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Aliases for FUT7 Gene

Aliases for FUT7 Gene

  • Fucosyltransferase 7 (Alpha (1,3) Fucosyltransferase) 2 3
  • Galactoside 3-L-Fucosyltransferase 3 4
  • Selectin Ligand Synthase 3 4
  • Fucosyltransferase VII 3 4
  • Fuc-TVII 3 4
  • FucT-VII 3 4
  • Alpha-(1,3)-Fucosyltransferase 7 3
  • Selectin-Ligand Synthase 3
  • Fucosyltransferase 7 4
  • EC 63
  • EC 2.4.1.- 4
  • EC 2.4.1 63

External Ids for FUT7 Gene

Previous GeneCards Identifiers for FUT7 Gene

  • GC09P131057
  • GC09M131614
  • GC09M133365
  • GC09M135281
  • GC09M137200
  • GC09M139044
  • GC09M139924
  • GC09M109383

Summaries for FUT7 Gene

Entrez Gene Summary for FUT7 Gene

  • The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUT7 Gene

FUT7 (Fucosyltransferase 7 (Alpha (1,3) Fucosyltransferase)) is a Protein Coding gene. Diseases associated with FUT7 include human granulocytic anaplasmosis and human t-cell leukemia virus type 1. Among its related pathways are Metabolism and Other types of O-glycan biosynthesis. GO annotations related to this gene include fucosyltransferase activity and alpha-(1->3)-fucosyltransferase activity. An important paralog of this gene is FUT6.

UniProtKB/Swiss-Prot for FUT7 Gene

  • May catalyze alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens

Gene Wiki entry for FUT7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT7 Gene

Genomics for FUT7 Gene

Regulatory Elements for FUT7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FUT7 Gene

137,030,174 bp from pter
137,033,010 bp from pter
2,837 bases
Minus strand

Genomic View for FUT7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FUT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT7 Gene

Proteins for FUT7 Gene

  • Protein details for FUT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 7
    Protein Accession:
    Secondary Accessions:
    • B2R7U7
    • Q6DK54

    Protein attributes for FUT7 Gene

    342 amino acids
    Molecular mass:
    39239 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FUT7 Gene

Proteomics data for FUT7 Gene at MOPED

Selected DME Specific Peptides for FUT7 Gene

Post-translational modifications for FUT7 Gene

  • Ubiquitination at Lys240
  • Glycosylation at Asn81 and Asn291
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for FUT7 (Fucosyltransferase 7/FUT7)

Domains for FUT7 Gene

Gene Families for FUT7 Gene

Protein Domains for FUT7 Gene

Suggested Antigen Peptide Sequences for FUT7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 10 family.
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT7: view

Function for FUT7 Gene

Molecular function for FUT7 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3),7 (FucT-VII),leukocyte,catalyzing in sialyl-Lewis X synthesis
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-L-fucose + alpha-2,3-Neu-N-acetyl-1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + alpha-2,3-Neu-N-acetyl-1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl-R
UniProtKB/Swiss-Prot Function:
May catalyze alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens

Enzyme Numbers (IUBMB) for FUT7 Gene

Gene Ontology (GO) - Molecular Function for FUT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity TAS 8207002
GO:0046920 alpha-(1->3)-fucosyltransferase activity TAS 11698403
genes like me logo Genes that share ontologies with FUT7: view
genes like me logo Genes that share phenotypes with FUT7: view

Animal Models for FUT7 Gene

MGI Knock Outs for FUT7:

miRNA for FUT7 Gene

miRTarBase miRNAs that target FUT7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FUT7

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for FUT7 Gene

Localization for FUT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT7 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

Jensen Localization Image for FUT7 Gene COMPARTMENTS Subcellular localization image for FUT7 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
lysosome 1

Gene Ontology (GO) - Cellular Components for FUT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus TAS 11698403
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with FUT7: view

Pathways for FUT7 Gene

genes like me logo Genes that share pathways with FUT7: view

UniProtKB/Swiss-Prot Q11130-FUT7_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for FUT7 Gene

Gene Ontology (GO) - Biological Process for FUT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA --
GO:0002522 leukocyte migration involved in immune response IEA --
GO:0006486 protein glycosylation TAS 11698403
GO:0036065 fucosylation TAS 11698403
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT7: view

Compounds for FUT7 Gene

(1) HMDB Compounds for FUT7 Gene

Compound Synonyms Cas Number PubMed IDs
  • GDP-beta-L-fucose

(8) Novoseek inferred chemical compound relationships for FUT7 Gene

Compound -log(P) Hits PubMed IDs
slex 86.2 17
polylactosamine 77.7 6
gdp fucose 77.7 1
n-acetyllactosamine 46.7 1
sialic acid 45.8 2
genes like me logo Genes that share compounds with FUT7: view

Transcripts for FUT7 Gene

mRNA/cDNA for FUT7 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT7 Gene

Fucosyltransferase 7 (alpha (1,3) fucosyltransferase):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FUT7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUT7 Gene

No ASD Table

Relevant External Links for FUT7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FUT7 Gene

mRNA expression in normal human tissues for FUT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FUT7 Gene

This gene is overexpressed in Whole Blood (45.3).

Protein differential expression in normal tissues for FUT7 Gene

This gene is overexpressed in Spleen (45.3) and Adipocyte (23.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FUT7 Gene

SOURCE GeneReport for Unigene cluster for FUT7 Gene Hs.457

mRNA Expression by UniProt/SwissProt for FUT7 Gene

Tissue specificity: Leukocytic/myeloid lineage cells
genes like me logo Genes that share expressions with FUT7: view

Expression partners for FUT7 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for FUT7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUT7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FUT7 35
  • 83.62 (n)
  • 82.25 (a)
FUT7 36
  • 82 (a)
(Canis familiaris)
Mammalia FUT7 35
  • 80.21 (n)
  • 78.95 (a)
FUT7 36
  • 80 (a)
(Mus musculus)
Mammalia Fut7 35
  • 78.5 (n)
  • 80.47 (a)
Fut7 16
Fut7 36
  • 70 (a)
(Rattus norvegicus)
Mammalia Fut7 35
  • 79.63 (n)
  • 80.99 (a)
(Monodelphis domestica)
Mammalia FUT7 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia FUT7 36
  • 61 (a)
(Gallus gallus)
Aves FUT7 35
  • 62.26 (n)
  • 54.08 (a)
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fut7 35
  • 60.55 (n)
  • 52.79 (a)
(Danio rerio)
Actinopterygii LOC100333727 35
  • 53.01 (n)
  • 45.9 (a)
Species with no ortholog for FUT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FUT7 Gene

Gene Tree for FUT7 (if available)
Gene Tree for FUT7 (if available)

Paralogs for FUT7 Gene

Paralogs for FUT7 Gene

(5) SIMAP similar genes for FUT7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FUT7: view

Variants for FUT7 Gene

Sequence variations from dbSNP and Humsavar for FUT7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs4880192 -- 137,032,610(+) CCGGA(A/G)GCTAA utr-variant-5-prime
rs10732706 -- 137,032,508(+) TCCCA(C/T)GGCAG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FUT7 Gene

Variant ID Type Subtype PubMed ID
nsv469918 CNV Loss 18288195
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8415n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
nsv894483 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894500 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894503 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8425n71 CNV Loss 21882294
nsv894514 CNV Loss 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8433n71 CNV Gain 21882294
nsv894550 CNV Gain 21882294
dgv8437n71 CNV Gain 21882294
dgv8438n71 CNV Loss 21882294
dgv8439n71 CNV Loss 21882294
nsv894565 CNV Loss 21882294
dgv8440n71 CNV Loss 21882294
nsv894567 CNV Loss 21882294

Relevant External Links for FUT7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT7 Gene

Disorders for FUT7 Gene

(1) University of Copenhagen DISEASES for FUT7 Gene

(8) Novoseek inferred disease relationships for FUT7 Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 37 1
inflammation 13.5 2
leukemia 1.58 1
cancer lung 0 1
metastasis 0 1

Relevant External Links for FUT7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FUT7: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for FUT7 Gene

Publications for FUT7 Gene

  1. Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes. (PMID: 8182079) Sasaki K. … Nishi T. (J. Biol. Chem. 1994) 2 3 4 23
  2. Molecular cloning of a cDNA encoding a novel human leukocyte alpha- 1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant. (PMID: 8207002) Natsuka S. … Lowe J.B. (J. Biol. Chem. 1994) 2 3 4 23
  3. Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures. (PMID: 11425803) de Vries T. … Macher B.A. (Glycobiology 2001) 3 4 23
  4. Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligands. (PMID: 8626519) Smith P.L. … Lowe J.B. (J. Biol. Chem. 1996) 3 23
  5. Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element. (PMID: 12506041) Hiraiwa N. … Kannagi R. (Blood 2003) 3 23

Products for FUT7 Gene

Sources for FUT7 Gene

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