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Aliases for KCNE4 Gene

Aliases for KCNE4 Gene

  • Potassium Channel, Voltage Gated Subfamily E Regulatory Beta Subunit 4 2 3
  • Potassium Voltage-Gated Channel, Isk-Related Family, Member 4 2 3
  • Minimum Potassium Ion Channel-Related Peptide 3 3 4
  • Potassium Channel Subunit Beta MiRP3 3 4
  • MIRP3 3 6
  • Cardiac Voltage-Gated Potassium Channel Accessory Subunit 4 3
  • Potassium Voltage-Gated Channel Subfamily E Member 4 3
  • MINK-Related Peptide 3 3
  • MinK-Related Peptide 3 4

External Ids for KCNE4 Gene

Summaries for KCNE4 Gene

Entrez Gene Summary for KCNE4 Gene

  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNE4 Gene

KCNE4 (Potassium Channel, Voltage Gated Subfamily E Regulatory Beta Subunit 4) is a Protein Coding gene. Among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include voltage-gated potassium channel activity.

UniProtKB/Swiss-Prot for KCNE4 Gene

  • Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current

Tocris Summary for KCNE4 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNE4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNE4 Gene

Genomics for KCNE4 Gene

Genomic Location for KCNE4 Gene

Start:
223,051,814 bp from pter
End:
223,198,399 bp from pter
Size:
146,586 bases
Orientation:
Plus strand

Genomic View for KCNE4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNE4 Gene

Regulatory Elements for KCNE4 Gene

Proteins for KCNE4 Gene

  • Protein details for KCNE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWG9-KCNE4_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily E member 4
    Protein Accession:
    Q8WWG9
    Secondary Accessions:
    • B7Z275
    • Q53SM4
    • Q96CC4

    Protein attributes for KCNE4 Gene

    Size:
    221 amino acids
    Molecular mass:
    23806 Da
    Quaternary structure:
    • Associates with KCNQ1/KVLQT1.
    SequenceCaution:
    • Sequence=AAH14429.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL49979.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for KCNE4 Gene

Proteomics data for KCNE4 Gene at MOPED

Post-translational modifications for KCNE4 Gene

Other Protein References for KCNE4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNE4 Gene

Domains for KCNE4 Gene

Gene Families for KCNE4 Gene

HGNC:
  • KCN :Potassium channels

Protein Domains for KCNE4 Gene

UniProtKB/Swiss-Prot:

KCNE4_HUMAN
Family:
  • Belongs to the potassium channel KCNE family.:
    • Q8WWG9
genes like me logo Genes that share domains with KCNE4: view

Function for KCNE4 Gene

Molecular function for KCNE4 Gene

UniProtKB/Swiss-Prot Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current

Gene Ontology (GO) - Molecular Function for KCNE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005249 voltage-gated potassium channel activity IEA --
genes like me logo Genes that share ontologies with KCNE4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNE4 Gene

Localization for KCNE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNE4 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNE4 Gene COMPARTMENTS Subcellular localization image for KCNE4 gene
Compartment Confidence
nucleus 2
plasma membrane 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with KCNE4: view

Pathways for KCNE4 Gene

genes like me logo Genes that share pathways with KCNE4: view

Pathways by source for KCNE4 Gene

1 Qiagen pathway for KCNE4 Gene
1 PharmGKB pathway for KCNE4 Gene

Gene Ontology (GO) - Biological Process for KCNE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNE4: view

Compounds for KCNE4 Gene

(5) Tocris Compounds for KCNE4 Gene

Compound Action Cas Number
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties [325457-99-6]
JNJ 303 Potent and selective IKs blocker [878489-28-2]
ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro [220384-25-8]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]
genes like me logo Genes that share compounds with KCNE4: view

Transcripts for KCNE4 Gene

mRNA/cDNA for KCNE4 Gene

Unigene Clusters for KCNE4 Gene

Potassium voltage-gated channel, Isk-related family, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNE4 Gene

No ASD Table

Relevant External Links for KCNE4 Gene

GeneLoc Exon Structure for
KCNE4
ECgene alternative splicing isoforms for
KCNE4

Expression for KCNE4 Gene

mRNA expression in normal human tissues for KCNE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNE4 Gene

This gene is overexpressed in Artery - Tibial (4.4).

SOURCE GeneReport for Unigene cluster for KCNE4 Gene Hs.348522

mRNA Expression by UniProt/SwissProt for KCNE4 Gene

Q8WWG9-KCNE4_HUMAN
Tissue specificity: Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart.
genes like me logo Genes that share expressions with KCNE4: view

Orthologs for KCNE4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNE4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNE4 36
  • 99.1 (n)
  • 98.64 (a)
KCNE4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNE4 36
  • 88.1 (n)
  • 88.69 (a)
KCNE4 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNE4 36
  • 87.18 (n)
  • 83.71 (a)
KCNE4 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcne4 36
  • 86.67 (n)
  • 90 (a)
Kcne4 16
Kcne4 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNE4 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNE4 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcne4 36
  • 87.25 (n)
  • 90.59 (a)
chicken
(Gallus gallus)
Aves KCNE4 36
  • 72.6 (n)
  • 73.01 (a)
KCNE4 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNE4 37
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcne4 36
  • 55.63 (n)
  • 52.32 (a)
zebrafish
(Danio rerio)
Actinopterygii kcne4 36
  • 56.62 (n)
  • 50.68 (a)
kcne4 37
  • 43 (a)
OneToOne
Species with no ortholog for KCNE4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNE4 Gene

ENSEMBL:
Gene Tree for KCNE4 (if available)
TreeFam:
Gene Tree for KCNE4 (if available)

Paralogs for KCNE4 Gene

Selected SIMAP similar genes for KCNE4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNE4: view

No data available for Paralogs for KCNE4 Gene

Variants for KCNE4 Gene

Sequence variations from dbSNP and Humsavar for KCNE4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3795884 -- 223,053,645(-) GGCAA(A/G)CATAT utr-variant-3-prime
rs3795885 -- 223,053,615(-) CAGAA(C/T)CCCAA utr-variant-3-prime
rs3795886 -- 223,052,911(-) CCGCC(A/G)CCGGC reference, synonymous-codon
rs7561445 -- 223,054,755(+) CCTGT(A/G)GTCAA utr-variant-3-prime
rs7602495 -- 223,051,362(+) GCCTC(C/G/T)GCATG upstream-variant-2KB

Relevant External Links for KCNE4 Gene

HapMap Linkage Disequilibrium report
KCNE4
Human Gene Mutation Database (HGMD)
KCNE4

No data available for Structural Variations from Database of Genomic Variants (DGV) for KCNE4 Gene

Disorders for KCNE4 Gene

(1) University of Copenhagen DISEASES for KCNE4 Gene

Relevant External Links for KCNE4

Genetic Association Database (GAD)
KCNE4
Human Genome Epidemiology (HuGE) Navigator
KCNE4
genes like me logo Genes that share disorders with KCNE4: view

No data available for UniProtKB/Swiss-Prot for KCNE4 Gene

Publications for KCNE4 Gene

  1. KCNE4 suppresses Kv1.3 currents by modulating trafficking, surface expression and channel gating. (PMID: 19773357) SolAc L. … Felipe A. (J. Cell. Sci. 2009) 3 23
  2. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. (PMID: 10219239) Abbott G.W. … Goldstein S.A.N. (Cell 1999) 2 3
  3. KCNE4 is an inhibitory subunit to the KCNQ1 channel. (PMID: 12096056) Grunnet M. … Klaerke D.A. (J. Physiol. (Lond.) 2002) 3 4
  4. Novel gene hKCNE4 slows the activation of the KCNQ1 channel. (PMID: 12670483) Teng S. … Hui R. (Biochem. Biophys. Res. Commun. 2003) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for KCNE4 Gene

Sources for KCNE4 Gene

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