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Aliases for FUT1 Gene

Aliases for FUT1 Gene

  • Fucosyltransferase 1 (H Blood Group) 2 3 5
  • Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase) 2 3
  • GDP-L-Fucose:Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 1 3 4
  • Blood Group H Alpha 2-Fucosyltransferase 3 4
  • Alpha(1,2)FT 1 3 4
  • EC 4 63
  • HSC 3 4
  • H 3 4
  • Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase, Bombay Phenotype Included) 2
  • Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase, H Blood Group) 3
  • Galactoside 2-Alpha-L-Fucosyltransferase 2
  • Alpha(1,2) Fucosyltransferase 1 3
  • Alpha (1,2) Fucosyltransferase 3
  • 2-Alpha-L-Fucosyltransferase 3
  • Fucosyltransferase 1 4
  • HH 3

External Ids for FUT1 Gene

Previous HGNC Symbols for FUT1 Gene

  • H
  • HSC

Previous GeneCards Identifiers for FUT1 Gene

  • GC19M049964
  • GC19M049619
  • GC19M053927
  • GC19M053943
  • GC19M049251
  • GC19M045630

Summaries for FUT1 Gene

Entrez Gene Summary for FUT1 Gene

  • The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUT1 Gene

FUT1 (Fucosyltransferase 1 (H Blood Group)) is a Protein Coding gene. Diseases associated with FUT1 include cd45 deficiency. Among its related pathways are Glycosphingolipid biosynthesis - ganglio series and Glycosphingolipid biosynthesis - globo series. GO annotations related to this gene include fucosyltransferase activity and galactoside 2-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT2.

UniProtKB/Swiss-Prot for FUT1 Gene

  • Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.

Gene Wiki entry for FUT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT1 Gene

Genomics for FUT1 Gene

Regulatory Elements for FUT1 Gene

Genomic Location for FUT1 Gene

48,748,011 bp from pter
48,755,390 bp from pter
7,380 bases
Minus strand

Genomic View for FUT1 Gene

Genes around FUT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT1 Gene

Proteins for FUT1 Gene

  • Protein details for FUT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Galactoside 2-alpha-L-fucosyltransferase 1
    Protein Accession:
    Secondary Accessions:
    • O14505
    • O14506
    • O14507

    Protein attributes for FUT1 Gene

    365 amino acids
    Molecular mass:
    41251 Da
    Quaternary structure:
    No Data Available
    • There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.

neXtProt entry for FUT1 Gene

Proteomics data for FUT1 Gene at MOPED

Post-translational modifications for FUT1 Gene

  • Glycosylation at Asn 65 and Asn 327
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FUT1

Domains & Families for FUT1 Gene

Gene Families for FUT1 Gene

Protein Domains for FUT1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 11 family.
  • Belongs to the glycosyltransferase 11 family.
genes like me logo Genes that share domains with FUT1: view

Function for FUT1 Gene

Molecular function for FUT1 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,2),1 (synthesis of H blood antigen),regulating the expression of ABO antigenes in erythrocyte membranes and related antigens in several tissues
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
UniProtKB/Swiss-Prot Function:
Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.

Enzyme Numbers (IUBMB) for FUT1 Gene

genes like me logo Genes that share phenotypes with FUT1: view

Human Phenotype Ontology for FUT1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FUT1 Gene

MGI Knock Outs for FUT1:

Animal Model Products

  • Taconic Biosciences Mouse Models for FUT1

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for FUT1 Gene

Localization for FUT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT1 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

Jensen Localization Image for FUT1 Gene COMPARTMENTS Subcellular localization image for FUT1 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
extracellular 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for FUT1 Gene

Pathways & Interactions for FUT1 Gene

genes like me logo Genes that share pathways with FUT1: view

Pathways by source for FUT1 Gene

UniProtKB/Swiss-Prot P19526-FUT1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for FUT1 Gene

Gene Ontology (GO) - Biological Process for FUT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA,TAS 2118655
genes like me logo Genes that share ontologies with FUT1: view

No data available for SIGNOR curated interactions for FUT1 Gene

Drugs & Compounds for FUT1 Gene

(1) Drugs for FUT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(2) Additional Compounds for FUT1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
genes like me logo Genes that share compounds with FUT1: view

Transcripts for FUT1 Gene

Unigene Clusters for FUT1 Gene

Fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUT1 Gene

No ASD Table

Relevant External Links for FUT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FUT1 Gene

mRNA expression in normal human tissues for FUT1 Gene

mRNA differential expression in normal tissues according to GTEx for FUT1 Gene

This gene is overexpressed in Pancreas (x9.8) and Stomach (x5.6).

SOURCE GeneReport for Unigene cluster for FUT1 Gene Hs.69747

genes like me logo Genes that share expression patterns with FUT1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FUT1 Gene

Orthologs for FUT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FUT1 35
  • 81.71 (n)
  • 78.83 (a)
FUT1 36
  • 68 (a)
(Canis familiaris)
Mammalia FUT1 35
  • 84.2 (n)
  • 83.56 (a)
-- 36
  • 52 (a)
(Mus musculus)
Mammalia Fut1 35
  • 77.25 (n)
  • 78.83 (a)
Fut1 16
Fut1 36
  • 75 (a)
(Pan troglodytes)
Mammalia FUT1 35
  • 99.36 (n)
  • 98.63 (a)
FUT1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fut1 35
  • 78.03 (n)
  • 77.09 (a)
(Monodelphis domestica)
Mammalia FUT1 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia FUT1 36
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fut1 35
  • 57.29 (n)
  • 56.23 (a)
Species with no ortholog for FUT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT1 Gene

Gene Tree for FUT1 (if available)
Gene Tree for FUT1 (if available)

Paralogs for FUT1 Gene

Paralogs for FUT1 Gene

genes like me logo Genes that share paralogs with FUT1: view

Variants for FUT1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FUT1 Gene

Nonfunctional mutant of FUT1 are the cause of the H-Bombay blood group.

Sequence variations from dbSNP and Humsavar for FUT1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_003417 -
VAR_003418 -
VAR_003419 -
VAR_003420 -
VAR_003421 -

Structural Variations from Database of Genomic Variants (DGV) for FUT1 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv3967n71 CNV Loss 21882294
dgv3968n71 CNV Loss 21882294
nsv912244 CNV Gain 21882294
nsv833855 CNV Loss 17160897
esv2718685 CNV Deletion 23290073

Variation tolerance for FUT1 Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUT1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System

Disorders for FUT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FUT1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cd45 deficiency
- elite association - COSMIC cancer census association via MalaCards
Search FUT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FUT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FUT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT1 Gene

Publications for FUT1 Gene

  1. Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system. (PMID: 9299444) Koda Y. … Kimura H. (Biochem. Biophys. Res. Commun. 1997) 3 4 23 67
  2. Identification of 14 new alleles at the fucosyltransferase 1, 2, and 3 loci in Styrian blood donors, Austria. (PMID: 19572973) Matzhold E.M. … Lanzer G. (Transfusion 2009) 3 23
  3. Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis. (PMID: 18205178) Moehler T.M. … Schwartz-Albiez R. (J. Cell. Physiol. 2008) 3 23
  4. Changes in the invasive and metastatic capacities of HT-29/M3 cells induced by the expression of fucosyltransferase 1. (PMID: 17459061) MejA-as-Luque R. … de BolA^s C. (Cancer Sci. 2007) 3 23
  5. [Molecular genetic analysis of FUT1 and FUT2 gene in para-Bombay Chinese: a novel FUT1 allele is identified]. (PMID: 17922418) Su Y.q. … Li D.C. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007) 3 23

Products for FUT1 Gene

Sources for FUT1 Gene

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