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Aliases for SGK3 Gene

Aliases for SGK3 Gene

  • Serum/Glucocorticoid Regulated Kinase Family, Member 3 2 3
  • SGKL 3 4 6
  • CISK 3 4 6
  • Cytokine-Independent Survival Kinase 3 4
  • EC 2.7.11.1 4 63
  • Serum/Glucocorticoid Regulated Kinase-Like 2
  • Serum/Glucocorticoid-Regulated Kinase-Like 4
  • Serum/Glucocorticoid-Regulated Kinase 3 4
  • Serine/Threonine-Protein Kinase Sgk3 3
  • EC 2.7.11 63
  • SGK2 3

External Ids for SGK3 Gene

Previous HGNC Symbols for SGK3 Gene

  • SGK2
  • SGKL

Previous GeneCards Identifiers for SGK3 Gene

  • GC08P067851
  • GC08P067624
  • GC08P063176

Summaries for SGK3 Gene

Entrez Gene Summary for SGK3 Gene

  • This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for SGK3 Gene

SGK3 (Serum/Glucocorticoid Regulated Kinase Family, Member 3) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Insulin Signaling. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for SGK3 Gene

  • Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.

Gene Wiki entry for SGK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGK3 Gene

Genomics for SGK3 Gene

Regulatory Elements for SGK3 Gene

Genomic Location for SGK3 Gene

Start:
66,712,418 bp from pter
End:
66,862,022 bp from pter
Size:
149,605 bases
Orientation:
Plus strand

Genomic View for SGK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SGK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGK3 Gene

Proteins for SGK3 Gene

  • Protein details for SGK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BR1-SGK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Sgk3
    Protein Accession:
    Q96BR1
    Secondary Accessions:
    • A8K5W3
    • B3KQC2
    • Q9P1Q7
    • Q9UKG5

    Protein attributes for SGK3 Gene

    Size:
    496 amino acids
    Molecular mass:
    57108 Da
    Quaternary structure:
    • Interacts with GSK3B and FLII. Interacts with PDPK1 in a phosphorylation-dependent manner.
    SequenceCaution:
    • Sequence=AAF12758.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SGK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SGK3 Gene

Proteomics data for SGK3 Gene at MOPED

Post-translational modifications for SGK3 Gene

  • Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-320.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for SGK3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96BR1

UniProtKB/Swiss-Prot:

SGK3_HUMAN :
  • Q96BR1
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with SGK3: view

Function for SGK3 Gene

Molecular function for SGK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Two specific sites, one in the kinase domain (Thr-320) and the other in the C-terminal regulatory region (Ser-486), need to be phosphorylated for its full activation
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
UniProtKB/Swiss-Prot Induction: Induced by estrogen/ER in breast cancer cells.

Enzyme Numbers (IUBMB) for SGK3 Gene

Gene Ontology (GO) - Molecular Function for SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10548550
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005246 calcium channel regulator activity TAS 16460280
GO:0005515 protein binding IPI 16888620
genes like me logo Genes that share ontologies with SGK3: view
genes like me logo Genes that share phenotypes with SGK3: view

Animal Models for SGK3 Gene

MGI Knock Outs for SGK3:

miRNA for SGK3 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for SGK3 Gene

Localization for SGK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGK3 Gene

Cytoplasmic vesicle. Early endosome. Recycling endosome. Note=Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SGK3 Gene COMPARTMENTS Subcellular localization image for SGK3 gene
Compartment Confidence
endosome 5
cytosol 4
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005769 early endosome IEA --
GO:0005829 cytosol TAS --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with SGK3: view

Pathways for SGK3 Gene

genes like me logo Genes that share pathways with SGK3: view

Pathways by source for SGK3 Gene

1 Cell Signaling Technology pathway for SGK3 Gene
1 BioSystems pathway for SGK3 Gene

Gene Ontology (GO) - Biological Process for SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth TAS 20919962
GO:0006468 protein phosphorylation IEA --
GO:0006950 response to stress TAS 10548550
GO:0030334 regulation of cell migration TAS 20919962
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with SGK3: view

Compounds for SGK3 Gene

(2) HMDB Compounds for SGK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(8) Novoseek inferred chemical compound relationships for SGK3 Gene

Compound -log(P) Hits PubMed IDs
serine 47.3 4
phosphatidylinositol 45 7
threonine 38.1 1
alanine 28.3 2
glutamate 19.9 5
genes like me logo Genes that share compounds with SGK3: view

Transcripts for SGK3 Gene

Unigene Clusters for SGK3 Gene

Serum/glucocorticoid regulated kinase family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SGK3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16
SP1: -
SP2: - - -
SP3: -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for SGK3 Gene

GeneLoc Exon Structure for
SGK3
ECgene alternative splicing isoforms for
SGK3

Expression for SGK3 Gene

mRNA expression in normal human tissues for SGK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SGK3 Gene

SOURCE GeneReport for Unigene cluster for SGK3 Gene Hs.613417

mRNA Expression by UniProt/SwissProt for SGK3 Gene

Q96BR1-SGK3_HUMAN
Tissue specificity: Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER-positive breast tumors than ER-negative breast tumors.
genes like me logo Genes that share expressions with SGK3: view

No data available for mRNA differential expression in normal tissues for SGK3 Gene

Orthologs for SGK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGK3 35
  • 99.8 (n)
  • 99.8 (a)
SGK3 36
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 98 (a)
OneToMany
SGK3 35
  • 93.27 (n)
  • 97.96 (a)
dog
(Canis familiaris)
Mammalia SGK3 35
  • 94.83 (n)
  • 98.78 (a)
SGK3 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sgk3 35
  • 90.39 (n)
  • 96.77 (a)
Sgk3 16
Sgk3 36
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sgk3 35
  • 88.1 (n)
  • 94.35 (a)
chicken
(Gallus gallus)
Aves SGK3 35
  • 84.19 (n)
  • 93.87 (a)
SGK3 36
  • 94 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 92 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sgk3 35
  • 75.35 (n)
  • 76.81 (a)
zebrafish
(Danio rerio)
Actinopterygii C24H8orf44 36
  • 79 (a)
OneToMany
sgk3 35
  • 72.22 (n)
  • 79.01 (a)
worm
(Caenorhabditis elegans)
Secernentea sgk-1 36
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK1 36
  • 28 (a)
ManyToMany
YPK2 36
  • 28 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sck2 35
  • 51.37 (n)
  • 45.9 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2814 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9294 36
  • 64 (a)
OneToMany
Species with no ortholog for SGK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGK3 Gene

ENSEMBL:
Gene Tree for SGK3 (if available)
TreeFam:
Gene Tree for SGK3 (if available)

Paralogs for SGK3 Gene

genes like me logo Genes that share paralogs with SGK3: view

Variants for SGK3 Gene

Sequence variations from dbSNP and Humsavar for SGK3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
VAR_035636 A breast cancer sample
VAR_041076 -

Structural Variations from Database of Genomic Variants (DGV) for SGK3 Gene

Variant ID Type Subtype PubMed ID
nsv831346 CNV Loss 17160897
esv2675141 CNV Deletion 23128226
nsv6238 CNV Insertion 18451855
esv2466698 CNV Insertion 19546169
esv1319586 CNV Insertion 17803354
esv2062022 CNV Deletion 18987734
nsv6239 CNV Insertion 18451855

Relevant External Links for SGK3 Gene

HapMap Linkage Disequilibrium report
SGK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGK3 Gene

Disorders for SGK3 Gene

No disorders were found for SGK3 Gene.

No data available for UniProtKB/Swiss-Prot for SGK3 Gene

Publications for SGK3 Gene

  1. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (PMID: 10548550) Kobayashi T. … Cohen P. (Biochem. J. 1999) 2 3 4 23
  2. Cloning and mapping of a novel human Serum/Glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1. (PMID: 10585774) Dai F. … Zhao S. (Genomics 1999) 2 3 4 23
  3. K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. (PMID: 12397388) Gamper N. … Lang F. (Pflugers Arch. 2002) 3 4 23
  4. Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms. (PMID: 12590200) Henke G. … Lang F. (Kidney Blood Press. Res. 2002) 3 4 23
  5. Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms. (PMID: 12634932) Embark H.M. … Lang F. (Pflugers Arch. 2003) 3 4 23

Products for SGK3 Gene

  • Addgene plasmids for SGK3

Sources for SGK3 Gene

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