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Aliases for IL27 Gene

Aliases for IL27 Gene

  • Interleukin 27 2 3 5
  • IL-27 Subunit Alpha 3 4
  • Interleukin-30 3 4
  • IL-27-A 3 4
  • IL27-A 3 4
  • IL27A 3 4
  • IL30 3 4
  • P28 3 4
  • Interleukin-27 Subunit Alpha 3
  • IL-27 P28 Subunit 3
  • Interleukin 30 2
  • IL27p28 3
  • IL-27A 3
  • IL-27 3

External Ids for IL27 Gene

Previous HGNC Symbols for IL27 Gene

  • IL30

Previous GeneCards Identifiers for IL27 Gene

  • GC16P028586
  • GC16M028418
  • GC16M026536

Summaries for IL27 Gene

Entrez Gene Summary for IL27 Gene

  • The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]

GeneCards Summary for IL27 Gene

IL27 (Interleukin 27) is a Protein Coding gene. Diseases associated with IL27 include Eosinophilic Granulomatosis With Polyangiitis. Among its related pathways are Innate Immune System and IL27-mediated signaling events. GO annotations related to this gene include receptor binding and interleukin-27 receptor binding.

UniProtKB/Swiss-Prot for IL27 Gene

  • Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replication.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL27 Gene

Genomics for IL27 Gene

Regulatory Elements for IL27 Gene

Enhancers for IL27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G028531 1.5 FANTOM5 Ensembl ENCODE 10.8 -7.3 -7257 3.7 ELF3 CBX3 ARID4B RAD21 RARA YY1 ZNF121 ZNF366 IKZF2 MIXL1 SULT1A2 TUFM APOBR SGF29 NPIPB7 CLN3 IL27 ENSG00000251417 SULT1A1 SPNS1
GH16G028542 1.7 FANTOM5 Ensembl ENCODE 6.1 -17.2 -17165 1.9 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SULT1A2 TUFM NFATC2IP ENSG00000260853 NPIPB7 APOBR CLN3 SGF29 EIF3CL ENSG00000260367
GH16G028617 1.3 FANTOM5 Ensembl ENCODE 7 -91.4 -91432 1.2 ELF3 SOX13 TFAP4 PKNOX1 SAP130 ARID4B CEBPG ZNF384 RARA NR2F6 TUFM IL27 SBK1 PIR38771 SULT1A1
GH16G028525 1.1 ENCODE 0.7 -1.0 -1021 3.8 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF766 KLF13 SP3 SP5 SULT1A2 TUFM CLN3 APOBR NPIPB7 SGF29 ENSG00000251417 IL27 PIR42560
GH16G028524 0.7 ENCODE 0.7 +1.6 1580 0.8 CTCF TAF1 DDX20 RAD21 YY1 ZNF766 ZNF366 SMARCA5 STAT1 REST SULT1A2 CLN3 APOBR ENSG00000251417 IL27 PIR49782 GC16P028499
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL27 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL27 Gene

Chromosome:
16
Start:
28,499,069 bp from pter
End:
28,526,399 bp from pter
Size:
27,331 bases
Orientation:
Minus strand

Genomic View for IL27 Gene

Genes around IL27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL27 Gene

Proteins for IL27 Gene

  • Protein details for IL27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEV9-IL27A_HUMAN
    Recommended name:
    Interleukin-27 subunit alpha
    Protein Accession:
    Q8NEV9
    Secondary Accessions:
    • A0N0L2
    • Q6P676

    Protein attributes for IL27 Gene

    Size:
    243 amino acids
    Molecular mass:
    27493 Da
    Quaternary structure:
    • Heterodimer with EBI3; not disulfide-linked. This heterodimer is known as interleukin IL-27.

neXtProt entry for IL27 Gene

Post-translational modifications for IL27 Gene

Other Protein References for IL27 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IL27

No data available for DME Specific Peptides for IL27 Gene

Domains & Families for IL27 Gene

Gene Families for IL27 Gene

Protein Domains for IL27 Gene

Suggested Antigen Peptide Sequences for IL27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NEV9

UniProtKB/Swiss-Prot:

IL27A_HUMAN :
  • Belongs to the IL-6 superfamily.
Family:
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with IL27: view

Function for IL27 Gene

Molecular function for IL27 Gene

UniProtKB/Swiss-Prot Function:
Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replication.
UniProtKB/Swiss-Prot Induction:
Transiently induced by bacterial lipopolysaccharides (LPS) stimulation in monocytes.

Gene Ontology (GO) - Molecular Function for IL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA,ISS --
GO:0005125 cytokine activity IEA --
GO:0045523 interleukin-27 receptor binding IBA,ISS --
genes like me logo Genes that share ontologies with IL27: view
genes like me logo Genes that share phenotypes with IL27: view

Animal Models for IL27 Gene

MGI Knock Outs for IL27:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL27

miRNA for IL27 Gene

miRTarBase miRNAs that target IL27

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL27 Gene

Localization for IL27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL27 Gene

Secreted. Note=Does not seem to be secreted without coexpression of EBI3.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL27 gene
Compartment Confidence
extracellular 5
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS,IBA --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with IL27: view

Pathways & Interactions for IL27 Gene

genes like me logo Genes that share pathways with IL27: view

SIGNOR curated interactions for IL27 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IEA --
GO:0002376 immune system process IEA --
GO:0006954 inflammatory response IEA --
GO:0009617 response to bacterium IEA --
GO:0042129 regulation of T cell proliferation ISS,IBA --
genes like me logo Genes that share ontologies with IL27: view

Drugs & Compounds for IL27 Gene

No Compound Related Data Available

Transcripts for IL27 Gene

mRNA/cDNA for IL27 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL27 Gene

Interleukin 27:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL27 Gene

No ASD Table

Relevant External Links for IL27 Gene

GeneLoc Exon Structure for
IL27
ECgene alternative splicing isoforms for
IL27

Expression for IL27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL27 Gene

mRNA differential expression in normal tissues according to GTEx for IL27 Gene

This gene is overexpressed in Liver (x26.4) and Whole Blood (x10.1).

Protein differential expression in normal tissues from HIPED for IL27 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL27 Gene



Protein tissue co-expression partners for IL27 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL27 Gene:

IL27

SOURCE GeneReport for Unigene cluster for IL27 Gene:

Hs.528111

mRNA Expression by UniProt/SwissProt for IL27 Gene:

Q8NEV9-IL27A_HUMAN
Tissue specificity: Expressed in monocytes and in placenta.

Evidence on tissue expression from TISSUES for IL27 Gene

  • Lung(4)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with IL27: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL27 Gene

Orthologs for IL27 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL27 34 35
  • 99.35 (n)
mouse
(Mus musculus)
Mammalia Il27 34 16 35
  • 82.35 (n)
rat
(Rattus norvegicus)
Mammalia Il27 34
  • 80.69 (n)
cow
(Bos Taurus)
Mammalia IL27 34 35
  • 79.72 (n)
dog
(Canis familiaris)
Mammalia IL27 34 35
  • 77.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IL27 35
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL27 35
  • 51 (a)
OneToOne
Species where no ortholog for IL27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL27 Gene

ENSEMBL:
Gene Tree for IL27 (if available)
TreeFam:
Gene Tree for IL27 (if available)

Paralogs for IL27 Gene

No data available for Paralogs for IL27 Gene

Variants for IL27 Gene

Sequence variations from dbSNP and Humsavar for IL27 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000008119 -- 28,511,608(+) ACTCC(A/G)GAGGC intron-variant
rs1000024692 -- 28,523,152(+) TCATC(C/T)TTCTT intron-variant
rs1000325951 -- 28,503,889(+) GTGGG(C/T)CTGGC reference, missense
rs1000444768 -- 28,511,166(+) AGCCA(A/C)CACGC intron-variant
rs1000480983 -- 28,522,872(+) ACTGC(A/G)CACGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL27 Gene

Variant ID Type Subtype PubMed ID
esv2758640 CNV gain+loss 17122850
nsv1059555 CNV gain 25217958
nsv509608 CNV insertion 20534489
nsv833180 CNV loss 17160897

Variation tolerance for IL27 Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.25; 81.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL27 Gene

Disorders for IL27 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL27 Gene - From: GeneCards

Disorder Aliases PubMed IDs
eosinophilic granulomatosis with polyangiitis
  • churg-strauss syndrome
- elite association - COSMIC cancer census association via MalaCards
Search IL27 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL27

Genetic Association Database (GAD)
IL27
Human Genome Epidemiology (HuGE) Navigator
IL27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL27
genes like me logo Genes that share disorders with IL27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL27 Gene

Publications for IL27 Gene

  1. Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population. (PMID: 17318299) Chae S.-C. … Chung H.-T. (J. Hum. Genet. 2007) 3 4 22 46 64
  2. Interleukin-27 polymorphisms are associated with inflammatory bowel diseases in a Korean population. (PMID: 19686419) Li C.S. … Chae S.C. (J. Gastroenterol. Hepatol. 2009) 3 22 46 64
  3. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. (PMID: 12121660) Pflanz S. … Kastelein R.A. (Immunity 2002) 2 3 4 64
  4. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PMID: 21829393) Plagnol V. … Todd J.A. (PLoS Genet. 2011) 3 46 64
  5. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. (PMID: 20176734) Wang K. … Hakonarson H. (Hum. Mol. Genet. 2010) 3 46 64

Products for IL27 Gene

Sources for IL27 Gene

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