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Aliases for MTCH2 Gene

Aliases for MTCH2 Gene

  • Mitochondrial Carrier 2 2 3
  • Met-Induced Mitochondrial Protein 3 4
  • MIMP 3 4
  • Mitochondrial Carrier Homolog 2 (C. Elegans) 2
  • Solute Carrier Family 25, Member 50 3
  • Mitochondrial Carrier Homolog 2 3
  • Solute Carrier Family 25 2
  • 2310034D24Rik 3
  • Member 50 2
  • SLC25A50 3
  • HSPC032 3

External Ids for MTCH2 Gene

Previous GeneCards Identifiers for MTCH2 Gene

  • GC11U990208
  • GC11M048517
  • GC11M047670
  • GC11M047604
  • GC11M047600
  • GC11M047595
  • GC11M047639
  • GC11M047341
  • GC11M047745
  • GC11M048081
  • GC11M048804
  • GC11M049909

Summaries for MTCH2 Gene

GeneCards Summary for MTCH2 Gene

MTCH2 (Mitochondrial Carrier 2) is a Protein Coding gene. An important paralog of this gene is MTCH1.

UniProtKB/Swiss-Prot for MTCH2 Gene

  • The substrate transported is not yet known. Induces mitochondrial depolarization

Gene Wiki entry for MTCH2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTCH2 Gene

Genomics for MTCH2 Gene

Regulatory Elements for MTCH2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MTCH2 Gene

47,617,306 bp from pter
47,642,654 bp from pter
25,349 bases
Minus strand

Genomic View for MTCH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTCH2 Gene

Proteins for MTCH2 Gene

  • Protein details for MTCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial carrier homolog 2
    Protein Accession:
    Secondary Accessions:
    • B2R7L8

    Protein attributes for MTCH2 Gene

    303 amino acids
    Molecular mass:
    33331 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTCH2 Gene

Proteomics data for MTCH2 Gene at MOPED

Post-translational modifications for MTCH2 Gene

  • Ubiquitination at Lys90, Lys100, Lys122, Lys293, and Lys300
  • Modification sites at PhosphoSitePlus

Other Protein References for MTCH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MTCH2 Gene

Domains for MTCH2 Gene

Gene Families for MTCH2 Gene

  • SLC :Solute carriers

Protein Domains for MTCH2 Gene

Suggested Antigen Peptide Sequences for MTCH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y6C9
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 2 Solcar repeats.
genes like me logo Genes that share domains with MTCH2: view

Function for MTCH2 Gene

Molecular function for MTCH2 Gene

UniProtKB/Swiss-Prot Function:
The substrate transported is not yet known. Induces mitochondrial depolarization

Animal Model Products

CRISPR Products

miRNA for MTCH2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTCH2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTCH2 Gene

Localization for MTCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTCH2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MTCH2 Gene COMPARTMENTS Subcellular localization image for MTCH2 gene
Compartment Confidence
mitochondrion 5
extracellular 2
cytosol 1
lysosome 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MTCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with MTCH2: view

Pathways for MTCH2 Gene

SuperPathways for MTCH2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0070585 protein localization to mitochondrion IMP 23744079
GO:0097284 hepatocyte apoptotic process IEA --
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process IEA --
genes like me logo Genes that share ontologies with MTCH2: view

No data available for Pathways by source for MTCH2 Gene

Transcripts for MTCH2 Gene

Unigene Clusters for MTCH2 Gene

Mitochondrial carrier 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTCH2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTCH2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5: - -

Relevant External Links for MTCH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTCH2 Gene

mRNA expression in normal human tissues for MTCH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MTCH2 Gene

This gene is overexpressed in Nasal epithelium (31.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTCH2 Gene

SOURCE GeneReport for Unigene cluster for MTCH2 Gene Hs.269944

genes like me logo Genes that share expressions with MTCH2: view

Expression partners for MTCH2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MTCH2 Gene

Orthologs for MTCH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTCH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MTCH2 35
  • 92.63 (n)
  • 94.39 (a)
MTCH2 36
  • 94 (a)
(Canis familiaris)
Mammalia MTCH2 35
  • 94.33 (n)
  • 94.56 (a)
-- 36
  • 82 (a)
-- 36
  • 75 (a)
(Mus musculus)
Mammalia Mtch2 35
  • 91.09 (n)
  • 93.73 (a)
Mtch2 16
Mtch2 36
  • 94 (a)
(Pan troglodytes)
Mammalia MTCH2 35
  • 100 (n)
  • 100 (a)
MTCH2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mtch2 35
  • 90.87 (n)
  • 92.41 (a)
(Monodelphis domestica)
Mammalia MTCH2 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia MTCH2 36
  • 77 (a)
(Gallus gallus)
Aves MTCH2 35
  • 70.41 (n)
  • 80.27 (a)
MTCH2 36
  • 79 (a)
(Anolis carolinensis)
Reptilia MTCH2 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76005 35
mtch2 35
  • 68.81 (n)
  • 71.86 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC64562 35
(Danio rerio)
Actinopterygii mtch2 35
  • 66.78 (n)
  • 70.37 (a)
mtch2 36
  • 68 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.100 35
fruit fly
(Drosophila melanogaster)
Insecta CG10920 37
  • 34 (a)
Mtch 37
  • 38 (a)
Mtch 35
  • 46.64 (n)
  • 40.68 (a)
CG10920 36
  • 24 (a)
Mtch 36
  • 34 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006963 35
  • 47.02 (n)
  • 40.3 (a)
(Caenorhabditis elegans)
Secernentea mtch-1 35
  • 43.35 (n)
  • 30.74 (a)
mtch-1 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10453 36
  • 35 (a)
Species with no ortholog for MTCH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTCH2 Gene

Gene Tree for MTCH2 (if available)
Gene Tree for MTCH2 (if available)

Paralogs for MTCH2 Gene

Paralogs for MTCH2 Gene

Selected SIMAP similar genes for MTCH2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MTCH2: view

Variants for MTCH2 Gene

Sequence variations from dbSNP and Humsavar for MTCH2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs9089 -- 47,617,511(-) CTTCC(C/T)TCCCC utr-variant-3-prime
rs1056027 -- 47,627,766(-) atgct(G/T)taatc intron-variant
rs1064608 - 47,618,877(-) AGGTC(C/G)CCTTT reference, missense, utr-variant-3-prime
rs1568166 -- 47,643,639(+) AAAGG(A/C)ATTGT upstream-variant-2KB
rs3817334 -- 47,629,441(+) AAAGA(C/T)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTCH2 Gene

Variant ID Type Subtype PubMed ID
nsv832142 CNV Loss 17160897
nsv825872 CNV Gain 20364138
nsv509405 CNV Insertion 20534489
esv2744440 CNV Deletion 23290073
nsv469858 CNV Gain 16826518
nsv69 CNV Insertion 15895083
nsv315 CNV Insertion 18451855
esv995881 CNV Insertion 20482838
esv998557 CNV Insertion 20482838
esv1465053 CNV Insertion 17803354

Relevant External Links for MTCH2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTCH2 Gene

Disorders for MTCH2 Gene

Relevant External Links for MTCH2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MTCH2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MTCH2 Gene

Publications for MTCH2 Gene

  1. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K. … Nakamura Y. (J. Hum. Genet. 2009) 3 23 48
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization. (PMID: 12407445) Yerushalmi G.M. … Tsarfaty I. (Neoplasia 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (PMID: 19079261) Willer C.J. … Hirschhorn J.N. (Nat. Genet. 2009) 3 48

Products for MTCH2 Gene

Sources for MTCH2 Gene

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