Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FUT3 Gene

Aliases for FUT3 Gene

  • Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase, Lewis Blood Group) 2 3
  • Blood Group Lewis Alpha-4-Fucosyltransferase 3 4
  • Fucosyltransferase III 3 4
  • EC 2.4.1.65 4 63
  • Lewis FT 3 4
  • FucT-III 3 4
  • FT3B 3 4
  • LE 3 4
  • Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase, Lewis Blood Group Included) 2
  • Alpha-(1,3/1,4)-Fucosyltransferase 3
  • Fucosyltransferase 3 4
  • EC 2.4.1 63
  • CD174 3
  • Les 3

External Ids for FUT3 Gene

Previous HGNC Symbols for FUT3 Gene

  • LE

Previous GeneCards Identifiers for FUT3 Gene

  • GC19M005935
  • GC19M005782
  • GC19M005793
  • GC19M005602

Summaries for FUT3 Gene

Entrez Gene Summary for FUT3 Gene

  • The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUT3 Gene

FUT3 (Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase, Lewis Blood Group)) is a Protein Coding gene. Diseases associated with FUT3 include hypertropia and inflammatory breast carcinoma. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT6.

UniProtKB/Swiss-Prot for FUT3 Gene

  • May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links

Gene Wiki entry for FUT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT3 Gene

Genomics for FUT3 Gene

Regulatory Elements for FUT3 Gene

Genomic Location for FUT3 Gene

Chromosome:
19
Start:
5,842,888 bp from pter
End:
5,851,474 bp from pter
Size:
8,587 bases
Orientation:
Minus strand

Genomic View for FUT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FUT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT3 Gene

Proteins for FUT3 Gene

  • Protein details for FUT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21217-FUT3_HUMAN
    Recommended name:
    Galactoside 3(4)-L-fucosyltransferase
    Protein Accession:
    P21217
    Secondary Accessions:
    • B5U7U9
    • B5U7V0
    • Q32NE7
    • Q99448
    • Q99449

    Protein attributes for FUT3 Gene

    Size:
    361 amino acids
    Molecular mass:
    42117 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FUT3 Gene

Proteomics data for FUT3 Gene at MOPED

Post-translational modifications for FUT3 Gene

  • Glycosylation at Asn 154 and Asn 185
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for FUT3 (Fucosyltransferase 3/5 (FUT3/5))
  • R&D Systems Antibodies for FUT3 (Fucosyltransferase 3/FUT3)

Domains & Families for FUT3 Gene

Protein Domains for FUT3 Gene

Graphical View of Domain Structure for InterPro Entry

P21217

UniProtKB/Swiss-Prot:

FUT3_HUMAN :
  • Belongs to the glycosyltransferase 10 family.
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT3: view

Function for FUT3 Gene

Molecular function for FUT3 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3,4),3 (FucT-III),Lewis blood group
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R
UniProtKB/Swiss-Prot Function:
May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links

Enzyme Numbers (IUBMB) for FUT3 Gene

Gene Ontology (GO) - Molecular Function for FUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity IDA 12668675
GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA --
GO:0046920 alpha-(1->3)-fucosyltransferase activity IDA 1977660
genes like me logo Genes that share ontologies with FUT3: view
genes like me logo Genes that share phenotypes with FUT3: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FUT3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FUT3 Gene

Localization for FUT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT3 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUT3 Gene COMPARTMENTS Subcellular localization image for FUT3 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endosome 2
lysosome 2
nucleus 2
vacuole 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane IDA 1977660
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with FUT3: view

Pathways & Interactions for FUT3 Gene

genes like me logo Genes that share pathways with FUT3: view

UniProtKB/Swiss-Prot P21217-FUT3_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for FUT3 Gene

Gene Ontology (GO) - Biological Process for FUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation --
GO:0009312 oligosaccharide biosynthetic process IDA 1977660
GO:0009988 cell-cell recognition IC 12668675
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0036065 fucosylation IEA --
genes like me logo Genes that share ontologies with FUT3: view

No data available for SIGNOR curated interactions for FUT3 Gene

Drugs & Compounds for FUT3 Gene

(3) Drugs for FUT3 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
alanine Nutra 97
cysteine Nutra 143

(8) Additional Compounds for FUT3 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-L-fucose
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
15839-70-0
gdp fucose
glucose
GLYCOLIPID
n-acetyllactosamine
  • beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosamine
  • beta-D-Galactosyl-1,4-N-acetyl-D-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-beta-delta-glucosamine
  • beta-delta-Galactosyl-1,4-N-acetyl-delta-glucosamine
  • D-Galactopyranosyl
32181-59-2
genes like me logo Genes that share compounds with FUT3: view

Transcripts for FUT3 Gene

Unigene Clusters for FUT3 Gene

Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FUT3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUT3 Gene

No ASD Table

Relevant External Links for FUT3 Gene

GeneLoc Exon Structure for
FUT3
ECgene alternative splicing isoforms for
FUT3

Expression for FUT3 Gene

mRNA expression in normal human tissues for FUT3 Gene

mRNA differential expression in normal tissues according to GTEx for FUT3 Gene

This gene is overexpressed in Esophagus - Mucosa (x16.3), Colon - Transverse (x11.2), Minor Salivary Gland (x6.9), Small Intestine - Terminal Ileum (x4.9), and Vagina (x4.5).

Protein differential expression in normal tissues from HIPED for FUT3 Gene

This gene is overexpressed in Nasal epithelium (59.7) and Saliva (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FUT3 Gene



SOURCE GeneReport for Unigene cluster for FUT3 Gene Hs.169238

mRNA Expression by UniProt/SwissProt for FUT3 Gene

P21217-FUT3_HUMAN
Tissue specificity: Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver
genes like me logo Genes that share expression patterns with FUT3: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for FUT3 Gene

Orthologs for FUT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUT3 35
  • 98.43 (n)
  • 98.61 (a)
FUT3 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 66 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FUT5 36
  • 66 (a)
ManyToMany
FUT5 36
  • 66 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta FucTA 37
  • 35 (a)
FucTC 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea fut-3 35
  • 41.77 (n)
  • 33.43 (a)
Species with no ortholog for FUT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FUT3 Gene

ENSEMBL:
Gene Tree for FUT3 (if available)
TreeFam:
Gene Tree for FUT3 (if available)

Paralogs for FUT3 Gene

Paralogs for FUT3 Gene

(5) SIMAP similar genes for FUT3 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with FUT3: view

Variants for FUT3 Gene

Sequence variations from dbSNP and Humsavar for FUT3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs372725 -- 5,844,433(+) CCATG(C/T)TGAAC reference, missense
rs407645 -- 5,844,409(+) GGTGC(C/T)GGCAG reference, missense
rs410044 -- 5,843,537(-) CACCT(A/G)CTGGG utr-variant-3-prime
rs417341 -- 5,844,389(-) TGGAC(A/G)GATAC reference, missense
rs422073 -- 5,843,568(+) CCCCA(A/G)CAGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FUT3 Gene

Variant ID Type Subtype PubMed ID
dgv3693n71 CNV Loss 21882294
dgv3694n71 CNV Loss 21882294

Variation tolerance for FUT3 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.86; 91.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUT3 Gene

HapMap Linkage Disequilibrium report
FUT3
Human Gene Mutation Database (HGMD)
FUT3
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT3 Gene

Disorders for FUT3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FUT3 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hypertropia
  • strabismus
inflammatory breast carcinoma
  • mastitis carcinomatosa
colorectal cancer
  • colorectal cancer, somatic
- elite association
Search FUT3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FUT3

Genetic Association Database (GAD)
FUT3
Human Genome Epidemiology (HuGE) Navigator
FUT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUT3
genes like me logo Genes that share disorders with FUT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT3 Gene

Publications for FUT3 Gene

  1. Identification of 14 new alleles at the fucosyltransferase 1, 2, and 3 loci in Styrian blood donors, Austria. (PMID: 19572973) Matzhold E.M. … Lanzer G. (Transfusion 2009) 23 67
  2. Genetic variation of FUT3 in Ghanaians, Caucasians, and Mongolians. (PMID: 19175549) Soejima M. … Koda Y. (Transfusion 2009) 23 67
  3. Induction of sialyl-Lex expression by herpes simplex virus type 1 is dependent on viral immediate early RNA-activated transcription of host fucosyltransferase genes. (PMID: 19369700) NystrAPm K. … Olofsson S. (Glycobiology 2009) 23 67
  4. IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa. (PMID: 17944600) Groux-Degroote S. … Delannoy P. (Biochem. J. 2008) 23 67
  5. [Identification of the hemolytic transfusion reaction caused by lewis antibody using serological and molecular biological methods]. (PMID: 18928626) Hong X.Z. … Yan L.X. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008) 23 67

Products for FUT3 Gene

Sources for FUT3 Gene

Back to Top

Content