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Aliases for PRDX5 Gene

Aliases for PRDX5 Gene

  • Peroxiredoxin 5 2 3
  • Peroxisomal Antioxidant Enzyme 2 3 4
  • Liver Tissue 2D-Page Spot 71B 2 3 4
  • Thioredoxin Peroxidase PMP20 2 3 4
  • Antioxidant Enzyme B166 2 3 4
  • TPx Type VI 2 3 4
  • AOEB166 3 4 6
  • Thioredoxin Reductase 3 4
  • Alu Co-Repressor 1 2 3
  • Peroxiredoxin V 3 4
  • EC 1.11.1.15 4 63
  • Prx-V 3 4
  • ACR1 3 4
  • PLP 3 4
  • Epididymis Secretory Protein Li 55 3
  • Peroxiredoxin-5, Mitochondrial 3
  • Alu Corepressor 1 4
  • HEL-S-55 3
  • SBBI10 3
  • PMP20 3
  • PRDX6 3
  • B166 3
  • PRXV 3

External Ids for PRDX5 Gene

Summaries for PRDX5 Gene

Entrez Gene Summary for PRDX5 Gene

  • This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRDX5 Gene

PRDX5 (Peroxiredoxin 5) is a Protein Coding gene. Diseases associated with PRDX5 include fuchs' endothelial dystrophy and corticobasal degeneration. Among its related pathways are Metabolism and Cellular Senescence. GO annotations related to this gene include receptor binding and peroxidase activity.

UniProtKB/Swiss-Prot for PRDX5 Gene

  • Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling

Gene Wiki entry for PRDX5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX5 Gene

Genomics for PRDX5 Gene

Genomic Location for PRDX5 Gene

Start:
64,317,962 bp from pter
End:
64,321,823 bp from pter
Size:
3,862 bases
Orientation:
Plus strand

Genomic View for PRDX5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRDX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX5 Gene

Regulatory Elements for PRDX5 Gene

Proteins for PRDX5 Gene

  • Protein details for PRDX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30044-PRDX5_HUMAN
    Recommended name:
    Peroxiredoxin-5, mitochondrial
    Protein Accession:
    P30044
    Secondary Accessions:
    • A6NC19
    • A6NG06
    • B7ZLJ4
    • B7ZVW3
    • Q14CK0
    • Q6IAF2
    • Q9UBU5
    • Q9UJU4
    • Q9UKX4

    Protein attributes for PRDX5 Gene

    Size:
    214 amino acids
    Molecular mass:
    22086 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAF17200.1; Type=Frameshift; Positions=14, 30; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRDX5 Gene

    Alternative splice isoforms for PRDX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRDX5 Gene

Proteomics data for PRDX5 Gene at MOPED

Selected DME Specific Peptides for PRDX5 Gene

Post-translational modifications for PRDX5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys83

Other Protein References for PRDX5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PRDX5 Gene

Suggested Antigen Peptide Sequences for PRDX5 Gene

Graphical View of Domain Structure for InterPro Entry

P30044

UniProtKB/Swiss-Prot:

PRDX5_HUMAN
Domain:
  • Contains 1 thioredoxin domain.:
    • P30044
Family:
  • Belongs to the peroxiredoxin 2 family.:
    • P30044
genes like me logo Genes that share domains with PRDX5: view

No data available for Gene Families for PRDX5 Gene

Function for PRDX5 Gene

Molecular function for PRDX5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 2 R-SH + ROOH = R-S-S-R + H(2)O + ROH
UniProtKB/Swiss-Prot Function: Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling

Enzyme Numbers (IUBMB) for PRDX5 Gene

Gene Ontology (GO) - Molecular Function for PRDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001016 RNA polymerase III regulatory region DNA binding IDA 10095767
GO:0004601 peroxidase activity IDA 10521424
GO:0005102 receptor binding IPI 10514471
GO:0016209 antioxidant activity IDA 10514471
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with PRDX5: view

Phenotypes for PRDX5 Gene

genes like me logo Genes that share phenotypes with PRDX5: view

miRNA for PRDX5 Gene

miRTarBase miRNAs that target PRDX5

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PRDX5 Gene

Localization for PRDX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX5 Gene

Isoform Mitochondrial: Mitochondrion.
Isoform Cytoplasmic+peroxisomal: Cytoplasm. Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRDX5 Gene COMPARTMENTS Subcellular localization image for PRDX5 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 5
peroxisome 5
chloroplast 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005634 nucleus IDA 10095767
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with PRDX5: view

Pathways for PRDX5 Gene

genes like me logo Genes that share pathways with PRDX5: view

Pathways by source for PRDX5 Gene

2 BioSystems pathways for PRDX5 Gene

Gene Ontology (GO) - Biological Process for PRDX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006954 inflammatory response TAS 10521424
GO:0006979 response to oxidative stress IDA 10514471
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with PRDX5: view

Compounds for PRDX5 Gene

(2) HMDB Compounds for PRDX5 Gene

Compound Synonyms Cas Number PubMed IDs
Hydrogen peroxide
  • Hydrogen peroxide
7722-84-1
Water
  • Dihydrogen oxide
7732-18-5

(3) Drugbank Compounds for PRDX5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Auranofin
34031-32-8 target inhibitor
Benzoic Acid
65-85-0 target
Diminazene
  • 1,3-TRIS-(4'AMIDINOPHENYL)TRIAZINE
536-71-0 target

(98) Novoseek inferred chemical compound relationships for PRDX5 Gene

Compound -log(P) Hits PubMed IDs
selenocysteine 92.7 42
selenium 84 63
dithiol 83.8 5
auranofin 83.4 7
nadph 80.2 78
genes like me logo Genes that share compounds with PRDX5: view

Transcripts for PRDX5 Gene

Unigene Clusters for PRDX5 Gene

Peroxiredoxin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5: - - - - - -
SP6: - - - - - - -
SP7:
SP8:

Relevant External Links for PRDX5 Gene

GeneLoc Exon Structure for
PRDX5
ECgene alternative splicing isoforms for
PRDX5

Expression for PRDX5 Gene

mRNA expression in normal human tissues for PRDX5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRDX5 Gene

SOURCE GeneReport for Unigene cluster for PRDX5 Gene Hs.502823

mRNA Expression by UniProt/SwissProt for PRDX5 Gene

P30044-PRDX5_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with PRDX5: view

No data available for mRNA differential expression in normal tissues for PRDX5 Gene

Orthologs for PRDX5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRDX5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRDX5 35
  • 99.69 (n)
  • 99.53 (a)
PRDX5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRDX5 35
  • 83.77 (n)
  • 81.87 (a)
PRDX5 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRDX5 35
  • 84.94 (n)
  • 85.54 (a)
mouse
(Mus musculus)
Mammalia Prdx5 35
  • 86.11 (n)
  • 87.22 (a)
Prdx5 16
Prdx5 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRDX5 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX5 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdx5 35
  • 85.31 (n)
  • 88.14 (a)
lizard
(Anolis carolinensis)
Reptilia PRDX5 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prdx5 35
  • 65.2 (n)
  • 67.3 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9314 35
zebrafish
(Danio rerio)
Actinopterygii prdx5 35
  • 63.96 (n)
  • 61.25 (a)
prdx5 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001325 35
  • 60.86 (n)
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta Prx5 35
  • 62.37 (n)
  • 59.51 (a)
Prx5 36
  • 53 (a)
OneToOne
CG7217 37
  • 57 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL154C 35
  • 48.41 (n)
  • 40.48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AHP1 36
  • 24 (a)
OneToOne
AHP1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07271g 35
  • 46.83 (n)
  • 39.29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons TPX1 35
  • 50.53 (n)
  • 43.95 (a)
rice
(Oryza sativa)
Liliopsida Os01g0675100 35
  • 49.9 (n)
  • 44.03 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06880 35
  • 52.8 (n)
  • 44.1 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC330.06c 35
  • 42.7 (n)
  • 35.29 (a)
Species with no ortholog for PRDX5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRDX5 Gene

ENSEMBL:
Gene Tree for PRDX5 (if available)
TreeFam:
Gene Tree for PRDX5 (if available)

Paralogs for PRDX5 Gene

genes like me logo Genes that share paralogs with PRDX5: view

No data available for Paralogs for PRDX5 Gene

Variants for PRDX5 Gene

Sequence variations from dbSNP and Humsavar for PRDX5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs566049 -- 64,320,963(+) CCCTT(A/G)GCCTC intron-variant
rs627425 -- 64,320,170(+) AGGTA(C/T)TGGGG intron-variant
rs646153 -- 64,322,116(+) ggtgt(C/T)tgcca downstream-variant-500B
rs1047143 -- 64,321,688(+) CAGCT(C/T)TGAGG reference, synonymous-codon
rs1047189 -- 64,321,729(+) CCTAT(C/T)TCACC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PRDX5 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
nsv897685 CNV Loss 21882294
esv2667562 CNV Deletion 23128226
esv27107 CNV Loss 19812545

Relevant External Links for PRDX5 Gene

HapMap Linkage Disequilibrium report
PRDX5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX5 Gene

Disorders for PRDX5 Gene

(1) University of Copenhagen DISEASES for PRDX5 Gene

(36) Novoseek inferred disease relationships for PRDX5 Gene

Disease -log(P) Hits PubMed IDs
selenium deficiency 77.7 4
cancer 44.3 30
melanoma amelanotic 25.9 2
tumors 25.2 14
adenocarcinoma lung 22.1 3

Relevant External Links for PRDX5

Genetic Association Database (GAD)
PRDX5
Human Genome Epidemiology (HuGE) Navigator
PRDX5
genes like me logo Genes that share disorders with PRDX5: view

No data available for UniProtKB/Swiss-Prot for PRDX5 Gene

Publications for PRDX5 Gene

  1. Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family. (PMID: 10521424) Knoops B. … Bernard A. (J. Biol. Chem. 1999) 2 3 4 23
  2. A novel human DNA-binding protein with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase- III-driven transcription of the Alu-family retroposons in vitro. (PMID: 10095767) Kropotov A. … Tomilin N. (Eur. J. Biochem. 1999) 3 4 23
  3. Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5-A resolution. (PMID: 11518528) Declercq J.-P. … Knoops B. (J. Mol. Biol. 2001) 3 4 23
  4. Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate. (PMID: 10751410) Seo M.S. … Rhee S.G. (J. Biol. Chem. 2000) 3 4 23
  5. The crystal structures of oxidized forms of human peroxiredoxin 5 with an intramolecular disulfide bond confirm the proposed enzymatic mechanism for atypical 2-Cys peroxiredoxins. (PMID: 18489898) Smeets A. … Declercq J.P. (Arch. Biochem. Biophys. 2008) 3 4 23

Products for PRDX5 Gene

Sources for PRDX5 Gene

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