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Aliases for ZNF318 Gene

Aliases for ZNF318 Gene

  • Zinc Finger Protein 318 2 3 5
  • Endocrine Regulatory Protein 3 4
  • Testicular Zinc Finger 3
  • Endocrine Regulator 3
  • HRIHFB2436 3
  • ZFP318 3
  • TZF 3

External Ids for ZNF318 Gene

Previous GeneCards Identifiers for ZNF318 Gene

  • GC06M043280
  • GC06M043332
  • GC06M043346
  • GC06M043022

Summaries for ZNF318 Gene

GeneCards Summary for ZNF318 Gene

ZNF318 (Zinc Finger Protein 318) is a Protein Coding gene. Among its related pathways are Androgen receptor signaling pathway. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF318 Gene

  • Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity).

Gene Wiki entry for ZNF318 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF318 Gene

Genomics for ZNF318 Gene

Regulatory Elements for ZNF318 Gene

Promoters for ZNF318 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF318 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF318 Gene

Chromosome:
6
Start:
43,307,134 bp from pter
End:
43,369,478 bp from pter
Size:
62,345 bases
Orientation:
Minus strand

Genomic View for ZNF318 Gene

Genes around ZNF318 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF318 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF318 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF318 Gene

Proteins for ZNF318 Gene

  • Protein details for ZNF318 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VUA4-ZN318_HUMAN
    Recommended name:
    Zinc finger protein 318
    Protein Accession:
    Q5VUA4
    Secondary Accessions:
    • O94796
    • Q4G0E4
    • Q8NEM6
    • Q9UNU8
    • Q9Y2W9

    Protein attributes for ZNF318 Gene

    Size:
    2279 amino acids
    Molecular mass:
    251112 Da
    Quaternary structure:
    • Interacts with the N-terminal domain of AR.
    SequenceCaution:
    • Sequence=AAD17298.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD47387.1; Type=Frameshift; Positions=4, 44; Evidence={ECO:0000305}; Sequence=AAH98434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH98434.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 1214.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF318 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF318 Gene

Proteomics data for ZNF318 Gene at MOPED

Post-translational modifications for ZNF318 Gene

  • Ubiquitination at Lys 1866
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF318 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF318 Gene

Domains & Families for ZNF318 Gene

Gene Families for ZNF318 Gene

Protein Domains for ZNF318 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF318 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VUA4

UniProtKB/Swiss-Prot:

ZN318_HUMAN :
  • Contains 2 matrin-type zinc fingers.
Similarity:
  • Contains 2 matrin-type zinc fingers.
genes like me logo Genes that share domains with ZNF318: view

Function for ZNF318 Gene

Molecular function for ZNF318 Gene

UniProtKB/Swiss-Prot Function:
Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity).
genes like me logo Genes that share phenotypes with ZNF318: view

Animal Models for ZNF318 Gene

MGI Knock Outs for ZNF318:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF318 Gene

Localization for ZNF318 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF318 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF318 Gene COMPARTMENTS Subcellular localization image for ZNF318 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF318 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF318: view

Pathways & Interactions for ZNF318 Gene

genes like me logo Genes that share pathways with ZNF318: view

Pathways by source for ZNF318 Gene

1 BioSystems pathway for ZNF318 Gene

Gene Ontology (GO) - Biological Process for ZNF318 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with ZNF318: view

No data available for SIGNOR curated interactions for ZNF318 Gene

Drugs & Compounds for ZNF318 Gene

(1) Drugs for ZNF318 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ZNF318 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZNF318: view

Transcripts for ZNF318 Gene

Unigene Clusters for ZNF318 Gene

Zinc finger protein 318:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF318 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - -
SP2: - - - - - -
SP3:
SP4:
SP5: - - - -

Relevant External Links for ZNF318 Gene

GeneLoc Exon Structure for
ZNF318
ECgene alternative splicing isoforms for
ZNF318

Expression for ZNF318 Gene

mRNA expression in normal human tissues for ZNF318 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF318 Gene

This gene is overexpressed in Pancreas (15.4), Serum (14.2), Synovial fluid (12.6), and Testis (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF318 Gene



SOURCE GeneReport for Unigene cluster for ZNF318 Gene Hs.509718

mRNA Expression by UniProt/SwissProt for ZNF318 Gene

Q5VUA4-ZN318_HUMAN
Tissue specificity: Expressed in endocrine tissue.
genes like me logo Genes that share expression patterns with ZNF318: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZNF318 Gene

Orthologs for ZNF318 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF318 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF318 36
  • 99 (a)
OneToOne
ZNF318 35
  • 99.34 (n)
  • 99.19 (a)
cow
(Bos Taurus)
Mammalia ZNF318 35
  • 88.05 (n)
  • 84.34 (a)
ZNF318 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF318 36
  • 86 (a)
OneToOne
ZNF318 35
  • 88.7 (n)
  • 86.51 (a)
mouse
(Mus musculus)
Mammalia Zfp318 16
Zfp318 36
  • 73 (a)
OneToOne
Zfp318 35
  • 82.06 (n)
  • 75.25 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF318 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp318 35
  • 82.47 (n)
  • 76.24 (a)
chicken
(Gallus gallus)
Aves ZNF318 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF318 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CU571336.2 36
  • 26 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9776 36
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
CSA.4713 36
  • 26 (a)
OneToMany
Species with no ortholog for ZNF318:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF318 Gene

ENSEMBL:
Gene Tree for ZNF318 (if available)
TreeFam:
Gene Tree for ZNF318 (if available)

Paralogs for ZNF318 Gene

No data available for Paralogs for ZNF318 Gene

Variants for ZNF318 Gene

Sequence variations from dbSNP and Humsavar for ZNF318 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036056 A breast cancer sample
VAR_036057 A breast cancer sample
rs34541323 - 43,356,114(+) CCTGG(A/C/G)TGGAG nc-transcript-variant, reference, missense
rs9357410 - 43,354,726(+) TATGA(C/G)TGATG nc-transcript-variant, reference, missense
rs10948072 - 43,340,123(+) TTGGG(A/G)TCACC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF318 Gene

Variant ID Type Subtype PubMed ID
nsv348832 CNV Insertion 16902084
esv2629858 CNV Deletion 19546169
esv26917 CNV Loss 19812545

Variation tolerance for ZNF318 Gene

Residual Variation Intolerance Score: 0.687% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.56; 72.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF318 Gene

HapMap Linkage Disequilibrium report
ZNF318

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF318 Gene

Disorders for ZNF318 Gene

Relevant External Links for ZNF318

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF318

No disorders were found for ZNF318 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF318 Gene

Publications for ZNF318 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 67
  2. Opposite effects of alternative TZF spliced variants on androgen receptor. (PMID: 16446156) Tao R.H. … Takayanagi R. (Biochem. Biophys. Res. Commun. 2006) 3 23
  3. A zinc finger protein TZF is a novel corepressor of androgen receptor. (PMID: 15882980) Ishizuka M. … Hagiwara H. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis. (PMID: 10873617) Inoue A. … Hagiwara H. (Biochem. Biophys. Res. Commun. 2000) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ZNF318 Gene

Sources for ZNF318 Gene

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