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Aliases for HIST1H2BA Gene

Aliases for HIST1H2BA Gene

  • Histone Cluster 1, H2ba 2 3
  • TSH2B 3 4 6
  • H2B Histone Family, Member U, (Testis-Specific) 2 3
  • Testis-Specific Histone H2B 3 4
  • Histone H2B, Testis 3 4
  • Histone 1, H2ba 2 3
  • TSH2B.1 3 4
  • Histone H2B Type 1-A 3
  • BA317E16.3 3
  • H2BFU 3
  • STBP 3

External Ids for HIST1H2BA Gene

Previous GeneCards Identifiers for HIST1H2BA Gene

  • GC06P025785
  • GC06P025835
  • GC06P025727
  • GC06P025670

Summaries for HIST1H2BA Gene

Entrez Gene Summary for HIST1H2BA Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H2BA Gene

HIST1H2BA (Histone Cluster 1, H2ba) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is H2BFWT.

UniProtKB/Swiss-Prot for HIST1H2BA Gene

  • Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H2BA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BA Gene

Genomics for HIST1H2BA Gene

Regulatory Elements for HIST1H2BA Gene

Genomic Location for HIST1H2BA Gene

Start:
25,726,909 bp from pter
End:
25,727,345 bp from pter
Size:
437 bases
Orientation:
Plus strand

Genomic View for HIST1H2BA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H2BA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2BA Gene

Proteins for HIST1H2BA Gene

  • Protein details for HIST1H2BA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A08-H2B1A_HUMAN
    Recommended name:
    Histone H2B type 1-A
    Protein Accession:
    Q96A08
    Secondary Accessions:
    • B2R544
    • Q6NZ98
    • Q6NZA0
    • Q6NZA1

    Protein attributes for HIST1H2BA Gene

    Size:
    127 amino acids
    Molecular mass:
    14167 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

    Three dimensional structures from OCA and Proteopedia for HIST1H2BA Gene

neXtProt entry for HIST1H2BA Gene

Proteomics data for HIST1H2BA Gene at MOPED

Post-translational modifications for HIST1H2BA Gene

  • Acetylated during spermatogenesis. Acetylated form is most abundant in spermatogonia compared to spermatocytes and round spermatids (By similarity).
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Methylated at Lys-118 in spermatogonia, spermatocytes and round spermatids.
  • Monoubiquitination at Lys-36 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-122 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylated at Thr-117 in spermatogonia, spermatocytes and round spermatids.
  • Ubiquitination at Lys48, Lys110, Lys118, and Lys122
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2BA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2BA Gene

Domains for HIST1H2BA Gene

Gene Families for HIST1H2BA Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H2BA Gene

Suggested Antigen Peptide Sequences for HIST1H2BA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A08

UniProtKB/Swiss-Prot:

H2B1A_HUMAN :
  • Q96A08
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST1H2BA: view

Function for HIST1H2BA Gene

Molecular function for HIST1H2BA Gene

UniProtKB/Swiss-Prot Function: Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Ontology (GO) - Molecular Function for HIST1H2BA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IBA --
GO:0043565 sequence-specific DNA binding --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H2BA: view

miRNA for HIST1H2BA Gene

miRTarBase miRNAs that target HIST1H2BA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2BA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST1H2BA Gene

Localization for HIST1H2BA Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BA Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2BA Gene COMPARTMENTS Subcellular localization image for HIST1H2BA gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for HIST1H2BA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome ISS --
GO:0000788 nuclear nucleosome IBA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HIST1H2BA: view

Pathways for HIST1H2BA Gene

genes like me logo Genes that share pathways with HIST1H2BA: view

Pathways by source for HIST1H2BA Gene

1 BioSystems pathway for HIST1H2BA Gene
29 Reactome pathways for HIST1H2BA Gene
3 KEGG pathways for HIST1H2BA Gene

Gene Ontology (GO) - Biological Process for HIST1H2BA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006334 nucleosome assembly ISS --
GO:0006337 nucleosome disassembly ISS --
GO:0006954 inflammatory response IEA --
GO:0031639 plasminogen activation IEA --
genes like me logo Genes that share ontologies with HIST1H2BA: view

Transcripts for HIST1H2BA Gene

mRNA/cDNA for HIST1H2BA Gene

(37) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2BA Gene

Histone cluster 1, H2ba:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2BA

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HIST1H2BA
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2BA Gene

No ASD Table

Relevant External Links for HIST1H2BA Gene

GeneLoc Exon Structure for
HIST1H2BA
ECgene alternative splicing isoforms for
HIST1H2BA

Expression for HIST1H2BA Gene

mRNA expression in normal human tissues for HIST1H2BA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H2BA Gene

This gene is overexpressed in Testis (49.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H2BA Gene

SOURCE GeneReport for Unigene cluster for HIST1H2BA Gene Hs.591786

mRNA Expression by UniProt/SwissProt for HIST1H2BA Gene

Q96A08-H2B1A_HUMAN
Tissue specificity: Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level). Also found in some fat cells.
genes like me logo Genes that share expressions with HIST1H2BA: view

In Situ Assay Products

Orthologs for HIST1H2BA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HIST1H2BA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST1H2BA 35
  • 97.9 (n)
  • 100 (a)
HIST1H2BA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HIST1H2BA 35
  • 80.58 (n)
  • 93.7 (a)
HIST1H2BA 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
LOC488253 35
  • 79.79 (n)
  • 90.55 (a)
mouse
(Mus musculus)
Mammalia Hist1h2ba 35
  • 80.31 (n)
  • 94.49 (a)
Hist1h2ba 16
Hist1h2ba 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIST1H2BA 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hist1h2ba 35
  • 80.05 (n)
  • 92.91 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 73 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii HIST1H2BA 36
  • 86 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta His2B:CG33900 36
  • 82 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea his-11 36
  • 80 (a)
ManyToMany
his-15 36
  • 80 (a)
ManyToMany
his-20 36
  • 79 (a)
ManyToMany
his-22 36
  • 79 (a)
ManyToMany
his-29 36
  • 80 (a)
ManyToMany
his-34 36
  • 80 (a)
ManyToMany
his-39 36
  • 76 (a)
ManyToMany
his-4 36
  • 79 (a)
ManyToMany
his-41 36
  • 80 (a)
ManyToMany
his-44 36
  • 80 (a)
ManyToMany
his-48 36
  • 80 (a)
ManyToMany
his-52 36
  • 79 (a)
ManyToMany
his-54 36
  • 69 (a)
ManyToMany
his-58 36
  • 80 (a)
ManyToMany
his-62 36
  • 80 (a)
ManyToMany
his-66 36
  • 80 (a)
ManyToMany
his-8 36
  • 79 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HTB1 36
  • 66 (a)
ManyToMany
HTB2 36
  • 66 (a)
ManyToMany
Species with no ortholog for HIST1H2BA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HIST1H2BA Gene

ENSEMBL:
Gene Tree for HIST1H2BA (if available)
TreeFam:
Gene Tree for HIST1H2BA (if available)

Paralogs for HIST1H2BA Gene

Paralogs for HIST1H2BA Gene

genes like me logo Genes that share paralogs with HIST1H2BA: view

Variants for HIST1H2BA Gene

Sequence variations from dbSNP and Humsavar for HIST1H2BA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9356984 -- 25,725,253(+) GTCCC(A/G)TTCCT upstream-variant-2KB
rs9379783 -- 25,724,979(+) GTAGA(C/T)ATCAA upstream-variant-2KB
rs9379784 -- 25,725,278(+) CTAGT(A/G)TCTCA upstream-variant-2KB
rs16890968 -- 25,725,410(+) TTTAA(C/G)ATTAA upstream-variant-2KB
rs16890970 -- 25,725,458(+) GAAAC(C/T)ACCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2BA Gene

Variant ID Type Subtype PubMed ID
nsv883488 CNV Gain 21882294

Relevant External Links for HIST1H2BA Gene

HapMap Linkage Disequilibrium report
HIST1H2BA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2BA Gene

Disorders for HIST1H2BA Gene

Relevant External Links for HIST1H2BA

Genetic Association Database (GAD)
HIST1H2BA
genes like me logo Genes that share disorders with HIST1H2BA: view

No data available for UniProtKB/Swiss-Prot for HIST1H2BA Gene

Publications for HIST1H2BA Gene

  1. Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization. (PMID: 12213818) Zalensky A.O. … Bradbury E.M. (J. Biol. Chem. 2002) 2 3 4
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F. … Kasprzak K.S. (Mol. Cell. Biochem. 2005) 3 4

Products for HIST1H2BA Gene

Sources for HIST1H2BA Gene

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