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Aliases for FSHR Gene

Aliases for FSHR Gene

  • Follicle Stimulating Hormone Receptor 2 3 5
  • Follitropin Receptor 3 4
  • LGR1 3 4
  • FSH Receptor 3
  • FSHR1 3
  • FSHRO 3
  • FSH-R 4
  • ODG1 3

External Ids for FSHR Gene

Previous HGNC Symbols for FSHR Gene

  • ODG1

Previous GeneCards Identifiers for FSHR Gene

  • GC02M049220
  • GC02M049358
  • GC02M049164
  • GC02M049101
  • GC02M049189
  • GC02M048923
  • GC02M048962

Summaries for FSHR Gene

Entrez Gene Summary for FSHR Gene

  • The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for FSHR Gene

FSHR (Follicle Stimulating Hormone Receptor) is a Protein Coding gene. Diseases associated with FSHR include Ovarian Hyperstimulation Syndrome and Ovarian Dysgenesis 1. Among its related pathways are Peptide ligand-binding receptors and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled peptide receptor activity. An important paralog of this gene is TSHR.

UniProtKB/Swiss-Prot for FSHR Gene

  • Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways.

Gene Wiki entry for FSHR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSHR Gene

Genomics for FSHR Gene

Regulatory Elements for FSHR Gene

Enhancers for FSHR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FSHR on UCSC Golden Path with GeneCards custom track

Promoters for FSHR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FSHR on UCSC Golden Path with GeneCards custom track

Genomic Location for FSHR Gene

48,866,435 bp from pter
49,154,537 bp from pter
288,103 bases
Minus strand

Genomic View for FSHR Gene

Genes around FSHR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSHR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSHR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSHR Gene

Proteins for FSHR Gene

  • Protein details for FSHR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Follicle-stimulating hormone receptor
    Protein Accession:
    Secondary Accessions:
    • A8K947
    • G5CBS7
    • G5E967
    • J3KQ00
    • Q05AH0
    • Q16225
    • Q4QRJ3
    • Q4ZFZ2
    • Q53RW2

    Protein attributes for FSHR Gene

    695 amino acids
    Molecular mass:
    78265 Da
    Quaternary structure:
    • Interacts with ARRB2.

    Three dimensional structures from OCA and Proteopedia for FSHR Gene

    Alternative splice isoforms for FSHR Gene


neXtProt entry for FSHR Gene

Proteomics data for FSHR Gene at MOPED

Post-translational modifications for FSHR Gene

  • N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FSHR Gene

Antibody Products

No data available for DME Specific Peptides for FSHR Gene

Domains & Families for FSHR Gene

Gene Families for FSHR Gene

Suggested Antigen Peptide Sequences for FSHR Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LRRNT domain.
  • Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
  • Contains 9 LRR (leucine-rich) repeats.
  • Contains 1 LRRNT domain.
  • Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
  • Contains 9 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FSHR: view

Function for FSHR Gene

Molecular function for FSHR Gene

GENATLAS Biochemistry:
follicle stimulating hormone receptor,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways.
genes like me logo Genes that share phenotypes with FSHR: view

Human Phenotype Ontology for FSHR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FSHR Gene

MGI Knock Outs for FSHR:

Animal Model Products

miRNA for FSHR Gene

miRTarBase miRNAs that target FSHR

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for FSHR Gene

Localization for FSHR Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSHR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FSHR Gene COMPARTMENTS Subcellular localization image for FSHR gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for FSHR Gene

Pathways & Interactions for FSHR Gene

genes like me logo Genes that share pathways with FSHR: view

Gene Ontology (GO) - Biological Process for FSHR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001545 primary ovarian follicle growth IBA --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0003073 regulation of systemic arterial blood pressure IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 9020851
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with FSHR: view

No data available for SIGNOR curated interactions for FSHR Gene

Drugs & Compounds for FSHR Gene

(31) Drugs for FSHR Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Follitropin beta Approved Pharma binder, Target, agonist 0
Urofollitropin Approved Pharma binder, Target, agonist 0
Suramin Approved Pharma Antagonist, Target, antagonist 18
Choriogonadotropin alfa Approved Pharma binder, Target 0
Menotropins Approved Pharma binder, Target 53

(20) Additional Compounds for FSHR Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FSH deglycosylated alpha/beta
genes like me logo Genes that share compounds with FSHR: view

Transcripts for FSHR Gene

mRNA/cDNA for FSHR Gene

Unigene Clusters for FSHR Gene

Follicle stimulating hormone receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FSHR Gene

No ASD Table

Relevant External Links for FSHR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FSHR Gene

mRNA expression in normal human tissues for FSHR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FSHR Gene

This gene is overexpressed in Testis (x22.0) and Ovary (x9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FSHR Gene

SOURCE GeneReport for Unigene cluster for FSHR Gene Hs.1428

mRNA Expression by UniProt/SwissProt for FSHR Gene

Tissue specificity: Sertoli cells and ovarian granulosa cells.
genes like me logo Genes that share expression patterns with FSHR: view

Protein tissue co-expression partners for FSHR Gene

Primer Products

No data available for Protein differential expression in normal tissues for FSHR Gene

Orthologs for FSHR Gene

This gene was present in the common ancestor of animals.

Orthologs for FSHR Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FSHR 35
  • 90.26 (n)
  • 89.87 (a)
  • 90 (a)
(Canis familiaris)
Mammalia FSHR 35
  • 90.85 (n)
  • 91.76 (a)
  • 92 (a)
(Mus musculus)
Mammalia Fshr 35
  • 86.38 (n)
  • 87.91 (a)
Fshr 16
Fshr 36
  • 88 (a)
(Pan troglodytes)
Mammalia FSHR 35
  • 99.33 (n)
  • 98.7 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Fshr 35
  • 87.41 (n)
  • 89.82 (a)
(Monodelphis domestica)
Mammalia FSHR 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
(Gallus gallus)
Aves FSHR 35
  • 73.51 (n)
  • 74.15 (a)
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
-- 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fshr 35
  • 68.05 (n)
  • 69.88 (a)
African clawed frog
(Xenopus laevis)
Amphibia fshr-A 35
(Danio rerio)
Actinopterygii Dr.24986 35
fshr 35
  • 63.03 (n)
  • 59.02 (a)
fshr 36
  • 56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12133 35
fruit fly
(Drosophila melanogaster)
Insecta Fsh 37
  • 35 (a)
rk 37
  • 32 (a)
Lgr1 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea C50H2.1 37
  • 30 (a)
fshr-1 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for FSHR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FSHR Gene

Gene Tree for FSHR (if available)
Gene Tree for FSHR (if available)

Paralogs for FSHR Gene

Paralogs for FSHR Gene

(3) SIMAP similar genes for FSHR Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FSHR: view

Variants for FSHR Gene

Sequence variations from dbSNP and Humsavar for FSHR Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6165 - 48,963,902(-) CTCAG(A/C/G)CTAGG intron-variant, reference, missense
rs6167 - 48,963,249(-) GACAG(A/C/G)CCTTT intron-variant, reference, missense
rs6166 - 48,962,782(-) CACCA(A/G)TGGTT intron-variant, reference, missense
rs28928870 Ovarian hyperstimulation syndrome (OHSS) 48,963,475(-) TTTCA(A/C/T)TGTCT intron-variant, reference, missense
rs28928871 Ovarian hyperstimulation syndrome (OHSS) 48,963,122(-) CTAGT(A/G)ACACC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FSHR Gene

Variant ID Type Subtype PubMed ID
nsv874007 CNV Loss 21882294
nsv874008 CNV Loss 21882294
nsv834003 CNV Loss 17160897
nsv874009 CNV Loss 21882294
esv2720037 CNV Deletion 23290073
esv2751895 CNV Loss 17911159
esv2667546 CNV Deletion 23128226
nsv523955 CNV Loss 19592680
nsv518852 CNV Loss 19592680
nsv817862 CNV Gain 17921354
esv259989 OTHER Complex 20981092
nsv874010 CNV Loss 21882294
nsv829208 CNV Gain 20364138
nsv2720 CNV Loss 18451855
dgv218n21 CNV Loss 19592680
nsv527059 CNV Gain 19592680
esv2720038 CNV Deletion 23290073
nsv214070 CNV Loss 16902084
dgv4113n71 CNV Loss 21882294
nsv817873 CNV Gain 17921354
esv28189 CNV Loss 19812545

Variation tolerance for FSHR Gene

Residual Variation Intolerance Score: 5.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.93; 89.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FSHR Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSHR Gene

Disorders for FSHR Gene

MalaCards: The human disease database

(28) MalaCards diseases for FSHR Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian hyperstimulation syndrome
  • secondary meig's syndrome
ovarian dysgenesis 1
  • premature ovarian failure, autosomal recessive
ovarian response to fsh stimulation
  • absence of menstruation
ovarian mucinous cystadenocarcinoma
  • mucinous cystadenocarcinoma of ovary
- elite association - COSMIC cancer census association via MalaCards
Search FSHR in MalaCards View complete list of genes associated with diseases


  • Ovarian dysgenesis 1 (ODG1) [MIM:233300]: An autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, poorly developed streak ovaries, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). {ECO:0000269 PubMed:10551778, ECO:0000269 PubMed:11889179, ECO:0000269 PubMed:12571157, ECO:0000269 PubMed:12915623, ECO:0000269 PubMed:7553856, ECO:0000269 PubMed:9769327, ECO:0000269 PubMed:9851774}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Ovarian hyperstimulation syndrome (OHSS) [MIM:608115]: Disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. {ECO:0000269 PubMed:12930927, ECO:0000269 PubMed:12930928, ECO:0000269 PubMed:15080154, ECO:0000269 PubMed:16278261, ECO:0000269 PubMed:17721928, ECO:0000269 PubMed:24058690, ECO:0000269 PubMed:25581598}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FSHR

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FSHR: view

No data available for Genatlas for FSHR Gene

Publications for FSHR Gene

  1. Distribution and function of FSH receptor genetic variants in normal men. (PMID: 12059813) Asatiani K. … Simoni M. (Andrologia 2002) 3 4 48 67
  2. Follitropin receptors contain cryptic ligand binding sites. (PMID: 17059863) Lin W. … Moyle W.R. (Mol. Cell. Endocrinol. 2007) 3 23 25
  3. Follicle stimulating hormone receptor (FSHR) antagonist and epithelial ovarian cancer (EOC). (PMID: 17552360) Bose C.K. (J. Exp. Ther. Oncol. 2007) 23 25 26
  4. FSH receptor, KL1/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis. (PMID: 19342032) GonzA!lez-FernA!ndez R. … Avila J. (Fertil. Steril. 2010) 3 23
  5. FSHR single nucleotide polymorphism frequencies in proven fathers and infertile men in Southeast Turkey. (PMID: 20454649) Balkan M. … Budak T. (J. Biomed. Biotechnol. 2010) 3 23

Products for FSHR Gene

Sources for FSHR Gene