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Aliases for PRDX5 Gene

Aliases for PRDX5 Gene

  • Peroxiredoxin 5 2 3 5
  • Peroxisomal Antioxidant Enzyme 2 3 4
  • Liver Tissue 2D-Page Spot 71B 2 3 4
  • Thioredoxin Peroxidase PMP20 2 3 4
  • Antioxidant Enzyme B166 2 3 4
  • TPx Type VI 2 3 4
  • Alu Co-Repressor 1 2 3
  • Peroxiredoxin V 3 4
  • EC 1.11.1.15 4 56
  • AOEB166 3 4
  • Prx-V 3 4
  • ACR1 3 4
  • PLP 3 4
  • Epididymis Secretory Protein Li 55 3
  • Peroxiredoxin-5, Mitochondrial 3
  • Thioredoxin Reductase 3
  • Alu Corepressor 1 4
  • HEL-S-55 3
  • SBBI10 3
  • PMP20 3
  • PRDX6 3
  • B166 3
  • PRXV 3

External Ids for PRDX5 Gene

Previous GeneCards Identifiers for PRDX5 Gene

  • GC11P066601
  • GC11P065767
  • GC11P064336
  • GC11P063860
  • GC11P063842
  • GC11P064085
  • GC11P060413

Summaries for PRDX5 Gene

Entrez Gene Summary for PRDX5 Gene

  • This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]

GeneCards Summary for PRDX5 Gene

PRDX5 (Peroxiredoxin 5) is a Protein Coding gene. Diseases associated with PRDX5 include Fuchs' Endothelial Dystrophy and Corticobasal Degeneration. Among its related pathways are Gene Expression and Detoxification of Reactive Oxygen Species. Gene Ontology (GO) annotations related to this gene include receptor binding and protein dimerization activity.

UniProtKB/Swiss-Prot for PRDX5 Gene

  • Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

Gene Wiki entry for PRDX5 Gene

Additional gene information for PRDX5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX5 Gene

Genomics for PRDX5 Gene

GeneHancer (GH) Regulatory Elements for PRDX5 Gene

Promoters and enhancers for PRDX5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I064316 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.0 46 4.1 HDGF FOXA2 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 TRMT112 PRDX5 PIR36303 SF1 POLA2 ZFPL1 ENSG00000257086 PLCB3 ZNHIT2 DNAJC4
GH11I064267 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 10.9 -47.4 -47388 7.2 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MCM3 SP3 NFYC GPR137 ZFPL1 SF1 POLA2 PLCB3 TRMT112 DNAJC4 ENSG00000257086 FAU LOC102723878
GH11I064347 Enhancer 0.8 ENCODE 11.8 +30.3 30293 1.9 BCOR KLF1 JUN CHD4 MAX ZMYM3 CEBPG POLR2A FOXK2 PATZ1 LOC102723878 MIR1237 TRMT112 PRDX5 ESRRA CATSPERZ ENSG00000207024 KCNK4 KCNK4-TEX40 BAD
GH11I064274 Enhancer 0.8 ENCODE dbSUPER 10.9 -41.8 -41783 2.9 KLF1 RFX1 SIN3A EBF1 SP1 ZFHX2 JUND IKZF1 ADNP RCOR1 LOC102723878 DNAJC4 ESRRA PRDX5 TRMT112 ENSG00000231680 GPR137 BAD
GH11I064354 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.8 +39.9 39886 6.6 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A ZBTB7B YY1 RPS6KA4 LOC102723878 PLCB3 ENSG00000231680 TRPT1 MARK2 PPP1R14B ESRRA PRDX5 TRMT112
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRDX5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRDX5 gene promoter:

Genomic Locations for PRDX5 Gene

Genomic Locations for PRDX5 Gene
chr11:64,318,088-64,321,823
(GRCh38/hg38)
Size:
3,736 bases
Orientation:
Plus strand
chr11:64,085,560-64,089,295
(GRCh37/hg19)

Genomic View for PRDX5 Gene

Genes around PRDX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX5 Gene

Proteins for PRDX5 Gene

  • Protein details for PRDX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30044-PRDX5_HUMAN
    Recommended name:
    Peroxiredoxin-5, mitochondrial
    Protein Accession:
    P30044
    Secondary Accessions:
    • A6NC19
    • A6NG06
    • B7ZLJ4
    • B7ZVW3
    • Q14CK0
    • Q6IAF2
    • Q9UBU5
    • Q9UJU4
    • Q9UKX4

    Protein attributes for PRDX5 Gene

    Size:
    214 amino acids
    Molecular mass:
    22086 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys Prx, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
    SequenceCaution:
    • Sequence=AAF17200.1; Type=Frameshift; Positions=14, 30; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRDX5 Gene

    Alternative splice isoforms for PRDX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRDX5 Gene

Selected DME Specific Peptides for PRDX5 Gene

P30044:
  • KVNLAELFK
  • VPGAFTP
  • PGAFTPGCSKTHLPGFVEQA
  • FGNRRLKRFSMV
  • VEVFEGEPG
  • FGKETDLLLDDSL

Post-translational modifications for PRDX5 Gene

No Post-translational modifications

Other Protein References for PRDX5 Gene

Domains & Families for PRDX5 Gene

Gene Families for PRDX5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRDX5 Gene

Graphical View of Domain Structure for InterPro Entry

P30044

UniProtKB/Swiss-Prot:

PRDX5_HUMAN :
  • Belongs to the peroxiredoxin family. Prx5 subfamily.
Family:
  • Belongs to the peroxiredoxin family. Prx5 subfamily.
genes like me logo Genes that share domains with PRDX5: view

Function for PRDX5 Gene

Molecular function for PRDX5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 R-SH + ROOH = R-S-S-R + H(2)O + ROH.
UniProtKB/Swiss-Prot Function:
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

Enzyme Numbers (IUBMB) for PRDX5 Gene

Phenotypes From GWAS Catalog for PRDX5 Gene

Gene Ontology (GO) - Molecular Function for PRDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001016 RNA polymerase III regulatory region DNA binding IDA 10095767
GO:0004601 peroxidase activity IDA,IEA 10521424
GO:0005102 receptor binding IPI 20178365
GO:0008379 thioredoxin peroxidase activity EXP 10514471
GO:0016209 antioxidant activity IEA --
genes like me logo Genes that share ontologies with PRDX5: view
genes like me logo Genes that share phenotypes with PRDX5: view

Animal Model Products

Clone Products

  • Addgene plasmids for PRDX5

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRDX5 Gene

Localization for PRDX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX5 Gene

Isoform Mitochondrial: Mitochondrion.
Isoform Cytoplasmic+peroxisomal: Cytoplasm. Peroxisome matrix. Note=Imported into peroxisomes via peroxisomal targeting signal 1 receptor PEX5. {ECO:0000269 PubMed:10514471}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRDX5 gene
Compartment Confidence
extracellular 5
mitochondrion 5
peroxisome 5
nucleus 5
cytosol 5
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Mitochondria (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA,HDA 23580065
GO:0005634 nucleus IDA 10095767
GO:0005737 cytoplasm IEA,IDA 15785239
GO:0005739 mitochondrion IDA,IEA 10521424
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with PRDX5: view

Pathways & Interactions for PRDX5 Gene

genes like me logo Genes that share pathways with PRDX5: view

Pathways by source for PRDX5 Gene

Gene Ontology (GO) - Biological Process for PRDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response TAS 10521424
GO:0006979 response to oxidative stress IDA 10521424
GO:0016480 negative regulation of transcription by RNA polymerase III IDA 10095767
GO:0034599 cellular response to oxidative stress TAS --
genes like me logo Genes that share ontologies with PRDX5: view

No data available for SIGNOR curated interactions for PRDX5 Gene

Drugs & Compounds for PRDX5 Gene

(48) Drugs for PRDX5 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Auranofin Approved, Investigational Pharma Activation, Activator, Target, inhibitor Thioredoxin reductase inhibitor; induces MPT 11
Benzoic Acid Approved, Investigational Pharma Target 8
Hydrogen peroxide Approved, Vet_approved Pharma 73
Water Approved Pharma 0
Diminazene Experimental Pharma Target 0

(54) Additional Compounds for PRDX5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRDX5: view

Transcripts for PRDX5 Gene

Unigene Clusters for PRDX5 Gene

Peroxiredoxin 5:
Representative Sequences:

Clone Products

  • Addgene plasmids for PRDX5

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5: - - - - - -
SP6: - - - - - - -
SP7:
SP8:

Relevant External Links for PRDX5 Gene

GeneLoc Exon Structure for
PRDX5
ECgene alternative splicing isoforms for
PRDX5

Expression for PRDX5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRDX5 Gene

Protein differential expression in normal tissues from HIPED for PRDX5 Gene

This gene is overexpressed in Nasal epithelium (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRDX5 Gene



Protein tissue co-expression partners for PRDX5 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRDX5 Gene:

PRDX5

SOURCE GeneReport for Unigene cluster for PRDX5 Gene:

Hs.502823

mRNA Expression by UniProt/SwissProt for PRDX5 Gene:

P30044-PRDX5_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PRDX5 Gene

  • Nervous system(4.8)
  • Lung(4.7)
  • Liver(4.6)
  • Adrenal gland(4.5)
  • Heart(3.1)
  • Kidney(3)
  • Muscle(3)
  • Thyroid gland(2.9)
  • Eye(2.8)
  • Blood(2.7)
  • Skin(2.7)
  • Intestine(2.6)
  • Stomach(2.1)
  • Bone marrow(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with PRDX5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDX5 Gene

Orthologs for PRDX5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRDX5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRDX5 33 34
  • 99.69 (n)
mouse
(Mus musculus)
Mammalia Prdx5 33 16 34
  • 86.11 (n)
rat
(Rattus norvegicus)
Mammalia Prdx5 33
  • 85.31 (n)
dog
(Canis familiaris)
Mammalia PRDX5 33
  • 84.94 (n)
cow
(Bos Taurus)
Mammalia PRDX5 33 34
  • 83.77 (n)
oppossum
(Monodelphis domestica)
Mammalia PRDX5 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX5 34
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRDX5 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prdx5 33
  • 65.2 (n)
zebrafish
(Danio rerio)
Actinopterygii prdx5 33 34
  • 63.96 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9314 33
fruit fly
(Drosophila melanogaster)
Insecta Prx5 33 34
  • 62.37 (n)
CG7217 35
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001325 33
  • 60.86 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL154C 33
  • 48.41 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07271g 33
  • 46.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AHP1 34 36
  • 24 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons TPX1 33
  • 50.53 (n)
rice
(Oryza sativa)
Liliopsida Os01g0675100 33
  • 49.9 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06880 33
  • 52.8 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC330.06c 33
  • 42.7 (n)
Species where no ortholog for PRDX5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRDX5 Gene

ENSEMBL:
Gene Tree for PRDX5 (if available)
TreeFam:
Gene Tree for PRDX5 (if available)

Paralogs for PRDX5 Gene

genes like me logo Genes that share paralogs with PRDX5: view

No data available for Paralogs for PRDX5 Gene

Variants for PRDX5 Gene

Sequence variations from dbSNP and Humsavar for PRDX5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
VAR_036406 A breast cancer sample p.Phe157Leu
rs1000039151 -- 64,317,749(+) C/T upstream_transcript_variant
rs1000505630 -- 64,320,113(+) A/G intron_variant
rs1002157591 -- 64,318,958(+) G/T intron_variant
rs1002492776 -- 64,318,856(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRDX5 Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
esv2667562 CNV deletion 23128226
esv27107 CNV loss 19812545
esv3626659 CNV loss 21293372
nsv469961 CNV loss 18288195
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for PRDX5 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRDX5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRDX5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX5 Gene

Disorders for PRDX5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PRDX5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fuchs' endothelial dystrophy
  • fced
corticobasal degeneration
  • cbgd
morgagni cataract
  • hypermature cataract
malaria
  • malaria, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search PRDX5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRDX5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRDX5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX5 Gene

Publications for PRDX5 Gene

  1. Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family. (PMID: 10521424) Knoops B … Bernard A (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. The crystal structures of oxidized forms of human peroxiredoxin 5 with an intramolecular disulfide bond confirm the proposed enzymatic mechanism for atypical 2-Cys peroxiredoxins. (PMID: 18489898) Smeets A … Declercq JP (Archives of biochemistry and biophysics 2008) 3 4 22 58
  3. Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution. (PMID: 11518528) Declercq JP … Knoops B (Journal of molecular biology 2001) 3 4 22 58
  4. Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis. (PMID: 10679306) Zhou Y … Jin DY (Biochemical and biophysical research communications 2000) 3 4 22 58
  5. Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate. (PMID: 10751410) Seo MS … Rhee SG (The Journal of biological chemistry 2000) 3 4 22 58

Products for PRDX5 Gene

  • Addgene plasmids for PRDX5

Sources for PRDX5 Gene

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