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Aliases for FSHB Gene

Aliases for FSHB Gene

  • Follicle Stimulating Hormone, Beta Polypeptide 2 3
  • Follicle-Stimulating Hormone Beta Subunit 2 3 4
  • Follitropin Beta Chain 3 4
  • FSH-Beta 3 4
  • FSH-B 3 4
  • Follitropin Subunit Beta 3
  • Follitropin, Beta Chain 3
  • Follitropin 2
  • Beta Chain 2
  • HH24 3

External Ids for FSHB Gene

Previous GeneCards Identifiers for FSHB Gene

  • GC11P031850
  • GC11P031028
  • GC11P030292
  • GC11P030217
  • GC11P029945

Summaries for FSHB Gene

Entrez Gene Summary for FSHB Gene

  • The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for FSHB Gene

FSHB (Follicle Stimulating Hormone, Beta Polypeptide) is a Protein Coding gene. Diseases associated with FSHB include follicle-stimulating hormone deficiency, isolated and pandas. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein heterodimerization activity and follicle-stimulating hormone activity. An important paralog of this gene is TSHB.

UniProtKB/Swiss-Prot for FSHB Gene

  • Stimulates development of follicle and spermatogenesis in the reproductive organs

Gene Wiki entry for FSHB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSHB Gene

Genomics for FSHB Gene

Regulatory Elements for FSHB Gene

Genomic Location for FSHB Gene

30,231,016 bp from pter
30,235,277 bp from pter
4,262 bases
Plus strand

Genomic View for FSHB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FSHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSHB Gene

Proteins for FSHB Gene

  • Protein details for FSHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Follitropin subunit beta
    Protein Accession:
    Secondary Accessions:
    • A2TF08
    • A5JVV3
    • Q14D61

    Protein attributes for FSHB Gene

    129 amino acids
    Molecular mass:
    14700 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

    Three dimensional structures from OCA and Proteopedia for FSHB Gene

neXtProt entry for FSHB Gene

Proteomics data for FSHB Gene at MOPED

Post-translational modifications for FSHB Gene

  • Glycosylation at Asn25 and Asn42
  • Modification sites at PhosphoSitePlus

Other Protein References for FSHB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FSHB Gene

Domains for FSHB Gene

Gene Families for FSHB Gene

Suggested Antigen Peptide Sequences for FSHB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycoprotein hormones subunit beta family.
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with FSHB: view

Function for FSHB Gene

Molecular function for FSHB Gene

GENATLAS Biochemistry:
follicle stimulating hormone,beta polypeptide
UniProtKB/Swiss-Prot Function:
Stimulates development of follicle and spermatogenesis in the reproductive organs

Gene Ontology (GO) - Molecular Function for FSHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 8220432
GO:0005515 protein binding IPI 11222739
GO:0016913 follicle-stimulating hormone activity IMP 11514332
genes like me logo Genes that share ontologies with FSHB: view
genes like me logo Genes that share phenotypes with FSHB: view

Animal Models for FSHB Gene

MGI Knock Outs for FSHB:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FSHB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FSHB Gene

Localization for FSHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSHB Gene


Subcellular locations from

Jensen Localization Image for FSHB Gene COMPARTMENTS Subcellular localization image for FSHB gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FSHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IDA 14602737
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FSHB: view

Pathways for FSHB Gene

genes like me logo Genes that share pathways with FSHB: view

Pathways by source for FSHB Gene

Gene Ontology (GO) - Biological Process for FSHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development --
GO:0006701 progesterone biosynthetic process TAS 14557487
GO:0007165 signal transduction TAS 8220432
GO:0007179 transforming growth factor beta receptor signaling pathway IEP 14557487
GO:0007292 female gamete generation TAS 8220432
genes like me logo Genes that share ontologies with FSHB: view

Compounds for FSHB Gene


Pharmaceutical: Available under the names Gonal-F or Metrodin HP (Serono) and Puregon (Organon). Used in the treatment of infertility in women with proven hypopituitarism or who have not responded to clomifene; or in superovulation treatment for assisted conception (such as in vitro fertilization). Metrodin HP is also used in the treatment of hypogonadotrophic hypogonadism in men for the stimulation of spermatogenesis

(21) Novoseek inferred chemical compound relationships for FSHB Gene

Compound -log(P) Hits PubMed IDs
gnrh 79.8 51
ptx1 75.3 1
organon 70.3 6
ganirelix 69.7 6
ribonucleic acid 59.1 2
genes like me logo Genes that share compounds with FSHB: view

Transcripts for FSHB Gene

mRNA/cDNA for FSHB Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FSHB Gene

Follicle stimulating hormone, beta polypeptide:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FSHB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSHB Gene

No ASD Table

Relevant External Links for FSHB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FSHB Gene

mRNA expression in normal human tissues for FSHB Gene

mRNA differential expression in normal tissues according to GTEx for FSHB Gene

This gene is overexpressed in Pituitary (52.5).

SOURCE GeneReport for Unigene cluster for FSHB Gene Hs.36975

genes like me logo Genes that share expressions with FSHB: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for FSHB Gene

Orthologs for FSHB Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSHB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FSHB 35
  • 86.05 (n)
  • 88.37 (a)
-- 36
  • 85 (a)
  • 88 (a)
(Canis familiaris)
Mammalia FSHB 35
  • 79.59 (n)
  • 79.07 (a)
  • 79 (a)
(Mus musculus)
Mammalia Fshb 35
  • 85.01 (n)
  • 86.05 (a)
Fshb 16
Fshb 36
  • 85 (a)
(Pan troglodytes)
Mammalia FSHB 35
  • 98.45 (n)
  • 98.45 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Fshb 35
  • 83.98 (n)
  • 82.95 (a)
(Monodelphis domestica)
Mammalia FSHB 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia FSHB 36
  • 70 (a)
(Gallus gallus)
Aves FSHB 35
  • 72.22 (n)
  • 68.25 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia FSHB 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fshb 35
  • 63.82 (n)
  • 55.81 (a)
(Danio rerio)
Actinopterygii fshb 35
  • 55.43 (n)
  • 47.83 (a)
fshb 36
  • 38 (a)
Species with no ortholog for FSHB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSHB Gene

Gene Tree for FSHB (if available)
Gene Tree for FSHB (if available)

Paralogs for FSHB Gene

Paralogs for FSHB Gene

(9) SIMAP similar genes for FSHB Gene using alignment to 3 proteins: Pseudogenes for FSHB Gene

genes like me logo Genes that share paralogs with FSHB: view

Variants for FSHB Gene

Sequence variations from dbSNP and Humsavar for FSHB Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs6169 -- 30,233,638(+) GTATA(C/T)GAAAC reference, synonymous-codon
rs6170 - 30,231,961(+) CAATA(G/T)CTGTG reference, missense
rs506197 -- 30,234,276(+) CAATG(A/G)CTTCT utr-variant-3-prime
rs506306 -- 30,234,320(+) GAAGA(C/G)GATGT utr-variant-3-prime
rs550312 -- 30,231,642(+) CTGCT(G/T)AAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FSHB Gene

Variant ID Type Subtype PubMed ID
nsv437712 CNV Loss 16327808

Relevant External Links for FSHB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSHB Gene

Disorders for FSHB Gene

(1) OMIM Diseases for FSHB Gene (136530)


  • Isolated follicle-stimulating hormone deficiency (IFSHD) [MIM:229070]: Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. {ECO:0000269 PubMed:8220432, ECO:0000269 PubMed:9271483, ECO:0000269 PubMed:9280841}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for FSHB Gene

(15) Novoseek inferred disease relationships for FSHB Gene

Disease -log(P) Hits PubMed IDs
ovarian hyperstimulation syndrome 71.8 1
gonadotropins increased 66.2 1
pituitary adenoma nonfunctioning 62.8 1
infertility 62.3 4
puberty delayed 61.7 3

Genatlas disease for FSHB Gene

delayed puberty,primary amenorrhea,infertility (FSH deficiency,isolated),hypogonadism in man

Relevant External Links for FSHB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FSHB: view

Publications for FSHB Gene

  1. Delayed puberty and hypogonadism caused by mutations in the follicle- stimulating hormone beta-subunit gene. (PMID: 9271483) Layman L.C. … Jameson J.L. (N. Engl. J. Med. 1997) 3 4 23
  2. Association of AccI polymorphism in the follicle-stimulating hormone beta gene with polycystic ovary syndrome. (PMID: 11119757) Tong Y. … Ng S.C. (Fertil. Steril. 2000) 3 23 48
  3. Increased Prevalance of the -211 T allele of follicle stimulating hormone (FSH) beta subunit promoter polymorphism and lower serum FSH in infertile men. (PMID: 19897680) Grigorova M. … Laan M. (J. Clin. Endocrinol. Metab. 2010) 3 23 48
  4. DNA sequence and regional assignment of the human follicle- stimulating hormone beta-subunit gene to the short arm of human chromosome 11. (PMID: 2885163) Watkins P.C. … Shows T.B. (DNA 1987) 2 3 4
  5. A reevaluation of the amino acid sequence of human follitropin beta- subunit. (PMID: 3151250) Shome B. … Ward D.N. (J. Protein Chem. 1988) 2 3 4

Products for FSHB Gene

Sources for FSHB Gene

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