Aliases for RASGRP3 Gene
External Ids for RASGRP3 Gene
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
GeneCards Summary for RASGRP3 Gene
RASGRP3 (RAS Guanyl Releasing Protein 3 (Calcium And DAG-Regulated)) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Ras signaling pathway. GO annotations related to this gene include calcium ion binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RASGRP4.
UniProtKB/Swiss-Prot for RASGRP3 Gene
Guanine nucleotide exchange factor (GEF) for Ras and Rap1.