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Aliases for ADAM2 Gene

Aliases for ADAM2 Gene

  • ADAM Metallopeptidase Domain 2 2 3
  • Cancer/Testis Antigen 15 2 3 4
  • FTNB 3 4 6
  • PH30 3 4 6
  • Fertilin Subunit Beta 3 4
  • PH30-Beta 3 4
  • CRYN1 3 6
  • CRYN2 3 6
  • CT15 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 2 3
  • Fertilin Beta 2
  • EC 3.4.24 64
  • PH-30b 3
  • ADAM 2 4
  • PH-30 4

External Ids for ADAM2 Gene

Previous Symbols for ADAM2 Gene

  • FTNB

Summaries for ADAM2 Gene

Entrez Gene Summary for ADAM2 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

GeneCards Summary for ADAM2 Gene

ADAM2 (ADAM Metallopeptidase Domain 2) is a Protein Coding gene. Among its related pathways are Reproduction and Reproduction. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM22.

UniProtKB/Swiss-Prot for ADAM2 Gene

  • Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein

Gene Wiki entry for ADAM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM2 Gene

Genomics for ADAM2 Gene

Genomic Location for ADAM2 Gene

Start:
39,743,735 bp from pter
End:
39,838,289 bp from pter
Size:
94,555 bases
Orientation:
Minus strand

Genomic View for ADAM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM2 Gene

Regulatory Elements for ADAM2 Gene

Proteins for ADAM2 Gene

  • Protein details for ADAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99965-ADAM2_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 2
    Protein Accession:
    Q99965
    Secondary Accessions:
    • P78326
    • Q9UQQ8

    Protein attributes for ADAM2 Gene

    Size:
    735 amino acids
    Molecular mass:
    82457 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin subunit alpha is a pseudogene

    Alternative splice isoforms for ADAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM2 Gene

Proteomics data for ADAM2 Gene at MOPED

Selected DME Specific Peptides for ADAM2 Gene

Post-translational modifications for ADAM2 Gene

  • The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn122, Asn220, Asn353, Asn459, and Asn566

Other Protein References for ADAM2 Gene

Domains for ADAM2 Gene

Gene Families for ADAM2 Gene

HGNC:
  • ADAM :ADAM metallopeptidase domain containing
IUPHAR :

UniProtKB/Swiss-Prot:

ADAM2_HUMAN
Domain:
  • A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding:
    • Q99965
  • Contains 1 disintegrin domain.:
    • Q99965
  • Contains 1 EGF-like domain.:
    • Q99965
  • Contains 1 peptidase M12B domain.:
    • Q99965
genes like me logo Genes that share domains with ADAM2: view

Function for ADAM2 Gene

Molecular function for ADAM2 Gene

GENATLAS Biochemistry: a disintegrin and metalloprotease (inactive) domain 2,fertilin,subunit beta,membrane anchored cell surface adhesion protein,expressed in male testis,putatively binding to an unknown receptor on oocyte vitelline membrane,may be involved in male fertility
UniProtKB/Swiss-Prot Function: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein

Enzyme Numbers (IUBMB) for ADAM2 Gene

Gene Ontology (GO) - Molecular Function for ADAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005178 integrin binding TAS 9041139
GO:0005515 protein binding --
GO:0008237 metallopeptidase activity TAS 9041139
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAM2: view

Phenotypes for ADAM2 Gene

MGI mutant phenotypes for ADAM2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ADAM2: view

Animal Models for ADAM2 Gene

MGI Knock Outs for ADAM2:

miRNA for ADAM2 Gene

miRTarBase miRNAs that target ADAM2

No data available for Transcription Factor Targeting and HOMER Transcription for ADAM2 Gene

Localization for ADAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM2 Gene COMPARTMENTS Subcellular localization image for ADAM2 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for ADAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9041139
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with ADAM2: view

Pathways for ADAM2 Gene

SuperPathways for ADAM2 Gene

Superpath Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with ADAM2: view

Pathways by source for ADAM2 Gene

Gene Ontology (GO) - Biological Process for ADAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007155 cell adhesion IEA --
GO:0007229 integrin-mediated signaling pathway --
GO:0007338 single fertilization TAS --
GO:0007339 binding of sperm to zona pellucida TAS --
genes like me logo Genes that share ontologies with ADAM2: view

Compounds for ADAM2 Gene

(2) Novoseek inferred chemical compound relationships for ADAM2 Gene

Compound -log(P) Hits PubMed IDs
tripeptide 51.6 2
lipid 0 1
genes like me logo Genes that share compounds with ADAM2: view

Transcripts for ADAM2 Gene

Unigene Clusters for ADAM2 Gene

ADAM metallopeptidase domain 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1:
SP2: -
SP3: - - - - -

Relevant External Links for ADAM2 Gene

GeneLoc Exon Structure for
ADAM2
ECgene alternative splicing isoforms for
ADAM2

Expression for ADAM2 Gene

mRNA expression in normal human tissues for ADAM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM2 Gene

This gene is overexpressed in Testis (52.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADAM2 Gene

SOURCE GeneReport for Unigene cluster for ADAM2 Gene Hs.177959

mRNA Expression by UniProt/SwissProt for ADAM2 Gene

Q99965-ADAM2_HUMAN
Tissue specificity: Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues
genes like me logo Genes that share expressions with ADAM2: view

Orthologs for ADAM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM2 36
  • 99.09 (n)
  • 97.96 (a)
ADAM2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAM2 36
  • 77.38 (n)
  • 65.92 (a)
ADAM2 37
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM2 36
  • 80.57 (n)
  • 70.24 (a)
ADAM2 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam2 36
  • 68.88 (n)
  • 60.88 (a)
Adam2 16
Adam2 37
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAM2 37
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM2 37
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adam2 36
  • 69.06 (n)
  • 61.07 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 38 (a)
OneToMany
-- 37
  • 41 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 42 (a)
OneToMany
-- 37
  • 38 (a)
OneToMany
Species with no ortholog for ADAM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADAM2 Gene

ENSEMBL:
Gene Tree for ADAM2 (if available)
TreeFam:
Gene Tree for ADAM2 (if available)

Paralogs for ADAM2 Gene

Paralogs for ADAM2 Gene

Selected SIMAP similar genes for ADAM2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADAM2: view

Variants for ADAM2 Gene

Sequence variations from dbSNP and Humsavar for ADAM2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs182147 -- 39,767,601(-) AATTT(C/T)TAAAT intron-variant
rs201967 -- 39,750,775(-) TAACT(G/T)TCTTT intron-variant
rs201968 -- 39,750,577(+) CATTG(C/T)TGTGG intron-variant
rs201969 -- 39,749,608(+) CAATG(C/T)AGTTT intron-variant
rs201970 -- 39,749,176(+) AGTAA(A/C)ACATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM2 Gene

Variant ID Type Subtype PubMed ID
nsv890833 CNV Loss 21882294
nsv890836 CNV Loss 21882294
nsv890837 CNV Loss 21882294
nsv890839 CNV Loss 21882294
nsv890840 CNV Loss 21882294
esv2736904 CNV Deletion 23290073
nsv526355 CNV Loss 19592680
esv2665158 CNV Deletion 23128226
esv2667185 CNV Deletion 23128226

Relevant External Links for ADAM2 Gene

HapMap Linkage Disequilibrium report
ADAM2

Disorders for ADAM2 Gene

(1) University of Copenhagen DISEASES for ADAM2 Gene

genes like me logo Genes that share disorders with ADAM2: view

No data available for UniProtKB/Swiss-Prot for ADAM2 Gene

Publications for ADAM2 Gene

  1. Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB). (PMID: 9070941) Burkin H.R. … Affara N.A. (Genomics 1997) 2 3 4 23
  2. Molecular cloning of the human fertilin beta subunit. (PMID: 8702389) Gupta S.K. … Hollis G.F. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23
  3. Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member. (PMID: 9041139) Vidaeus C.M. … Herr J.C. (Mol. Reprod. Dev. 1997) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos. (PMID: 18292840) Depa-MartynA^w M. … Jedrzejczak P. (Folia Histochem. Cytobiol. 2007) 3 23

Products for ADAM2 Gene

Sources for ADAM2 Gene

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