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Aliases for ALOX5 Gene

Aliases for ALOX5 Gene

  • Arachidonate 5-Lipoxygenase 2 3
  • EC 1.13.11.34 4 64
  • 5-LO 3 4
  • LOG5 3 4
  • Arachidonic 5-Lipoxygenase Delta-10-13 Isoform 3
  • Arachidonic 5-Lipoxygenase Delta-P10 Isoform 3
  • Arachidonic 5-Lipoxygenase Alpha-10 Isoform 3
  • Arachidonic 5-Lipoxygenase Delta-13 Isoform 3
  • Arachidonic Acid 5-Lipoxygenase 3
  • Leukotriene A4 Synthase 3
  • 5-Lipoxygenase 4
  • EC 1.13.11 64
  • 5-LOX 3
  • LOX-5 3
  • 5LPG 3

External Ids for ALOX5 Gene

Summaries for ALOX5 Gene

Entrez Gene Summary for ALOX5 Gene

  • This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for ALOX5 Gene

ALOX5 (Arachidonate 5-Lipoxygenase) is a Protein Coding gene. Diseases associated with ALOX5 include asthma and atherosclerosis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include iron ion binding and arachidonate 5-lipoxygenase activity. An important paralog of this gene is ALOX12.

UniProtKB/Swiss-Prot for ALOX5 Gene

  • Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

Tocris Summary for ALOX5 Gene

  • Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1 have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation, growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma, atherosclerosis, osteoporosis and some cancers.

Gene Wiki entry for ALOX5 Gene

PharmGKB "VIP" Summary for ALOX5 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for ALOX5 Gene

Genomics for ALOX5 Gene

Genomic Location for ALOX5 Gene

Start:
45,374,176 bp from pter
End:
45,446,119 bp from pter
Size:
71,944 bases
Orientation:
Plus strand

Genomic View for ALOX5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALOX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALOX5 Gene

Regulatory Elements for ALOX5 Gene

Proteins for ALOX5 Gene

  • Protein details for ALOX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09917-LOX5_HUMAN
    Recommended name:
    Arachidonate 5-lipoxygenase
    Protein Accession:
    P09917
    Secondary Accessions:
    • B7ZLS0
    • E5FPY5
    • E5FPY7
    • E5FPY8
    • Q5JQ14

    Protein attributes for ALOX5 Gene

    Size:
    674 amino acids
    Molecular mass:
    77983 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 2 calcium ions per subunit.;
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 1 Fe cation per subunit.;
    Quaternary structure:
    • Interacts with ALOX5AP and LTC4S. Interacts with COTL1, the interaction is required for stability and efficient catalytic activity.

    Three dimensional structures from OCA and Proteopedia for ALOX5 Gene

    Alternative splice isoforms for ALOX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALOX5 Gene

Proteomics data for ALOX5 Gene at MOPED

Post-translational modifications for ALOX5 Gene

  • Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALOX5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ALOX5 Gene

Gene Families for ALOX5 Gene

HGNC:
  • ALOX :Arachidonate lipoxygenases
IUPHAR :

UniProtKB/Swiss-Prot:

LOX5_HUMAN
Domain:
  • Contains 1 lipoxygenase domain.:
    • P09917
  • Contains 1 PLAT domain.:
    • P09917
Family:
  • Belongs to the lipoxygenase family.:
    • P09917
genes like me logo Genes that share domains with ALOX5: view

Function for ALOX5 Gene

Molecular function for ALOX5 Gene

GENATLAS Biochemistry: arachidonate-5-lipoxygenase,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling,carcinogenesis,atheroma and asthma formation,involved in leukotriene metabolism
UniProtKB/Swiss-Prot CatalyticActivity: Arachidonate + O(2) = leukotriene A(4) + H(2)O.
UniProtKB/Swiss-Prot Function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

Enzyme Numbers (IUBMB) for ALOX5 Gene

Gene Ontology (GO) - Molecular Function for ALOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004051 arachidonate 5-lipoxygenase activity IDA 21233389
GO:0005506 iron ion binding IDA 21233389
GO:0005515 protein binding IPI 11297527
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ALOX5: view
genes like me logo Genes that share phenotypes with ALOX5: view

Animal Models for ALOX5 Gene

MGI Knock Outs for ALOX5:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ALOX5 Gene

Localization for ALOX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALOX5 Gene

Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALOX5 Gene COMPARTMENTS Subcellular localization image for ALOX5 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ALOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus --
GO:0005635 nuclear envelope TAS --
GO:0005641 nuclear envelope lumen IDA 8245774
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with ALOX5: view

Pathways for ALOX5 Gene

genes like me logo Genes that share pathways with ALOX5: view

UniProtKB/Swiss-Prot P09917-LOX5_HUMAN

  • Pathway: Lipid metabolism; leukotriene A4 biosynthesis

Gene Ontology (GO) - Biological Process for ALOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002540 leukotriene production involved in inflammatory response IEA --
GO:0006691 leukotriene metabolic process TAS --
GO:0006954 inflammatory response --
GO:0019369 arachidonic acid metabolic process TAS --
GO:0019370 leukotriene biosynthetic process IDA 21233389
genes like me logo Genes that share ontologies with ALOX5: view

Compounds for ALOX5 Gene

(5) Tocris Compounds for ALOX5 Gene

Compound Action Cas Number
Baicalein 5- and 12-Lipoxygenase inhibitor [491-67-8]
BAY-X 1005 Orally active 5-lipoxygenase activating protein (FLAP) inhibitor [128253-31-6]
BW-B 70C 5-Lipoxygenase inhibitor [134470-38-5]
MK 886 Inhibitor of 5-lipoxygenase-activating protein (FLAP) [118414-82-7]
Zileuton Orally active 5-LOX inhibitor [111406-87-2]

(12) HMDB Compounds for ALOX5 Gene

Compound Synonyms Cas Number PubMed IDs
18R-HEPE
  • 18(R)-hydroxyeicosa-5Z,8Z,11E,14Z,16E-pentaenoate
Not Available
5(S)-Hydroperoxyeicosatetraenoic acid
  • 5-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
71774-08-8
5-HPETE
  • 5(S)-HPETE
74581-83-2
9(S)-HPODE
Not Available
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1

(14) Drugbank Compounds for ALOX5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aminosalicylic Acid
  • 4-aminosalicylic acid
65-49-6 target inhibitor
Balsalazide
  • Balsalazida [Spanish]
80573-04-2 target inhibitor
Diclofenac
  • Diclofenac Acid
15307-86-5 target potentiator
Diethylcarbamazine
  • Carbamazine
90-89-1 target inhibitor
Heme
target

(3) IUPHAR Ligand for ALOX5 Gene

Ligand Type Action Affinity Pubmed IDs
zileuton Inhibitor Inhibition
5-LOX activating protein Activator Activation
CJ13610 Inhibitor Inhibition

(144) Novoseek inferred chemical compound relationships for ALOX5 Gene

Compound -log(P) Hits PubMed IDs
leukotriene b4 95.7 151
zileuton 95.7 122
arachidonic acid 94 216
5-hydroxyeicosatetraenoic acid 92.8 36
mk 886 91.1 44

(1) PharmGKB related drug/compound annotations for ALOX5 Gene

Drug/compound Annotation
montelukast CA
genes like me logo Genes that share compounds with ALOX5: view

Transcripts for ALOX5 Gene

Unigene Clusters for ALOX5 Gene

Arachidonate 5-lipoxygenase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALOX5 Gene

No ASD Table

Relevant External Links for ALOX5 Gene

GeneLoc Exon Structure for
ALOX5
ECgene alternative splicing isoforms for
ALOX5

Expression for ALOX5 Gene

mRNA expression in normal human tissues for ALOX5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALOX5 Gene

This gene is overexpressed in Whole Blood (28.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALOX5 Gene

SOURCE GeneReport for Unigene cluster for ALOX5 Gene Hs.89499

genes like me logo Genes that share expressions with ALOX5: view

Orthologs for ALOX5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALOX5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALOX5 36
  • 97.42 (n)
  • 97.02 (a)
ALOX5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALOX5 36
  • 90.11 (n)
  • 91.99 (a)
ALOX5 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALOX5 36
  • 90.16 (n)
  • 93.62 (a)
ALOX5 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alox5 36
  • 87.88 (n)
  • 93.47 (a)
Alox5 16
Alox5 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALOX5 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALOX5 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alox5 36
  • 86.29 (n)
  • 92.94 (a)
chicken
(Gallus gallus)
Aves ALOX5 36
  • 76.85 (n)
  • 83.68 (a)
ALOX5 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALOX5 37
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia alox5 36
  • 71.07 (n)
  • 78.19 (a)
zebrafish
(Danio rerio)
Actinopterygii ALOX5 (1 of 4) 37
  • 58 (a)
OneToMany
alox5a 36
  • 70.18 (n)
  • 74.63 (a)
alox5a 37
  • 74 (a)
OneToMany
alox5b.2 37
  • 57 (a)
OneToMany
alox5b.3 37
  • 59 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LOX5 36
  • 44.58 (n)
  • 33.73 (a)
corn
(Zea mays)
Liliopsida Zm.14487 36
rice
(Oryza sativa)
Liliopsida Os03g0699700 36
  • 46.5 (n)
  • 34.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 31 (a)
ManyToMany
-- 37
  • 38 (a)
ManyToMany
-- 37
  • 32 (a)
ManyToMany
CSA.6148 37
  • 35 (a)
ManyToMany
Species with no ortholog for ALOX5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALOX5 Gene

ENSEMBL:
Gene Tree for ALOX5 (if available)
TreeFam:
Gene Tree for ALOX5 (if available)

Paralogs for ALOX5 Gene

Paralogs for ALOX5 Gene

Selected SIMAP similar genes for ALOX5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ALOX5: view

Variants for ALOX5 Gene

Sequence variations from dbSNP and Humsavar for ALOX5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs702365 -- 45,438,883(+) CTCCT(C/G)CCTCC intron-variant
rs702366 -- 45,438,924(+) CTTCT(A/G)GGGTC intron-variant
rs745986 -- 45,383,460(+) CCTTC(A/G)GCTTG intron-variant
rs892689 -- 45,381,856(-) ATTTA(C/G)CCAAG intron-variant
rs892690 -- 45,375,240(-) CCCTC(A/G)CGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALOX5 Gene

Variant ID Type Subtype PubMed ID
nsv895105 CNV Gain 21882294
nsv895107 CNV Loss 21882294
nsv466910 CNV Loss 19166990
dgv651n71 CNV Gain 21882294
esv2567160 CNV Deletion 19546169
nsv895110 CNV Loss 21882294
esv2513283 CNV Deletion 19546169

Relevant External Links for ALOX5 Gene

HapMap Linkage Disequilibrium report
ALOX5
Human Gene Mutation Database (HGMD)
ALOX5

Disorders for ALOX5 Gene

(1) OMIM Diseases for ALOX5 Gene (152390)

(5) University of Copenhagen DISEASES for ALOX5 Gene

(94) Novoseek inferred disease relationships for ALOX5 Gene

Disease -log(P) Hits PubMed IDs
asthma 72.7 139
inflammation 68.1 100
leukemia basophilic 60.2 13
asthma exercise-induced 59.4 5
ear edema 59.3 4

Relevant External Links for ALOX5

Genetic Association Database (GAD)
ALOX5
Human Genome Epidemiology (HuGE) Navigator
ALOX5
genes like me logo Genes that share disorders with ALOX5: view

No data available for UniProtKB/Swiss-Prot for ALOX5 Gene

Publications for ALOX5 Gene

  1. Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5- lipoxygenase. (PMID: 1939225) Nguyen T. … Riendeau D. (J. Biol. Chem. 1991) 3 4 23
  2. Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser- 271 by MAPK-activated protein kinase 2 (MK2). (PMID: 11844797) Werz O. … Radmark O. (J. Biol. Chem. 2002) 3 4 23
  3. 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. (PMID: 8245774) Woods J.W. … Singer I.I. (J. Exp. Med. 1993) 3 4 23
  4. Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population. (PMID: 12911785) Sayers I. … Holgate S.T. (Clin. Exp. Allergy 2003) 3 23 49
  5. Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. (PMID: 14749922) Choi J.H. … Shin H.D. (Hum. Genet. 2004) 3 23 49

Products for ALOX5 Gene

Sources for ALOX5 Gene

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