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Aliases for MTOR Gene

Aliases for MTOR Gene

  • Mechanistic Target Of Rapamycin (Serine/Threonine Kinase) 2 3
  • Rapamycin And FKBP12 Target 1 2 3 4
  • Mammalian Target Of Rapamycin 2 3 4
  • FRAP1 3 4 6
  • FK506-Binding Protein 12-Rapamycin Complex-Associated Protein 1 3 4
  • FK506 Binding Protein 12-Rapamycin Associated Protein 2 2 3
  • FKBP12-Rapamycin Complex-Associated Protein 1 2 3
  • Rapamycin Associated Protein FRAP2 2 3
  • FKBP-Rapamycin Associated Protein 2 3
  • Rapamycin Target Protein 1 3 4
  • FRAP2 3 4
  • RAFT1 3 4
  • RAPT1 3 4
  • FRAP 3 4
  • DJ576K7.1 (FK506 Binding Protein 12-Rapamycin Associated Protein 1) 2
  • FK506 Binding Protein 12-Rapamycin Associated Protein 1 2
  • FKBP12-Rapamycin Complex-Associated Protein 4
  • Serine/Threonine-Protein Kinase MTOR 3
  • Mechanistic Target Of Rapamycin 4
  • Rapamycin Target Protein 2
  • EC 2.7.11.1 4
  • MTOR 4

External Ids for MTOR Gene

Previous Symbols for MTOR Gene

  • FRAP
  • FRAP2
  • FRAP1

Summaries for MTOR Gene

Entrez Gene Summary for MTOR Gene

  • The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for MTOR Gene

MTOR (Mechanistic Target Of Rapamycin (Serine/Threonine Kinase)) is a Protein Coding gene. Diseases associated with MTOR include tuberous sclerosis and paronychia. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include protein serine/threonine kinase activity and drug binding. An important paralog of this gene is SMG1.

UniProtKB/Swiss-Prot for MTOR Gene

  • Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at Ser-758, disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at Ser-473 of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at Ser-422.

Gene Wiki entry for MTOR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTOR Gene

Genomics for MTOR Gene

Genomic Location for MTOR Gene

Start:
11,106,531 bp from pter
End:
11,262,557 bp from pter
Size:
156,027 bases
Orientation:
Minus strand

Genomic View for MTOR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTOR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTOR Gene

No data available for Regulatory Elements for MTOR Gene

Proteins for MTOR Gene

  • Protein details for MTOR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42345-MTOR_HUMAN
    Recommended name:
    Serine/threonine-protein kinase mTOR
    Protein Accession:
    P42345
    Secondary Accessions:
    • Q4LE76
    • Q5TER1
    • Q6LE87
    • Q96QG3
    • Q9Y4I3

    Protein attributes for MTOR Gene

    Size:
    2549 amino acids
    Molecular mass:
    288892 Da
    Quaternary structure:
    • Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. The mTORC1 complex is a 1 Md obligate dimer of two stoichiometric heterotetramers with overall dimensions of 290 A x 210 A x 135 A. It has a rhomboid shape and a central cavity, the dimeric interfaces are formed by interlocking interactions between the two MTOR and the two RPTOR subunits. the MLST8 subunits forms distal foot-like protuberances, and contacts only one MTOR within the complex, while the small PRAS40 localizes to the midsection of the central core, in close proximity to RPTOR. Part of the mammalian target of rapamycin COmplex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Interacts with PPAPDC3 and PML. Interacts with PRR5 and RICTOR; the interaction is direct within the mTORC2 complex. Interacts with UBQLN1. Interacts with TTI1 and TELO2. Interacts with CLIP1; phosphorylates and regulates CLIP1. Interacts with NBN. Interacts with HTR6 (PubMed:23027611).
    SequenceCaution:
    • Sequence=AAC39933.1; Type=Frameshift; Positions=956, 999; Evidence={ECO:0000305}; Sequence=BAE06077.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MTOR Gene

neXtProt entry for MTOR Gene

Proteomics data for MTOR Gene at MOPED

Post-translational modifications for MTOR Gene

  • Autophosphorylates when part of mTORC1 or mTORC2. Phosphorylation at Ser-1261, Ser-2159 and Thr-2164 promotes autophosphorylation. Phosphorylation in the kinase domain modulates the interactions of MTOR with RPTOR and PRAS40 and leads to increased intrinsic mTORC1 kinase activity. Phosphorylation at Thr-2173 in the ATP-binding region by AKT1 strongly reduces kinase activity.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys309, Lys616, Lys1293, Lys1635, Lys1655, and Lys2166

Other Protein References for MTOR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MTOR Gene

Domains for MTOR Gene

UniProtKB/Swiss-Prot:

MTOR_HUMAN
Domain:
  • The kinase domain (PI3K/PI4K) is intrinsically active but has a highly restricted catalytic center.:
    • P42345
  • The FAT domain forms three discontinuous subdomains of alpha-helical TPR repeats plus a single subdomain of HEAT repeats. The four domains pack sequentially to form a C-shaped a-solenoid that clamps onto the kinase domain (PubMed:23636326).:
    • P42345
  • Contains 1 FAT domain.:
    • P42345
  • Contains 1 FATC domain.:
    • P42345
  • Contains 1 PI3K/PI4K domain.:
    • P42345
Family:
  • Belongs to the PI3/PI4-kinase family.:
    • P42345
Similarity:
  • Contains 32 HEAT repeats.:
    • P42345
  • Contains 16 TPR repeats.:
    • P42345
genes like me logo Genes that share domains with MTOR: view

Function for MTOR Gene

Molecular function for MTOR Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activation of mTORC1 by growth factors such as insulin involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase a potent activator of the protein kinase activity of mTORC1. Insulin-stimulated and amino acid-dependent phosphorylation at Ser-1261 promotes autophosphorylation and the activation of mTORC1. Activation by amino acids requires relocalization of the mTORC1 complex to lysosomes that is mediated by the Ragulator complex, SLC38A9, and the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD (PubMed:18497260, PubMed:20381137, PubMed:25561175, PubMed:25567906). On the other hand, low cellular energy levels can inhibit mTORC1 through activation of PRKAA1 while hypoxia inhibits mTORC1 through a REDD1-dependent mechanism which may also require PRKAA1. The kinase activity of MTOR within the mTORC1 complex is positively regulated by MLST8 and negatively regulated by DEPTOR and AKT1S1. MTOR phosphorylates RPTOR which in turn inhibits mTORC1. MTOR is the target of the immunosuppressive and anti-cancer drug rapamycin which acts in complex with FKBP1A/FKBP12, and specifically inhibits its kinase activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. It may be regulated by RHEB but in an indirect manner through the PI3K signaling pathway.
UniProtKB/Swiss-Prot Function: Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at Ser-758, disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at Ser-473 of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at Ser-422.

Enzyme Numbers (IUBMB) for MTOR Gene

Gene Ontology (GO) - Molecular Function for MTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001030 RNA polymerase III type 1 promoter DNA binding IDA 20233713
GO:0001031 RNA polymerase III type 2 promoter DNA binding IDA 20233713
GO:0001032 RNA polymerase III type 3 promoter DNA binding IDA 20233713
GO:0001156 TFIIIC-class transcription factor binding IDA 20543138
GO:0004674 protein serine/threonine kinase activity TAS --
genes like me logo Genes that share ontologies with MTOR: view
genes like me logo Genes that share phenotypes with MTOR: view

Animal Models for MTOR Gene

MGI Knock Outs for MTOR:

No data available for Transcription Factor Targeting and HOMER Transcription for MTOR Gene

Localization for MTOR Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTOR Gene

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Cytoplasm. Nucleus, PML body. Note=Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTOR Gene COMPARTMENTS Subcellular localization image for MTOR gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
golgi apparatus 5
lysosome 5
mitochondrion 5
vacuole 5
nucleus 3
plasma membrane 3
cytoskeleton 2
endosome 2
extracellular 2

Gene Ontology (GO) - Cellular Components for MTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 11853878
GO:0005741 mitochondrial outer membrane IEA --
genes like me logo Genes that share ontologies with MTOR: view

Pathways for MTOR Gene

SuperPathways for MTOR Gene

Superpath Contained pathways
1 Insulin receptor signalling cascade
2 PI-3K cascade
3 Signaling by FGFR
4 Translation Insulin regulation of translation
5 mTOR Pathway
genes like me logo Genes that share pathways with MTOR: view

Gene Ontology (GO) - Biological Process for MTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IBA --
GO:0001934 positive regulation of protein phosphorylation IDA 20233713
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0005979 regulation of glycogen biosynthetic process IEA --
GO:0006109 regulation of carbohydrate metabolic process --
genes like me logo Genes that share ontologies with MTOR: view

Compounds for MTOR Gene

(14) ApexBio Compounds for MTOR Gene

Compound Action Cas Number
AZD2014 orally bioavailable inhibitor of the mTOR [1009298-59-2]
AZD8055 Potent, selective, and ATP-competitive mTOR inhibitor [1009298-09-2]
Everolimus (RAD001) mTOR inhibitor, Rapamycin Sirolimus derivative, antifungal and immunosuppresant [159351-69-6]
GDC-0349 small molecule anticaner drug candidate [1207360-89-1]
GDC-mTOR inhibitor Potent and selective ATP-competitive inhibitor of mTOR. [1207358-59-5]
GSK2126458 highly potent PI3K and mTOR inhibitor [1086062-66-9]
INK 128 (MLN0128) potent and selective inhibitor of TORC1 and TORC2. [1224844-38-5]
KU-0063794 Selective inhibitor of mammalian target of rapamycin (mTOR) [938440-64-3]
PP242 Selective and ATP-competitive mTOR inhibitor [1092351-67-1]
Rapamycin (Sirolimus) mTOR inhibitor, antifungal and immunosuppresant compound [53123-88-9]
Temsirolimus mTOR inhibitor, derived from Rapamycin (Sirolimus) [162635-04-3]
Torin 1 Potent and selective mTOR inhibitor [1222998-36-8]
WYE-354 Inhibitor of several PI3Ks at micromolar levels [1062169-56-5]
XL388 novel, highly potent, selective, and ATP-competitive mTOR inhibitor [1251156-08-7]

(4) Drugbank Compounds for MTOR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Everolimus
  • Afinitor
159351-69-6 target inhibitor
Pimecrolimus
  • ASM 981
137071-32-0 target potentiator
Sirolimus
  • (-)-Rapamycin
53123-88-9 target inhibitor
Temsirolimus
162635-04-3 target inhibitor

(58) Novoseek inferred chemical compound relationships for MTOR Gene

Compound -log(P) Hits PubMed IDs
rapamycin 95.4 221
everolimus 81.9 28
temsirolimus 78.9 11
ap 23573 78.5 3
ly294002 77 22

(1) PharmGKB related drug/compound annotations for MTOR Gene

Drug/compound Annotation
everolimus
genes like me logo Genes that share compounds with MTOR: view

Transcripts for MTOR Gene

Unigene Clusters for MTOR Gene

Mechanistic target of rapamycin (serine/threonine kinase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTOR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: - - -
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for MTOR Gene

GeneLoc Exon Structure for
MTOR
ECgene alternative splicing isoforms for
MTOR

Expression for MTOR Gene

mRNA expression in normal human tissues for MTOR Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTOR Gene

SOURCE GeneReport for Unigene cluster for MTOR Gene Hs.338207

mRNA Expression by UniProt/SwissProt for MTOR Gene

P42345-MTOR_HUMAN
Tissue specificity: Expressed in numerous tissues, with highest levels in testis.
genes like me logo Genes that share expressions with MTOR: view

Orthologs for MTOR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MTOR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTOR 36
  • 99.32 (n)
  • 99.4 (a)
MTOR 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTOR 36
  • 92.3 (n)
  • 99.45 (a)
MTOR 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTOR 36
  • 92.04 (n)
  • 99.1 (a)
MTOR 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtor 36
  • 90.38 (n)
  • 98.94 (a)
Mtor 16
Mtor 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTOR 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 93 (a)
OneToMany
-- 37
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mtor 36
  • 90.94 (n)
  • 98.9 (a)
chicken
(Gallus gallus)
Aves MTOR 36
  • 82.3 (n)
  • 97.22 (a)
MTOR 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTOR 37
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9731 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mtor 36
  • 76.4 (n)
  • 89.32 (a)
Str.15506 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3686 36
zebrafish
(Danio rerio)
Actinopterygii mtor 36
  • 78.59 (n)
  • 90.85 (a)
mtor 37
  • 89 (a)
OneToOne
wufc22h08 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007873 36
  • 57.39 (n)
  • 57.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tor 36
  • 57.96 (n)
  • 56.44 (a)
Tor 37
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea let-363 37
  • 35 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR420W 36
  • 52.43 (n)
  • 47.11 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOR2 36
  • 50.55 (n)
  • 45.58 (a)
TOR2 37
  • 43 (a)
OneToMany
TOR2 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13948g 36
  • 51.4 (n)
  • 47.03 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11338 36
thale cress
(Arabidopsis thaliana)
eudicotyledons TOR 36
  • 51.91 (n)
  • 46 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1352 36
rice
(Oryza sativa)
Liliopsida Os.17756 36
Os05g0235300 36
  • 55.24 (n)
  • 53.04 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7658 36
bread mold
(Neurospora crassa)
Ascomycetes NCU05608 36
  • 53.97 (n)
  • 48.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tor2 36
  • 51.97 (n)
  • 49.2 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4144 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
OneToOne
Species with no ortholog for MTOR:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MTOR Gene

ENSEMBL:
Gene Tree for MTOR (if available)
TreeFam:
Gene Tree for MTOR (if available)

Paralogs for MTOR Gene

Paralogs for MTOR Gene

Selected SIMAP similar genes for MTOR Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MTOR: view

Variants for MTOR Gene

Sequence variations from dbSNP and Humsavar for MTOR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2536 -- 11,106,656(+) TAATT(C/T)CCAAT utr-variant-3-prime
rs2754 -- 11,107,295(-) TATTG(A/T)CAGAA utr-variant-3-prime
rs718206 -- 11,234,417(+) CAGAC(A/T)TTTCT intron-variant
rs742824 -- 11,213,965(+) CAGTT(A/G)TAAGA intron-variant
rs868080 -- 11,124,432(-) GTCTC(A/G)TGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTOR Gene

Variant ID Type Subtype PubMed ID
esv267860 CNV Insertion 20981092
esv2658000 CNV Deletion 23128226

Relevant External Links for MTOR Gene

HapMap Linkage Disequilibrium report
MTOR
Human Gene Mutation Database (HGMD)
MTOR

Disorders for MTOR Gene

(58) Novoseek inferred disease relationships for MTOR Gene

Disease -log(P) Hits PubMed IDs
tuberous sclerosis 80 21
cancer 61.9 83
tumors 59.9 113
lymphangioleiomyomatosis 59.6 1
carcinoma renal cell 53.4 7

Relevant External Links for MTOR

Genetic Association Database (GAD)
MTOR
Human Genome Epidemiology (HuGE) Navigator
MTOR
genes like me logo Genes that share disorders with MTOR: view

No data available for UniProtKB/Swiss-Prot for MTOR Gene

Publications for MTOR Gene

  1. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. (PMID: 8008069) Brown E.J. … Schreiber S.L. (Nature 1994) 2 3 4 23
  2. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. (PMID: 11930000) Desai B.N. … Schreiber S.L. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23
  3. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. (PMID: 8662507) Choi J. … Clardy J. (Science 1996) 3 4 23
  4. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. (PMID: 12718876) Kim D.-H. … Sabatini D.M. (Mol. Cell 2003) 3 4 23
  5. The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. (PMID: 12231510) Choi J.H. … Zheng X.F. (EMBO Rep. 2002) 3 4 23

Products for MTOR Gene

  • Addgene plasmids for MTOR

Sources for MTOR Gene

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