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Aliases for PRKD3 Gene

Aliases for PRKD3 Gene

  • Protein Kinase D3 2 3
  • PRKCN 3 4 6
  • Protein Kinase C Nu Type 3 4
  • Protein Kinase EPK2 3 4
  • EC 2.7.11.13 4 63
  • NPKC-NU 3 4
  • EPK2 3 4
  • Serine/Threonine-Protein Kinase D3 3
  • Protein Kinase C, Nu 2
  • EC 2.7.11 63
  • PKC-NU 3
  • PKD3 3

External Ids for PRKD3 Gene

Previous HGNC Symbols for PRKD3 Gene

  • PRKCN

Previous GeneCards Identifiers for PRKD3 Gene

  • GC02M037389
  • GC02M037477
  • GC02M037217

Summaries for PRKD3 Gene

Entrez Gene Summary for PRKD3 Gene

  • This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]

GeneCards Summary for PRKD3 Gene

PRKD3 (Protein Kinase D3) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Development FGFR signaling pathway. GO annotations related to this gene include identical protein binding and protein kinase C activity. An important paralog of this gene is PRKD1.

UniProtKB/Swiss-Prot for PRKD3 Gene

  • Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).

Tocris Summary for PRKD3 Gene

  • The protein kinase D (PKD) family of serine/threonine protein kinases contains three members; PKD1, PKD2 and PKD2. These enzymes occupy a unique position in the signal transduction pathway initiated by diacylglycerol (DAG) and protein kinase C (PKC). PKDs are direct targets of DAG, and also lie downstream of PKC in a novel signal transduction pathway that is implicated in a variety of biological processes. Structurally, PKDs contain an N' terminal cysteine-rich domain (CRD), which binds phorbol esters with high affinity and has a role in mediating PKD translocation to the plasma membrane upon activation. The PH domains have an autoregulatory phosphorylation site (PKD1 and PKD2 only) and the catalytic domains have a high degree of homology to myosin light chain and calmodulin-dependent kinases. In the inactivated state, PKD1 and PKD2 are localized mainly to the cytoplasm, whilst PKD3 is found both in the cytoplasm and nucleus. Kinase activity of these enzymes is repressed by their CRD and PH domains. PKDs are activated by a variety of stimuli including regulatory peptides, lysophosphatidic acid, thrombin, PDGF, IGF-1, oxidative stress, cholecystokinin, Gbetagamma, ATP and more. These stimuli produce a rapid generation of DAG, which induces CRD-mediated PKD translocation from the cytosol to the plasma membrane. Novel PKCs are also recruited to the plasma membrane in response to DAG generation. Novel PKCs are allosterically activated by DAG, and transphosphorylate PKDs. This stabilizes PKD in its active conformation. Activated PKD dissociates from the plasma membrane, translocates to the cytosol and subsequently to the nucleus. PKDs have been implicated in fundamental physiological processes including signal transduction, membrane trafficking, and cell survival, migration, differentiation and proliferation. PKD upregulates the ERK and Ras signaling pathways, and suppresses the JNK signaling pathway. These enzymes regulate the budding of secretory vesicles from the trans-Golgi network and promote integrin recruitment to focal adhesions. In addition, PKDs have a role in regulating apoptosis and have functions in cell survival pathways induced by oxidative stress. They also have a role in immune regulation. Despite the plethora of physiological processes PKDs are involved in, only a few direct targets are known. These include kidins220, an integral membrane protein of neuroendocrine cells, c-Jun and RIN1, a protein that associates with Ras and 14.3.3 and activates the Ras-MEK-ERK pathway.

Gene Wiki entry for PRKD3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKD3 Gene

Genomics for PRKD3 Gene

Regulatory Elements for PRKD3 Gene

Genomic Location for PRKD3 Gene

Start:
37,250,502 bp from pter
End:
37,324,808 bp from pter
Size:
74,307 bases
Orientation:
Minus strand

Genomic View for PRKD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKD3 Gene

Proteins for PRKD3 Gene

  • Protein details for PRKD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94806-KPCD3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase D3
    Protein Accession:
    O94806
    Secondary Accessions:
    • D6W587
    • Q53TR7
    • Q8NEL8

    Protein attributes for PRKD3 Gene

    Size:
    890 amino acids
    Molecular mass:
    100471 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRKD3 Gene

    Alternative splice isoforms for PRKD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKD3 Gene

Proteomics data for PRKD3 Gene at MOPED

Post-translational modifications for PRKD3 Gene

  • Ubiquitination at Lys293
  • Modification sites at PhosphoSitePlus

Other Protein References for PRKD3 Gene

Antibody Products

  • R&D Systems Antibodies for PRKD3 (PRKD3/nPKC nu)
  • Cell Signaling Technology (CST) Antibodies for PRKD3 (PKD3)

Domains for PRKD3 Gene

Gene Families for PRKD3 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for PRKD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94806

UniProtKB/Swiss-Prot:

KPCD3_HUMAN :
  • O94806
Domain:
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with PRKD3: view

Function for PRKD3 Gene

Molecular function for PRKD3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains 1 and 2 bind both DAG and phorbol ester with high affinity and mediate translocation to the cell membrane. Autophosphorylation of Ser-735 and phosphorylation of Ser-731 by PKC relieves auto-inhibition by the PH domain.
UniProtKB/Swiss-Prot Function: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).

Enzyme Numbers (IUBMB) for PRKD3 Gene

Gene Ontology (GO) - Molecular Function for PRKD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004697 protein kinase C activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 17196367
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PRKD3: view
genes like me logo Genes that share phenotypes with PRKD3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKD3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PRKD3 Gene

Localization for PRKD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKD3 Gene

Cytoplasm. Membrane. Note=Translocation to the cell membrane is required for kinase activation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKD3 Gene COMPARTMENTS Subcellular localization image for PRKD3 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2
mitochondrion 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PRKD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PRKD3: view

Pathways for PRKD3 Gene

genes like me logo Genes that share pathways with PRKD3: view

Gene Ontology (GO) - Biological Process for PRKD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway TAS 10231560
GO:0009103 lipopolysaccharide biosynthetic process --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with PRKD3: view

Compounds for PRKD3 Gene

Compound Products

(4) Tocris Compounds for PRKD3 Gene

Compound Action Cas Number
CID 2011756 Pan protein kinase D (PKD) inhibitor; cell permeable [638156-11-3]
CID 755673 Selective protein kinase D inhibitor [521937-07-5]
CRT 0066101 Potent protein kinase D (PKD) inhibitor
kb NB 142-70 Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327) [1233533-04-4]

(4) ApexBio Compounds for PRKD3 Gene

Compound Action Cas Number
CID 2011756 novel and potent inhibitor of PKD1 [638156-11-3]
CID 755673 Selective PKD inhibitor [521937-07-5]
CRT 0066101 Potent inhibitor of PKD
kb NB 142-70 selective PKD inhibitor [1233533-04-4]

(846) HMDB Compounds for PRKD3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available

(2) Novoseek inferred chemical compound relationships for PRKD3 Gene

Compound -log(P) Hits PubMed IDs
threonine 62.8 2
serine 59.2 3
genes like me logo Genes that share compounds with PRKD3: view

Transcripts for PRKD3 Gene

Unigene Clusters for PRKD3 Gene

Protein kinase D3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKD3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PRKD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKD3 Gene

No ASD Table

Relevant External Links for PRKD3 Gene

GeneLoc Exon Structure for
PRKD3
ECgene alternative splicing isoforms for
PRKD3

Expression for PRKD3 Gene

mRNA expression in normal human tissues for PRKD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKD3 Gene

SOURCE GeneReport for Unigene cluster for PRKD3 Gene Hs.660757

mRNA Expression by UniProt/SwissProt for PRKD3 Gene

O94806-KPCD3_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with PRKD3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PRKD3 Gene

Orthologs for PRKD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKD3 35
  • 100 (n)
  • 100 (a)
PRKD3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKD3 35
  • 93.63 (n)
  • 97.64 (a)
PRKD3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKD3 35
  • 94.61 (n)
  • 97.19 (a)
PRKD3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkd3 35
  • 89.7 (n)
  • 95.96 (a)
Prkd3 16
Prkd3 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKD3 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKD3 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkd3 35
  • 89.93 (n)
  • 95.84 (a)
chicken
(Gallus gallus)
Aves PRKD3 35
  • 82.21 (n)
  • 89.78 (a)
PRKD3 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKD3 36
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii prkd3 35
  • 74.01 (n)
  • 84.34 (a)
prkd3 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000070 35
  • 55.19 (n)
  • 60.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta PKD 35
  • 55.77 (n)
  • 59.4 (a)
worm
(Caenorhabditis elegans)
Secernentea dkf-1 36
  • 41 (a)
ManyToMany
dkf-2 35
  • 55.75 (n)
  • 56.38 (a)
F48G7.9 36
  • 18 (a)
ManyToMany
R12G8.1 36
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
Species with no ortholog for PRKD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PRKD3 Gene

ENSEMBL:
Gene Tree for PRKD3 (if available)
TreeFam:
Gene Tree for PRKD3 (if available)

Paralogs for PRKD3 Gene

Paralogs for PRKD3 Gene

genes like me logo Genes that share paralogs with PRKD3: view

Variants for PRKD3 Gene

Sequence variations from dbSNP and Humsavar for PRKD3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs8243 -- 37,250,651(-) AGTTT(G/T)ACCTG utr-variant-3-prime, downstream-variant-500B
rs9318 -- 37,250,771(-) TTTGG(C/T)TATAT utr-variant-3-prime
rs759460 -- 37,320,993(-) CCAGA(A/G)TAAAT intron-variant
rs876461 -- 37,288,815(-) GCCTC(C/T)CAAAG intron-variant
rs876462 -- 37,288,737(-) AGAGC(A/C)GCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKD3 Gene

Variant ID Type Subtype PubMed ID
nsv828953 CNV Loss 20364138

Relevant External Links for PRKD3 Gene

HapMap Linkage Disequilibrium report
PRKD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKD3 Gene

Disorders for PRKD3 Gene

(1) University of Copenhagen DISEASES for PRKD3 Gene

Relevant External Links for PRKD3

Genetic Association Database (GAD)
PRKD3
genes like me logo Genes that share disorders with PRKD3: view

No data available for UniProtKB/Swiss-Prot for PRKD3 Gene

Publications for PRKD3 Gene

  1. PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu. (PMID: 10231560) Hayashi A. … Saito T. (Biochim. Biophys. Acta 1999) 2 3 4 23
  2. Regulation of protein kinase Cnu by the B-cell antigen receptor. (PMID: 12506120) Matthews S.A. … Scharenberg A.M. (J. Biol. Chem. 2003) 3 23
  3. Protein kinase C nu/protein kinase D3 nuclear localization, catalytic activation, and intracellular redistribution in response to G protein-coupled receptor agonists. (PMID: 12676944) Rey O. … Rozengurt E. (J. Biol. Chem. 2003) 3 23
  4. Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network. (PMID: 14743217) Yeaman C. … Malhotra V. (Nat. Cell Biol. 2004) 3 23
  5. Protein kinase C-independent effects of protein kinase D3 in glucose transport in L6 myotubes. (PMID: 15496505) Chen J. … Wang Q.J. (Mol. Pharmacol. 2005) 3 23

Products for PRKD3 Gene

  • Addgene plasmids for PRKD3

Sources for PRKD3 Gene

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