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Aliases for SPDYA Gene

Aliases for SPDYA Gene

  • Speedy/RINGO Cell Cycle Regulator Family Member A 2 3 5
  • Rapid Inducer Of G2/M Progression In Oocytes A 3 4
  • HSpy/Ringo A 3 4
  • Speedy-1 3 4
  • RINGO A 3 4
  • SPDY1 3 4
  • SPY1 3 4
  • Speedy Homolog A (Xenopus Laevis) 2
  • Speedy Homolog 1 (Drosophila) 2
  • Speedy Homolog A 3
  • Speedy Protein A 3
  • RINGO3 3
  • RINGOA 3

External Ids for SPDYA Gene

Previous HGNC Symbols for SPDYA Gene

  • SPDY1

Previous GeneCards Identifiers for SPDYA Gene

  • GC02P028828
  • GC02P029007

Summaries for SPDYA Gene

GeneCards Summary for SPDYA Gene

SPDYA (Speedy/RINGO Cell Cycle Regulator Family Member A) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is SPDYC.

UniProtKB/Swiss-Prot for SPDYA Gene

  • Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2.

Gene Wiki entry for SPDYA Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPDYA Gene

Genomics for SPDYA Gene

Regulatory Elements for SPDYA Gene

Enhancers for SPDYA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G028747 2 FANTOM5 Ensembl ENCODE dbSUPER 12 -30.4 -30372 9.3 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 TRMT61B TOGARAM2 PPP1CB SPDYA ENSG00000230730 WDR43 FOSL2 LOC100505774
GH02G028582 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -198.4 -198380 3.8 HDGF PKNOX1 ARNT SIN3A ZNF766 FOS KLF13 SP3 JUNB SMARCB1 PPP1CB SPDYA ENSG00000230730 FOSL2 SNRPGP7
GH02G028609 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -169.7 -169709 6.6 PKNOX1 FEZF1 BRCA1 ZNF2 GLIS2 GATA2 FOS DEK TSHZ1 SMARCB1 ENSG00000230730 PPP1CB LOC100505774 SPDYA PLB1 TRMT61B SNRPGP7
GH02G028593 1.5 Ensembl ENCODE dbSUPER 11.5 -187.0 -186958 3.8 PKNOX1 SIN3A ARID4B ZNF2 ZNF48 ZNF766 ZNF143 FOS DEK SP3 ENSG00000230730 PPP1CB SPDYA LOC100505774 PLB1 C2orf71 SNRPGP7
GH02G028588 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -194.2 -194198 0.8 CBX3 RNF2 SIN3A RBBP5 REST DPF2 NR3C1 POLR2A HDAC2 IKZF1 PPP1CB FOSL2 SPDYA LOC100505774 ENSG00000230730 SNRPGP7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPDYA on UCSC Golden Path with GeneCards custom track

Genomic Location for SPDYA Gene

Chromosome:
2
Start:
28,782,517 bp from pter
End:
28,850,611 bp from pter
Size:
68,095 bases
Orientation:
Plus strand

Genomic View for SPDYA Gene

Genes around SPDYA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPDYA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPDYA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPDYA Gene

Proteins for SPDYA Gene

  • Protein details for SPDYA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MJ70-SPDYA_HUMAN
    Recommended name:
    Speedy protein A
    Protein Accession:
    Q5MJ70
    Secondary Accessions:
    • Q53R05
    • Q5MJ69

    Protein attributes for SPDYA Gene

    Size:
    313 amino acids
    Molecular mass:
    36463 Da
    Quaternary structure:
    • Interacts with CDK1, CDK2 and CDKN1B/KIP1. Found in a complex with both CDK2 and CDKN1B/KIP1.

    Alternative splice isoforms for SPDYA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPDYA Gene

Post-translational modifications for SPDYA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPDYA Gene

No data available for DME Specific Peptides for SPDYA Gene

Domains & Families for SPDYA Gene

Gene Families for SPDYA Gene

Protein Domains for SPDYA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPDYA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5MJ70

UniProtKB/Swiss-Prot:

SPDYA_HUMAN :
  • The C-terminus is required for CDK2-activation, but not CDK2-binding.
  • Belongs to the Speedy/Ringo family.
Domain:
  • The C-terminus is required for CDK2-activation, but not CDK2-binding.
Family:
  • Belongs to the Speedy/Ringo family.
genes like me logo Genes that share domains with SPDYA: view

Function for SPDYA Gene

Molecular function for SPDYA Gene

UniProtKB/Swiss-Prot Function:
Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2.

Gene Ontology (GO) - Molecular Function for SPDYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 11980914
genes like me logo Genes that share ontologies with SPDYA: view
genes like me logo Genes that share phenotypes with SPDYA: view

Animal Model Products

miRNA for SPDYA Gene

miRTarBase miRNAs that target SPDYA

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPDYA Gene

Localization for SPDYA Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPDYA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPDYA gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SPDYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 11980914
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SPDYA: view

Pathways & Interactions for SPDYA Gene

SuperPathways for SPDYA Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with SPDYA: view

Pathways by source for SPDYA Gene

Gene Ontology (GO) - Biological Process for SPDYA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 11980914
GO:0006974 cellular response to DNA damage stimulus IDA,IEA 12839962
GO:0007049 cell cycle IEA --
GO:0007140 male meiosis IEA,ISS --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with SPDYA: view

No data available for SIGNOR curated interactions for SPDYA Gene

Transcripts for SPDYA Gene

Unigene Clusters for SPDYA Gene

Speedy homolog A (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPDYA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - - - -
SP9: - -
SP10:
SP11: -
SP12:
SP13:

ExUns: 13a · 13b ^ 14a · 14b · 14c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SPDYA Gene

GeneLoc Exon Structure for
SPDYA
ECgene alternative splicing isoforms for
SPDYA

Expression for SPDYA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPDYA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPDYA Gene

This gene is overexpressed in Testis (x26.0).

Protein differential expression in normal tissues from HIPED for SPDYA Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPDYA Gene



Protein tissue co-expression partners for SPDYA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPDYA Gene:

SPDYA

SOURCE GeneReport for Unigene cluster for SPDYA Gene:

Hs.511956

mRNA Expression by UniProt/SwissProt for SPDYA Gene:

Q5MJ70-SPDYA_HUMAN
Tissue specificity: Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase.
genes like me logo Genes that share expression patterns with SPDYA: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPDYA Gene

Orthologs for SPDYA Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPDYA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPDYA 34 35
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia SPDYA 34 35
  • 92.52 (n)
dog
(Canis familiaris)
Mammalia SPDYA 34 35
  • 92.45 (n)
rat
(Rattus norvegicus)
Mammalia Spdya 34
  • 89.64 (n)
mouse
(Mus musculus)
Mammalia Spdya 34 16 35
  • 88.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SPDYA 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPDYA 34 35
  • 70.71 (n)
lizard
(Anolis carolinensis)
Reptilia SPDYA 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spdya 34
  • 66.34 (n)
African clawed frog
(Xenopus laevis)
Amphibia ls27 34
zebrafish
(Danio rerio)
Actinopterygii spdya 34 35
  • 67.92 (n)
Dr.15895 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13761 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToMany
Species where no ortholog for SPDYA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPDYA Gene

ENSEMBL:
Gene Tree for SPDYA (if available)
TreeFam:
Gene Tree for SPDYA (if available)

Paralogs for SPDYA Gene

Paralogs for SPDYA Gene

(2) SIMAP similar genes for SPDYA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPDYA: view

Variants for SPDYA Gene

Sequence variations from dbSNP and Humsavar for SPDYA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000034166 -- 28,822,255(+) AAGTT(A/G)ACTAT intron-variant
rs1000096406 -- 28,826,071(+) GTTTG(A/G)CACTG intron-variant
rs1000121486 -- 28,830,039(+) GAGGC(C/T)GAGGC intron-variant
rs1000239799 -- 28,810,701(+) GGGCG(C/G)GGGGC upstream-variant-2KB
rs1000311080 -- 28,846,203(+) AGCTC(A/G)AGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPDYA Gene

Variant ID Type Subtype PubMed ID
nsv471901 CNV novel sequence insertion 20440878
nsv819532 CNV loss 19587683

Variation tolerance for SPDYA Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPDYA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPDYA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPDYA Gene

Disorders for SPDYA Gene

Relevant External Links for SPDYA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPDYA

No disorders were found for SPDYA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPDYA Gene

Publications for SPDYA Gene

  1. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. (PMID: 15611625) Cheng A. … Solomon M.J. (Cell Cycle 2005) 2 3 4 64
  2. Human Spy1 promotes survival of mammalian cells following DNA damage. (PMID: 12839962) Barnes E.A. … Donoghue D.J. (Cancer Res. 2003) 2 3 4 64
  3. Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2. (PMID: 11980914) Porter L.A. … Donoghue D.J. (J. Cell Biol. 2002) 2 3 4 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SPDYA Gene

Sources for SPDYA Gene

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