Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPL36 Gene

Aliases for RPL36 Gene

  • Ribosomal Protein L36 2 3 5
  • Large Ribosomal Subunit Protein EL36 3 4
  • 60S Ribosomal Protein L36 3
  • L36 3

External Ids for RPL36 Gene

Previous GeneCards Identifiers for RPL36 Gene

  • GC19P005782
  • GC19P005621
  • GC19P005641
  • GC19P005451

Summaries for RPL36 Gene

Entrez Gene Summary for RPL36 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L36E family of ribosomal proteins. It is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL36 Gene

RPL36 (Ribosomal Protein L36) is a Protein Coding gene. Diseases associated with RPL36 include Retinitis Pigmentosa 59 and Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL36 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL36 Gene

Genomics for RPL36 Gene

Regulatory Elements for RPL36 Gene

Enhancers for RPL36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G005626 1.5 Ensembl ENCODE dbSUPER 28.8 -46.6 -46572 3.3 HDGF ATF1 PKNOX1 ZNF766 ELK1 KLF13 CAVIN1 ZNF592 SREBF1 MEF2D RPL36 HSD11B1L C19orf70 SAFB2
GH19G005689 1.2 ENCODE 33.7 +17.2 17155 5.0 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 SSRP1 SNRPEP4 ENSG00000267571 SAFB SAFB2 VMAC RPL36 LONP1 GTF2F1 HSD11B1L SLC25A41
GH19G005717 1.4 ENCODE dbSUPER 20 +44.3 44309 4.4 CREB3L1 MLX DMAP1 FEZF1 YY1 ZNF143 SP3 NFYC MEF2D ZNF610 SNRPEP4 SAFB ENSG00000267571 RPL36 VMAC LONP1 CATSPERD GC19M005694
GH19G006527 1.4 ENCODE dbSUPER 18.6 +855.7 855697 6.2 YBX1 ZNF143 ZNF548 SP3 MCM3 TBX21 MEF2D ZNF610 GLIS1 RCOR2 SAFB2 ZNF557 SNRPEP4 SAFB ENSG00000267571 GTF2F1 RPL36 GPR108 ENSG00000269680 VMAC
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL36 on UCSC Golden Path with GeneCards custom track

Promoters for RPL36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106406 539 2001 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 SSRP1

Genomic Location for RPL36 Gene

5,674,947 bp from pter
5,691,876 bp from pter
16,930 bases
Plus strand

Genomic View for RPL36 Gene

Genes around RPL36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL36 Gene

Proteins for RPL36 Gene

  • Protein details for RPL36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L36
    Protein Accession:
    Secondary Accessions:
    • B2R4Y1
    • D6W634
    • Q6FIG1
    • Q9UQF6

    Protein attributes for RPL36 Gene

    105 amino acids
    Molecular mass:
    12254 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL36 Gene

neXtProt entry for RPL36 Gene

Post-translational modifications for RPL36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPL36 Gene

No data available for DME Specific Peptides for RPL36 Gene

Domains & Families for RPL36 Gene

Gene Families for RPL36 Gene

Protein Domains for RPL36 Gene


Suggested Antigen Peptide Sequences for RPL36 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL36 family.
  • Belongs to the eukaryotic ribosomal protein eL36 family.
genes like me logo Genes that share domains with RPL36: view

Function for RPL36 Gene

Gene Ontology (GO) - Molecular Function for RPL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome NAS 12962325
genes like me logo Genes that share ontologies with RPL36: view
genes like me logo Genes that share phenotypes with RPL36: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL36 Gene

Localization for RPL36 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL36 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005730 nucleolus IDA 16791210
GO:0005737 cytoplasm IDA 16791210
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL36: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL36 Gene

Pathways & Interactions for RPL36 Gene

genes like me logo Genes that share pathways with RPL36: view

Pathways by source for RPL36 Gene

1 KEGG pathway for RPL36 Gene
1 GeneGo (Thomson Reuters) pathway for RPL36 Gene

Gene Ontology (GO) - Biological Process for RPL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL36: view

No data available for SIGNOR curated interactions for RPL36 Gene

Drugs & Compounds for RPL36 Gene

No Compound Related Data Available

Transcripts for RPL36 Gene

Unigene Clusters for RPL36 Gene

Ribosomal protein L36:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL36 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b

Relevant External Links for RPL36 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL36 Gene

Protein differential expression in normal tissues from HIPED for RPL36 Gene

This gene is overexpressed in Nasal epithelium (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL36 Gene

Protein tissue co-expression partners for RPL36 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL36 Gene:


SOURCE GeneReport for Unigene cluster for RPL36 Gene:


Evidence on tissue expression from TISSUES for RPL36 Gene

  • Skin(4.5)
  • Kidney(4.4)
  • Blood(4.3)
  • Nervous system(4)
  • Liver(3.4)
  • Adrenal gland(2.6)
  • Bone marrow(2.5)
  • Lymph node(2.5)
  • Muscle(2.5)
  • Pancreas(2.5)
  • Spleen(2.5)
  • Intestine(2.4)
  • Stomach(2.4)
  • Gall bladder(2.2)
  • Lung(2.2)
  • Heart(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with RPL36: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL36 Gene

Orthologs for RPL36 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL36 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL36 34 35
  • 99.37 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 98 (a)
-- 35
  • 91 (a)
(Mus musculus)
Mammalia Rpl36-ps3 35
  • 98 (a)
Gm4604 34 16
  • 86.98 (n)
(Ornithorhynchus anatinus)
Mammalia RPL36 35
  • 96 (a)
(Bos Taurus)
Mammalia -- 35
  • 92 (a)
RPL36 34 35
  • 90.16 (n)
-- 35
  • 88 (a)
(Canis familiaris)
Mammalia RPL36 34 35
  • 91.84 (n)
(Rattus norvegicus)
Mammalia Rpl36 34
  • 86.67 (n)
(Gallus gallus)
Aves RPL36 35
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8714 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.29254 34
(Danio rerio)
Actinopterygii rpl36 35
  • 92 (a)
Dr.1335 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8943 34
fruit fly
(Drosophila melanogaster)
Insecta RpL36 36 35
  • 62 (a)
(Caenorhabditis elegans)
Secernentea rpl-36 35
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL36B 35 37
  • 46 (a)
RPL36A 35
  • 45 (a)
(Glycine max)
eudicotyledons Gma.1156 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4420 35
  • 73 (a)
Species where no ortholog for RPL36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL36 Gene

Gene Tree for RPL36 (if available)
Gene Tree for RPL36 (if available)

Paralogs for RPL36 Gene

No data available for Paralogs for RPL36 Gene

Variants for RPL36 Gene

Sequence variations from dbSNP and Humsavar for RPL36 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001159971 -- 5,691,638(+) GCCCT(C/T)TCCCT downstream-variant-500B, utr-variant-3-prime
rs1002071399 -- 5,689,016(+) CGGCC(C/T)CTCAA downstream-variant-500B, upstream-variant-2KB
rs1002103875 -- 5,689,343(+) GCCAC(A/C)CGATT upstream-variant-2KB
rs1002413035 -- 5,690,868(+) TCTGA(C/T)GCAGG intron-variant
rs1002730634 -- 5,689,746(+) GTTCA(C/T)GCCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL36 Gene

Variant ID Type Subtype PubMed ID
nsv1062851 CNV gain 25217958
nsv953952 CNV deletion 24416366

Variation tolerance for RPL36 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL36 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL36 Gene

Disorders for RPL36 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RPL36 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa 59
  • rp59
diamond-blackfan anemia
  • diamond-blackfan anemia 1
- elite association - COSMIC cancer census association via MalaCards
Search RPL36 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPL36

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL36: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL36 Gene

Publications for RPL36 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova T.I. … Karpova G.G. (J. Protein Chem. 2003) 3 4 64
  3. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4 64
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64

Products for RPL36 Gene

Sources for RPL36 Gene

Loading form....