Aliases for MTCH2 Gene
Aliases for MTCH2 Gene
External Ids for MTCH2 Gene
- HGNC: 17587
- Entrez Gene: 23788
- Ensembl: ENSG00000109919
- OMIM: 613221
- UniProtKB: Q9Y6C9
Previous GeneCards Identifiers for MTCH2 Gene
- GC11U990208
- GC11M048517
- GC11M047670
- GC11M047604
- GC11M047600
- GC11M047595
- GC11M047639
- GC11M047341
- GC11M047745
- GC11M048081
- GC11M048804
- GC11M049909
- GC11M047855
- GC11M047959
- GC11M050806
- GC11M051601
- GC11M052263
Summaries for MTCH2 Gene
-
This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA can give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]
GeneCards Summary for MTCH2 Gene
MTCH2 (Mitochondrial Carrier 2) is a Protein Coding gene. Diseases associated with MTCH2 include Obesity. An important paralog of this gene is MTCH1.
UniProtKB/Swiss-Prot for MTCH2 Gene
-
The substrate transported is not yet known. Induces mitochondrial depolarization.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTCH2 Gene
Genomics for MTCH2 Gene
Regulatory Elements for MTCH2 Gene
Enhancers for MTCH2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MTCH2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MTCH2 gene promoter:
Regulatory Element Products
Genomic Location for MTCH2 Gene
- Chromosome:
- 11
- Start:
- 47,605,204 bp from pter
- End:
- 47,642,654 bp from pter
- Size:
- 37,451 bases
- Orientation:
- Minus strand
Genomic View for MTCH2 Gene
Genes around MTCH2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by Ensembl
- 11p11.2 by Entrez Gene
- 11p11.2 by HGNC
MTCH2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MTCH2 Gene
Proteins for MTCH2 Gene
-
Protein details for MTCH2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6C9-MTCH2_HUMAN
- Recommended name:
- Mitochondrial carrier homolog 2
- Protein Accession:
- Q9Y6C9
- B2R7L8
Protein attributes for MTCH2 Gene
- Size:
- 303 amino acids
- Molecular mass:
- 33331 Da
- Quaternary structure:
- No Data Available
Protein Expression for MTCH2 Gene
Post-translational modifications for MTCH2 Gene
Other Protein References for MTCH2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for MTCH2
-
Custom Antibody ServicesOriGene Antibodies for MTCH2
- Novus Biologicals Antibodies for MTCH2
-
Abcam antibodies for MTCH2
- Invitrogen Antibodies for MTCH2
- antibodies-online Antibodies for MTCH2: See all 44
- GeneTex MTCH2 antibody for MTCH2
Protein Products
-
OriGene Purified Proteins for MTCH2
- Search Origene for MassSpec and Protein Over-expression Lysates for MTCH2
- Origene Custom Protein Services for MTCH2
- antibodies-online Proteins for MTCH2: See all 4
- Search antibodies-online for peptides
- GeneTex Proteins for MTCH2
Assay Products
No data available for DME Specific Peptides for MTCH2 Gene
Domains & Families for MTCH2 Gene
Gene Families for MTCH2 Gene
- HGNC:
Protein Domains for MTCH2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MTCH2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y6C9- Family:
-
- Belongs to the mitochondrial carrier (TC 2.A.29) family.
Function for MTCH2 Gene
Molecular function for MTCH2 Gene
- UniProtKB/Swiss-Prot Function:
- The substrate transported is not yet known. Induces mitochondrial depolarization.
Phenotypes for MTCH2 Gene
- MGI mutant phenotypes for MTCH2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for MTCH2:
Animal Models for MTCH2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for MTCH2
-
ViGene Biosciences lentiviral particle packaged cDNA for MTCH2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTCH2 gene
- Search ViGene Biosciences for MTCH2
CRISPR Products
-
OriGene CRISPR knockouts for MTCH2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTCH2
- GenScript: Design CRISPR guide RNA sequences for MTCH2
miRNA for MTCH2 Gene
- miRTarBase miRNAs that target MTCH2
miRNA Products
- Search ViGene Biosciences for MTCH2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MTCH2
- Browse OriGene Inhibitory RNA Products For MTCH2
-
ViGene Biosciences ready-to-package AAV shRNAs for MTCH2 gene
Clone Products
-
OriGene ORF clones in human for MTCH2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MTCH2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for MTCH2
-
ViGene Biosciences adenoviral particle packaged cDNA for MTCH2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MTCH2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTCH2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTCH2 Gene
Localization for MTCH2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MTCH2 Gene
- Mitochondrion inner membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| plasma membrane | 1 |
| peroxisome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 21630459 |
| GO:0005739 | mitochondrion | IBA,IEA | -- |
| GO:0005741 | mitochondrial outer membrane | IEA | -- |
| GO:0005743 | mitochondrial inner membrane | IEA | -- |
| GO:0016020 | membrane | IEA,IDA | 19946888 |
Pathways & Interactions for MTCH2 Gene
No Data Available
Interacting Proteins for MTCH2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006089 | lactate metabolic process | IEA | -- |
| GO:0006810 | transport | IEA | -- |
| GO:0010917 | negative regulation of mitochondrial membrane potential | IEA | -- |
| GO:0035701 | hematopoietic stem cell migration | IEA | -- |
| GO:0042775 | mitochondrial ATP synthesis coupled electron transport | IEA | -- |
No data available for Pathways by source for MTCH2 Gene
Transcripts for MTCH2 Gene
mRNA/cDNA for MTCH2 Gene
- (10) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (420) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MTCH2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MTCH2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MTCH2
- GenScript: Design CRISPR guide RNA sequences for MTCH2
miRNA Products
- Search ViGene Biosciences for MTCH2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MTCH2
- Browse OriGene Inhibitory RNA Products For MTCH2
-
ViGene Biosciences ready-to-package AAV shRNAs for MTCH2 gene
Clone Products
-
OriGene ORF clones in human for MTCH2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MTCH2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||
| SP6: |
Expression for MTCH2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Nasal epithelium (31.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTCH2 Gene
NURSA nuclear receptor signaling pathways regulating expression of MTCH2 Gene:
MTCH2SOURCE GeneReport for Unigene cluster for MTCH2 Gene:
Hs.269944Evidence on tissue expression from TISSUES for MTCH2 Gene
- Nervous system(4.9)
- Liver(4.5)
- Blood(4.3)
- Kidney(2.6)
Primer Products
-
OriGene qPCR primer pairs for MTCH2
-
OriGene qPCR primer pairs and template standards for MTCH2
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTCH2 Gene
Orthologs for MTCH2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MTCH2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | MTCH2 34 |
|
||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | MTCH2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Mtch2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mtch2 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MTCH2 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MTCH2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MTCH2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MTCH2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mtch2 34 |
|
||
| MGC76005 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC64562 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mtch2 34 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.100 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006963 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Mtch 36 34 35 |
|
||
| CG10920 36 35 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | mtch-1 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10453 35 |
|
OneToMany |
- Species where no ortholog for MTCH2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MTCH2 Gene
(2) SIMAP similar genes for MTCH2 Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for MTCH2 Gene
Variants for MTCH2 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000011411 | -- | 47,605,422(+) | GCTGA(-/T)TTTTT | utr-variant-3-prime | |
| rs1000040260 | -- | 47,638,235(+) | TTTCC(A/G)TATGT | intron-variant | |
| rs1000113549 | -- | 47,637,849(+) | ATTCT(A/C)ATAGC | intron-variant | |
| rs1000149005 | -- | 47,626,712(+) | GGTTC(C/T)AGTGA | intron-variant | |
| rs1000179993 | -- | 47,610,391(+) | ACTCT(A/G)TGCCA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1465053 | CNV | insertion | 17803354 |
| esv2744440 | CNV | deletion | 23290073 |
| esv3626206 | CNV | loss | 21293372 |
| esv995881 | CNV | insertion | 20482838 |
| esv998557 | CNV | insertion | 20482838 |
| nsv315 | CNV | insertion | 18451855 |
| nsv469858 | CNV | gain | 16826518 |
| nsv509405 | CNV | insertion | 20534489 |
| nsv69 | CNV | insertion | 15895083 |
| nsv825872 | CNV | gain | 20364138 |
| nsv832142 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.52;
88.84% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MTCH2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTCH2 Gene
Disorders for MTCH2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| obesity |
|
|
Search MTCH2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for MTCH2
No data available for UniProtKB/Swiss-Prot and Genatlas for MTCH2 Gene
Publications for MTCH2 Gene
- Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K. … Nakamura Y. (J. Hum. Genet. 2009) 3 22 46 64
- Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa? (PMID: 19746409) Brandys M.K. … Adan R.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
- Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. (PMID: 19812171) Li S. … Loos R.J. (Am. J. Clin. Nutr. 2010) 3 46 64
- Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus. (PMID: 19910641) He M. … Qi L. (Arterioscler. Thromb. Vasc. Biol. 2010) 3 46 64
- Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study. (PMID: 19910938) Haupt A. … Staiger H. (Obesity (Silver Spring) 2010) 3 46 64
Products for MTCH2 Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for MTCH2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MTCH2
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- OriGene qPCR primer pairs and template standards for MTCH2
- OriGene qPCR primer pairs for MTCH2
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- OriGene ORF clones in human for MTCH2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for MTCH2 in any vector
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- GenScript: Design CRISPR guide RNA sequences for MTCH2
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- Novus Biologicals Antibodies for MTCH2
- Novus Biologicals proteins and lysates for MTCH2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for MTCH2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for MTCH2: See all 44
- Search antibodies-online for kits
- antibodies-online Proteins for MTCH2: See all 4
- Search antibodies-online for peptides
- GeneTex MTCH2 antibody for MTCH2
- GeneTex Proteins for MTCH2
- ViGene Biosciences adenoviral particle packaged cDNA for MTCH2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MTCH2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MTCH2 gene
- Search ViGene Biosciences for MTCH2
- Horizon Cell Lines for MTCH2
- Cyagen custom Knockout/knockin (KOKI) mouse models for MTCH2
- VectorBuilder custom plasmid, inducible vectors for MTCH2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTCH2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MTCH2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (141) ENCODE
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer