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Aliases for ALPL Gene

Aliases for ALPL Gene

  • Alkaline Phosphatase, Liver/Bone/Kidney 2 3
  • Alkaline Phosphatase Liver/Bone/Kidney Isozyme 3 4
  • EC 3.1.3.1 4 63
  • AP-TNAP 3 4
  • TNSALP 3 4
  • Liver/Bone/Kidney-Type Alkaline Phosphatase 3
  • Alkaline Phosphomonoesterase 3
  • Tissue-Nonspecific ALP 3
  • Glycerophosphatase 3
  • APTNAP 3
  • TNAP 3
  • HOPS 3

External Ids for ALPL Gene

Previous HGNC Symbols for ALPL Gene

  • HOPS

Previous GeneCards Identifiers for ALPL Gene

  • GC01P021405
  • GC01P020871
  • GC01P020981
  • GC01P021305
  • GC01P021581
  • GC01P021708
  • GC01P021835
  • GC01P020079

Summaries for ALPL Gene

Entrez Gene Summary for ALPL Gene

  • This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]

GeneCards Summary for ALPL Gene

ALPL (Alkaline Phosphatase, Liver/Bone/Kidney) is a Protein Coding gene. Diseases associated with ALPL include hypophosphatasia and perinatal lethal hypophosphatasia. Among its related pathways are Endochondral Ossification and Metabolism. GO annotations related to this gene include phosphatase activity and alkaline phosphatase activity. An important paralog of this gene is ALPP.

UniProtKB/Swiss-Prot for ALPL Gene

  • This isozyme may play a role in skeletal mineralization

Gene Wiki entry for ALPL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALPL Gene

Genomics for ALPL Gene

Regulatory Elements for ALPL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ALPL Gene

Chromosome:
1
Start:
21,508,982 bp from pter
End:
21,578,412 bp from pter
Size:
69,431 bases
Orientation:
Plus strand

Genomic View for ALPL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPL Gene

Proteins for ALPL Gene

  • Protein details for ALPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05186-PPBT_HUMAN
    Recommended name:
    Alkaline phosphatase, tissue-nonspecific isozyme
    Protein Accession:
    P05186
    Secondary Accessions:
    • A1A4E7
    • B2RMP8
    • B7Z387
    • B7Z4Y6
    • O75090
    • Q2TAI7
    • Q59EJ7
    • Q5BKZ5
    • Q5VTG5
    • Q6NZI8
    • Q8WU32
    • Q9UBK0

    Protein attributes for ALPL Gene

    Size:
    524 amino acids
    Molecular mass:
    57305 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion.;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions.;
    Quaternary structure:
    • Homodimer
    SequenceCaution:
    • Sequence=BAD93051.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ALPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALPL Gene

Proteomics data for ALPL Gene at MOPED

Post-translational modifications for ALPL Gene

Other Protein References for ALPL Gene

Antibody Products

  • R&D Systems Antibodies for ALPL (Alkaline Phosphatase/ALPL)
  • Cell Signaling Technology (CST) Antibodies for ALPL (ALPL)

Domains & Families for ALPL Gene

Gene Families for ALPL Gene

Suggested Antigen Peptide Sequences for ALPL Gene

Graphical View of Domain Structure for InterPro Entry

P05186

UniProtKB/Swiss-Prot:

PPBT_HUMAN :
  • Belongs to the alkaline phosphatase family.
Family:
  • Belongs to the alkaline phosphatase family.
genes like me logo Genes that share domains with ALPL: view

Function for ALPL Gene

Molecular function for ALPL Gene

GENATLAS Biochemistry:
phosphatase alkaline,liver/bone/kidney,non specific
UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate.
UniProtKB/Swiss-Prot Function:
This isozyme may play a role in skeletal mineralization

Enzyme Numbers (IUBMB) for ALPL Gene

Gene Ontology (GO) - Molecular Function for ALPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004035 alkaline phosphatase activity IEA --
GO:0005515 protein binding IPI 15208311
GO:0016462 pyrophosphatase activity IDA 19874193
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with ALPL: view
genes like me logo Genes that share phenotypes with ALPL: view

Animal Models for ALPL Gene

MGI Knock Outs for ALPL:

Animal Model Products

CRISPR Products

miRNA for ALPL Gene

miRTarBase miRNAs that target ALPL

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALPL

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ALPL Gene

Localization for ALPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALPL Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALPL Gene COMPARTMENTS Subcellular localization image for ALPL gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 3
cytosol 3
nucleus 3
vacuole 3
endoplasmic reticulum 2
golgi apparatus 2
lysosome 2
mitochondrion 2
peroxisome 2
endosome 1

Gene Ontology (GO) - Cellular Components for ALPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 16210410
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ALPL: view

Pathways & Interactions for ALPL Gene

genes like me logo Genes that share pathways with ALPL: view

Pathways by source for ALPL Gene

1 Cell Signaling Technology pathway for ALPL Gene
2 KEGG pathways for ALPL Gene
1 GeneGo (Thomson Reuters) pathway for ALPL Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for ALPL Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ALPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 9781036
GO:0001649 osteoblast differentiation IDA 16210410
GO:0001958 endochondral ossification IEA --
GO:0003006 developmental process involved in reproduction IEA --
GO:0006470 protein dephosphorylation --
genes like me logo Genes that share ontologies with ALPL: view

Drugs & Compounds for ALPL Gene

(21) Drugs for ALPL Gene - From: HMDB, ApexBio, NovoSeek, FDA Approved Drugs, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amifostine Approved, Investigational Pharma Enzyme 81
Fospropofol Approved, Illicit Pharma Enzyme, substrate 21
Ethyol Approved December 8, 1995 Pharma 0
Pyridoxine Approved Nutra 152,152
1-Butanol Experimental Pharma 0

(15) Additional Compounds for ALPL Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
dihydroneopterin triphosphate
  • 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate
  • 6-(L-Erythro-1,2-Dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
  • 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin
  • 7,8-Dihydroneopterin 3'-triphosphate
  • 7,8-Dihydroneopterin triphosphate
20574-65-6
Dihydroxyacetone phosphate
  • 1,3-Dihydroxy-2-Propanone mono(dihydrogen phosphate)
  • 1,3-Dihydroxy-2-propanone phosphate
  • 1,3-Dihydroxyacetone 1-phosphate
  • 1-Hydroxy-3-(phosphonooxy)-2-Propanone
  • 1-Hydroxy-3-(phosphonooxy)acetone
57-04-5
Isobutanol
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
78-83-1
genes like me logo Genes that share compounds with ALPL: view

Transcripts for ALPL Gene

Unigene Clusters for ALPL Gene

Alkaline phosphatase, liver/bone/kidney:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALPL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALPL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c
SP1: - - - -
SP2: - - -
SP3:
SP4: -
SP5:

Relevant External Links for ALPL Gene

GeneLoc Exon Structure for
ALPL
ECgene alternative splicing isoforms for
ALPL

Expression for ALPL Gene

mRNA expression in normal human tissues for ALPL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALPL Gene

This gene is overexpressed in Whole Blood (x36.4).

Protein differential expression in normal tissues from HIPED for ALPL Gene

This gene is overexpressed in Nasal epithelium (28.9), Cerebral cortex (8.7), and Adrenal (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ALPL Gene



SOURCE GeneReport for Unigene cluster for ALPL Gene Hs.75431

genes like me logo Genes that share expression patterns with ALPL: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ALPL Gene

Orthologs for ALPL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALPL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ALPL 35
  • 89.47 (n)
  • 91.35 (a)
ALPL 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALPL 35
  • 89.55 (n)
  • 90.57 (a)
ALP 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alpl 35
  • 85.15 (n)
  • 91.49 (a)
Alpl 16
Alpl 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ALPL 35
  • 94.37 (n)
  • 92.71 (a)
ALPL 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alpl 35
  • 86.2 (n)
  • 91.68 (a)
oppossum
(Monodelphis domestica)
Mammalia ALPL 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALPL 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves ALPL 35
  • 73.93 (n)
  • 76.6 (a)
ALPL 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALPL 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485467 35
  • 71.31 (n)
  • 73.97 (a)
zebrafish
(Danio rerio)
Actinopterygii alp3 35
  • 60.04 (n)
  • 60.89 (a)
zgc56672 35
alpl 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Aph-4 37
  • 42 (a)
CG10592 37
  • 43 (a)
CG10827 37
  • 43 (a)
CG16771 37
  • 42 (a)
CG1809 37
  • 44 (a)
CG3264 37
  • 41 (a)
CG3290 37
  • 41 (a)
CG3292 37
  • 40 (a)
CG5150 37
  • 42 (a)
CG5656 37
  • 44 (a)
CG8105 37
  • 38 (a)
CG8147 35
  • 53.42 (n)
  • 46.29 (a)
Aph-4 36
  • 32 (a)
ManyToMany
CG10592 36
  • 36 (a)
ManyToMany
CG10827 36
  • 36 (a)
ManyToMany
CG16771 36
  • 30 (a)
ManyToMany
CG1809 36
  • 37 (a)
ManyToMany
CG3264 36
  • 35 (a)
ManyToMany
CG3290 36
  • 34 (a)
ManyToMany
CG3292 36
  • 31 (a)
ManyToMany
CG5150 36
  • 35 (a)
ManyToMany
CG5361 36
  • 21 (a)
ManyToMany
CG5656 36
  • 35 (a)
ManyToMany
CG8105 36
  • 35 (a)
ManyToMany
CG8147 36
  • 34 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001684 35
  • 54.2 (n)
  • 46.79 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO8 36
  • 21 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1365 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
CSA.180 36
  • 39 (a)
ManyToMany
CSA.4362 36
  • 38 (a)
ManyToMany
Species with no ortholog for ALPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALPL Gene

ENSEMBL:
Gene Tree for ALPL (if available)
TreeFam:
Gene Tree for ALPL (if available)

Paralogs for ALPL Gene

Paralogs for ALPL Gene

(3) SIMAP similar genes for ALPL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ALPL: view

Variants for ALPL Gene

Sequence variations from dbSNP and Humsavar for ALPL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs56336047 -- 21,523,278(+) TGGGC(A/G)ACAGA intron-variant
rs56240604 -- 21,525,401(+) GGCAG(C/T)GCTTG intron-variant
rs56222534 -- 21,537,412(+) CTTTG(C/T)GGAGC intron-variant
rs56218223 -- 21,566,480(+) GAGAC(A/G)GGGTT intron-variant
rs56204396 -- 21,566,850(+) CCTCA(A/G)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALPL Gene

Variant ID Type Subtype PubMed ID
nsv870456 CNV Gain 21882294
esv34155 CNV Loss 18971310
dgv42e1 CNV Complex 17122850
nsv428432 CNV Gain 18775914
nsv834391 CNV Loss 17160897
esv1457635 CNV Insertion 17803354
nsv517096 CNV Loss 19592680
dgv189n71 CNV Loss 21882294
esv2745075 CNV Deletion 23290073
dgv190n71 CNV Loss 21882294
nsv871612 CNV Loss 21882294
nsv460740 CNV Loss 19166990
esv2672081 CNV Deletion 23128226
nsv871706 CNV Loss 21882294
nsv508359 CNV Loss 20534489
nsv509002 CNV Insertion 20534489

Variation tolerance for ALPL Gene

Residual Variation Intolerance Score: 17.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.82; 83.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALPL Gene

HapMap Linkage Disequilibrium report
ALPL
Human Gene Mutation Database (HGMD)
ALPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALPL Gene

Disorders for ALPL Gene

MalaCards: The human disease database

(95) MalaCards diseases for ALPL Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hypophosphatasia
  • deficiency of alkaline phosphatase [ambiguous]
perinatal lethal hypophosphatasia
  • perinatal lethal rathburn disease
hypophosphatasia, infantile
  • infantile hypophosphatasia
hypophosphatasia, childhood
  • hypophosphatasia childhood type
hypophosphatasia, adult
  • odontohypophosphatasia
- elite association
Search ALPL in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PPBT_HUMAN
  • Hypophosphatasia (HOPS) [MIM:146300]: A metabolic bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase. Four forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. The adult form is mild and characterized by recurrent fractures, osteomalacia, rickets, and loss of teeth. Some cases are asymptomatic, while some patients manifest dental features without skeletal manifestations (odontohypophosphatasia). {ECO:0000269 PubMed:10094560, ECO:0000269 PubMed:10332035, ECO:0000269 PubMed:10679946, ECO:0000269 PubMed:10690885, ECO:0000269 PubMed:10834525, ECO:0000269 PubMed:11438998, ECO:0000269 PubMed:11745997, ECO:0000269 PubMed:11760847, ECO:0000269 PubMed:11834095, ECO:0000269 PubMed:11855933, ECO:0000269 PubMed:11999978, ECO:0000269 PubMed:12815606, ECO:0000269 PubMed:12920074, ECO:0000269 PubMed:1409720, ECO:0000269 PubMed:15135428, ECO:0000269 PubMed:15694177, ECO:0000269 PubMed:3174660, ECO:0000269 PubMed:7833929, ECO:0000269 PubMed:8406453, ECO:0000269 PubMed:8954059, ECO:0000269 PubMed:9452105, ECO:0000269 PubMed:9747027, ECO:0000269 PubMed:9781036}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hypophosphatasia childhood type (HOPSC) [MIM:241510]: A bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hypophosphatasia infantile type (HOPSI) [MIM:241500]: A severe bone disease characterized by defective skeletal mineralization and biochemically by deficient activity of the tissue non-specific isoenzyme of alkaline phosphatase. Three more or less distinct types of infantile hypophosphatasia can be identified: (1) type 1 with onset in utero or in early postnatal life, craniostenosis, severe skeletal abnormalities, hypercalcemia, and death in the first year or so of life; (2) type 2 with later, more gradual development of symptoms, moderately severe rachitic skeletal changes and premature loss of teeth; (3) type 3 with no symptoms, the condition being determined on routine studies. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ALPL

Genetic Association Database (GAD)
ALPL
Human Genome Epidemiology (HuGE) Navigator
ALPL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALPL
genes like me logo Genes that share disorders with ALPL: view

No data available for Genatlas for ALPL Gene

Publications for ALPL Gene

  1. The mesenchymal stem cell antigen MSCA-1 is identical to tissue non-specific alkaline phosphatase. (PMID: 19860546) Sobiesiak M. … BA1hring H.J. (Stem Cells Dev. 2010) 23 67
  2. Association of ALPL and ENPP1 gene polymorphisms with bone strength related skeletal traits in a Chuvashian population. (PMID: 19931660) Ermakov S. … NA1rnberg P. (Bone 2010) 23 67
  3. Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick. (PMID: 20053388) Macrae V.E. … Farquharson C. (Bone 2010) 23 67
  4. Physiological role of alkaline phosphatase explored in hypophosphatasia. (PMID: 20392236) Whyte M.P. (Ann. N. Y. Acad. Sci. 2010) 23 67
  5. Tissue-nonspecific alkaline phosphatase is required for the calcification of collagen in serum: a possible mechanism for biomineralization. (PMID: 19098289) Price P.A. … Chan W.S. (J. Biol. Chem. 2009) 23 67

Products for ALPL Gene

Sources for ALPL Gene

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