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Aliases for PRKD2 Gene

Aliases for PRKD2 Gene

  • Protein Kinase D2 2 3 5
  • EC 2.7.11.13 4 63
  • NPKC-D2 3 4
  • PKD2 3 4
  • EC 2.7.11 63
  • HSPC187 3

External Ids for PRKD2 Gene

Previous GeneCards Identifiers for PRKD2 Gene

  • GC19M047568
  • GC19M051853
  • GC19M051869
  • GC19M047177
  • GC19M043602

Summaries for PRKD2 Gene

Entrez Gene Summary for PRKD2 Gene

  • The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKD2 Gene

PRKD2 (Protein Kinase D2) is a Protein Coding gene. Among its related pathways are Insulin secretion and Ras signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKD1.

UniProtKB/Swiss-Prot for PRKD2 Gene

  • Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. In response to oxidative stress, is phosphorylated at Tyr-438 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B. In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77. Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation. During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens. In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway. During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane. Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis. In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN. Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells. Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion.

Tocris Summary for PRKD2 Gene

  • The protein kinase D (PKD) family of serine/threonine protein kinases has three members: PKD1-3. They occupy a unique position in signaling pathways initiated by diacylglycerol and protein kinase C. PKDs are involved in cell survival, migration, differentiation and proliferation.

Gene Wiki entry for PRKD2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKD2 Gene

Genomics for PRKD2 Gene

Regulatory Elements for PRKD2 Gene

Enhancers for PRKD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRKD2 on UCSC Golden Path with GeneCards custom track

Promoters for PRKD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRKD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRKD2 Gene

Chromosome:
19
Start:
46,674,275 bp from pter
End:
46,717,127 bp from pter
Size:
42,853 bases
Orientation:
Minus strand

Genomic View for PRKD2 Gene

Genes around PRKD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKD2 Gene

Proteins for PRKD2 Gene

  • Protein details for PRKD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZL6-KPCD2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase D2
    Protein Accession:
    Q9BZL6
    Secondary Accessions:
    • M0R2R2
    • Q8NCK8
    • Q8TB08
    • Q9P0T6
    • Q9Y3X8

    Protein attributes for PRKD2 Gene

    Size:
    878 amino acids
    Molecular mass:
    96750 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts (via C-terminus) with LCK. Interacts (via N-terminal AP-rich region) with CIB1 isoform 2.
    SequenceCaution:
    • Sequence=AAF36107.1; Type=Frameshift; Positions=604, 606, 738, 744, 755, 758, 833, 854; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRKD2 Gene

    Alternative splice isoforms for PRKD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKD2 Gene

Proteomics data for PRKD2 Gene at MOPED

Post-translational modifications for PRKD2 Gene

  • Phosphorylation of Ser-876 correlates with the activation status of the kinase. Ser-706 is probably phosphorylated by PKC. Phosphorylation at Ser-244 by CSNK1D and CSNK1E promotes nuclear localization and substrate targeting. Phosphorylation at Ser-244, Ser-706 and Ser-710 is required for nuclear localization. Phosphorylated at Tyr-438 by ABL1 in response to oxidative stress.
  • Ubiquitination at Lys 178
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKD2 (PRKD2)
  • Cloud-Clone Corp. Antibodies for PRKD2

Domains & Families for PRKD2 Gene

Gene Families for PRKD2 Gene

Suggested Antigen Peptide Sequences for PRKD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZL6

UniProtKB/Swiss-Prot:

KPCD2_HUMAN :
  • Contains 1 PH domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
Domain:
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with PRKD2: view

Function for PRKD2 Gene

Molecular function for PRKD2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains bind DAG, mediating translocation to membranes. Autophosphorylation of Ser-710 and phosphorylation of Ser-706 by PKC relieves auto-inhibition by the PH domain.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. In response to oxidative stress, is phosphorylated at Tyr-438 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B. In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77. Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation. During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens. In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway. During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane. Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis. In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN. Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells. Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion.

Enzyme Numbers (IUBMB) for PRKD2 Gene

genes like me logo Genes that share phenotypes with PRKD2: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRKD2 Gene

Localization for PRKD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKD2 Gene

Cytoplasm. Cell membrane. Nucleus. Golgi apparatus, trans-Golgi network. Note=Translocation to the cell membrane is required for kinase activation. Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. {ECO:0000269 PubMed:17962809}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKD2 Gene COMPARTMENTS Subcellular localization image for PRKD2 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 4
plasma membrane 4

No data available for Gene Ontology (GO) - Cellular Components for PRKD2 Gene

Pathways & Interactions for PRKD2 Gene

genes like me logo Genes that share pathways with PRKD2: view

SIGNOR curated interactions for PRKD2 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PRKD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0006468 protein phosphorylation IEA,NAS 11062248
GO:0007155 cell adhesion IEA --
GO:0018105 peptidyl-serine phosphorylation IDA 18440775
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IMP 19001381
genes like me logo Genes that share ontologies with PRKD2: view

Drugs & Compounds for PRKD2 Gene

(9) Drugs for PRKD2 Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
CID 2011756 Pharma PKD inhibitor, Pan protein kinase D (PKD) inhibitor; cell permeable 0
CID 755673 Pharma PKD inhibitor, Selective protein kinase D inhibitor 0
bryostatin Pharma inhibitor 0
BRYOSTATIN-1 Pharma 0

(7) Additional Compounds for PRKD2 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(4) Tocris Compounds for PRKD2 Gene

Compound Action Cas Number
CID 2011756 Pan protein kinase D (PKD) inhibitor; cell permeable 638156-11-3
CID 755673 Selective protein kinase D inhibitor 521937-07-5
CRT 0066101 Potent protein kinase D (PKD) inhibitor
kb NB 142-70 Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327) 1233533-04-4

(2) ApexBio Compounds for PRKD2 Gene

Compound Action Cas Number
CID 2011756 PKD inhibitor 638156-11-3
CID 755673 PKD inhibitor 521937-07-5
genes like me logo Genes that share compounds with PRKD2: view

Transcripts for PRKD2 Gene

Unigene Clusters for PRKD2 Gene

Protein kinase D2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKD2 Gene

No ASD Table

Relevant External Links for PRKD2 Gene

GeneLoc Exon Structure for
PRKD2
ECgene alternative splicing isoforms for
PRKD2

Expression for PRKD2 Gene

mRNA expression in normal human tissues for PRKD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKD2 Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for PRKD2 Gene

This gene is overexpressed in CD8 Tcells (18.0), Lymph node (15.6), and CD4 Tcells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRKD2 Gene



SOURCE GeneReport for Unigene cluster for PRKD2 Gene Hs.466987

mRNA Expression by UniProt/SwissProt for PRKD2 Gene

Q9BZL6-KPCD2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with PRKD2: view

Protein tissue co-expression partners for PRKD2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PRKD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRKD2 35
  • 90.43 (n)
  • 95.7 (a)
bta-mir-2897 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKD2 35
  • 91.15 (n)
  • 96.13 (a)
PRKD2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkd2 35
  • 88.56 (n)
  • 95.65 (a)
Prkd2 16
Prkd2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRKD2 35
  • 96.48 (n)
  • 95.82 (a)
PRKD2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkd2 35
  • 88.33 (n)
  • 95.54 (a)
oppossum
(Monodelphis domestica)
Mammalia PRKD2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKD2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15204 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9355 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01058041.1 36
  • 43 (a)
OneToMany
PRKD2 (1 of 5) 36
  • 61 (a)
OneToMany
PRKD2 (2 of 5) 36
  • 86 (a)
OneToMany
PRKD2 (3 of 5) 36
  • 67 (a)
OneToMany
PRKD2 (4 of 5) 36
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta PKD 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F48G7.10 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3354 36
  • 29 (a)
ManyToMany
Species with no ortholog for PRKD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKD2 Gene

ENSEMBL:
Gene Tree for PRKD2 (if available)
TreeFam:
Gene Tree for PRKD2 (if available)

Paralogs for PRKD2 Gene

Paralogs for PRKD2 Gene

genes like me logo Genes that share paralogs with PRKD2: view

Variants for PRKD2 Gene

Sequence variations from dbSNP and Humsavar for PRKD2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs45455991 - 46,700,950(+) CGGCA(C/T)ATCTG reference, missense
rs55716765 - 46,693,964(+) GGGCG(A/G)CCTCA reference, missense
rs34325043 - 46,689,698(+) CAGGC(C/T)CTGCA reference, missense
rs55933311 - 46,678,417(+) GCTCC(A/C/G)GGGGC reference, missense
VAR_042334 A lung adenocarcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for PRKD2 Gene

Variant ID Type Subtype PubMed ID
nsv833849 CNV Loss 17160897
dgv3961n71 CNV Loss 21882294
nsv912189 CNV Loss 21882294
nsv833850 CNV Loss 17160897

Variation tolerance for PRKD2 Gene

Residual Variation Intolerance Score: 9.45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKD2 Gene

HapMap Linkage Disequilibrium report
PRKD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKD2 Gene

Disorders for PRKD2 Gene

Relevant External Links for PRKD2

Genetic Association Database (GAD)
PRKD2
Human Genome Epidemiology (HuGE) Navigator
PRKD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKD2

No disorders were found for PRKD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRKD2 Gene

Publications for PRKD2 Gene

  1. Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase d family of serine threonine kinases. (PMID: 11062248) Sturany S. … Seufferlein T. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. PKD2 interacts with Lck and regulates NFAT activity in T cells. (PMID: 19192391) Li Q. … Luo Y. (BMB Rep. 2009) 3 23
  3. The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity. (PMID: 19581308) Kunkel M.T. … Newton A.C. (J. Biol. Chem. 2009) 3 23
  4. Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis. (PMID: 19001381) Hao Q. … Tang H. (J. Biol. Chem. 2009) 3 23
  5. PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells. (PMID: 17570131) Yuan J. … Rozengurt E. (J. Cell. Biochem. 2008) 3 23

Products for PRKD2 Gene

Sources for PRKD2 Gene