Aliases for MTCH2 Gene
Aliases for MTCH2 Gene
External Ids for MTCH2 Gene
- HGNC: 17587
- Entrez Gene: 23788
- Ensembl: ENSG00000109919
- OMIM: 613221
- UniProtKB: Q9Y6C9
Previous GeneCards Identifiers for MTCH2 Gene
- GC11U990208
- GC11M048517
- GC11M047670
- GC11M047604
- GC11M047600
- GC11M047595
- GC11M047639
- GC11M047341
- GC11M047745
- GC11M048081
- GC11M048804
- GC11M049909
- GC11M047855
- GC11M047959
- GC11M050806
- GC11M051601
- GC11M052263
- GC11M052923
- GC11M053591
Summaries for MTCH2 Gene
-
This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]
GeneCards Summary for MTCH2 Gene
MTCH2 (Mitochondrial Carrier 2) is a Protein Coding gene. An important paralog of this gene is MTCH1.
UniProtKB/Swiss-Prot for MTCH2 Gene
-
The substrate transported is not yet known. Induces mitochondrial depolarization.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTCH2 Gene
Genomics for MTCH2 Gene
GeneHancer (GH) Regulatory Elements for MTCH2 Gene
Promoters and enhancers for MTCH2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MTCH2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MTCH2 Gene
Genomic Locations for MTCH2 Gene
- chr11:47,605,204-47,642,654
- (GRCh38/hg38)
- Size:
- 37,451 bases
- Orientation:
- Minus strand
- chr11:47,638,858-47,664,206
- (GRCh37/hg19)
Genomic View for MTCH2 Gene
Genes around MTCH2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by Ensembl
- 11p11.2 by Entrez Gene
- 11p11.2 by HGNC
MTCH2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MTCH2 Gene
Proteins for MTCH2 Gene
-
Protein details for MTCH2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6C9-MTCH2_HUMAN
- Recommended name:
- Mitochondrial carrier homolog 2
- Protein Accession:
- Q9Y6C9
- B2R7L8
Protein attributes for MTCH2 Gene
- Size:
- 303 amino acids
- Molecular mass:
- 33331 Da
- Quaternary structure:
- No Data Available
Protein Expression for MTCH2 Gene
Post-translational modifications for MTCH2 Gene
- Ubiquitination at Lys90, Lys100, isoforms=122, isoforms=293, and isoforms=300
Other Protein References for MTCH2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MTCH2
- Novus Biologicals Antibodies for MTCH2
-
Abcam antibodies for MTCH2
- Invitrogen Antibodies for MTCH2
- GeneTex MTCH2 antibody for MTCH2
Protein Products
-
OriGene Purified Proteins for MTCH2
- Search Origene for MassSpec and Protein Over-expression Lysates for MTCH2
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- antibodies-online: Search results for 4 available MTCH2 Proteins ranked by validation data
- Compare Top MTCH2 Proteins
-
Quality Products:
- GeneTex Proteins for MTCH2
-
Abcam proteins for MTCH2
Assay Products
No data available for DME Specific Peptides for MTCH2 Gene
Domains & Families for MTCH2 Gene
Gene Families for MTCH2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for MTCH2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MTCH2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y6C9- Family:
-
- Belongs to the mitochondrial carrier (TC 2.A.29) family.
Function for MTCH2 Gene
Molecular function for MTCH2 Gene
- UniProtKB/Swiss-Prot Function:
- The substrate transported is not yet known. Induces mitochondrial depolarization.
Phenotypes From GWAS Catalog for MTCH2 Gene
Phenotypes for MTCH2 Gene
- MGI mutant phenotypes for MTCH2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for MTCH2:
Animal Models for MTCH2 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for MTCH2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTCH2 gene
- Search ViGene Biosciences for MTCH2
CRISPR Products
-
OriGene CRISPR knockouts for MTCH2
- genomics-online: gRNA clones - Search results for 126 available MTCH2 gene related products
- Overview of 126 available MTCH2 gene related products
- Applied Biological Materials CRISPR for MTCH2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTCH2
- GenScript: Design CRISPR guide RNA sequences for MTCH2
miRNA for MTCH2 Gene
- miRTarBase miRNAs that target MTCH2
miRNA Products
- Search ViGene Biosciences for MTCH2
Inhibitory RNA Products
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- Overview of 126 available MTCH2 gene related products
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Clone Products
- Sino Biological Human cDNA Clone for MTCH2
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTCH2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MTCH2
- Applied Biological Materials Clones for MTCH2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MTCH2
-
ViGene Biosciences adenoviral particle packaged cDNA for MTCH2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MTCH2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTCH2 gene
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTCH2 Gene
Localization for MTCH2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MTCH2 Gene
- Mitochondrion inner membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| plasma membrane | 1 |
| peroxisome | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Mitochondria (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005739 | mitochondrion | IBA | -- |
| GO:0005743 | mitochondrial inner membrane | IEA | -- |
| GO:0016020 | membrane | IBA,IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for MTCH2 Gene
No Data Available
Interacting Proteins for MTCH2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0043065 | positive regulation of apoptotic process | IBA | -- |
| GO:0070585 | protein localization to mitochondrion | IMP | 23744079 |
No data available for Pathways by source for MTCH2 Gene
Transcripts for MTCH2 Gene
mRNA/cDNA for MTCH2 Gene
- (10) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (420) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MTCH2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MTCH2
- genomics-online: gRNA clones - Search results for 126 available MTCH2 gene related products
- Overview of 126 available MTCH2 gene related products
- Applied Biological Materials CRISPR for MTCH2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTCH2
- GenScript: Design CRISPR guide RNA sequences for MTCH2
miRNA Products
- Search ViGene Biosciences for MTCH2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MTCH2
- Browse OriGene Inhibitory RNA Products For MTCH2
- genomics-online: shRNA clones - Search results for 126 available MTCH2 gene related products
- Overview of 126 available MTCH2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MTCH2 gene
Clone Products
- Sino Biological Human cDNA Clone for MTCH2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MTCH2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTCH2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MTCH2
- Applied Biological Materials Clones for MTCH2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||
| SP6: |
Expression for MTCH2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Nasal epithelium (31.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTCH2 Gene
NURSA nuclear receptor signaling pathways regulating expression of MTCH2 Gene:
MTCH2SOURCE GeneReport for Unigene cluster for MTCH2 Gene:
Hs.269944Evidence on tissue expression from TISSUES for MTCH2 Gene
- Nervous system(4.9)
- Liver(4.5)
- Blood(4.2)
- Kidney(2.6)
Primer Products
-
OriGene qPCR primer pairs for MTCH2
-
OriGene qPCR primer pairs and template standards for MTCH2
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTCH2 Gene
Orthologs for MTCH2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MTCH2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MTCH2 33 |
|
||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | MTCH2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mtch2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mtch2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MTCH2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MTCH2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MTCH2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MTCH2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mtch2 33 |
|
||
| MGC76005 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC64562 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mtch2 33 34 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.100 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006963 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Mtch 35 33 34 |
|
||
| CG10920 35 34 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | mtch-1 33 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10453 34 |
|
OneToMany |
- Species where no ortholog for MTCH2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MTCH2 Gene
(2) SIMAP similar genes for MTCH2 Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for MTCH2 Gene
Variants for MTCH2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000040260 | -- | 47,638,235(-) | A/G | intron_variant | |
| rs1000113549 | -- | 47,637,849(-) | A/C | intron_variant | |
| rs1000149005 | -- | 47,626,712(-) | C/T | intron_variant | |
| rs1000179993 | -- | 47,610,391(-) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000290449 | -- | 47,617,694(-) | G/A | 3_prime_UTR_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1465053 | CNV | insertion | 17803354 |
| esv2744440 | CNV | deletion | 23290073 |
| esv3626206 | CNV | loss | 21293372 |
| esv995881 | CNV | insertion | 20482838 |
| esv998557 | CNV | insertion | 20482838 |
| nsv315 | CNV | insertion | 18451855 |
| nsv469858 | CNV | gain | 16826518 |
| nsv509405 | CNV | insertion | 20534489 |
| nsv69 | CNV | insertion | 15895083 |
| nsv825872 | CNV | gain | 20364138 |
| nsv832142 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.52;
88.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MTCH2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTCH2 Gene
Disorders for MTCH2 Gene
Additional Disease Information for MTCH2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MTCH2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTCH2 Gene
Publications for MTCH2 Gene
- Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K … Nakamura Y (Journal of human genetics 2009) 3 22 44 58
- Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus. (PMID: 19910641) He M … Qi L (Arteriosclerosis, thrombosis, and vascular biology 2010) 3 44 58
- Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B … Franks PW (Diabetologia 2010) 3 44 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
- Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. (PMID: 19812171) Li S … Loos RJ (The American journal of clinical nutrition 2010) 3 44 58
Products for MTCH2 Gene
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- Invitrogen Antibodies for MTCH2
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- VectorBuilder custom plasmid, inducible vectors for MTCH2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTCH2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MTCH2
- antibodies-online: Search results for 51 available MTCH2 Antibodies ranked by validation data
- Compare Top MTCH2 Antibodies
- Quality Products:
- antibodies-online: Search results for available MTCH2 related products ranked by validation data
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- Overview of 126 available MTCH2 gene related products
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- Overview of 126 available MTCH2 gene related products
Sources for MTCH2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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