Aliases for GABPA Gene
- GA Binding Protein Transcription Factor Alpha Subunit 2 3 5
- GA Binding Protein Transcription Factor, Alpha Subunit 60kDa 2 3
- Human Nuclear Respiratory Factor-2 Subunit Alpha 2 3
- Nuclear Respiratory Factor 2 Alpha Subunit 2 3
- Nuclear Respiratory Factor 2 Subunit Alpha 3 4
- Transcription Factor E4TF1-60 3 4
- GABP Subunit Alpha 3 4
- E4TF1A 3 4
External Ids for GABPA Gene
Previous GeneCards Identifiers for GABPA Gene
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010]
GeneCards Summary for GABPA Gene
GABPA (GA Binding Protein Transcription Factor Alpha Subunit) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Transcriptional activation of mitochondrial biogenesis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is ETS2.
UniProtKB/Swiss-Prot for GABPA Gene
Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.