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Aliases for FUT8 Gene

Aliases for FUT8 Gene

  • Fucosyltransferase 8 2 3 4
  • Fucosyltransferase 8 (Alpha (1,6) Fucosyltransferase) 2 3 5
  • GDP-L-Fuc:N-Acetyl-Beta-D-Glucosaminide Alpha1,6-Fucosyltransferase 3 4
  • GDP-Fucose--Glycoprotein Fucosyltransferase 3 4
  • Glycoprotein 6-Alpha-L-Fucosyltransferase 3 4
  • Alpha1-6FucT 3 4
  • EC 2.4.1.68 4 63
  • Alpha (1,6) Fucosyltransferase 2

External Ids for FUT8 Gene

Previous GeneCards Identifiers for FUT8 Gene

  • GC14P063206
  • GC14P059672
  • GC14P063867
  • GC14P064947
  • GC14P065877
  • GC14P046046

Summaries for FUT8 Gene

Entrez Gene Summary for FUT8 Gene

  • This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

GeneCards Summary for FUT8 Gene

FUT8 (Fucosyltransferase 8) is a Protein Coding gene. Diseases associated with FUT8 include Pancreatic Acinar Cell Adenocarcinoma and Recurrent Respiratory Papillomatosis. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include SH3 domain binding and glycoprotein 6-alpha-L-fucosyltransferase activity.

UniProtKB/Swiss-Prot for FUT8 Gene

  • Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.

Gene Wiki entry for FUT8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT8 Gene

Genomics for FUT8 Gene

Regulatory Elements for FUT8 Gene

Enhancers for FUT8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FUT8 on UCSC Golden Path with GeneCards custom track

Genomic Location for FUT8 Gene

Chromosome:
14
Start:
65,410,592 bp from pter
End:
65,744,121 bp from pter
Size:
333,530 bases
Orientation:
Plus strand

Genomic View for FUT8 Gene

Genes around FUT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT8 Gene

Proteins for FUT8 Gene

  • Protein details for FUT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYC5-FUT8_HUMAN
    Recommended name:
    Alpha-(1,6)-fucosyltransferase
    Protein Accession:
    Q9BYC5
    Secondary Accessions:
    • B4DFS7
    • G3V5N0
    • O00235
    • Q8IUA5
    • Q9BYC6
    • Q9P2U5
    • Q9P2U6

    Protein attributes for FUT8 Gene

    Size:
    575 amino acids
    Molecular mass:
    66516 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FUT8 Gene

    Alternative splice isoforms for FUT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUT8 Gene

Proteomics data for FUT8 Gene at MOPED

Post-translational modifications for FUT8 Gene

Domains & Families for FUT8 Gene

Gene Families for FUT8 Gene

Protein Domains for FUT8 Gene

Suggested Antigen Peptide Sequences for FUT8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BYC5

UniProtKB/Swiss-Prot:

FUT8_HUMAN :
  • Contains 1 GT23 domain.
  • Belongs to the glycosyltransferase 23 family.
Domain:
  • Contains 1 GT23 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the glycosyltransferase 23 family.
genes like me logo Genes that share domains with FUT8: view

Function for FUT8 Gene

Molecular function for FUT8 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha (1,6),8,involved in the biosynthesis of asparagine-linked glycoprotein oligosaccharides
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine = GDP + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine.
UniProtKB/Swiss-Prot Function:
Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.

Enzyme Numbers (IUBMB) for FUT8 Gene

Gene Ontology (GO) - Molecular Function for FUT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with FUT8: view
genes like me logo Genes that share phenotypes with FUT8: view

Animal Models for FUT8 Gene

MGI Knock Outs for FUT8:

Animal Model Products

  • Taconic Biosciences Mouse Models for FUT8

miRNA for FUT8 Gene

miRTarBase miRNAs that target FUT8

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FUT8 Gene

Localization for FUT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT8 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUT8 Gene COMPARTMENTS Subcellular localization image for FUT8 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
cytosol 3
endoplasmic reticulum 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FUT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FUT8: view

Pathways & Interactions for FUT8 Gene

genes like me logo Genes that share pathways with FUT8: view

UniProtKB/Swiss-Prot Q9BYC5-FUT8_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for FUT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development NAS 11698403
GO:0006487 protein N-linked glycosylation TAS 9133635
GO:0007179 transforming growth factor beta receptor signaling pathway IEA --
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007585 respiratory gaseous exchange IEA --
genes like me logo Genes that share ontologies with FUT8: view

No data available for SIGNOR curated interactions for FUT8 Gene

Drugs & Compounds for FUT8 Gene

(1) Drugs for FUT8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(4) Additional Compounds for FUT8 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-L-fucose
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
15839-70-0
genes like me logo Genes that share compounds with FUT8: view

Transcripts for FUT8 Gene

Unigene Clusters for FUT8 Gene

Fucosyltransferase 8 (alpha (1,6) fucosyltransferase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUT8 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - -
SP8: - - -
SP9:

Relevant External Links for FUT8 Gene

GeneLoc Exon Structure for
FUT8
ECgene alternative splicing isoforms for
FUT8

Expression for FUT8 Gene

mRNA expression in normal human tissues for FUT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FUT8 Gene

This gene is overexpressed in Nasal epithelium (36.1), Breast (12.4), and Bone (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FUT8 Gene



SOURCE GeneReport for Unigene cluster for FUT8 Gene Hs.597649

genes like me logo Genes that share expression patterns with FUT8: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FUT8 Gene

Orthologs for FUT8 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FUT8 35
  • 93.57 (n)
  • 98.09 (a)
FUT8 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FUT8 35
  • 93.62 (n)
  • 97.74 (a)
FUT8 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fut8 35
  • 91.77 (n)
  • 96.52 (a)
Fut8 16
Fut8 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FUT8 35
  • 99.83 (n)
  • 100 (a)
FUT8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fut8 35
  • 92.12 (n)
  • 96.7 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia FUT8 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves FUT8 35
  • 83.48 (n)
  • 93.91 (a)
FUT8 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FUT8 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fut8 35
  • 78.03 (n)
  • 90.78 (a)
Str.230 35
African clawed frog
(Xenopus laevis)
Amphibia fut8-A 35
zebrafish
(Danio rerio)
Actinopterygii Dr.5303 35
fut8a 35
  • 71.77 (n)
  • 81.22 (a)
FUT8 (2 of 2) 36
  • 76 (a)
OneToMany
fut8a 36
  • 80 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta FucT6 37
  • 46 (a)
FucT6 35
  • 52.7 (n)
  • 49.91 (a)
FucT6 36
  • 40 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001888 35
  • 53.15 (n)
  • 52.32 (a)
worm
(Caenorhabditis elegans)
Secernentea fut-8 35
  • 50.61 (n)
  • 40.43 (a)
fut-8 36
  • 36 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11077 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for FUT8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUT8 Gene

ENSEMBL:
Gene Tree for FUT8 (if available)
TreeFam:
Gene Tree for FUT8 (if available)

Paralogs for FUT8 Gene

No data available for Paralogs for FUT8 Gene

Variants for FUT8 Gene

Sequence variations from dbSNP and Humsavar for FUT8 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs35949016 - 65,669,445(+) ATGCA(A/C)AGACA nc-transcript-variant, reference, missense
rs2229678 - 65,616,075(+) ATTAC(A/C)AGAAA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs7140251 -- 65,617,782(+) CTACC(A/C)AAAAT intron-variant
rs7140261 -- 65,507,238(+) GATCA(A/G)GTTGC intron-variant
rs7140341 -- 65,603,699(+) ATACA(C/G)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUT8 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073
nsv832818 CNV Gain 17160897
nsv510639 CNV Loss 20534489
nsv7255 OTHER Inversion 18451855
esv2672840 CNV Deletion 23128226
nsv456327 CNV Loss 19166990
nsv832819 CNV Gain 17160897
esv2748793 CNV Deletion 23290073
esv2748794 CNV Deletion 23290073
esv2413773 CNV Deletion 18987734
esv2664690 CNV Deletion 23128226
nsv902026 CNV Loss 21882294
esv2659861 CNV Deletion 23128226
esv2748795 CNV Deletion 23290073
nsv517316 CNV Loss 19592680
esv2748797 CNV Deletion 23290073
esv2748798 CNV Deletion 23290073
esv1713819 CNV Deletion 17803354
esv2677649 CNV Deletion 23128226
esv1385928 CNV Deletion 17803354

Variation tolerance for FUT8 Gene

Residual Variation Intolerance Score: 20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.29; 81.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUT8 Gene

Human Gene Mutation Database (HGMD)
FUT8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT8 Gene

Disorders for FUT8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FUT8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pancreatic acinar cell adenocarcinoma
  • pancreatic acinar cell carcinoma
recurrent respiratory papillomatosis
  • adult-onset recurrent respiratory papillomatosis
leukocyte adhesion deficiency
  • leukocyte adhesion deficiency, type iii
- elite association - COSMIC cancer census association via MalaCards
Search FUT8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FUT8

Genetic Association Database (GAD)
FUT8
Human Genome Epidemiology (HuGE) Navigator
FUT8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUT8
genes like me logo Genes that share disorders with FUT8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT8 Gene

Publications for FUT8 Gene

  1. Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8. (PMID: 17172260) Ihara H. … Taniguchi N. (Glycobiology 2007) 3 4 23 67
  2. Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells. (PMID: 19302290) Osumi D. … Taniguchi N. (Cancer Sci. 2009) 3 23
  3. Core fucose and bisecting GlcNAc, the direct modifiers of the N-glycan core: their functions and target proteins. (PMID: 19508951) Takahashi M. … Taniguchi N. (Carbohydr. Res. 2009) 3 23
  4. N-Glycan fucosylation of epidermal growth factor receptor modulates receptor activity and sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor. (PMID: 18754874) Matsumoto K. … Nishio K. (Cancer Sci. 2008) 3 23
  5. Effects of inhibitor of Src kinases, SU6656, on differentiation of megakaryocytic progenitors and activity of alpha1,6-fucosyltransferase. (PMID: 18854874) Kaminska J. … Bany-Laszewicz U. (Acta Biochim. Pol. 2008) 3 23

Products for FUT8 Gene

Sources for FUT8 Gene

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