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Aliases for IL17RA Gene

Aliases for IL17RA Gene

  • Interleukin 17 Receptor A 2 3 5
  • IL-17 Receptor A 3 4
  • IL-17RA 3 4
  • CDw217 3 4
  • IL17R 3 4
  • Interleukin 17 Receptor 2
  • CD217 Antigen 4
  • HIL-17R 3
  • CANDF5 3
  • CD217 3

External Ids for IL17RA Gene

Previous HGNC Symbols for IL17RA Gene

  • IL17R

Previous GeneCards Identifiers for IL17RA Gene

  • GC22P015947
  • GC22P017565
  • GC22P001385

Summaries for IL17RA Gene

Entrez Gene Summary for IL17RA Gene

  • Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

GeneCards Summary for IL17RA Gene

IL17RA (Interleukin 17 Receptor A) is a Protein Coding gene. Diseases associated with IL17RA include candidiasis, familial, 5, autosomal recessive and chronic mucocutaneous candidiasis. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include interleukin-17 receptor activity. An important paralog of this gene is IL17RB.

UniProtKB/Swiss-Prot for IL17RA Gene

  • Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).

Gene Wiki entry for IL17RA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17RA Gene

Genomics for IL17RA Gene

Regulatory Elements for IL17RA Gene

Promoters for IL17RA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL17RA on UCSC Golden Path with GeneCards custom track

Genomic Location for IL17RA Gene

Chromosome:
22
Start:
17,084,954 bp from pter
End:
17,115,694 bp from pter
Size:
30,741 bases
Orientation:
Plus strand

Genomic View for IL17RA Gene

Genes around IL17RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17RA Gene

Proteins for IL17RA Gene

  • Protein details for IL17RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F46-I17RA_HUMAN
    Recommended name:
    Interleukin-17 receptor A
    Protein Accession:
    Q96F46
    Secondary Accessions:
    • O43844
    • Q20WK1

    Protein attributes for IL17RA Gene

    Size:
    866 amino acids
    Molecular mass:
    96122 Da
    Quaternary structure:
    • Forms heterodimers with IL17RE; the heterodimer binds IL17C (PubMed:21993848). Forms heterodimers with IL17RC; the heterodimer binds IL17A and IL17F homodimers as well as the heterodimer formed by IL17A and IL17F (PubMed:16785495, PubMed:18684971).

    Three dimensional structures from OCA and Proteopedia for IL17RA Gene

    Alternative splice isoforms for IL17RA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL17RA Gene

Proteomics data for IL17RA Gene at MOPED

Post-translational modifications for IL17RA Gene

  • Glycosylated.
  • Glycosylation at Asn 49, Asn 54, Asn 67, Asn 206, Asn 225, Asn 242, and Asn 265
  • Modification sites at PhosphoSitePlus

Other Protein References for IL17RA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL17RA (IL-17 RA/IL-17 R)
  • Cell Signaling Technology (CST) Antibodies for IL17RA (IL17RA)

No data available for DME Specific Peptides for IL17RA Gene

Domains & Families for IL17RA Gene

Gene Families for IL17RA Gene

Protein Domains for IL17RA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IL17RA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96F46

UniProtKB/Swiss-Prot:

I17RA_HUMAN :
  • Contains 1 SEFIR domain.
Domain:
  • Contains 1 SEFIR domain.
genes like me logo Genes that share domains with IL17RA: view

Function for IL17RA Gene

Molecular function for IL17RA Gene

UniProtKB/Swiss-Prot Function:
Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).
genes like me logo Genes that share phenotypes with IL17RA: view

Human Phenotype Ontology for IL17RA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL17RA Gene

MGI Knock Outs for IL17RA:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for IL17RA Gene

Localization for IL17RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17RA Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL17RA Gene COMPARTMENTS Subcellular localization image for IL17RA gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 3
cytosol 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for IL17RA Gene

Pathways & Interactions for IL17RA Gene

genes like me logo Genes that share pathways with IL17RA: view

SIGNOR curated interactions for IL17RA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL17RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway NAS 9367539
GO:0019221 cytokine-mediated signaling pathway NAS 9367539
GO:0071345 cellular response to cytokine stimulus IEA --
GO:0071621 granulocyte chemotaxis IEA --
GO:0072537 fibroblast activation IDA 21145111
genes like me logo Genes that share ontologies with IL17RA: view

Drugs & Compounds for IL17RA Gene

(1) Additional Compounds for IL17RA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL17RA: view

Transcripts for IL17RA Gene

Unigene Clusters for IL17RA Gene

Interleukin 17 receptor A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17RA Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for IL17RA Gene

GeneLoc Exon Structure for
IL17RA
ECgene alternative splicing isoforms for
IL17RA

Expression for IL17RA Gene

mRNA expression in normal human tissues for IL17RA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17RA Gene

This gene is overexpressed in Whole Blood (x17.9).

Protein differential expression in normal tissues from HIPED for IL17RA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.0), Testis (27.4), and Monocytes (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL17RA Gene



SOURCE GeneReport for Unigene cluster for IL17RA Gene Hs.48353

mRNA Expression by UniProt/SwissProt for IL17RA Gene

Q96F46-I17RA_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with IL17RA: view

Protein tissue co-expression partners for IL17RA Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for IL17RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17RA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17RA 35
  • 99.34 (n)
  • 99.19 (a)
IL17RA 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL17RA 36
  • 67 (a)
OneToOne
IL17RA 35
  • 77.17 (n)
  • 71.03 (a)
dog
(Canis familiaris)
Mammalia IL17RA 35
  • 79.28 (n)
  • 74.35 (a)
IL17RA 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il17ra 16
Il17ra 35
  • 76.51 (n)
  • 69.98 (a)
Il17ra 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL17RA 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL17RA 36
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il17ra 35
  • 75.68 (n)
  • 70.04 (a)
chicken
(Gallus gallus)
Aves IL17RA 35
  • 57.65 (n)
  • 48.97 (a)
IL17RA 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL17RA 36
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX942819.1 36
  • 35 (a)
OneToMany
IL17RA (1 of 4) 36
  • 31 (a)
OneToMany
IL17RA (3 of 4) 36
  • 30 (a)
OneToMany
il17ra2 36
  • 31 (a)
OneToMany
LOC561494 35
  • 46.21 (n)
  • 37.52 (a)
Species with no ortholog for IL17RA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17RA Gene

ENSEMBL:
Gene Tree for IL17RA (if available)
TreeFam:
Gene Tree for IL17RA (if available)

Paralogs for IL17RA Gene

Paralogs for IL17RA Gene

genes like me logo Genes that share paralogs with IL17RA: view

Variants for IL17RA Gene

Sequence variations from dbSNP and Humsavar for IL17RA Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs879577 - 17,108,319(-) CAGCC(A/G/T)CAGGC reference, missense
rs17850765 - 17,108,958(+) GGTCC(A/G)CTGTC reference, missense
rs12484684 - 17,108,904(+) GAGCC(A/C/T)GGGCG reference, missense
rs1654 -- 17,115,498(-) GCAGG(C/G)GTTTC utr-variant-3-prime
rs1656 -- 17,115,432(-) CTCTC(C/T)CTGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IL17RA Gene

Variant ID Type Subtype PubMed ID
nsv828923 CNV Gain 20364138
nsv509805 CNV Insertion 20534489
nsv521478 CNV Loss 19592680
nsv518600 CNV Loss 19592680
esv2723938 CNV Deletion 23290073
esv2723939 CNV Deletion 23290073
dgv773e201 CNV Deletion 23290073
nsv519563 CNV Loss 19592680

Variation tolerance for IL17RA Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.97; 92.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL17RA Gene

HapMap Linkage Disequilibrium report
IL17RA
Human Gene Mutation Database (HGMD)
IL17RA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17RA Gene

Disorders for IL17RA Gene

MalaCards: The human disease database

(9) MalaCards diseases for IL17RA Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
candidiasis, familial, 5, autosomal recessive
  • familial chronic mucocutaneous candidiasis, autosomal recessive
chronic mucocutaneous candidiasis
  • cmc
candidiasis
  • disseminated candidiasis
stromal keratitis
balkan nephropathy
  • balkan endemic nephropathy
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

I17RA_HUMAN
  • Candidiasis, familial, 5 (CANDF5) [MIM:613953]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269 PubMed:21350122}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IL17RA

Genetic Association Database (GAD)
IL17RA
Human Genome Epidemiology (HuGE) Navigator
IL17RA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL17RA
genes like me logo Genes that share disorders with IL17RA: view

No data available for Genatlas for IL17RA Gene

Publications for IL17RA Gene

  1. Molecular characterization of the human interleukin (Il)-17 receptor. (PMID: 9367539) Yao Z. … Armitage R.J. (Cytokine 1997) 2 3 4 67
  2. IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain. (PMID: 19244213) Shen F. … Gaffen S.L. (Sci Signal 2009) 3 23
  3. Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway. (PMID: 18348982) Lindemann M.J. … Gaffen S.L. (J. Biol. Chem. 2008) 3 23
  4. IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood. (PMID: 18097068) Zrioual S. … Miossec P. (J. Immunol. 2008) 3 23
  5. The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. (PMID: 17277779) Qian Y. … Li X. (Nat. Immunol. 2007) 3 23

Products for IL17RA Gene

Sources for IL17RA Gene

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