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Aliases for PRDX5 Gene

Aliases for PRDX5 Gene

  • Peroxiredoxin 5 2 3 5
  • Peroxisomal Antioxidant Enzyme 2 3 4
  • Liver Tissue 2D-Page Spot 71B 2 3 4
  • Thioredoxin Peroxidase PMP20 2 3 4
  • Antioxidant Enzyme B166 2 3 4
  • TPx Type VI 2 3 4
  • Thioredoxin Reductase 3 4
  • Alu Co-Repressor 1 2 3
  • Peroxiredoxin V 3 4
  • EC 1.11.1.15 4 63
  • AOEB166 3 4
  • Prx-V 3 4
  • ACR1 3 4
  • PLP 3 4
  • Epididymis Secretory Protein Li 55 3
  • Alu Corepressor 1 4
  • HEL-S-55 3
  • SBBI10 3
  • PMP20 3
  • PRDX6 3
  • B166 3
  • PRXV 3

External Ids for PRDX5 Gene

Previous GeneCards Identifiers for PRDX5 Gene

  • GC11P066601
  • GC11P065767
  • GC11P064336
  • GC11P063860
  • GC11P063842
  • GC11P064085
  • GC11P060413

Summaries for PRDX5 Gene

Entrez Gene Summary for PRDX5 Gene

  • This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRDX5 Gene

PRDX5 (Peroxiredoxin 5) is a Protein Coding gene. Diseases associated with PRDX5 include fuchs' endothelial dystrophy and alopecia. Among its related pathways are Peroxisome and Cellular Senescence. GO annotations related to this gene include receptor binding and protein dimerization activity.

UniProtKB/Swiss-Prot for PRDX5 Gene

  • Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.

Gene Wiki entry for PRDX5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX5 Gene

Genomics for PRDX5 Gene

Regulatory Elements for PRDX5 Gene

Enhancers for PRDX5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRDX5 on UCSC Golden Path with GeneCards custom track

Promoters for PRDX5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRDX5 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRDX5 Gene

Chromosome:
11
Start:
64,318,088 bp from pter
End:
64,321,823 bp from pter
Size:
3,736 bases
Orientation:
Plus strand

Genomic View for PRDX5 Gene

Genes around PRDX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX5 Gene

Proteins for PRDX5 Gene

  • Protein details for PRDX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30044-PRDX5_HUMAN
    Recommended name:
    Peroxiredoxin-5, mitochondrial
    Protein Accession:
    P30044
    Secondary Accessions:
    • A6NC19
    • A6NG06
    • B7ZLJ4
    • B7ZVW3
    • Q14CK0
    • Q6IAF2
    • Q9UBU5
    • Q9UJU4
    • Q9UKX4

    Protein attributes for PRDX5 Gene

    Size:
    214 amino acids
    Molecular mass:
    22086 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAF17200.1; Type=Frameshift; Positions=14, 30; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRDX5 Gene

    Alternative splice isoforms for PRDX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRDX5 Gene

Proteomics data for PRDX5 Gene at MOPED

Selected DME Specific Peptides for PRDX5 Gene

Post-translational modifications for PRDX5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRDX5 Gene

Antibody Products

  • R&D Systems Antibodies for PRDX5 (Peroxiredoxin 5)

Domains & Families for PRDX5 Gene

Gene Families for PRDX5 Gene

Suggested Antigen Peptide Sequences for PRDX5 Gene

Graphical View of Domain Structure for InterPro Entry

P30044

UniProtKB/Swiss-Prot:

PRDX5_HUMAN :
  • Contains 1 thioredoxin domain.
  • Belongs to the peroxiredoxin 2 family.
Domain:
  • Contains 1 thioredoxin domain.
Family:
  • Belongs to the peroxiredoxin 2 family.
genes like me logo Genes that share domains with PRDX5: view

Function for PRDX5 Gene

Molecular function for PRDX5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 R-SH + ROOH = R-S-S-R + H(2)O + ROH.
UniProtKB/Swiss-Prot Function:
Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.

Enzyme Numbers (IUBMB) for PRDX5 Gene

Gene Ontology (GO) - Molecular Function for PRDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 10514471
GO:0072541 peroxynitrite reductase activity IDA 15280035
genes like me logo Genes that share ontologies with PRDX5: view
genes like me logo Genes that share phenotypes with PRDX5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRDX5

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRDX5 Gene

Localization for PRDX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX5 Gene

Isoform Mitochondrial: Mitochondrion.
Isoform Cytoplasmic+peroxisomal: Cytoplasm. Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRDX5 Gene COMPARTMENTS Subcellular localization image for PRDX5 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
peroxisome 5
chloroplast 2
cytoskeleton 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005737 cytoplasm IDA 10514471
GO:0005777 peroxisome IDA 10521424
genes like me logo Genes that share ontologies with PRDX5: view

Pathways & Interactions for PRDX5 Gene

genes like me logo Genes that share pathways with PRDX5: view

Pathways by source for PRDX5 Gene

1 KEGG pathway for PRDX5 Gene
1 GeneGo (Thomson Reuters) pathway for PRDX5 Gene

Gene Ontology (GO) - Biological Process for PRDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IMP 18262354
GO:0034614 cellular response to reactive oxygen species IMP 18262354
GO:0043066 negative regulation of apoptotic process IMP 18262354
GO:0051354 negative regulation of oxidoreductase activity IDA 15280035
GO:0070995 NADPH oxidation IDA 10751410
genes like me logo Genes that share ontologies with PRDX5: view

No data available for SIGNOR curated interactions for PRDX5 Gene

Drugs & Compounds for PRDX5 Gene

(42) Drugs for PRDX5 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Auranofin Approved Pharma Activation, Activator, Target, inhibitor Thioredoxin reductase inhibitor; induces MPT 9
Benzoic Acid Experimental Pharma Target 7
Diminazene Experimental Pharma Target 0
Hydrogen peroxide Pharma 47

(60) Additional Compounds for PRDX5 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PRDX5: view

Transcripts for PRDX5 Gene

Unigene Clusters for PRDX5 Gene

Peroxiredoxin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5: - - - - - -
SP6: - - - - - - -
SP7:
SP8:

Relevant External Links for PRDX5 Gene

GeneLoc Exon Structure for
PRDX5
ECgene alternative splicing isoforms for
PRDX5

Expression for PRDX5 Gene

mRNA expression in normal human tissues for PRDX5 Gene

Protein differential expression in normal tissues from HIPED for PRDX5 Gene

This gene is overexpressed in Nasal epithelium (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRDX5 Gene



SOURCE GeneReport for Unigene cluster for PRDX5 Gene Hs.502823

mRNA Expression by UniProt/SwissProt for PRDX5 Gene

P30044-PRDX5_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with PRDX5: view

Protein tissue co-expression partners for PRDX5 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PRDX5 Gene

Orthologs for PRDX5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRDX5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRDX5 35
  • 83.77 (n)
  • 81.87 (a)
PRDX5 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRDX5 35
  • 84.94 (n)
  • 85.54 (a)
mouse
(Mus musculus)
Mammalia Prdx5 35
  • 86.11 (n)
  • 87.22 (a)
Prdx5 16
Prdx5 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRDX5 35
  • 99.69 (n)
  • 99.53 (a)
PRDX5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdx5 35
  • 85.31 (n)
  • 88.14 (a)
oppossum
(Monodelphis domestica)
Mammalia PRDX5 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX5 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRDX5 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prdx5 35
  • 65.2 (n)
  • 67.3 (a)
zebrafish
(Danio rerio)
Actinopterygii prdx5 35
  • 63.96 (n)
  • 61.25 (a)
prdx5 36
  • 53 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9314 35
fruit fly
(Drosophila melanogaster)
Insecta CG7217 37
  • 57 (a)
Prx5 35
  • 62.37 (n)
  • 59.51 (a)
Prx5 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001325 35
  • 60.86 (n)
  • 60 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL154C 35
  • 48.41 (n)
  • 40.48 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07271g 35
  • 46.83 (n)
  • 39.29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AHP1 36
  • 24 (a)
OneToOne
AHP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TPX1 35
  • 50.53 (n)
  • 43.95 (a)
rice
(Oryza sativa)
Liliopsida Os01g0675100 35
  • 49.9 (n)
  • 44.03 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06880 35
  • 52.8 (n)
  • 44.1 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC330.06c 35
  • 42.7 (n)
  • 35.29 (a)
Species with no ortholog for PRDX5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRDX5 Gene

ENSEMBL:
Gene Tree for PRDX5 (if available)
TreeFam:
Gene Tree for PRDX5 (if available)

Paralogs for PRDX5 Gene

genes like me logo Genes that share paralogs with PRDX5: view

No data available for Paralogs for PRDX5 Gene

Variants for PRDX5 Gene

Sequence variations from dbSNP and Humsavar for PRDX5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_025049 -
VAR_036406 A breast cancer sample
rs566049 -- 64,320,963(+) CCCTT(A/G)GCCTC intron-variant
rs627425 -- 64,320,170(+) AGGTA(C/T)TGGGG intron-variant
rs646153 -- 64,322,116(+) ggtgt(C/T)tgcca downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PRDX5 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
nsv897685 CNV Loss 21882294
esv2667562 CNV Deletion 23128226
esv27107 CNV Loss 19812545

Variation tolerance for PRDX5 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRDX5 Gene

HapMap Linkage Disequilibrium report
PRDX5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX5 Gene

Disorders for PRDX5 Gene

MalaCards: The human disease database

(6) MalaCards diseases for PRDX5 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PRDX5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRDX5

Genetic Association Database (GAD)
PRDX5
Human Genome Epidemiology (HuGE) Navigator
PRDX5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRDX5
genes like me logo Genes that share disorders with PRDX5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX5 Gene

Publications for PRDX5 Gene

  1. Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family. (PMID: 10521424) Knoops B. … Bernard A. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Effect of auranofin on the mitochondrial generation of hydrogen peroxide. Role of thioredoxin reductase. (PMID: 16036347) Rigobello M.P. … Bindoli A. (Free Radic. Res. 2005) 23 25 26
  3. Discovery of fragment molecules that bind the human peroxiredoxin 5 active site. (PMID: 20305821) Barelier S. … Krimm I. (PLoS ONE 2010) 3 23
  4. Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cepsilon and selenoprotein thioredoxin reductase. (PMID: 19578042) Gundimeda U. … Gopalakrishna R. (Carcinogenesis 2009) 25 26
  5. Peroxiredoxin V contributes to antioxidant defense of lung epithelial cells. (PMID: 18219526) Avila P.C. … Serikov V.B. (Lung 2008) 3 23

Products for PRDX5 Gene

Sources for PRDX5 Gene

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