Aliases for RPL36 Gene
External Ids for RPL36 Gene
- HGNC: 13631
- Entrez Gene: 25873
- Ensembl: ENSG00000130255
- UniProtKB: Q9Y3U8
Previous GeneCards Identifiers for RPL36 Gene
- GC19P005782
- GC19P005621
- GC19P005641
- GC19P005451
Summaries for RPL36 Gene
-
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L36E family of ribosomal proteins. It is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
GeneCards Summary for RPL36 Gene
RPL36 (Ribosomal Protein L36) is a Protein Coding gene. Diseases associated with RPL36 include Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL36 Gene
Genomics for RPL36 Gene
Regulatory Elements for RPL36 Gene
Enhancers for RPL36 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around RPL36 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the RPL36 gene promoter:
Regulatory Element Products
Genomic Location for RPL36 Gene
- Chromosome:
- 19
- Start:
- 5,674,947 bp from pter
- End:
- 5,691,876 bp from pter
- Size:
- 16,930 bases
- Orientation:
- Plus strand
Genomic View for RPL36 Gene
Genes around RPL36 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by Ensembl
- 19p13.3 by Entrez Gene
- 19p13.2 by HGNC
RPL36 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RPL36 Gene
Proteins for RPL36 Gene
-
Protein details for RPL36 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y3U8-RL36_HUMAN
- Recommended name:
- 60S ribosomal protein L36
- Protein Accession:
- Q9Y3U8
- B2R4Y1
- D6W634
- Q6FIG1
- Q9UQF6
Protein attributes for RPL36 Gene
- Size:
- 105 amino acids
- Molecular mass:
- 12254 Da
- Quaternary structure:
- No Data Available
Protein Expression for RPL36 Gene
Post-translational modifications for RPL36 Gene
Other Protein References for RPL36 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for RPL36
- Novus Biologicals Antibodies for RPL36
- Abcam antibodies for RPL36
- Invitrogen Antibodies for RPL36
- antibodies-online Antibodies for RPL36: See all 38
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-
Santa Cruz Biotechnology (SCBT) Antibodies for RPL36
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for RPL36
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- antibodies-online Proteins for RPL36: See all 19
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- Abcam proteins for RPL36
Assay Products
- antibodies-online Kits for RPL36: See all 9
No data available for DME Specific Peptides for RPL36 Gene
Domains & Families for RPL36 Gene
Gene Families for RPL36 Gene
Protein Domains for RPL36 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RPL36 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y3U8- Family:
-
- Belongs to the ribosomal protein L36e family.
Function for RPL36 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003735 | structural constituent of ribosome | IEA,NAS | 12962325 |
Phenotypes for RPL36 Gene
- GenomeRNAi human phenotypes for RPL36:
-
- Increased vaccinia virus (VACV) infection
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Nucleoplasmic pre-40S maturation defects
- Nuclear 60S biogenesis defects
- Decreased viability
- Decreased shRNA abundance
- Decreased cell number
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability of wild-type and TP53 knockout cells
- Multipolar spindles
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for RPL36 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for RPL36
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPL36
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miRNA for RPL36 Gene
- miRTarBase miRNAs that target RPL36
-
- hsa-mir-615-3p (MIRT039808)
- hsa-mir-484 (MIRT042307)
- hsa-mir-320a (MIRT044707)
- hsa-mir-186-5p (MIRT044992)
- hsa-mir-3127-5p (MIRT457410)
- hsa-mir-8085 (MIRT457411)
- hsa-mir-6731-5p (MIRT457412)
- hsa-mir-6754-5p (MIRT457413)
- hsa-mir-4441 (MIRT457414)
- hsa-mir-4270 (MIRT457415)
- hsa-mir-211-3p (MIRT457416)
- hsa-mir-205-3p (MIRT457417)
- hsa-mir-6760-5p (MIRT457418)
- hsa-mir-195-5p (MIRT726682)
- hsa-mir-15b-5p (MIRT726683)
- hsa-mir-16-5p (MIRT726684)
- hsa-mir-15a-5p (MIRT726685)
miRNA Products
- Search ViGene Biosciences for RPL36
Clone Products
- OriGene clones in human for RPL36
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for RPL36 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RPL36 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RPL36 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL36 Gene
Localization for RPL36 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 5 |
| chloroplast | 2 |
| mitochondrion | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005730 | nucleolus | IDA | 16791210 |
| GO:0005840 | ribosome | IEA | -- |
| GO:0016020 | membrane | IDA | 19946888 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL36 Gene
Pathways & Interactions for RPL36 Gene
More details on SuperPathways for RPL36| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
.76
.60
|
|
| 2 | Influenza Viral RNA Transcription and Replication | ||
| 3 | Infectious disease |
.48
|
|
| 4 | rRNA processing |
.92
|
|
| 5 | Gene Expression |
.49
|
Pathways by source for RPL36 Gene
1 BioSystems pathway for RPL36 Gene
27 Reactome pathways for RPL36 Gene
1 KEGG pathway for RPL36 Gene
1 GeneGo (Thomson Reuters) pathway for RPL36 Gene
Interacting Proteins for RPL36 Gene
Selected Interacting proteins:
Q9Y3U8-RL36_HUMAN
ENSP00000252543
for RPL36 Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002181 | cytoplasmic translation | IBA | -- |
| GO:0006364 | rRNA processing | TAS | -- |
| GO:0006413 | translational initiation | TAS | -- |
| GO:0006415 | translational termination | TAS | -- |
| GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | TAS | -- |
No data available for SIGNOR curated interactions for RPL36 Gene
Transcripts for RPL36 Gene
mRNA/cDNA for RPL36 Gene
- (2) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (786) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for RPL36
-
Santa Cruz Biotechnology (SCBT) CRISPR for RPL36
- GenScript: Design CRISPR guide RNA sequences for RPL36
miRNA Products
- Search ViGene Biosciences for RPL36
Clone Products
- OriGene clones in human for RPL36
- OriGene ORF clones in human,mouse,rat for RPL36
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: |
Expression for RPL36 Gene
This gene is overexpressed in Nasal epithelium (18.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL36 Gene
SOURCE GeneReport for Unigene cluster for RPL36 Gene Hs.408018
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for RPL36
-
OriGene qPCR primer pairs and template standards for RPL36
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL36 Gene
Orthologs for RPL36 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | RPL36 35 |
|
||
| -- 36 |
|
OneToMany | |||
| -- 36 |
|
OneToMany | |||
| RPL36 36 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | RPL36 35 |
|
||
| RPL36 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Gm4604 35 |
|
||
| Gm4604 16 |
|
|
|||
| Rpl36-ps3 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | RPL36 35 |
|
||
| RPL36 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Rpl36 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
OneToMany | |
| -- 36 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | RPL36 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RPL36 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.8714 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.29254 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | Dr.1335 35 |
|
||
| rpl36 36 |
|
OneToOne | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8943 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | RpL36 37 |
|
|
|
| RpL36 36 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | rpl-36 36 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPL36A 36 |
|
OneToMany | |
| RPL36B 36 |
|
OneToMany | |||
| RPL36B 38 |
|
|
|||
| soybean (Glycine max) |
eudicotyledons | Gma.1156 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4420 36 |
|
OneToOne |
- Species with no ortholog for RPL36:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RPL36 Gene
Pseudogenes.org Pseudogenes for RPL36 Gene
- PGOHUM00000239939
- PGOHUM00000248577
- PGOHUM00000247852
- PGOHUM00000237063
- PGOHUM00000250607
- PGOHUM00000243935
- PGOHUM00000244051
- PGOHUM00000244508
- PGOHUM00000247522
- PGOHUM00000247672
- PGOHUM00000247676
- PGOHUM00000246305
- PGOHUM00000237913
- PGOHUM00000238006
- PGOHUM00000250720
- PGOHUM00000235777
- PGOHUM00000243606
- PGOHUM00000243633
- PGOHUM00000232967
- PGOHUM00000233514
- PGOHUM00000250033
- PGOHUM00000236754
- PGOHUM00000241959
No data available for Paralogs for RPL36 Gene
Variants for RPL36 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_051804 | - | ||||
| rs67905503 | -- | 5,689,246(+) | GAAAG(C/T)GCTAA | upstream-variant-2KB | |
| rs72210922 | -- | 5,689,653(+) | ATTTA(-/ATTT)TTTAT | upstream-variant-2KB | |
| rs75965064 | -- | 5,690,048(+) | ATAGG(C/G/T)GGAGT | upstream-variant-2KB | |
| rs187451530 | -- | 5,689,215(+) | GACAG(A/T)GCAAG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3693n71 | CNV | Loss | 21882294 |
| nsv910894 | CNV | Loss | 21882294 |
| dgv3694n71 | CNV | Loss | 21882294 |
| dgv3695n71 | CNV | Loss | 21882294 |
Residual Variation Intolerance Score:
56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.17;
3.80% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for RPL36 Gene
- Human Gene Mutation Database (HGMD)
- RPL36
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL36 Gene
Disorders for RPL36 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diamond-blackfan anemia |
|
|
Search RPL36 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for RPL36
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- RPL36
No data available for UniProtKB/Swiss-Prot and Genatlas for RPL36 Gene
Publications for RPL36 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
- ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
- Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
- Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. (PMID: 26527279) Campos E.I. … Reinberg D. (Mol. Cell 2015) 3
Products for RPL36 Gene
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- antibodies-online Antibodies for RPL36: See all 38
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- ViGene Biosciences adenoviral particle packaged cDNA for RPL36 gene
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Sources for RPL36 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon