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Aliases for PRKD3 Gene

Aliases for PRKD3 Gene

  • Protein Kinase D3 2 3 5
  • Protein Kinase C Nu Type 3 4
  • Protein Kinase EPK2 3 4
  • EC 2.7.11.13 4 56
  • NPKC-NU 3 4
  • PRKCN 3 4
  • EPK2 3 4
  • Serine/Threonine-Protein Kinase D3 3
  • Protein Kinase C, Nu 2
  • EC 2.7.11 56
  • PKC-NU 3
  • PKD3 3

External Ids for PRKD3 Gene

Previous HGNC Symbols for PRKD3 Gene

  • PRKCN

Previous GeneCards Identifiers for PRKD3 Gene

  • GC02M037389
  • GC02M037477
  • GC02M037217

Summaries for PRKD3 Gene

Entrez Gene Summary for PRKD3 Gene

  • This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]

GeneCards Summary for PRKD3 Gene

PRKD3 (Protein Kinase D3) is a Protein Coding gene. Among its related pathways are NFAT and Cardiac Hypertrophy and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKD1.

UniProtKB/Swiss-Prot for PRKD3 Gene

  • Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).

Tocris Summary for PRKD3 Gene

  • The protein kinase D (PKD) family of serine/threonine protein kinases has three members: PKD1-3. They occupy a unique position in signaling pathways initiated by diacylglycerol and protein kinase C. PKDs are involved in cell survival, migration, differentiation and proliferation.

Gene Wiki entry for PRKD3 Gene

Additional gene information for PRKD3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKD3 Gene

Genomics for PRKD3 Gene

GeneHancer (GH) Regulatory Elements for PRKD3 Gene

Promoters and enhancers for PRKD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I037322 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 556.8 -0.4 -359 4.3 PKNOX1 ATF1 FOXA2 ZFP64 ARID4B SIN3A ZNF2 ZNF48 YY1 GLIS2 PRKD3 LOC101929542 CEBPZ NDUFAF7 CEBPZOS GC02M037332 RNU6-939P
GH02I037318 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.4 +7.7 7716 0.1 PRKD3 GC02M037305
GH02I037349 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -24.9 -24902 1.2 SOX13 FOXA2 EBF1 FEZF1 ZIC2 ZNF644 TEAD3 POLR2A GATAD2A SOX5 CEBPZOS PRKD3 LOC101929542 NDUFAF7 HEATR5B STRN QPCT GC02P037427
GH02I037375 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11 -52.7 -52724 3.3 PKNOX1 ARNT FEZF1 ZNF2 IRF4 ZNF213 ZNF207 ATF7 RUNX3 SP3 LOC101929542 PRKD3 RNU6-939P CDC42EP3 RMDN2 CYP1B1 QPCT GPATCH11 GC02P037427
GH02I037388 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11 -65.6 -65553 3 ELF3 PKNOX1 ATF1 FOXA2 SIN3A BATF IRF4 EGR1 SCRT2 ZNF143 PRKD3 LOC101929542 QPCT RNU6-939P CYP1B1 RMDN2 CDC42EP3 EIF2AK2 GC02P037427
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRKD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRKD3 gene promoter:

Genomic Locations for PRKD3 Gene

Genomic Locations for PRKD3 Gene
chr2:37,250,502-37,324,808
(GRCh38/hg38)
Size:
74,307 bases
Orientation:
Minus strand
chr2:37,477,645-37,551,951
(GRCh37/hg19)

Genomic View for PRKD3 Gene

Genes around PRKD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKD3 Gene

Proteins for PRKD3 Gene

  • Protein details for PRKD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94806-KPCD3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase D3
    Protein Accession:
    O94806
    Secondary Accessions:
    • D6W587
    • Q53TR7
    • Q8NEL8

    Protein attributes for PRKD3 Gene

    Size:
    890 amino acids
    Molecular mass:
    100471 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRKD3 Gene

    Alternative splice isoforms for PRKD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKD3 Gene

Selected DME Specific Peptides for PRKD3 Gene

O94806:
  • AIDLINNLLQVKMRKRYSVDK
  • QCKDCKFNCHKRCA
  • LHFKNIVHCDLKPENVLLASA
  • VNLECMFETPE
  • IPNNCSG
  • VKVPHTF
  • GCGLNYHKRCAF
  • KEGWMVHYTS
  • TISPSTSNNIPLMRVVQS
  • LLKGLFRQG
  • EDFQIRPH
  • QIQENVDI
  • GYNRSLDMWSVGVI
  • GERYITHESDD
  • QKFPECGF
  • EGDLVEVVLSA
  • YYKEIPLSEIL
  • SVPRPLQPE
  • TQILVALR
  • VYGGKHRKTGRDVA
  • YVSLSGTFPFNEDEDI
  • LSHPWLQ
  • HSYTRPT
  • DMWSVGVI
  • DQIQNAAFMYP
  • RFPTKQESQLRNEVAILQNLHHPG
  • GLVRQGL
  • VAIKVIDK
  • AIRQALMPV
  • YLAPEVL
  • YDKILLF

Post-translational modifications for PRKD3 Gene

No Post-translational modifications

Antibody Products

  • R&D Systems Antibodies for PRKD3 (PRKD3/nPKC nu)
  • Cell Signaling Technology (CST) Antibodies for PRKD3 (PRKD3)
  • Abcam antibodies for PRKD3
  • Cloud-Clone Corp. Antibodies for PRKD3
  • Santa Cruz Biotechnology (SCBT) Antibodies for PRKD3

Domains & Families for PRKD3 Gene

Gene Families for PRKD3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRKD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94806

UniProtKB/Swiss-Prot:

KPCD3_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
genes like me logo Genes that share domains with PRKD3: view

Function for PRKD3 Gene

Molecular function for PRKD3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains 1 and 2 bind both DAG and phorbol ester with high affinity and mediate translocation to the cell membrane. Autophosphorylation of Ser-735 and phosphorylation of Ser-731 by PKC relieves auto-inhibition by the PH domain.
UniProtKB/Swiss-Prot Function:
Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).

Enzyme Numbers (IUBMB) for PRKD3 Gene

Phenotypes From GWAS Catalog for PRKD3 Gene

Gene Ontology (GO) - Molecular Function for PRKD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004697 protein kinase C activity IEA,TAS --
GO:0005515 protein binding IPI 17196367
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PRKD3: view
genes like me logo Genes that share phenotypes with PRKD3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKD3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRKD3 Gene

Localization for PRKD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKD3 Gene

Cytoplasm. Membrane. Note=Translocation to the cell membrane is required for kinase activation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKD3 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PRKD3: view

Pathways & Interactions for PRKD3 Gene

genes like me logo Genes that share pathways with PRKD3: view

SIGNOR curated interactions for PRKD3 Gene

Other effect:

Gene Ontology (GO) - Biological Process for PRKD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,TAS --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway TAS 10231560
GO:0016310 phosphorylation IEA --
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with PRKD3: view

Drugs & Compounds for PRKD3 Gene

(11) Drugs for PRKD3 Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
ATP Investigational Nutra Agonist 0
CID 2011756 Pharma PKD inhibitor, Pan protein kinase D (PKD) inhibitor; cell permeable 0
CID 755673 Pharma PKD inhibitor, Selective protein kinase D inhibitor 0
bryostatin Pharma inhibitor 0

(5) Additional Compounds for PRKD3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1-Myristoyl-2-pentadecanoyl-sn-glycerol
  • DAG(14:0/15:0)
  • DAG(29:0)
  • DG(14:0/15:0)
  • DG(29:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonoyl-sn-glycerol
  • DAG(16:1/20:4)
  • DAG(16:1n7/20:4n6)
  • DAG(16:1w7/20:4w6)
  • DAG(36:5)
Diglycerides Group C
  • 1-Pentadecanoyl-3-behenoyl-sn-glycerol
  • 1-Pentadecanoyl-3-docosanoyl-sn-glycerol
  • DAG(15:0/0:0/22:0)
  • DAG(37:0)
  • DG(37:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(4) Tocris Compounds for PRKD3 Gene

Compound Action Cas Number
CID 2011756 Pan protein kinase D (PKD) inhibitor; cell permeable 638156-11-3
CID 755673 Selective protein kinase D inhibitor 521937-07-5
CRT 0066101 Potent protein kinase D (PKD) inhibitor 1883545-60-5
kb NB 142-70 Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327) 1233533-04-4

(2) ApexBio Compounds for PRKD3 Gene

Compound Action Cas Number
CID 2011756 PKD inhibitor 638156-11-3
CID 755673 PKD inhibitor 521937-07-5
genes like me logo Genes that share compounds with PRKD3: view

Drug Products

Transcripts for PRKD3 Gene

Unigene Clusters for PRKD3 Gene

Protein kinase D3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKD3

Alternative Splicing Database (ASD) splice patterns (SP) for PRKD3 Gene

No ASD Table

Relevant External Links for PRKD3 Gene

GeneLoc Exon Structure for
PRKD3
ECgene alternative splicing isoforms for
PRKD3

Expression for PRKD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRKD3 Gene

This gene is overexpressed in Lymph node (35.6), Placenta (8.6), Pancreas (8.2), and Platelet (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKD3 Gene



Protein tissue co-expression partners for PRKD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRKD3 Gene:

PRKD3

SOURCE GeneReport for Unigene cluster for PRKD3 Gene:

Hs.660757

mRNA Expression by UniProt/SwissProt for PRKD3 Gene:

O94806-KPCD3_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PRKD3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKD3 Gene

Orthologs for PRKD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKD3 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia PRKD3 33 34
  • 94.61 (n)
oppossum
(Monodelphis domestica)
Mammalia PRKD3 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKD3 34 33
  • 93.63 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKD3 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkd3 33
  • 89.93 (n)
mouse
(Mus musculus)
Mammalia Prkd3 16 34 33
  • 89.7 (n)
chicken
(Gallus gallus)
Aves PRKD3 33 34
  • 82.21 (n)
lizard
(Anolis carolinensis)
Reptilia PRKD3 34
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii prkd3 33 34
  • 74.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta PKD 33
  • 55.77 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000070 33
  • 55.19 (n)
worm
(Caenorhabditis elegans)
Secernentea dkf-2 33
  • 55.75 (n)
dkf-1 34
  • 41 (a)
ManyToMany
R12G8.1 34
  • 33 (a)
ManyToMany
F48G7.9 34
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
Species where no ortholog for PRKD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PRKD3 Gene

ENSEMBL:
Gene Tree for PRKD3 (if available)
TreeFam:
Gene Tree for PRKD3 (if available)

Paralogs for PRKD3 Gene

Paralogs for PRKD3 Gene

genes like me logo Genes that share paralogs with PRKD3: view

Variants for PRKD3 Gene

Sequence variations from dbSNP and Humsavar for PRKD3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
VAR_042336 A glioblastoma multiforme sample p.Val716Met
rs1000027274 -- 37,250,290(-) G/A downstream_transcript_variant
rs1000082960 -- 37,271,991(-) C/A intron_variant
rs1000100824 -- 37,281,998(-) C/A intron_variant
rs1000217341 -- 37,304,569(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRKD3 Gene

Variant ID Type Subtype PubMed ID
nsv828953 CNV loss 20364138
nsv953770 CNV duplication 24416366

Variation tolerance for PRKD3 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.68; 72.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRKD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKD3 Gene

Disorders for PRKD3 Gene

Additional Disease Information for PRKD3

No disorders were found for PRKD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRKD3 Gene

Publications for PRKD3 Gene

  1. PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu. (PMID: 10231560) Hayashi A … Saito T (Biochimica et biophysica acta 1999) 2 3 4 22 58
  2. Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family. (PMID: 18076381) Chen J … Wang QJ (The Biochemical journal 2008) 3 4 58
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  4. The nuclear import of protein kinase D3 requires its catalytic activity. (PMID: 16380377) Rey O … Rozengurt E (The Journal of biological chemistry 2006) 3 22 58
  5. Protein kinase C-independent effects of protein kinase D3 in glucose transport in L6 myotubes. (PMID: 15496505) Chen J … Wang QJ (Molecular pharmacology 2005) 3 22 58

Products for PRKD3 Gene

  • Addgene plasmids for PRKD3

Sources for PRKD3 Gene

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