Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FUT5 Gene

Aliases for FUT5 Gene

  • Fucosyltransferase 5 (Alpha (1,3) Fucosyltransferase) 2 3
  • Galactoside 3-L-Fucosyltransferase 3 4
  • Fucosyltransferase V 3 4
  • EC 2.4.1.65 4 63
  • FUC-TV 3 4
  • FucT-V 3 4
  • Alpha (1,3) Fucosyltransferase 3
  • Fucosyltransferase 5 4
  • EC 2.4.1 63

External Ids for FUT5 Gene

Previous GeneCards Identifiers for FUT5 Gene

  • GC19M005957
  • GC19M005805
  • GC19M005816
  • GC19M005625

Summaries for FUT5 Gene

GeneCards Summary for FUT5 Gene

FUT5 (Fucosyltransferase 5 (Alpha (1,3) Fucosyltransferase)) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. GO annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT6.

UniProtKB/Swiss-Prot for FUT5 Gene

  • May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens

Gene Wiki entry for FUT5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT5 Gene

Genomics for FUT5 Gene

Regulatory Elements for FUT5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FUT5 Gene

Chromosome:
19
Start:
5,865,826 bp from pter
End:
5,870,540 bp from pter
Size:
4,715 bases
Orientation:
Minus strand

Genomic View for FUT5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FUT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT5 Gene

Proteins for FUT5 Gene

  • Protein details for FUT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q11128-FUT5_HUMAN
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 5
    Protein Accession:
    Q11128
    Secondary Accessions:
    • A8K4X2

    Protein attributes for FUT5 Gene

    Size:
    374 amino acids
    Molecular mass:
    43008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FUT5 Gene

Proteomics data for FUT5 Gene at MOPED

Post-translational modifications for FUT5 Gene

  • Glycosylation at Asn 60, Asn 105, Asn 167, and Asn 198
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FUT5 Gene

Gene Families for FUT5 Gene

Protein Domains for FUT5 Gene

Suggested Antigen Peptide Sequences for FUT5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q11128

UniProtKB/Swiss-Prot:

FUT5_HUMAN :
  • Belongs to the glycosyltransferase 10 family.
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT5: view

Function for FUT5 Gene

Molecular function for FUT5 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3),5 (FucT-V),plasma
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R
UniProtKB/Swiss-Prot Function:
May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens

Enzyme Numbers (IUBMB) for FUT5 Gene

Gene Ontology (GO) - Molecular Function for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity TAS 1339443
GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA --
GO:0046920 alpha-(1->3)-fucosyltransferase activity TAS 11698403
genes like me logo Genes that share ontologies with FUT5: view
genes like me logo Genes that share phenotypes with FUT5: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FUT5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FUT5 Gene

Localization for FUT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT5 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUT5 Gene COMPARTMENTS Subcellular localization image for FUT5 gene
Compartment Confidence
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus TAS 11698403
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with FUT5: view

Pathways & Interactions for FUT5 Gene

genes like me logo Genes that share pathways with FUT5: view

Pathways by source for FUT5 Gene

UniProtKB/Swiss-Prot Q11128-FUT5_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for FUT5 Gene

Gene Ontology (GO) - Biological Process for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 1339443
GO:0006486 protein glycosylation TAS 11698403
GO:0036065 fucosylation TAS 1339443
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT5: view

No data available for SIGNOR curated interactions for FUT5 Gene

Drugs & Compounds for FUT5 Gene

(1) Drugs for FUT5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(3) Additional Compounds for FUT5 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-L-fucose
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
15839-70-0
gdp
gdp fucose
genes like me logo Genes that share compounds with FUT5: view

Transcripts for FUT5 Gene

mRNA/cDNA for FUT5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT5 Gene

Fucosyltransferase 5 (alpha (1,3) fucosyltransferase):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FUT5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUT5 Gene

No ASD Table

Relevant External Links for FUT5 Gene

GeneLoc Exon Structure for
FUT5
ECgene alternative splicing isoforms for
FUT5

Expression for FUT5 Gene

mRNA expression in normal human tissues for FUT5 Gene

Protein differential expression in normal tissues from HIPED for FUT5 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FUT5 Gene



SOURCE GeneReport for Unigene cluster for FUT5 Gene Hs.631843

mRNA Expression by UniProt/SwissProt for FUT5 Gene

Q11128-FUT5_HUMAN
Tissue specificity: Liver, colon and testis and trace amounts in T-cells and brain
genes like me logo Genes that share expression patterns with FUT5: view

Protein tissue co-expression partners for FUT5 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FUT5 Gene

Orthologs for FUT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUT5 35
  • 98.31 (n)
  • 97.86 (a)
FUT5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 68 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FUT5 36
  • 67 (a)
ManyToMany
FUT5 36
  • 67 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta FucTA 37
  • 35 (a)
FucTC 37
  • 32 (a)
FucTC 35
  • 26 (n)
  • 8.11 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000365 35
  • 52.95 (n)
  • 40 (a)
Species with no ortholog for FUT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT5 Gene

ENSEMBL:
Gene Tree for FUT5 (if available)
TreeFam:
Gene Tree for FUT5 (if available)

Paralogs for FUT5 Gene

Paralogs for FUT5 Gene

(5) SIMAP similar genes for FUT5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FUT5: view

Variants for FUT5 Gene

Sequence variations from dbSNP and Humsavar for FUT5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs374028 -- 5,866,538(+) GTGAG(A/G)CCCTA utr-variant-3-prime
rs407788 -- 5,866,571(+) TGAGG(C/T)CCCGG utr-variant-3-prime
rs702065 -- 5,866,829(+) TCGGG(C/T)GGCAG reference, synonymous-codon
rs778970 - 5,867,166(+) ACCAC(A/G)GCTCC reference, missense
rs778971 -- 5,867,737(-) CCCAG(A/C)TACTC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FUT5 Gene

Variant ID Type Subtype PubMed ID
dgv3693n71 CNV Loss 21882294
nsv910904 CNV Loss 21882294
nsv482210 CNV Gain 20164927
nsv910905 CNV Loss 21882294

Variation tolerance for FUT5 Gene

Residual Variation Intolerance Score: 85.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.97; 94.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUT5 Gene

HapMap Linkage Disequilibrium report
FUT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT5 Gene

Disorders for FUT5 Gene

Relevant External Links for FUT5

Human Genome Epidemiology (HuGE) Navigator
FUT5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUT5
genes like me logo Genes that share disorders with FUT5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUT5 Gene

Publications for FUT5 Gene

  1. Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells. (PMID: 19781661) Carvalho A.S. … Reis C.A. (Int. J. Biochem. Cell Biol. 2010) 23 67
  2. Induction of sialyl-Lex expression by herpes simplex virus type 1 is dependent on viral immediate early RNA-activated transcription of host fucosyltransferase genes. (PMID: 19369700) NystrAPm K. … Olofsson S. (Glycobiology 2009) 23 67
  3. Glycosylation related actions of glycodelin: gamete, cumulus cell, immune cell and clinical associations. (PMID: 17329396) SeppAolAo M. … Yeung W.S. (Hum. Reprod. Update 2007) 23 67
  4. Site-specific fucosylation of sialylated polylactosamines by alpha1,3/4-fucosyltransferases-V and -VI Is defined by amino acids near the N terminus of the catalytic domain. (PMID: 17604274) Shetterly S. … Holmes E.H. (J. Biol. Chem. 2007) 23 67
  5. Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding. (PMID: 17148576) Chiu P.C. … Yeung W.S. (J. Cell. Sci. 2007) 23 67

Products for FUT5 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FUT5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FUT5
    • Block miRNA regulation of FUT5 using miScript Target Protectors

    Sources for FUT5 Gene

    Back to Top

    Content