Aliases for GCA Gene
External Ids for GCA Gene
Previous GeneCards Identifiers for GCA Gene
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation. [provided by RefSeq, Jul 2008]
GeneCards Summary for GCA Gene
GCA (Grancalcin, EF-Hand Calcium Binding Protein) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is PDCD6.
UniProtKB/Swiss-Prot for GCA Gene
Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions