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Aliases for GABRR2 Gene

Aliases for GABRR2 Gene

  • Gamma-Aminobutyric Acid (GABA) A Receptor, Rho 2 2 3
  • Gamma-Aminobutyric Acid (GABA) Receptor, Rho 2 2
  • GABA(A) Receptor Subunit Rho-2 4
  • GABA(A) Receptor 2
  • GABA(C) Receptor 4
  • Rho 2 2

External Ids for GABRR2 Gene

Previous GeneCards Identifiers for GABRR2 Gene

  • GC06M089913
  • GC06M089962
  • GC06M090023
  • GC06M089967
  • GC06M087184

Summaries for GABRR2 Gene

Entrez Gene Summary for GABRR2 Gene

  • GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA receptor complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for GABRR2 Gene

GABRR2 (Gamma-Aminobutyric Acid (GABA) A Receptor, Rho 2) is a Protein Coding gene. Among its related pathways are Circadian entrainment and GABA receptor activation. GO annotations related to this gene include protein domain specific binding and extracellular ligand-gated ion channel activity. An important paralog of this gene is GABRR1.

UniProtKB/Swiss-Prot for GABRR2 Gene

  • GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission

Tocris Summary for GABRR2 Gene

  • GABAC receptors are Cys-loop ionotropic ligand-gated ion channels mediating the fast synaptic inhibitory effects of GABA. Despite differing in physiology, biochemistry and pharmacology, GABAC receptors are viewed as a subclass of GABAA receptors. GABAC receptors exist as both homo- and hetero-oligomeric pentamers of the 3 GABAC subunits which have so far been discovered; rho1, rho2, rho3. The resulting ion channel is not blocked or modulated by GABAA receptor ligands, but is 10 times more sensitive to the effects of GABA and selectively blocked by TPMPA. In addition, the GABAC receptor has a longer channel opening time and is slower to desensitize. GABAC receptors are expressed in various brain regions and particularly high levels are found in the retina.

Gene Wiki entry for GABRR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GABRR2 Gene

Genomics for GABRR2 Gene

Regulatory Elements for GABRR2 Gene

Genomic Location for GABRR2 Gene

89,257,121 bp from pter
89,315,299 bp from pter
58,179 bases
Minus strand

Genomic View for GABRR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GABRR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GABRR2 Gene

Proteins for GABRR2 Gene

  • Protein details for GABRR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-aminobutyric acid receptor subunit rho-2
    Protein Accession:
    Secondary Accessions:
    • A2BDE4
    • Q9H153

    Protein attributes for GABRR2 Gene

    465 amino acids
    Molecular mass:
    54151 Da
    Quaternary structure:
    • Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 (By similarity).

    Alternative splice isoforms for GABRR2 Gene


neXtProt entry for GABRR2 Gene

Proteomics data for GABRR2 Gene at MOPED

Post-translational modifications for GABRR2 Gene

  • Glycosylation at Asn120 and Asn254
  • Modification sites at PhosphoSitePlus

Other Protein References for GABRR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GABRR2 Gene

Domains for GABRR2 Gene

Gene Families for GABRR2 Gene

  • GABR :GABA receptors
  • GABRA :Ligand-gated ion channels / GABA(A) receptors

Suggested Antigen Peptide Sequences for GABRR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P28476
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub-subfamily.
genes like me logo Genes that share domains with GABRR2: view

Function for GABRR2 Gene

Molecular function for GABRR2 Gene

GENATLAS Biochemistry:
gamma-aminobutyric acid (GABA) C receptor,ionotropic,rho 2,preferentially expressed in retina,subunit part of a trimeric receptor,mediating inhibitory neurotransmission
UniProtKB/Swiss-Prot Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission

Gene Ontology (GO) - Molecular Function for GABRR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004890 GABA-A receptor activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005254 chloride channel activity IEA --
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with GABRR2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GABRR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GABRR2 Gene

Localization for GABRR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GABRR2 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GABRR2 Gene COMPARTMENTS Subcellular localization image for GABRR2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GABRR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1315307
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GABRR2: view

Pathways for GABRR2 Gene

genes like me logo Genes that share pathways with GABRR2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GABRR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 1315307
GO:0006811 ion transport --
GO:0007165 signal transduction TAS 1315307
GO:0007214 gamma-aminobutyric acid signaling pathway IEA --
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with GABRR2: view

Compounds for GABRR2 Gene

(3) Tocris Compounds for GABRR2 Gene

Compound Action Cas Number
THIP hydrochloride GABAA agonist [85118-33-8]
TPMPA Selective GABAC antagonist [182485-36-5]
ZAPA sulfate Agonist at 'low affinity' GABAA receptor. More potent than GABA/muscimol [371962-01-5]

(2) HMDB Compounds for GABRR2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Cl2
Gamma-Aminobutyric acid
  • 3-Carboxypropylamine

(22) Drugbank Compounds for GABRR2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
37115-32-5 target potentiator
28981-97-7 target potentiator
  • 7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiaxepin-2(1H)-one
1812-30-2 target potentiator
58-25-3 target potentiator
75696-02-5 target potentiator

(13) IUPHAR Ligand for GABRR2 Gene

Ligand Type Action Affinity Pubmed IDs
aza-THIP Antagonist Antagonist
TBPS Channel blocker None
piperidine-4-sulphonic acid Agonist Full agonist
muscimol Agonist Full agonist
isoguvacine Agonist Full agonist
trans-3-ACPBPA Antagonist Antagonist
cis-3-ACPBPA Antagonist Antagonist
THIP Agonist Agonist
5-Me-IAA Agonist Full agonist
(??)-cis-2-CAMP Agonist Full agonist
isonipecotic acid Agonist Full agonist
picrotoxin Channel blocker None
TPMPA Antagonist Antagonist
genes like me logo Genes that share compounds with GABRR2: view

Transcripts for GABRR2 Gene

mRNA/cDNA for GABRR2 Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GABRR2 Gene

Gamma-aminobutyric acid (GABA) A receptor, rho 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GABRR2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GABRR2 Gene

No ASD Table

Relevant External Links for GABRR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GABRR2 Gene

mRNA expression in normal human tissues for GABRR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for GABRR2 Gene Hs.719891

genes like me logo Genes that share expressions with GABRR2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for GABRR2 Gene

Orthologs for GABRR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GABRR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GABRR2 35
  • 90.75 (n)
  • 93.55 (a)
  • 91 (a)
(Canis familiaris)
Mammalia GABRR2 35
  • 92.76 (n)
  • 95.27 (a)
  • 90 (a)
(Mus musculus)
Mammalia Gabrr2 35
  • 88.17 (n)
  • 90.11 (a)
Gabrr2 16
Gabrr2 36
  • 86 (a)
(Pan troglodytes)
Mammalia GABRR2 35
  • 99.28 (n)
  • 99.57 (a)
  • 94 (a)
(Rattus norvegicus)
Mammalia Gabrr2 35
  • 88.24 (n)
  • 91.18 (a)
(Monodelphis domestica)
Mammalia GABRR2 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia GABRR2 36
  • 87 (a)
(Gallus gallus)
Aves GABRR2 35
  • 80.89 (n)
  • 86.85 (a)
  • 83 (a)
(Anolis carolinensis)
Reptilia GABRR2 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gabrr2 35
  • 76.17 (n)
  • 84.02 (a)
(Danio rerio)
Actinopterygii Dr.15556 35
gabrr2b 35
  • 72 (n)
  • 75.33 (a)
gabrr2a 36
  • 77 (a)
gabrr2b 36
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6927 37
  • 24 (a)
Rdl 37
  • 43 (a)
(Caenorhabditis elegans)
Secernentea C39B10.2 37
  • 35 (a)
C53D6.3 37
  • 30 (a)
F09G2.5 37
  • 28 (a)
F11H8.2 37
  • 35 (a)
F55D10.5 37
  • 25 (a)
F58G6.4 37
  • 28 (a)
gab-1 37
  • 51 (a)
gbr-6 37
  • 31 (a)
K10D6.1 37
  • 30 (a)
T15B7.16 37
  • 32 (a)
T20B12.9 37
  • 27 (a)
T27E9.9 37
  • 30 (a)
W10G11.16 37
  • 33 (a)
Y46G5A.26 37
  • 35 (a)
Y71D11A.5 37
  • 31 (a)
Y73F8A.2 37
  • 27 (a)
Species with no ortholog for GABRR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GABRR2 Gene

Gene Tree for GABRR2 (if available)
Gene Tree for GABRR2 (if available)

Paralogs for GABRR2 Gene

Selected SIMAP similar genes for GABRR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GABRR2: view

Variants for GABRR2 Gene

Sequence variations from dbSNP and Humsavar for GABRR2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs176056 -- 89,269,832(-) GTAGG(C/T)ATGCA intron-variant
rs282115 -- 89,271,993(-) AAAAG(C/T)GGTGA intron-variant
rs282116 -- 89,271,767(-) CAAAG(A/G)TAGAG intron-variant
rs282117 -- 89,271,694(-) GACGT(A/G)CAGGT reference, synonymous-codon
rs282118 -- 89,271,024(-) tcctt(C/T)aggac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GABRR2 Gene

Variant ID Type Subtype PubMed ID
esv1009113 CNV Deletion 20482838
esv995301 CNV Deletion 20482838
nsv527444 CNV Loss 19592680
nsv521230 CNV Loss 19592680
nsv526732 CNV Loss 19592680
esv2732408 CNV Deletion 23290073
esv2732409 CNV Deletion 23290073

Relevant External Links for GABRR2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GABRR2 Gene

Disorders for GABRR2 Gene

Relevant External Links for GABRR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for GABRR2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for GABRR2 Gene

Publications for GABRR2 Gene

  1. Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. (PMID: 1315307) Cutting G.R. … Uhl G.R. (Genomics 1992) 2 3 4
  2. Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. (PMID: 17913586) Cavalleri G.L. … Goldstein D.B. (Lancet Neurol 2007) 3 48
  3. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. (PMID: 19078961) Craddock N. … O'Donovan M.C. (Mol. Psychiatry 2010) 3 48
  4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48
  5. GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. (PMID: 19536785) Xuei X. … Edenberg H.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48

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