addgene plasmids for RCHY1

Sources for RCHY1 Gene

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