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Aliases for RASGRP3 Gene

Aliases for RASGRP3 Gene

  • RAS Guanyl Releasing Protein 3 2 3
  • RAS Guanyl Releasing Protein 3 (Calcium And DAG-Regulated) 2 3 5
  • Calcium- And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor III 2 3
  • Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor III 3 4
  • Guanine Nucleotide Exchange Factor For Rap1 3 4
  • GRP3 3 4
  • CalDAG-GEFIII 3
  • KIAA0846 4

External Ids for RASGRP3 Gene

Previous GeneCards Identifiers for RASGRP3 Gene

  • GC02P033619
  • GC02P033635
  • GC02P033573
  • GC02P033514
  • GC02P033395
  • GC02P033661

Summaries for RASGRP3 Gene

Entrez Gene Summary for RASGRP3 Gene

  • Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RASGRP3 Gene

RASGRP3 (RAS Guanyl Releasing Protein 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include calcium ion binding and GTPase activator activity. An important paralog of this gene is RASGEF1A.

UniProtKB/Swiss-Prot for RASGRP3 Gene

  • Guanine nucleotide exchange factor (GEF) for Ras and Rap1.

Gene Wiki entry for RASGRP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGRP3 Gene

Genomics for RASGRP3 Gene

Regulatory Elements for RASGRP3 Gene

Promoters for RASGRP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RASGRP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RASGRP3 Gene

Chromosome:
2
Start:
33,436,324 bp from pter
End:
33,564,750 bp from pter
Size:
128,427 bases
Orientation:
Plus strand

Genomic View for RASGRP3 Gene

Genes around RASGRP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASGRP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASGRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASGRP3 Gene

Proteins for RASGRP3 Gene

  • Protein details for RASGRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV61-GRP3_HUMAN
    Recommended name:
    Ras guanyl-releasing protein 3
    Protein Accession:
    Q8IV61
    Secondary Accessions:
    • D6W583
    • O94931
    • Q53SD7

    Protein attributes for RASGRP3 Gene

    Size:
    690 amino acids
    Molecular mass:
    78332 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74869.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASGRP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASGRP3 Gene

Proteomics data for RASGRP3 Gene at MOPED

Post-translational modifications for RASGRP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RASGRP3 (RASGRP3)

No data available for DME Specific Peptides for RASGRP3 Gene

Domains & Families for RASGRP3 Gene

Gene Families for RASGRP3 Gene

Suggested Antigen Peptide Sequences for RASGRP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IV61

UniProtKB/Swiss-Prot:

GRP3_HUMAN :
  • Contains 2 EF-hand domains.
  • Belongs to the RASGRP family.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 2 EF-hand domains.
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 Ras-GEF domain.
Family:
  • Belongs to the RASGRP family.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with RASGRP3: view

Function for RASGRP3 Gene

Molecular function for RASGRP3 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for Ras and Rap1.

Gene Ontology (GO) - Molecular Function for RASGRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005088 Ras guanyl-nucleotide exchange factor activity IEA,TAS --
GO:0005096 GTPase activator activity IEA,IDA 10934204
GO:0019900 kinase binding IEA --
genes like me logo Genes that share ontologies with RASGRP3: view
genes like me logo Genes that share phenotypes with RASGRP3: view

Animal Models for RASGRP3 Gene

MGI Knock Outs for RASGRP3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASGRP3 Gene

Localization for RASGRP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RASGRP3 Gene COMPARTMENTS Subcellular localization image for RASGRP3 gene
Compartment Confidence
plasma membrane 5
cytosol 2
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RASGRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RASGRP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASGRP3 Gene

Pathways & Interactions for RASGRP3 Gene

SuperPathways for RASGRP3 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Immune System
3 Downstream signaling events of B Cell Receptor (BCR)
4 Signaling by GPCR
5 Developmental Biology
genes like me logo Genes that share pathways with RASGRP3: view

SIGNOR curated interactions for RASGRP3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RASGRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0043087 regulation of GTPase activity IEA --
GO:0043547 positive regulation of GTPase activity IEA,TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with RASGRP3: view

Drugs & Compounds for RASGRP3 Gene

(3) Drugs for RASGRP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for RASGRP3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with RASGRP3: view

Transcripts for RASGRP3 Gene

Unigene Clusters for RASGRP3 Gene

RAS guanyl releasing protein 3 (calcium and DAG-regulated):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASGRP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - -
SP9: -
SP10:

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for RASGRP3 Gene

GeneLoc Exon Structure for
RASGRP3
ECgene alternative splicing isoforms for
RASGRP3

Expression for RASGRP3 Gene

mRNA expression in normal human tissues for RASGRP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASGRP3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.7).

Protein differential expression in normal tissues from HIPED for RASGRP3 Gene

This gene is overexpressed in Heart (37.4) and Liver (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASGRP3 Gene



SOURCE GeneReport for Unigene cluster for RASGRP3 Gene Hs.143674

genes like me logo Genes that share expression patterns with RASGRP3: view

Protein tissue co-expression partners for RASGRP3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RASGRP3 Gene

Orthologs for RASGRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASGRP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASGRP3 36
  • 100 (a)
OneToOne
RASGRP3 35
  • 99.71 (n)
  • 99.85 (a)
cow
(Bos Taurus)
Mammalia RASGRP3 35
  • 93.47 (n)
  • 96.52 (a)
RASGRP3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RASGRP3 36
  • 96 (a)
OneToOne
RASGRP3 35
  • 93.81 (n)
  • 96.52 (a)
mouse
(Mus musculus)
Mammalia Rasgrp3 16
Rasgrp3 36
  • 94 (a)
OneToOne
Rasgrp3 35
  • 89.28 (n)
  • 94.35 (a)
oppossum
(Monodelphis domestica)
Mammalia RASGRP3 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASGRP3 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rasgrp3 35
  • 87.87 (n)
  • 92.69 (a)
chicken
(Gallus gallus)
Aves RASGRP3 35
  • 80.49 (n)
  • 87.63 (a)
RASGRP3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASGRP3 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasgrp3 35
  • 75 (n)
  • 80.29 (a)
zebrafish
(Danio rerio)
Actinopterygii rasgrp3 36
  • 72 (a)
OneToOne
rasgrp3 35
  • 70.5 (n)
  • 75.85 (a)
worm
(Caenorhabditis elegans)
Secernentea rgef-1 35
  • 50.19 (n)
  • 41.44 (a)
rgef-1 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for RASGRP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASGRP3 Gene

ENSEMBL:
Gene Tree for RASGRP3 (if available)
TreeFam:
Gene Tree for RASGRP3 (if available)

Paralogs for RASGRP3 Gene

(5) SIMAP similar genes for RASGRP3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RASGRP3: view

Variants for RASGRP3 Gene

Sequence variations from dbSNP and Humsavar for RASGRP3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs13388394 - 33,539,109(+) CCCCT(A/G)CGACG reference, missense
rs8256 -- 33,564,001(+) ACAGA(C/G)GTGCA utr-variant-3-prime
rs597593 -- 33,435,144(-) ATATC(C/T)CTTCA upstream-variant-2KB
rs654291 -- 33,443,111(-) GCAAC(A/G)GGGAG intron-variant
rs658692 -- 33,444,448(-) gtaag(C/G)ataaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RASGRP3 Gene

Variant ID Type Subtype PubMed ID
nsv517737 CNV Loss 19592680
nsv873792 CNV Loss 21882294
nsv828775 CNV Loss 20364138
esv2661374 CNV Deletion 23128226
dgv444n27 CNV Loss 19166990
nsv433177 CNV Loss 18776910
nsv516338 CNV Loss 19592680
nsv435723 CNV Deletion 17901297
nsv820684 CNV Deletion 20802225
esv28690 CNV Gain+Loss 19812545
nsv819369 CNV Gain 19587683
esv2462414 CNV Deletion 19546169
esv2199255 CNV Deletion 18987734
esv4426 CNV Deletion 18987735
esv2719890 CNV Deletion 23290073

Variation tolerance for RASGRP3 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RASGRP3 Gene

HapMap Linkage Disequilibrium report
RASGRP3
Human Gene Mutation Database (HGMD)
RASGRP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASGRP3 Gene

Disorders for RASGRP3 Gene

Relevant External Links for RASGRP3

Genetic Association Database (GAD)
RASGRP3
Human Genome Epidemiology (HuGE) Navigator
RASGRP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RASGRP3

No disorders were found for RASGRP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASGRP3 Gene

Publications for RASGRP3 Gene

  1. Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. (PMID: 10934204) Rebhun J.F. … Quilliam L.A. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells. (PMID: 15657177) Zheng Y. … Stone J.C. (Blood 2005) 3 23
  3. A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters. (PMID: 15572660) Roberts D.M. … Bautch V.L. (Mol. Cell. Biol. 2004) 3 23
  4. Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3. (PMID: 12730099) Teixeira C. … Stone J.C. (Blood 2003) 3 23
  5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3

Products for RASGRP3 Gene

Sources for RASGRP3 Gene

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