Aliases for ALOX5AP Gene
External Ids for ALOX5AP Gene
Previous GeneCards Identifiers for ALOX5AP Gene
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for ALOX5AP Gene
ALOX5AP (Arachidonate 5-Lipoxygenase Activating Protein) is a Protein Coding gene. Diseases associated with ALOX5AP include stroke, ischemic and gastroesophageal junction adenocarcinoma. Among its related pathways are Metabolism and Selenium Pathway. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is MGST2.
UniProtKB/Swiss-Prot for ALOX5AP Gene
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX.