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Aliases for STX12 Gene

Aliases for STX12 Gene

  • Syntaxin 12 2 3 5
  • Syntaxin-12 3
  • STX13 3
  • STX14 3

External Ids for STX12 Gene

Previous GeneCards Identifiers for STX12 Gene

  • GC01M027314
  • GC01P027073
  • GC01P027332
  • GC01P027704
  • GC01P027968
  • GC01P028099
  • GC01P026355

Summaries for STX12 Gene

GeneCards Summary for STX12 Gene

STX12 (Syntaxin 12) is a Protein Coding gene. Among its related pathways are Delta508-CFTR traffic / Sorting endosome formation in CF and Delta508-CFTR traffic / ER-to-Golgi in CF. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is STX7.

UniProtKB/Swiss-Prot for STX12 Gene

  • SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity).

Gene Wiki entry for STX12 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX12 Gene

Genomics for STX12 Gene

Regulatory Elements for STX12 Gene

Enhancers for STX12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G027685 1.4 FANTOM5 Ensembl ENCODE 11.2 -85.1 -85081 6.0 TBP SIN3A RAD21 ZNF366 RELB RCOR1 IKZF2 CBFB GATAD2B NR2F2 FAM76A STX12 RNU6-1245P PPP1R8 SCARNA1 TMEM222 ACTG1P20 RNU6-48P ENSG00000270605 PTAFR
GH01G027658 2 FANTOM5 Ensembl ENCODE dbSUPER 7.8 -111.9 -111931 6.3 HDGF PKNOX1 WRNIP1 ARID4B SIN3A ZNF143 ZNF207 FOS KLF13 DEK FGR THEMIS2 STX12 EYA3 GPN2 XKR8 FAM76A SYTL1 WASF2 ENSG00000233975
GH01G027712 0.7 ENCODE 16.8 -59.7 -59723 1.4 STAT1 NFIA TEAD4 USF2 MNT ZNF398 RAD51 NFIC ZNF692 GATA2 STX12 ENSG00000225886 RNU6-1245P PPP1R8 SCARNA1 RNU6-48P ACTG1P20 TMEM222 FAM76A GC01P027694
GH01G028110 2.1 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +339.4 339418 4.4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A YY1 ZNF766 FOS PTAFR EYA3 FGR RNU7-29P RNU6-176P THEMIS2 SCARNA1 RNU6-1245P PPP1R8 SESN2
GH01G028122 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.3 +350.4 350448 1.7 HDAC1 ATF1 PKNOX1 TCF12 ZNF121 ZNF766 EGR1 CREM SMARCA5 MIER1 PTAFR EYA3 DNAJC8 FGR ATPIF1 PHACTR4 SESN2 THEMIS2 SCARNA1 RNU6-1245P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around STX12 on UCSC Golden Path with GeneCards custom track

Promoters for STX12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003775 117 2201 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A ZNF2 YY1

Genomic Location for STX12 Gene

Chromosome:
1
Start:
27,773,183 bp from pter
End:
27,824,452 bp from pter
Size:
51,270 bases
Orientation:
Plus strand

Genomic View for STX12 Gene

Genes around STX12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX12 Gene

Proteins for STX12 Gene

  • Protein details for STX12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y82-STX12_HUMAN
    Recommended name:
    Syntaxin-12
    Protein Accession:
    Q86Y82
    Secondary Accessions:
    • B1AJQ7
    • O95564

    Protein attributes for STX12 Gene

    Size:
    276 amino acids
    Molecular mass:
    31642 Da
    Quaternary structure:
    • Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity). Associates with the BLOC-1 complex. Interacts with BLOC1S6.
    SequenceCaution:
    • Sequence=CAA22911.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STX12 Gene

neXtProt entry for STX12 Gene

Post-translational modifications for STX12 Gene

  • Ubiquitination at Lys44 and Lys58
  • Modification sites at PhosphoSitePlus

Other Protein References for STX12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for STX12 Gene

Domains & Families for STX12 Gene

Gene Families for STX12 Gene

Protein Domains for STX12 Gene

Suggested Antigen Peptide Sequences for STX12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y82

UniProtKB/Swiss-Prot:

STX12_HUMAN :
  • Belongs to the syntaxin family.
Family:
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX12: view

Function for STX12 Gene

Molecular function for STX12 Gene

UniProtKB/Swiss-Prot Function:
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity).

Gene Ontology (GO) - Molecular Function for STX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 12191018
genes like me logo Genes that share ontologies with STX12: view
genes like me logo Genes that share phenotypes with STX12: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STX12 Gene

Localization for STX12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX12 Gene

Endosome membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein. Endomembrane system; Single-pass type IV membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STX12 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
endosome 4
cytosol 3
nucleus 2
plasma membrane 1
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for STX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0000407 pre-autophagosomal structure IMP 24095276
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IEA --
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with STX12: view

Pathways & Interactions for STX12 Gene

genes like me logo Genes that share pathways with STX12: view

Gene Ontology (GO) - Biological Process for STX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IMP 24095276
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IBA --
GO:0006906 vesicle fusion IBA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with STX12: view

No data available for SIGNOR curated interactions for STX12 Gene

Drugs & Compounds for STX12 Gene

No Compound Related Data Available

Transcripts for STX12 Gene

Unigene Clusters for STX12 Gene

Syntaxin 12:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX12 Gene

No ASD Table

Relevant External Links for STX12 Gene

GeneLoc Exon Structure for
STX12
ECgene alternative splicing isoforms for
STX12

Expression for STX12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STX12 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STX12 Gene



Protein tissue co-expression partners for STX12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STX12 Gene:

STX12

SOURCE GeneReport for Unigene cluster for STX12 Gene:

Hs.523855

Evidence on tissue expression from TISSUES for STX12 Gene

  • Nervous system(4.9)
  • Intestine(4.3)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with STX12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STX12 Gene

Orthologs for STX12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STX12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STX12 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia STX12 34
  • 93.67 (n)
cow
(Bos Taurus)
Mammalia STX12 34 35
  • 93.07 (n)
mouse
(Mus musculus)
Mammalia Stx12 34 16 35
  • 91.44 (n)
rat
(Rattus norvegicus)
Mammalia Stx12 34
  • 90.4 (n)
oppossum
(Monodelphis domestica)
Mammalia STX12 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STX12 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves STX12 34 35
  • 78.61 (n)
lizard
(Anolis carolinensis)
Reptilia STX12 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stx12 34
  • 71.87 (n)
Str.17795 34
zebrafish
(Danio rerio)
Actinopterygii stx12 34 35
  • 69.21 (n)
stx12l 35
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Syx7 35
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea syx-7 34 35
  • 48.75 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP12 35 37
  • 20 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pep12 34
  • 46.62 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06777 34
  • 42.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToMany
Species where no ortholog for STX12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX12 Gene

ENSEMBL:
Gene Tree for STX12 (if available)
TreeFam:
Gene Tree for STX12 (if available)

Paralogs for STX12 Gene

Paralogs for STX12 Gene

(2) SIMAP similar genes for STX12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with STX12: view

Variants for STX12 Gene

Sequence variations from dbSNP and Humsavar for STX12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035643 A breast cancer sample
rs1000021133 -- 27,777,212(+) GGGTG(C/T)ATTAT intron-variant
rs1000058975 -- 27,776,086(+) AAGAA(A/C)GGAAA intron-variant
rs1000191154 -- 27,816,034(+) AGGGC(C/T)GGGCA intron-variant
rs1000216018 -- 27,795,394(+) TCCGC(C/T)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for STX12 Gene

Variant ID Type Subtype PubMed ID
esv3585563 CNV loss 21293372
nsv509069 CNV insertion 20534489
nsv947419 CNV duplication 23825009

Variation tolerance for STX12 Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STX12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
STX12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX12 Gene

Disorders for STX12 Gene

Relevant External Links for STX12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STX12

No disorders were found for STX12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX12 Gene

Publications for STX12 Gene

  1. Syntaxin 12, a member of the syntaxin family localized to the endosome. (PMID: 9507000) Tang B.L. … Hong W. (J. Biol. Chem. 1998) 2 3 22 64
  2. The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth. (PMID: 19546860) Ghiani C.A. … Dell'Angelica E.C. (Mol. Psychiatry 2010) 3 4 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for STX12 Gene

Sources for STX12 Gene

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