Aliases for PRDX5 Gene
External Ids for PRDX5 Gene
Previous GeneCards Identifiers for PRDX5 Gene
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRDX5 Gene
PRDX5 (Peroxiredoxin 5) is a Protein Coding gene. Diseases associated with PRDX5 include Asthma 2 and Fuchs' Endothelial Dystrophy. Among its related pathways are Cellular Senescence (REACTOME) and Selenium Micronutrient Network. GO annotations related to this gene include receptor binding and protein dimerization activity.
UniProtKB/Swiss-Prot for PRDX5 Gene
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.