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Aliases for FUT5 Gene

Aliases for FUT5 Gene

  • Fucosyltransferase 5 2 3 4 5
  • Galactoside 3-L-Fucosyltransferase 3 4
  • Alpha (1,3) Fucosyltransferase 2 3
  • Fucosyltransferase V 3 4
  • EC 4 63
  • FUC-TV 3 4
  • FucT-V 3 4
  • Fucosyltransferase 5 (Alpha (1,3) Fucosyltransferase) 3
  • EC 2.4.1 63

External Ids for FUT5 Gene

Previous GeneCards Identifiers for FUT5 Gene

  • GC19M005957
  • GC19M005805
  • GC19M005816
  • GC19M005625

Summaries for FUT5 Gene

GeneCards Summary for FUT5 Gene

FUT5 (Fucosyltransferase 5) is a Protein Coding gene. Among its related pathways are Glycosphingolipid biosynthesis - lacto and neolacto series and Metabolism. GO annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT6.

UniProtKB/Swiss-Prot for FUT5 Gene

  • May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.

Gene Wiki entry for FUT5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT5 Gene

Genomics for FUT5 Gene

Regulatory Elements for FUT5 Gene

Enhancers for FUT5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FUT5 on UCSC Golden Path with GeneCards custom track

Genomic Location for FUT5 Gene

5,865,826 bp from pter
5,870,540 bp from pter
4,715 bases
Minus strand

Genomic View for FUT5 Gene

Genes around FUT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT5 Gene

Proteins for FUT5 Gene

  • Protein details for FUT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 5
    Protein Accession:
    Secondary Accessions:
    • A8K4X2

    Protein attributes for FUT5 Gene

    374 amino acids
    Molecular mass:
    43008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FUT5 Gene

Proteomics data for FUT5 Gene at MOPED

Post-translational modifications for FUT5 Gene

  • Glycosylation at Asn 60, Asn 105, Asn 167, and Asn 198
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FUT5 Gene

Gene Families for FUT5 Gene

Protein Domains for FUT5 Gene

Suggested Antigen Peptide Sequences for FUT5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 10 family.
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT5: view

Function for FUT5 Gene

Molecular function for FUT5 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3),5 (FucT-V),plasma
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.
UniProtKB/Swiss-Prot Function:
May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.

Enzyme Numbers (IUBMB) for FUT5 Gene

genes like me logo Genes that share phenotypes with FUT5: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FUT5 Gene

Localization for FUT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT5 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

Jensen Localization Image for FUT5 Gene COMPARTMENTS Subcellular localization image for FUT5 gene
Compartment Confidence
golgi apparatus 5
extracellular 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FUT5: view

Pathways & Interactions for FUT5 Gene

genes like me logo Genes that share pathways with FUT5: view

Pathways by source for FUT5 Gene

UniProtKB/Swiss-Prot Q11128-FUT5_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for FUT5 Gene

Gene Ontology (GO) - Biological Process for FUT5 Gene


No data available for SIGNOR curated interactions for FUT5 Gene

Drugs & Compounds for FUT5 Gene

(1) Drugs for FUT5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(3) Additional Compounds for FUT5 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
genes like me logo Genes that share compounds with FUT5: view

Transcripts for FUT5 Gene

mRNA/cDNA for FUT5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT5 Gene

Fucosyltransferase 5 (alpha (1,3) fucosyltransferase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUT5 Gene

No ASD Table

Relevant External Links for FUT5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FUT5 Gene

mRNA expression in normal human tissues for FUT5 Gene

Protein differential expression in normal tissues from HIPED for FUT5 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FUT5 Gene

SOURCE GeneReport for Unigene cluster for FUT5 Gene Hs.631843

mRNA Expression by UniProt/SwissProt for FUT5 Gene

Tissue specificity: Liver, colon and testis and trace amounts in T-cells and brain.
genes like me logo Genes that share expression patterns with FUT5: view

Protein tissue co-expression partners for FUT5 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FUT5 Gene

Orthologs for FUT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FUT5 35
  • 98.31 (n)
  • 97.86 (a)
FUT5 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 68 (a)
(Canis familiaris)
Mammalia FUT5 36
  • 67 (a)
FUT5 36
  • 67 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
-- 36
  • 51 (a)
-- 36
  • 47 (a)
(Gallus gallus)
Aves -- 36
  • 45 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta FucTA 37
  • 35 (a)
FucTC 37
  • 32 (a)
FucTC 35
  • 26 (n)
  • 8.11 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000365 35
  • 52.95 (n)
  • 40 (a)
Species with no ortholog for FUT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT5 Gene

Gene Tree for FUT5 (if available)
Gene Tree for FUT5 (if available)

Paralogs for FUT5 Gene

Paralogs for FUT5 Gene

(5) SIMAP similar genes for FUT5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FUT5: view

Variants for FUT5 Gene

Sequence variations from dbSNP and Humsavar for FUT5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs778970 - 5,867,166(+) ACCAC(A/G)GCTCC reference, missense
rs4807054 - 5,866,713(+) GCAGC(A/G)TCTCC reference, missense
rs778971 -- 5,867,737(-) CCCAG(A/C)TACTC utr-variant-5-prime
rs778972 -- 5,867,902(-) CCCAT(C/T)GTACC intron-variant
rs778973 -- 5,868,260(+) GGGGA(C/T)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUT5 Gene

Variant ID Type Subtype PubMed ID
dgv3693n71 CNV Loss 21882294
nsv910904 CNV Loss 21882294
nsv482210 CNV Gain 20164927
nsv910905 CNV Loss 21882294

Variation tolerance for FUT5 Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.97; 94.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FUT5 Gene

Disorders for FUT5 Gene

Relevant External Links for FUT5

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FUT5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUT5 Gene

Publications for FUT5 Gene

  1. Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities. (PMID: 1740457) Weston B.W. … Lowe J.B. (J. Biol. Chem. 1992) 2 3 4 67
  2. Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding. (PMID: 17148576) Chiu P.C. … Yeung W.S. (J. Cell. Sci. 2007) 3 23
  3. Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue. (PMID: 10622713) Nishihara S. … Narimatsu H. (FEBS Lett. 1999) 3 23
  4. Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PMID: 7650030) Cameron H.S. … Weston B.W. (J. Biol. Chem. 1995) 3 23
  5. Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. (PMID: 7782074) McCurley R.S. … Weston B.W. (Genomics 1995) 3 23

Products for FUT5 Gene

Sources for FUT5 Gene