Aliases for RAD54B Gene
External Ids for RAD54B Gene
The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for RAD54B Gene
RAD54B (RAD54 Homolog B (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with RAD54B include colorectal cancer and lymphoma, non-hodgkin. Among its related pathways are Homologous recombination and Homologous recombination. GO annotations related to this gene include DNA helicase activity and DNA translocase activity. An important paralog of this gene is RAD54L.
UniProtKB/Swiss-Prot for RAD54B Gene
Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group.