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Aliases for ALOX5 Gene

Aliases for ALOX5 Gene

  • Arachidonate 5-Lipoxygenase 2 3 5
  • EC 1.13.11.34 4 63
  • 5-LO 3 4
  • LOG5 3 4
  • Arachidonic 5-Lipoxygenase Delta-10-13 Isoform 3
  • Arachidonic 5-Lipoxygenase Delta-P10 Isoform 3
  • Arachidonic 5-Lipoxygenase Alpha-10 Isoform 3
  • Arachidonic 5-Lipoxygenase Delta-13 Isoform 3
  • Arachidonic Acid 5-Lipoxygenase 3
  • Leukotriene A4 Synthase 3
  • 5-Lipoxygenase 4
  • EC 1.13.11 63
  • 5-LOX 3
  • LOX-5 3
  • 5LPG 3

External Ids for ALOX5 Gene

Previous GeneCards Identifiers for ALOX5 Gene

  • GC10P045171
  • GC10P045644
  • GC10P045153
  • GC10P045189
  • GC10P045869
  • GC10P042394

Summaries for ALOX5 Gene

Entrez Gene Summary for ALOX5 Gene

  • This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for ALOX5 Gene

ALOX5 (Arachidonate 5-Lipoxygenase) is a Protein Coding gene. Diseases associated with ALOX5 include asthma and arthus reaction. Among its related pathways are Metabolism and Selenium Pathway. GO annotations related to this gene include iron ion binding and arachidonate 5-lipoxygenase activity. An important paralog of this gene is ALOX15.

UniProtKB/Swiss-Prot for ALOX5 Gene

  • Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

Tocris Summary for ALOX5 Gene

  • Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX.

Gene Wiki entry for ALOX5 Gene

PharmGKB "VIP" Summary for ALOX5 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for ALOX5 Gene

Genomics for ALOX5 Gene

Regulatory Elements for ALOX5 Gene

Promoters for ALOX5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ALOX5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ALOX5 Gene

Chromosome:
10
Start:
45,374,176 bp from pter
End:
45,446,121 bp from pter
Size:
71,946 bases
Orientation:
Plus strand

Genomic View for ALOX5 Gene

Genes around ALOX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALOX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALOX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALOX5 Gene

Proteins for ALOX5 Gene

  • Protein details for ALOX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09917-LOX5_HUMAN
    Recommended name:
    Arachidonate 5-lipoxygenase
    Protein Accession:
    P09917
    Secondary Accessions:
    • B7ZLS0
    • E5FPY5
    • E5FPY7
    • E5FPY8
    • Q5JQ14

    Protein attributes for ALOX5 Gene

    Size:
    674 amino acids
    Molecular mass:
    77983 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    • Interacts with ALOX5AP and LTC4S. Interacts with COTL1, the interaction is required for stability and efficient catalytic activity.

    Three dimensional structures from OCA and Proteopedia for ALOX5 Gene

    Alternative splice isoforms for ALOX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALOX5 Gene

Proteomics data for ALOX5 Gene at MOPED

Post-translational modifications for ALOX5 Gene

  • Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALOX5 Gene

Antibody Products

  • R&D Systems Antibodies for ALOX5 (5-Lipoxygenase)
  • Cell Signaling Technology (CST) Antibodies for ALOX5 (5-LO)

Domains & Families for ALOX5 Gene

Gene Families for ALOX5 Gene

Graphical View of Domain Structure for InterPro Entry

P09917

UniProtKB/Swiss-Prot:

LOX5_HUMAN :
  • Contains 1 lipoxygenase domain.
  • Belongs to the lipoxygenase family.
Domain:
  • Contains 1 lipoxygenase domain.
  • Contains 1 PLAT domain.
Family:
  • Belongs to the lipoxygenase family.
genes like me logo Genes that share domains with ALOX5: view

Function for ALOX5 Gene

Molecular function for ALOX5 Gene

GENATLAS Biochemistry:
arachidonate-5-lipoxygenase,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling,carcinogenesis,atheroma and asthma formation,involved in leukotriene metabolism
UniProtKB/Swiss-Prot CatalyticActivity:
Arachidonate + O(2) = leukotriene A(4) + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

Enzyme Numbers (IUBMB) for ALOX5 Gene

genes like me logo Genes that share phenotypes with ALOX5: view

Animal Models for ALOX5 Gene

MGI Knock Outs for ALOX5:

Animal Model Products

  • Taconic Biosciences Mouse Models for ALOX5

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ALOX5 Gene

Localization for ALOX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALOX5 Gene

Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALOX5 Gene COMPARTMENTS Subcellular localization image for ALOX5 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 3
mitochondrion 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ALOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IEA --
GO:0042383 sarcolemma IEA --
genes like me logo Genes that share ontologies with ALOX5: view

Pathways & Interactions for ALOX5 Gene

genes like me logo Genes that share pathways with ALOX5: view

UniProtKB/Swiss-Prot P09917-LOX5_HUMAN

  • Pathway: Lipid metabolism; leukotriene A4 biosynthesis.

Gene Ontology (GO) - Biological Process for ALOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002526 acute inflammatory response IEA --
GO:0019370 leukotriene biosynthetic process IDA 21233389
GO:0019372 lipoxygenase pathway TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055093 response to hyperoxia IEA --
genes like me logo Genes that share ontologies with ALOX5: view

No data available for SIGNOR curated interactions for ALOX5 Gene

Drugs & Compounds for ALOX5 Gene

(81) Drugs for ALOX5 Gene - From: Novoseek, DrugBank, HMDB, DGIdb, IUPHAR, ApexBio, ClinicalTrials, Tocris, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zileuton Approved, Investigational, Withdrawn Pharma Inhibition, Inhibitor, inhibitor, Target 5-lipoxygenase (5-LOX) inhibitor, orally active 20
Montelukast Approved Pharma Antagonist, Target, other/unknown 264
Balsalazide Approved, Investigational Pharma inhibitor, Target 7
Meclofenamic acid Approved Pharma inhibitor, Target 1
Mesalazine Approved Pharma inhibitor, Target 0

(95) Additional Compounds for ALOX5 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Hpete
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-HPETE
74581-83-2
MK 886
118414-82-7
4'-Hydroxydiclofenac
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
64118-84-9
5(S)-Hydroperoxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
71774-08-8
9(S)-HPODE

(5) Tocris Compounds for ALOX5 Gene

Compound Action Cas Number
2-TEDC 5-, 12-, 15-Lipoxygenase inhibitor 132465-10-2
Baicalein 5- and 12-Lipoxygenase inhibitor 491-67-8
BW-B 70C 5-Lipoxygenase inhibitor 134470-38-5
MK 886 Inhibitor of 5-lipoxygenase-activating protein (FLAP) 118414-82-7
STEARDA Endogenous lipid, active in vivo. Enhances effects of endovanilloids at TRPV1 receptors 105955-10-0

(2) ApexBio Compounds for ALOX5 Gene

Compound Action Cas Number
Malotilate Tyrosine kinase inhibitors 59937-28-9
Zileuton 5-lipoxygenase (5-LOX) inhibitor, orally active 111406-87-2
genes like me logo Genes that share compounds with ALOX5: view

Drug Products

Transcripts for ALOX5 Gene

Unigene Clusters for ALOX5 Gene

Arachidonate 5-lipoxygenase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALOX5 Gene

No ASD Table

Relevant External Links for ALOX5 Gene

GeneLoc Exon Structure for
ALOX5
ECgene alternative splicing isoforms for
ALOX5

Expression for ALOX5 Gene

mRNA expression in normal human tissues for ALOX5 Gene

mRNA differential expression in normal tissues according to GTEx for ALOX5 Gene

This gene is overexpressed in Whole Blood (x28.6).

Protein differential expression in normal tissues from HIPED for ALOX5 Gene

This gene is overexpressed in Lymph node (23.1) and Peripheral blood mononuclear cells (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALOX5 Gene



SOURCE GeneReport for Unigene cluster for ALOX5 Gene Hs.89499

genes like me logo Genes that share expression patterns with ALOX5: view

Protein tissue co-expression partners for ALOX5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ALOX5 Gene

Orthologs for ALOX5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALOX5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ALOX5 35
  • 90.11 (n)
  • 91.99 (a)
ALOX5 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALOX5 35
  • 90.16 (n)
  • 93.62 (a)
ALOX5 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alox5 35
  • 87.88 (n)
  • 93.47 (a)
Alox5 16
Alox5 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ALOX5 35
  • 97.42 (n)
  • 97.02 (a)
ALOX5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alox5 35
  • 86.29 (n)
  • 92.94 (a)
oppossum
(Monodelphis domestica)
Mammalia ALOX5 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALOX5 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves ALOX5 35
  • 76.85 (n)
  • 83.68 (a)
ALOX5 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALOX5 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia alox5 35
  • 71.07 (n)
  • 78.19 (a)
zebrafish
(Danio rerio)
Actinopterygii alox5a 35
  • 70.18 (n)
  • 74.63 (a)
ALOX5 (1 of 4) 36
  • 58 (a)
OneToMany
alox5a 36
  • 74 (a)
OneToMany
alox5b.2 36
  • 57 (a)
OneToMany
alox5b.3 36
  • 59 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LOX5 35
  • 44.58 (n)
  • 33.73 (a)
rice
(Oryza sativa)
Liliopsida Os03g0699700 35
  • 46.5 (n)
  • 34.31 (a)
corn
(Zea mays)
Liliopsida Zm.14487 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
CSA.6148 36
  • 35 (a)
ManyToMany
Species with no ortholog for ALOX5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALOX5 Gene

ENSEMBL:
Gene Tree for ALOX5 (if available)
TreeFam:
Gene Tree for ALOX5 (if available)

Paralogs for ALOX5 Gene

Paralogs for ALOX5 Gene

(5) SIMAP similar genes for ALOX5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ALOX5: view

Variants for ALOX5 Gene

Sequence variations from dbSNP and Humsavar for ALOX5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_028018 -

Structural Variations from Database of Genomic Variants (DGV) for ALOX5 Gene

Variant ID Type Subtype PubMed ID
nsv895105 CNV Gain 21882294
nsv895107 CNV Loss 21882294
nsv466910 CNV Loss 19166990
dgv651n71 CNV Gain 21882294
esv2567160 CNV Deletion 19546169
nsv895110 CNV Loss 21882294
esv2513283 CNV Deletion 19546169

Variation tolerance for ALOX5 Gene

Residual Variation Intolerance Score: 8.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALOX5 Gene

HapMap Linkage Disequilibrium report
ALOX5
Human Gene Mutation Database (HGMD)
ALOX5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALOX5 Gene

Disorders for ALOX5 Gene

MalaCards: The human disease database

(15) MalaCards diseases for ALOX5 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, protection against
arthus reaction
  • arthus phenomenon
paranasal sinus disease
  • disorder of nasal sinus
atherosclerosis
  • arteriosclerosis
pleurisy
- elite association - COSMIC cancer census association via MalaCards
Search ALOX5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ALOX5

Genetic Association Database (GAD)
ALOX5
Human Genome Epidemiology (HuGE) Navigator
ALOX5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALOX5
genes like me logo Genes that share disorders with ALOX5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALOX5 Gene

Publications for ALOX5 Gene

  1. Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PMID: 15308583) Goodman J.E. … Harris C.C. (Carcinogenesis 2004) 3 4 48 67
  2. Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis. (PMID: 19645854) Zouboulis C.C. … Alestas T. (Exp. Dermatol. 2010) 23 25 26
  3. Zileuton, a new efficient and safe systemic anti-acne drug. (PMID: 20436887) Zouboulis C.C. (Dermatoendocrinol 2009) 23 25 26
  4. Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease. (PMID: 17394438) Berger W. … Cairns C.B. (Int. J. Clin. Pract. 2007) 23 25 26
  5. N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity. (PMID: 16531984) Taccone-Gallucci M. … Maccarrone M. (Kidney Int. 2006) 3 25 26

Products for ALOX5 Gene

Sources for ALOX5 Gene

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