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RCHY1 Gene(Protein Coding)

Ring Finger And CHY Zinc Finger Domain Containing 1

GCID:
GC04M075479
GIFtS:
50
Genes Participants
UDN Logo

Aliases for RCHY1 Gene

Aliases for RCHY1 Gene

  • Ring Finger And CHY Zinc Finger Domain Containing 1 2 3 5
  • ZNF363 2 3 4
  • Androgen-Receptor N-Terminal-Interacting Protein 2 3
  • P53-Induced Protein With A RING-H2 Domain 2 3
  • RING-Type E3 Ubiquitin Transferase RCHY1 3 4
  • E3 Ubiquitin-Protein Ligase Pirh2 3 4
  • Zinc Finger Protein 363 3 4
  • RING Finger Protein 199 3 4
  • Zinc Finger, CHY-Type 2 3
  • RNF199 3 4
  • ARNIP 3 4
  • CHIMP 3 4
  • PIRH2 3 4
  • Ring Finger And CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase 3
  • RING Finger And CHY Zinc Finger Domain-Containing Protein 1 3
  • Androgen Receptor N-Terminal-Interacting Protein 4
  • CH-Rich Interacting Match With PLAG1 3
  • CH-Rich-Interacting Match With PLAG1 4
  • P53-Induced RING-H2 Protein 4
  • EC 2.3.2.27 4
  • PRO1996 3
  • HPirh2 4
  • ZCHY 3

External Ids for RCHY1 Gene

Previous HGNC Symbols for RCHY1 Gene

  • ZNF363

Previous GeneCards Identifiers for RCHY1 Gene

  • GC04M076866
  • GC04M076762
  • GC04M076623
  • GC04M076405
  • GC04M072150

Summaries for RCHY1 Gene

Entrez Gene Summary for RCHY1 Gene

  • The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for RCHY1 Gene

RCHY1 (Ring Finger And CHY Zinc Finger Domain Containing 1) is a Protein Coding gene. Diseases associated with RCHY1 include Variola Minor. Among its related pathways are Innate Immune System and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ligase activity.

UniProtKB/Swiss-Prot for RCHY1 Gene

  • Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.

Gene Wiki entry for RCHY1 Gene

Additional gene information for RCHY1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCHY1 Gene

Genomics for RCHY1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for RCHY1 Gene

Promoters and enhancers for RCHY1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04I075511 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 567.1 +0.9 943 4.9 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A THAP6 RCHY1 NUP54
GH04I076192 Enhancer 1.5 Ensembl ENCODE dbSUPER 11.2 -683.0 -683029 9.7 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B FEZF1 YBX1 ZNF2 IRF4 NUP54 SCARB2 RCHY1 THAP6 ART3 NAAA GC04P076210
GH04I075494 Enhancer 0.4 Ensembl 16.2 +20.1 20059 0.6 BCL6B CEBPB RCHY1 THAP6 GC04M075464
GH04I075847 Enhancer 0.5 ENCODE 11.2 -332.9 -332859 0.2 ZBTB8A ZNF433 ZNF781 ZNF518A THAP6 LOC105377284 PPEF2 RCHY1 SDAD1 GC04P075831 LOC105377285
GH04I075561 Enhancer 0.7 ENCODE 5.6 -47.2 -47166 1.3 PKNOX1 NEUROD1 SIN3A RFX5 CTBP1 GATA3 SMARCE1 ZNF687 NRF1 CEBPB ODAPH RCHY1 CDKL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RCHY1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RCHY1 gene promoter:

Genomic Locations for RCHY1 Gene

Genomic Locations for RCHY1 Gene
chr4:75,479,037-75,514,764
(GRCh38/hg38)
Size:
35,728 bases
Orientation:
Minus strand
chr4:76,404,247-76,439,974
(GRCh37/hg19)

Genomic View for RCHY1 Gene

Genes around RCHY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCHY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCHY1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RCHY1 Gene

Proteins for RCHY1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RCHY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PM5-ZN363_HUMAN
    Recommended name:
    RING finger and CHY zinc finger domain-containing protein 1
    Protein Accession:
    Q96PM5
    Secondary Accessions:
    • B3KRG3
    • C7E541
    • C7E542
    • C7E543
    • D3YRV2
    • E7EMC8
    • E7ETW5
    • J3KPI0
    • Q2KN33
    • Q59GN7
    • Q86X26
    • Q96PR5

    Protein attributes for RCHY1 Gene

    Size:
    261 amino acids
    Molecular mass:
    30110 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE, UBE2D2 and GORAB/NTKLBP1.
    SequenceCaution:
    • Sequence=BAD92309.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RCHY1 Gene

    Alternative splice isoforms for RCHY1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RCHY1 Gene

Protein Expression for RCHY1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RCHY1 Gene

  • Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability.
  • Ubiquitination at isoforms=2, 6, 7, 8241

Other Protein References for RCHY1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RCHY1 Gene

Domains & Families for RCHY1 Gene

Gene Families for RCHY1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for RCHY1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RCHY1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RCHY1: view

No data available for UniProtKB/Swiss-Prot for RCHY1 Gene

Function for RCHY1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for RCHY1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated during the S phase of the cell cycle. Expressed at low levels during G phase.

Enzyme Numbers (IUBMB) for RCHY1 Gene

Phenotypes From GWAS Catalog for RCHY1 Gene

Gene Ontology (GO) - Molecular Function for RCHY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 19043414
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 15781263
GO:0008270 zinc ion binding IEA,IDA 19043414
genes like me logo Genes that share ontologies with RCHY1: view
genes like me logo Genes that share phenotypes with RCHY1: view

Animal Models for RCHY1 Gene

MGI Knock Outs for RCHY1:

Animal Model Products

CRISPR Products

miRNA for RCHY1 Gene

miRTarBase miRNAs that target RCHY1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RCHY1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RCHY1 Gene

Localization for RCHY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCHY1 Gene

Nucleus. Nucleus speckle. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RCHY1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RCHY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 19043414
GO:0005634 nucleus IDA,IEA 19483087
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 15781263
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RCHY1: view

Pathways & Interactions for RCHY1 Gene

genes like me logo Genes that share pathways with RCHY1: view

UniProtKB/Swiss-Prot Q96PM5-ZN363_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for RCHY1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RCHY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA,IDA 19043414
GO:0031398 positive regulation of protein ubiquitination IDA 19483087
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA 19483087
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA 19483087
GO:0070987 error-free translesion synthesis TAS --
genes like me logo Genes that share ontologies with RCHY1: view

Drugs & Compounds for RCHY1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for RCHY1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for RCHY1 Gene

(9) REFSEQ mRNAs :
(20) Additional mRNA sequences :
(175) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RCHY1 Gene

Ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RCHY1

Alternative Splicing Database (ASD) splice patterns (SP) for RCHY1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: -
SP2: -
SP3:
SP4: - -
SP5: -

Relevant External Links for RCHY1 Gene

GeneLoc Exon Structure for
RCHY1
ECgene alternative splicing isoforms for
RCHY1

Expression for RCHY1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RCHY1 Gene

mRNA expression in normal human tissues for RCHY1 Gene
mRNA expression by GTEx for RCHY1 GenemRNA expression by BioGPS for RCHY1 Gene

Protein differential expression in normal tissues from HIPED for RCHY1 Gene

This gene is overexpressed in NK cells (15.5), Peripheral blood mononuclear cells (13.6), and Fetal ovary (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RCHY1 Gene



NURSA nuclear receptor signaling pathways regulating expression of RCHY1 Gene:

RCHY1

SOURCE GeneReport for Unigene cluster for RCHY1 Gene:

Hs.48297

Evidence on tissue expression from TISSUES for RCHY1 Gene

  • Nervous system(4.8)
  • Blood(4.3)
  • Kidney(2.5)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with RCHY1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RCHY1 Gene

Orthologs for RCHY1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RCHY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia RCHY1 33 34
  • 99.74 (n)
dog
(Canis familiaris)
 Mammalia RCHY1 33 34
  • 92.66 (n)
cow
(Bos Taurus)
 Mammalia RCHY1 33 34
  • 90.29 (n)
mouse
(Mus musculus)
 Mammalia Rchy1 33 16 34
  • 88.25 (n)
oppossum
(Monodelphis domestica)
 Mammalia RCHY1 34
  • 87 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Rchy1 33
  • 86.33 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia RCHY1 34
  • 84 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves RCHY1 33 34
  • 70.65 (n)
tropical clawed frog
(Silurana tropicalis)
 Amphibia rchy1 33
  • 74.5 (n)
Str.10607 33
zebrafish
(Danio rerio)
 Actinopterygii rchy1 33 34
  • 68.37 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG16947 33 34
  • 53.19 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT3G62970 33
  • 54.99 (n)
rice
(Oryza sativa)
 Liliopsida Os12g0538500 33
  • 53.1 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.11347 34
  • 47 (a)
 OneToOne
Species where no ortholog for RCHY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RCHY1 Gene

ENSEMBL:
Gene Tree for RCHY1 (if available)
TreeFam:
Gene Tree for RCHY1 (if available)

Paralogs for RCHY1 Gene

(1) SIMAP similar genes for RCHY1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RCHY1: view

No data available for Paralogs for RCHY1 Gene

Variants for RCHY1 Gene

Sequence variations from dbSNP and Humsavar for RCHY1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000067470 -- 75,503,687(-) A/AA intron_variant
rs1000096697 -- 75,503,989(-) G/T intron_variant
rs1000234603 -- 75,478,554(-) G/A downstream_transcript_variant
rs1000253883 -- 75,510,787(-) A/C intron_variant
rs1000365525 -- 75,511,059(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RCHY1 Gene

Variant ID Type Subtype PubMed ID
nsv1111276 CNV tandem duplication 24896259
nsv1131809 CNV deletion 24896259
nsv1140180 CNV insertion 24896259
nsv1143097 CNV tandem duplication 24896259
nsv594687 CNV loss 21841781
nsv7363 OTHER inversion 18451855

Variation tolerance for RCHY1 Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RCHY1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RCHY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCHY1 Gene

Disorders for RCHY1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RCHY1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
variola minor
  • alastrim
- elite association - COSMIC cancer census association via MalaCards
Search RCHY1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RCHY1

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RCHY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RCHY1 Gene

Publications for RCHY1 Gene

  1. Molecular basis of Pirh2-mediated p53 ubiquitylation. (PMID: 19043414) Sheng Y … Arrowsmith CH (Nature structural & molecular biology 2008) 3 4 22 58
  2. PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53. (PMID: 17950244) Zheng G … Yang YC (Biochemical and biophysical research communications 2007) 3 4 22 58
  3. Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome. (PMID: 14701804) Logan IR … Robson CN (The Journal of biological chemistry 2004) 3 4 22 58
  4. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. (PMID: 12654245) Leng RP … Benchimol S (Cell 2003) 2 3 22 58
  5. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PMID: 22491018) Wang J … Platt A (The pharmacogenomics journal 2013) 3 44 58

Products for RCHY1 Gene

  • Addgene plasmids for RCHY1

Sources for RCHY1 Gene

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