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Aliases for GCA Gene

Aliases for GCA Gene

  • Grancalcin, EF-Hand Calcium Binding Protein 2 3
  • Grancalcin, EF-Hand Calcium-Binding Protein 2 3
  • GCL 3 4
  • Grancalcin, Penta-EF-Hand Protein 3
  • Grancalcin 3

External Ids for GCA Gene

Previous GeneCards Identifiers for GCA Gene

  • GC02P161254
  • GC02P161728
  • GC02P163164
  • GC02P163403
  • GC02P163026
  • GC02P162908
  • GC02P155082

Summaries for GCA Gene

Entrez Gene Summary for GCA Gene

  • This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for GCA Gene

GCA (Grancalcin, EF-Hand Calcium Binding Protein) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is PDCD6.

UniProtKB/Swiss-Prot for GCA Gene

  • Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions

Gene Wiki entry for GCA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCA Gene

Genomics for GCA Gene

Genomic Location for GCA Gene

162,318,823 bp from pter
162,379,967 bp from pter
61,145 bases
Plus strand

Genomic View for GCA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GCA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCA Gene

Proteins for GCA Gene

  • Protein details for GCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R5X3
    • Q53TB5
    • Q59EP3

    Protein attributes for GCA Gene

    217 amino acids
    Molecular mass:
    24010 Da
    Quaternary structure:
    • Homodimer. Interacts with SRI and LCP1.
    • This protein has been shown to bind calcium with high affinity
    • Sequence=BAD93005.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GCA Gene

neXtProt entry for GCA Gene

Proteomics data for GCA Gene at MOPED

Post-translational modifications for GCA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GCA Gene

No data available for DME Specific Peptides for GCA Gene

Domains for GCA Gene

Gene Families for GCA Gene

  • EFHAND :EF-hand domain containing

Protein Domains for GCA Gene

Suggested Antigen Peptide Sequences for GCA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P28676
  • Contains 4 EF-hand domains.
genes like me logo Genes that share domains with GCA: view

Function for GCA Gene

Molecular function for GCA Gene

UniProtKB/Swiss-Prot Function: Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions

Gene Ontology (GO) - Molecular Function for GCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
GO:0005509 calcium ion binding IDA 11717497
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IPI 11717497
GO:0046982 protein heterodimerization activity IPI 12804766
genes like me logo Genes that share ontologies with GCA: view
genes like me logo Genes that share phenotypes with GCA: view

Animal Models for GCA Gene

MGI Knock Outs for GCA:

miRNA for GCA Gene

miRTarBase miRNAs that target GCA

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GCA Gene

Localization for GCA Gene

Subcellular locations from UniProtKB/Swiss-Prot for GCA Gene

Cytoplasm. Cytoplasmic granule membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels.

Subcellular locations from

Jensen Localization Image for GCA Gene COMPARTMENTS Subcellular localization image for GCA gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GCA: view

Pathways for GCA Gene

SuperPathways for GCA Gene

No Data Available

Gene Ontology (GO) - Biological Process for GCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA --
GO:0061025 membrane fusion TAS 1530588
genes like me logo Genes that share ontologies with GCA: view

No data available for Pathways by source for GCA Gene

Compounds for GCA Gene

(1) HMDB Compounds for GCA Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(8) Novoseek inferred chemical compound relationships for GCA Gene

Compound -log(P) Hits PubMed IDs
cgmp 79.2 17
urodilatin 78.5 5
guanylate 74.1 13
phosphothreonine 56.8 1
phosphoserine 43.3 1
genes like me logo Genes that share compounds with GCA: view

Transcripts for GCA Gene

Unigene Clusters for GCA Gene

Grancalcin, EF-hand calcium binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GCA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP6: - - - - - - - - - -

Relevant External Links for GCA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GCA Gene

mRNA expression in normal human tissues for GCA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GCA Gene

This gene is overexpressed in Whole Blood (30.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GCA Gene

SOURCE GeneReport for Unigene cluster for GCA Gene Hs.377894

mRNA Expression by UniProt/SwissProt for GCA Gene

Tissue specificity: Detected in neutrophils and macrophages (at protein level). Highly expressed in bone marrow.
genes like me logo Genes that share expressions with GCA: view

Orthologs for GCA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GCA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GCA 35
  • 99.08 (n)
  • 98.16 (a)
GCA 36
  • 98 (a)
(Bos Taurus)
Mammalia GCA 35
  • 88.7 (n)
  • 81.67 (a)
GCA 36
  • 81 (a)
(Canis familiaris)
Mammalia GCA 35
  • 88.84 (n)
  • 85.12 (a)
GCA 36
  • 84 (a)
(Mus musculus)
Mammalia Gca 35
  • 83.72 (n)
  • 82.49 (a)
Gca 16
Gca 36
  • 81 (a)
(Monodelphis domestica)
Mammalia GCA 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia GCA 36
  • 70 (a)
(Rattus norvegicus)
Mammalia Gca 35
  • 82.49 (n)
  • 81.57 (a)
(Anolis carolinensis)
Reptilia GCA 36
  • 71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16710 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gca 35
  • 72.61 (n)
  • 75.25 (a)
Str.15515 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2717 35
(Danio rerio)
Actinopterygii Dr.5366 35
GCA 36
  • 63 (a)
zgc:92027 35
  • 66.5 (n)
  • 65.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17765 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEF1 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for GCA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GCA Gene

Gene Tree for GCA (if available)
Gene Tree for GCA (if available)

Paralogs for GCA Gene

Paralogs for GCA Gene

Selected SIMAP similar genes for GCA Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GCA: view

Variants for GCA Gene

Sequence variations from dbSNP and Humsavar for GCA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs984971 -- 162,368,011(+) ACATT(A/G)GTAAT intron-variant
rs1864431 -- 162,340,356(+) TCTTC(A/C/T)CCATG intron-variant
rs2033300 -- 162,342,778(+) AAGCA(G/T)TTCTT upstream-variant-2KB, intron-variant
rs2217418 -- 162,366,636(+) TTTTA(C/G)TTTGT intron-variant
rs2241662 -- 162,344,402(+) GGCGC(C/G)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GCA Gene

Variant ID Type Subtype PubMed ID
dgv4353n71 CNV Loss 21882294
nsv875354 CNV Loss 21882294

Relevant External Links for GCA Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GCA Gene

Disorders for GCA Gene

(4) Novoseek inferred disease relationships for GCA Gene

Disease -log(P) Hits PubMed IDs
cardiac hypertrophy 38.1 5
heart failure congestive 0.3 1
cardiovascular diseases 0 1
hypertrophy 0 1

Relevant External Links for GCA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GCA: view

No data available for UniProtKB/Swiss-Prot for GCA Gene

Publications for GCA Gene

  1. Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils. (PMID: 1530588) Teahan C.G. … Segal A.W. (Biochem. J. 1992) 2 3 4 23
  2. Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes. (PMID: 1737748) Boyhan A. … Segal A.W. (J. Biol. Chem. 1992) 2 3 4 23
  3. The PEF family proteins sorcin and grancalcin interact in vivo and in vitro. (PMID: 12804766) Hansen C. … Berchtold M.W. (FEBS Lett. 2003) 2 3 4 23
  4. Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner. (PMID: 11279160) Lollike K. … Cox J.A. (J. Biol. Chem. 2001) 3 4 23
  5. Crystal structure of human grancalcin, a member of the penta-EF-hand protein family. (PMID: 10903868) Jia J. … Cygler M. (J. Mol. Biol. 2000) 3 4 23

Products for GCA Gene

Sources for GCA Gene

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