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Aliases for ALPI Gene

Aliases for ALPI Gene

  • Alkaline Phosphatase, Intestinal 2 3 5
  • Intestinal Alkaline Phosphatase 3 4
  • EC 4 63
  • IAP 3 4
  • Alkaline Phosphomonoesterase 3
  • Glycerophosphatase 3
  • Kasahara Isozyme 3

External Ids for ALPI Gene

Previous GeneCards Identifiers for ALPI Gene

  • GC02P231377
  • GC02P232050
  • GC02P233284
  • GC02P233523
  • GC02P233146
  • GC02P233029
  • GC02P233320
  • GC02P225171

Summaries for ALPI Gene

Entrez Gene Summary for ALPI Gene

  • There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014]

GeneCards Summary for ALPI Gene

ALPI (Alkaline Phosphatase, Intestinal) is a Protein Coding gene. Among its related pathways are Folate biosynthesis and Metabolism. GO annotations related to this gene include magnesium ion binding and protease binding. An important paralog of this gene is ALPL.

Gene Wiki entry for ALPI Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALPI Gene

Genomics for ALPI Gene

Regulatory Elements for ALPI Gene

Enhancers for ALPI Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ALPI on UCSC Golden Path with GeneCards custom track

Genomic Location for ALPI Gene

232,456,112 bp from pter
232,460,745 bp from pter
4,634 bases
Plus strand

Genomic View for ALPI Gene

Genes around ALPI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALPI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALPI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPI Gene

Proteins for ALPI Gene

  • Protein details for ALPI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intestinal-type alkaline phosphatase
    Protein Accession:
    Secondary Accessions:
    • B2R7Y4
    • Q53S80
    • Q9UBV5
    • Q9UCL2

    Protein attributes for ALPI Gene

    528 amino acids
    Molecular mass:
    56812 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    • In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).

neXtProt entry for ALPI Gene

Proteomics data for ALPI Gene at MOPED

Post-translational modifications for ALPI Gene

  • Glycosylation at Asn 141, Asn 268, and Asn 429
  • Modification sites at PhosphoSitePlus

Other Protein References for ALPI Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ALPI Gene

Gene Families for ALPI Gene

Suggested Antigen Peptide Sequences for ALPI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alkaline phosphatase family.
  • Belongs to the alkaline phosphatase family.
genes like me logo Genes that share domains with ALPI: view

Function for ALPI Gene

Molecular function for ALPI Gene

GENATLAS Biochemistry:
phosphatase alkaline,intestinal
UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate.

Enzyme Numbers (IUBMB) for ALPI Gene

Gene Ontology (GO) - Molecular Function for ALPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with ALPI: view
genes like me logo Genes that share phenotypes with ALPI: view

Animal Models for ALPI Gene

MGI Knock Outs for ALPI:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALPI Gene

Localization for ALPI Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALPI Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for ALPI Gene COMPARTMENTS Subcellular localization image for ALPI gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ALPI Gene

Pathways & Interactions for ALPI Gene

genes like me logo Genes that share pathways with ALPI: view

Pathways by source for ALPI Gene

2 KEGG pathways for ALPI Gene
1 GeneGo (Thomson Reuters) pathway for ALPI Gene

Gene Ontology (GO) - Biological Process for ALPI Gene


No data available for SIGNOR curated interactions for ALPI Gene

Drugs & Compounds for ALPI Gene

(16) Drugs for ALPI Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1-Butanol Experimental Pharma 0
1-Proponol Experimental Pharma 0
4-Nitrophenol Experimental Pharma 0
4-Nitrophenyl phosphate Experimental Pharma 0
7,8-Dihydroneopterin Experimental Pharma 0

(31) Additional Compounds for ALPI Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
dihydroneopterin triphosphate
  • 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate
  • 6-(L-Erythro-1,2-Dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
  • 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin
  • 7,8-Dihydroneopterin 3'-triphosphate
  • 7,8-Dihydroneopterin triphosphate
Dihydroxyacetone phosphate
  • 1,3-Dihydroxy-2-Propanone mono(dihydrogen phosphate)
  • 1,3-Dihydroxy-2-propanone phosphate
  • 1,3-Dihydroxyacetone 1-phosphate
  • 1-Hydroxy-3-(phosphonooxy)-2-Propanone
  • 1-Hydroxy-3-(phosphonooxy)acetone
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol

(1) ApexBio Compounds for ALPI Gene

Compound Action Cas Number
(-)-p-Bromotetramisole Oxalate 62284-79-1
genes like me logo Genes that share compounds with ALPI: view

Transcripts for ALPI Gene

mRNA/cDNA for ALPI Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ALPI Gene

Alkaline phosphatase, intestinal:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALPI Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7

Relevant External Links for ALPI Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALPI Gene

mRNA expression in normal human tissues for ALPI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALPI Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x46.8) and Colon - Transverse (x4.7).

Protein differential expression in normal tissues from HIPED for ALPI Gene

This gene is overexpressed in Pancreatic juice (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ALPI Gene

SOURCE GeneReport for Unigene cluster for ALPI Gene Hs.37009

genes like me logo Genes that share expression patterns with ALPI: view

Protein tissue co-expression partners for ALPI Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ALPI Gene

Orthologs for ALPI Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALPI Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100125266 35
  • 81.77 (n)
  • 80.47 (a)
-- 36
  • 75 (a)
-- 36
  • 77 (a)
-- 36
  • 76 (a)
-- 36
  • 77 (a)
(Canis familiaris)
Mammalia ALPP 35
  • 84.71 (n)
  • 84.71 (a)
-- 36
  • 77 (a)
(Mus musculus)
Mammalia Akp3 35
  • 80.39 (n)
  • 80.52 (a)
Akp3 16
Akp3 36
  • 72 (a)
Alpi 36
  • 72 (a)
Alppl2 36
  • 75 (a)
(Pan troglodytes)
Mammalia ALPI 35
  • 99.18 (n)
  • 98.86 (a)
  • 89 (a)
(Rattus norvegicus)
Mammalia Akp3 35
  • 79.35 (n)
  • 79.8 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
(Gallus gallus)
Aves ALPP 35
  • 71.05 (n)
  • 71.34 (a)
-- 36
  • 67 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia alpi.1 35
  • 63.5 (n)
  • 67.98 (a)
(Danio rerio)
Actinopterygii alpi.2 35
  • 62.15 (n)
  • 63.77 (a)
alpi.1 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aph-4 37
  • 43 (a)
CG10592 37
  • 42 (a)
CG10827 37
  • 41 (a)
CG16771 37
  • 37 (a)
CG1809 37
  • 43 (a)
CG3264 37
  • 41 (a)
CG3290 37
  • 41 (a)
CG3292 37
  • 39 (a)
CG5150 37
  • 41 (a)
CG5656 37
  • 43 (a)
CG8105 37
  • 37 (a)
CG10827 35
  • 54.77 (n)
  • 44.71 (a)
Aph-4 36
  • 32 (a)
CG10592 36
  • 35 (a)
CG10827 36
  • 33 (a)
CG16771 36
  • 27 (a)
CG1809 36
  • 37 (a)
CG3264 36
  • 33 (a)
CG3290 36
  • 32 (a)
CG3292 36
  • 32 (a)
CG5150 36
  • 35 (a)
CG5361 36
  • 22 (a)
CG5656 36
  • 37 (a)
CG8105 36
  • 35 (a)
CG8147 36
  • 34 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011302 35
  • 54.14 (n)
  • 46.53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO8 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
-- 36
  • 40 (a)
-- 36
  • 38 (a)
CSA.180 36
  • 37 (a)
CSA.4362 36
  • 37 (a)
Species with no ortholog for ALPI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALPI Gene

Gene Tree for ALPI (if available)
Gene Tree for ALPI (if available)

Paralogs for ALPI Gene

Paralogs for ALPI Gene

(3) SIMAP similar genes for ALPI Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ALPI: view

Variants for ALPI Gene

Sequence variations from dbSNP and Humsavar for ALPI Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1047223 - 232,458,034(+) GATCC(A/G/T)CCGAG reference, missense
rs7559279 - 232,457,029(+) GACAC(A/G)CGGCA reference, missense
rs790052 -- 232,460,214(-) GAGCA(C/T)CTGCT utr-variant-3-prime
rs812591 -- 232,460,596(-) TGTGG(G/T)TGATT utr-variant-3-prime
rs813946 -- 232,458,738(-) TCGCT(C/T)TCATT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ALPI Gene

Variant ID Type Subtype PubMed ID
nsv522450 CNV Loss 19592680
nsv821918 CNV Gain 20364138
nsv875977 CNV Loss 21882294
dgv4449n71 CNV Gain 21882294
dgv4450n71 CNV Loss 21882294
dgv4451n71 CNV Gain+Loss 21882294
dgv494n27 CNV Gain 19166990
nsv875998 CNV Loss 21882294
nsv527789 CNV Loss 19592680
nsv875999 CNV Loss 21882294
nsv876000 CNV Gain 21882294
nsv482060 CNV Gain 20164927

Variation tolerance for ALPI Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ALPI Gene

Disorders for ALPI Gene

Relevant External Links for ALPI

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ALPI Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALPI Gene

Publications for ALPI Gene

  1. Cloning and sequencing of human intestinal alkaline phosphatase cDNA. (PMID: 3468508) Berger J. … Udenfriend S. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3 4 67
  2. Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition. (PMID: 18292227) Goldberg R.F. … Hodin R.A. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  3. Cathepsin C propeptide interacts with intestinal alkaline phosphatase and heat shock cognate protein 70 in human Caco-2 cells. (PMID: 18307834) Hirasaka K. … Nikawa T. (J Physiol Sci 2008) 3 23
  4. Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin. (PMID: 15715171) Wada A. … Hirayama T. (Int. J. Med. Microbiol. 2005) 3 23
  5. Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. (PMID: 15774940) Alkhoury F. … Hodin R.A. (Am. J. Physiol. Gastrointest. Liver Physiol. 2005) 3 23

Products for ALPI Gene

Sources for ALPI Gene