Aliases for GCA Gene
External Ids for GCA Gene
Previous GeneCards Identifiers for GCA Gene
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation. [provided by RefSeq, Jul 2008]
GeneCards Summary for GCA Gene
GCA (Grancalcin, EF-Hand Calcium Binding Protein) is a Protein Coding gene. Diseases associated with GCA include acromesomelic dysplasia. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is PDCD6.
UniProtKB/Swiss-Prot for GCA Gene
Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions