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Aliases for BCL6B Gene

Aliases for BCL6B Gene

  • B-Cell CLL/Lymphoma 6B 2 3
  • Zinc Finger Protein 62 2 3 4
  • B-Cell CLL/Lymphoma 6, Member B (Zinc Finger Protein) 2 3
  • Bcl6-Associated Zinc Finger Protein 3 4
  • B-Cell CLL/Lymphoma 6, Member B 2 5
  • ZNF62 3 4
  • BAZF 3 4
  • ZBTB28 3

External Ids for BCL6B Gene

Previous HGNC Symbols for BCL6B Gene

  • ZNF62

Previous GeneCards Identifiers for BCL6B Gene

  • GC17U990185
  • GC17P006871
  • GC17P007126
  • GC17P006867
  • GC17P006926

Summaries for BCL6B Gene

GeneCards Summary for BCL6B Gene

BCL6B (B-Cell CLL/Lymphoma 6B) is a Protein Coding gene. Diseases associated with BCL6B include lymphoma. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is BCL6.

UniProtKB/Swiss-Prot for BCL6B Gene

  • Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.

Gene Wiki entry for BCL6B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL6B Gene

Genomics for BCL6B Gene

Regulatory Elements for BCL6B Gene

Genomic Location for BCL6B Gene

Chromosome:
17
Start:
7,023,020 bp from pter
End:
7,030,290 bp from pter
Size:
7,271 bases
Orientation:
Plus strand

Genomic View for BCL6B Gene

Genes around BCL6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL6B Gene

Proteins for BCL6B Gene

  • Protein details for BCL6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N143-BCL6B_HUMAN
    Recommended name:
    B-cell CLL/lymphoma 6 member B protein
    Protein Accession:
    Q8N143
    Secondary Accessions:
    • Q6PCB4

    Protein attributes for BCL6B Gene

    Size:
    479 amino acids
    Molecular mass:
    51531 Da
    Quaternary structure:
    • Associates with BCL6 through the BTB domain.

neXtProt entry for BCL6B Gene

Proteomics data for BCL6B Gene at MOPED

Post-translational modifications for BCL6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL6B Gene

Antibody Products

No data available for DME Specific Peptides for BCL6B Gene

Domains & Families for BCL6B Gene

Gene Families for BCL6B Gene

Protein Domains for BCL6B Gene

Graphical View of Domain Structure for InterPro Entry

Q8N143

UniProtKB/Swiss-Prot:

BCL6B_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 5 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with BCL6B: view

Function for BCL6B Gene

Molecular function for BCL6B Gene

UniProtKB/Swiss-Prot Function:
Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.

Gene Ontology (GO) - Molecular Function for BCL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with BCL6B: view
genes like me logo Genes that share phenotypes with BCL6B: view

Animal Models for BCL6B Gene

MGI Knock Outs for BCL6B:

Animal Model Products

miRNA for BCL6B Gene

miRTarBase miRNAs that target BCL6B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL6B Gene

Localization for BCL6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL6B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL6B Gene COMPARTMENTS Subcellular localization image for BCL6B gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for BCL6B Gene

Pathways & Interactions for BCL6B Gene

SuperPathways for BCL6B Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCL6B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BCL6B Gene

Drugs & Compounds for BCL6B Gene

No Compound Related Data Available

Transcripts for BCL6B Gene

Unigene Clusters for BCL6B Gene

B-cell CLL/lymphoma 6, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCL6B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:
SP3: - -
SP4: -

Relevant External Links for BCL6B Gene

GeneLoc Exon Structure for
BCL6B
ECgene alternative splicing isoforms for
BCL6B

Expression for BCL6B Gene

mRNA expression in normal human tissues for BCL6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL6B Gene

This gene is overexpressed in Lung (x4.4).

Protein differential expression in normal tissues from HIPED for BCL6B Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BCL6B Gene



SOURCE GeneReport for Unigene cluster for BCL6B Gene Hs.22575

mRNA Expression by UniProt/SwissProt for BCL6B Gene

Q8N143-BCL6B_HUMAN
Tissue specificity: Ubiquitously expressed with higher expression found in heart and placenta.
genes like me logo Genes that share expression patterns with BCL6B: view

Protein tissue co-expression partners for BCL6B Gene

Primer Products

In Situ Assay Products

Orthologs for BCL6B Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL6B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BCL6B 35
  • 89.36 (n)
  • 92.18 (a)
BCL6B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCL6B 35
  • 89.33 (n)
  • 92.42 (a)
BCL6B 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcl6b 35
  • 86.99 (n)
  • 91.14 (a)
Bcl6b 16
Bcl6b 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BCL6B 35
  • 99.65 (n)
  • 99.79 (a)
BCL6B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcl6b 35
  • 86.72 (n)
  • 91.31 (a)
oppossum
(Monodelphis domestica)
Mammalia BCL6B 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCL6B 36
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BCL6B 36
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for BCL6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL6B Gene

ENSEMBL:
Gene Tree for BCL6B (if available)
TreeFam:
Gene Tree for BCL6B (if available)

Paralogs for BCL6B Gene

Paralogs for BCL6B Gene

genes like me logo Genes that share paralogs with BCL6B: view

Variants for BCL6B Gene

Sequence variations from dbSNP and Humsavar for BCL6B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs393059 -- 7,025,072(-) GCCTA(C/G/T)GCAGA intron-variant
rs421264 -- 7,029,898(+) GAGGC(G/T)GCAGG downstream-variant-500B
rs312460 -- 7,022,811(+) TCCCT(A/C)ACCTC upstream-variant-2KB
rs312461 -- 7,024,031(-) AGACA(C/T)GCGCA intron-variant
rs719035 -- 7,028,524(+) GTCCA(A/G)AATCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BCL6B Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv907634 CNV Loss 21882294
nsv457659 CNV Loss 19166990
esv269077 CNV Insertion 20981092
nsv827869 CNV Gain 20364138
esv259439 OTHER Complex 20981092
esv259689 OTHER Complex 20981092
esv987894 CNV Insertion 20482838
nsv111719 CNV Insertion 16902084
esv1009485 CNV Insertion 20482838
esv1378459 CNV Insertion 17803354
nsv112411 CNV Insertion 16902084

Variation tolerance for BCL6B Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL6B Gene

HapMap Linkage Disequilibrium report
BCL6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL6B Gene

Disorders for BCL6B Gene

MalaCards: The human disease database

(1) MalaCards diseases for BCL6B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards
Search BCL6B in MalaCards View complete list of genes associated with diseases

Relevant External Links for BCL6B

Genetic Association Database (GAD)
BCL6B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCL6B
genes like me logo Genes that share disorders with BCL6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCL6B Gene

Publications for BCL6B Gene

  1. BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. (PMID: 9632807) Okabe S. … Tokuhisa T. (Mol. Cell. Biol. 1998) 2 3 23 67
  2. Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU. (PMID: 25909168) Li X. … Guo M. (Oncotarget 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter. (PMID: 25008234) Deng J. … Hao X. (Open Biol 2014) 3
  5. B cell CLL/lymphoma 6 member B inhibits hepatocellular carcinoma metastases in vitro and in mice. (PMID: 25218345) Wang J. … Yu J. (Cancer Lett. 2014) 3

Products for BCL6B Gene

Sources for BCL6B Gene

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